This book intends to report the new progress of pseudotyped viruses, including the construction of pseudotyped viruses with different strategies or vectors for most important viruses. Especially for emerging viruses, optimization of the condition and parameters for assay development based on the pseudotyped viruses and widely application as surrogate of authentic virus to study the biological functions of virus, detection of neutralizing antibody, screening viral entry inhibiters, and others. It includes most pseudotyped viruses that have the protein of the target virus on the surface of the parent virus with incomplete genome. The book is likely to be of interest to all researchers in the field of virology, vaccine, and anti-viral drug development and evaluation.
Chapter
1. Pseudotyped Viruses.
Chapter
2. Assays based on Pseudotyped Viruses.
Chapter
3. Application of Pseudotyped Viruses.
Chapter
4. Pseudotyped Viruses for Retroviruses.
Chapter
5. Pseudotyped Virus for Papillomavirus.
Chapter
6. Pseudotyped Viruses for Marburgvirus and Ebolavirus.
Chapter
7. Pseudotyped Viruses for Coronaviruses.
Chapter
8. Pseudotyped Viruses for Influenza.
Chapter
9. Pseudotyped Virus Systems for Studies of Henipavirus.
Chapter
10. Pseudotyped Viruses for lyssavirus.
Chapter
11. Pseudotyped Viruses for Enterovirus.
Chapter
12. Pseudotyped Viruses for Orthohantavirus.
Chapter
13. Pseudotyped Viruses for Phlebovirus.
Chapter
14. Pseudotyped Virus for Bandavirus.
Chapter
15. Pseudotyped Viruses for Mammarenavirus.
Chapter
16. Pseudotyped Viruses for the Alphavirus -- Chikungunya Virus.
Chapter
17. Pseudotyped Virus for Flaviviridae.
Chapter
18. Replicating-competent VSV-vectored Pseudotyped Viruses.
Dr. Youchun Wang is now professor and executive director of Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, China. He used to be chief expert on quality control of vaccines and deputy director of the National Institutes for Food and Drug Controls (NIFDC), co-director of WHO Collaborating Center for Standardization and Evaluation of Biologicals, and director of NMPA Key Laboratory for Quality Research and Evaluation of Biological Products. He got his Medical Degree (MD) on Epidemiology from Peking Medical University and PhD on Virology from University College London (UCL). He has mainly done research works on hepatitis virus, HIV, HPV, and emerging viruses such as Ebola virus, SARS-CoV-2, and others. He now focuses on pseudotyped viruses for different viruses, especially for emerging viruses, and has also developed new methods for quality control of viral vaccines and diagnostics. He obtained several grants from WellcomeTrust in UK, Ministry of Science and Technology, National Foundation of Natural Science, and others in China. He has published more than 320 academic papers, 150 of which were published in Cell, Nature, Science, Cell Host & Microbe, and other SCI journals as the first or corresponding author. His book was also published by Springer Nature before. He has held several positions in academic associations, such as former Chairman of Medical Virology and Vice Chairman of Medical Microbiology and Immunology of Chinese Medical Association, former Vice Chairman of Chinese Laboratory Animal Association, former Chairman of Beijing Medical Virology, and Chairman of the vaccine committee of Chinese Pharmacopoeia.
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