Preface |
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xi | |
Acknowledgments |
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xiii | |
Contributors |
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xvii | |
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SECTION 1 Neurologic, Sedation, and Analgesia |
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1 Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest: The HACA Trial |
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3 | (6) |
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2 Decompressive Craniectomy in Diffuse Traumatic Brain Injury: The DECRA Trial |
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9 | (6) |
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3 Daily Interruption of Sedative Infusions in Critically 111 Patients Undergoing Mechanical Ventilation |
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15 | (6) |
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4 A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus |
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21 | (6) |
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5 Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol for Mechanically Ventilated Patients in Intensive Care: A Randomized Controlled Trial (The ABC Trial) |
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27 | (6) |
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6 A Protocol of No Sedation for Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Trial |
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33 | (6) |
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7 Intracranial Pressure Monitoring in Severe Traumatic Brain Injury |
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39 | (8) |
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SECTION 2 Cardiovascular, Resuscitation, Shock |
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8 Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock: The EGDT Trial |
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47 | (8) |
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9 Lactate Clearance versus Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy |
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55 | (6) |
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10 Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis: The PROWESS Study |
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61 | (7) |
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11 Saline versus Albumin for Resuscitation of Critically Ill Adults: The SAFE Study |
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68 | (6) |
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12 The Use of the Pulmonary Artery Catheter in Critical Care: The PAC-Man Trial |
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74 | (5) |
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13 Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock: The VASST |
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79 | (6) |
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14 Comparison of Dopamine and Norepinephrine in the Treatment of Shock: The SOAP II Trial |
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85 | (5) |
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15 CPR with Chest Compression Alone or with Rescue Breathing |
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90 | (5) |
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Christopher "Kit" Tainter |
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16 Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device |
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95 | (7) |
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17 Intraaortic Balloon Support in Myocardial Infarction Complicated by Cardiogenic Shock |
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102 | (6) |
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18 Angioplasty versus Fibrinolytics in Acute ST-Elevation Myocardial Infarction: The DANAMI-2 Trial |
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108 | (9) |
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SECTION 3 Pulmonary, ARDS |
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19 The Acute Respiratory Distress Syndrome Network: Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome |
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117 | (6) |
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20 Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome |
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123 | (6) |
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21 Prone Positioning in Severe Acute Respiratory Distress Syndrome: The PROSEVA Trial |
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129 | (6) |
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22 Efficacy and Economic Assessment of Conventional Ventilatory Support versus Extracorporeal Membrane Oxygenation for Severe Adult Respiratory Failure (CESAR): A Multicentre Randomized Controlled Trial |
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135 | (6) |
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23 Comparison of Two Fluid-Management Strategies in Acute Lung Injury: The FACTT Trial |
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141 | (6) |
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24 Positive End-Expiratory Pressure Setting in Adults with ALI and ARDS: The ExPress Trial |
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147 | (5) |
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25 Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome |
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152 | (5) |
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26 Effect of Early versus Late Tracheostomy Placement on Survival in Patients Receiving Mechanical Ventilation: The TracMan Trial |
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157 | (6) |
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27 Using Esophageal Pressures to Improve Oxygenation and Compliance in Acute Lung Injury |
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163 | (7) |
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28 A Comparison of Four Methods of Weaning Patients from Mechanical Ventilation |
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170 | (5) |
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29 Noninvasive Ventilation for Acute COPD Exacerbations |
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175 | (5) |
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30 High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome |
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180 | (7) |
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SECTION 4 Gastrointestinal/Nutrition |
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31 Risk Factors for Gastrointestinal Bleeding in Critically Ill Patients |
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187 | (5) |
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32 Early versus Late Parenteral Nutrition in the ICU: The EPaNIC (Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients) Trial |
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192 | (6) |
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33 Initial Trophic versus Full Enteral Feeding in Patients with Acute Lung Injury: The EDEN Randomized Trial |
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198 | (6) |
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34 Early versus On-Demand Nasoenteric Tube Feeding in Acute Pancreatitis |
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204 | (5) |
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35 Glutamine and Antioxidants in Critically Ill Patients: The REDOXS Trial |
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209 | (6) |
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36 Low-Dose Dopamine in Patients with Early Renal Dysfunction |
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215 | (6) |
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37 Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury |
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221 | (6) |
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38 Continuous Venovenous Hemodiafiltration versus Intermittent Hemodialysis for Acute Renal Failure in Patients with Multiple-Organ Dysfunction Syndrome: A Multicenter Randomized Trial |
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227 | (8) |
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39 A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care: The Transfusion Requirements in Critical Care (TRICC) Trial |
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235 | (6) |
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40 Reducing Mortality Among Bleeding Trauma Patients with Tranexamic Acid: The CRASH-2 (Clinical Randomization of an Antifibrinolytic in Significant Hemorrhage-2) Randomized Controlled Trial |
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241 | (7) |
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41 Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 versus a 1:1:2 Ration and Mortality in Patients with Severe Trauma: The PROPPR Randomized Clinical Trial |
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248 | (9) |
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42 Comparison of 8 versus 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults: A Randomized Trial |
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257 | (6) |
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43 Bronchoscopy with Bronchoalveolar Lavage versus Endotracheal Aspiration for the Diagnosis of Ventilator-Associated Pneumonia |
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263 | (6) |
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44 Randomized Trial of Combination versus Monotherapy for the Empiric Treatment of Suspected Ventilator-Associated Pneumonia |
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269 | (7) |
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45 Use of Procalcitonin to Reduce Patients' Exposure to Antibiotics in Intensive Care Units (PRORATA Trial): A Multicenter Randomized Controlled Trial |
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276 | (6) |
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46 Nasopharyngeal and Oropharyngeal Decontamination to Prevent Nosocomial Infection in Cardiac Surgery Patients |
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282 | (5) |
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47 An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU: The Keystone ICU Project |
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287 | (8) |
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48 The Normoglycemia in Intensive Care Evaluation: Survival Using Glucose Algorithm Regulation (NICE-SUGAR) Trial |
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295 | (6) |
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49 Hydrocortisone Therapy for Patients with Septic Shock: The CORTICUS Trial |
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301 | (8) |
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SECTION 9 Musculoskeletal |
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50 Daily Interruption of Sedation with Physical and Occupational Therapy in Mechanically Ventilated Patients |
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309 | (8) |
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Index |
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317 | |