Preface |
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xv | |
Authors |
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xvii | |
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1 | (6) |
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1.1 Effectiveness of acute pain management |
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1 | (2) |
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1.1.1 Assessment of effectiveness |
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1 | (1) |
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1.1.2 Variability in effectiveness |
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2 | (1) |
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1.2 Adverse effects of undertreated severe acute pain |
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3 | (1) |
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1.3 Acute pain management and patient outcomes |
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3 | (4) |
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1.3.1 Short-term outcomes |
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4 | (1) |
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4 | (1) |
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5 | (2) |
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Chapter 2 Delivery of effective acute pain management |
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7 | (8) |
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7 | (2) |
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7 | (1) |
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7 | (1) |
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8 | (1) |
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9 | (1) |
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9 | (1) |
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2.2 Guidelines and protocols |
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9 | (1) |
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10 | (5) |
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12 | (1) |
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Appendix 2.1 Examples of patient information available on the Internet |
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13 | (1) |
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Appendix 2.2 Example of an epidural analgesia information card given to patients on discharge from hospital |
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13 | (2) |
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Chapter 3 Assessment and monitoring |
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15 | (14) |
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15 | (1) |
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3.2 Assessment of pain and pain relief |
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16 | (6) |
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17 | (1) |
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17 | (1) |
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3.2.2.1 Unidimensional measures |
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18 | (2) |
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3.2.2.2 Assessment of neuropathic pain |
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20 | (1) |
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3.2.2.3 Other measures of pain |
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20 | (1) |
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3.2.2.4 Assessment of function |
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20 | (1) |
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21 | (1) |
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3.2.2.6 Patient satisfaction |
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21 | (1) |
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3.2.3 Effect of psychological factors on acute pain |
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21 | (1) |
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3.3 Assessment of adverse effects |
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22 | (7) |
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3.3.1 Opioid-induced ventilatory impairment |
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22 | (1) |
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3.3.1.1 Measurement of sedation score and respiratory rate |
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23 | (1) |
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3.3.1.2 Measurement of oxygen and carbon dioxide levels |
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23 | (2) |
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3.3.1.3 When and whom to monitor for OIVI |
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25 | (1) |
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3.3.2 Motor and sensory function, back pain |
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26 | (1) |
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26 | (1) |
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27 | (2) |
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Chapter 4 Pharmacology of opioids |
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29 | (24) |
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30 | (1) |
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30 | (1) |
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30 | (1) |
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31 | (1) |
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31 | (8) |
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31 | (2) |
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4.2.2 Effect on the respiratory system |
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33 | (1) |
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4.2.2.1 Depression of ventilation |
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33 | (1) |
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4.2.2.2 Cough suppression |
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34 | (1) |
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4.2.3 Nausea and vomiting |
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34 | (1) |
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35 | (1) |
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4.2.4 Other central nervous system effects |
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36 | (1) |
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36 | (1) |
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4.2.4.2 Cognitive impairment |
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36 | (1) |
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4.2.5 Gastrointestinal and genitourinary systems effects |
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36 | (1) |
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4.2.6 Cardiovascular effects |
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37 | (1) |
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37 | (1) |
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38 | (1) |
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4.2.9 Tolerance, opioid-induced hyperalgesia, physical dependence |
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38 | (1) |
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4.3 Predictors of opioid dose |
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39 | (1) |
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4.4 Titration of opioid dose |
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40 | (1) |
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4.4.1 Dose and dose interval |
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40 | (1) |
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4.4.2 Titration to pain relief, sedation, and other side effects |
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40 | (1) |
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4.5 Commonly used opioid agonists |
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41 | (5) |
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41 | (1) |
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41 | (1) |
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4.5.3 Fentanyl and its analogues |
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42 | (1) |
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42 | (1) |
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42 | (1) |
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43 | (1) |
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43 | (1) |
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44 | (1) |
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44 | (1) |
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45 | (1) |
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45 | (1) |
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46 | (1) |
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46 | (1) |
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46 | (1) |
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47 | (1) |
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47 | (1) |
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47 | (6) |
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47 | (1) |
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48 | (1) |
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48 | (1) |
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49 | (4) |
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Chapter 5 Pharmacology of local anesthetics |
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53 | (12) |
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53 | (2) |
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5.2 Efficacy of local anesthetics |
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55 | (1) |
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5.3 Adverse effects of local anesthetics and their management |
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56 | (3) |
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5.3.1 Local tissue toxicity |
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56 | (1) |
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57 | (1) |
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5.3.2.1 Central nervous system toxicity |
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58 | (1) |
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5.3.2.2 Cardiovascular toxicity |
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58 | (1) |
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5.3.3 Management of systemic toxicity |
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59 | (1) |
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5.4 Commonly used local anesthetic drugs |
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59 | (6) |
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59 | (1) |
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60 | (1) |
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60 | (1) |
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60 | (1) |
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61 | (1) |
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61 | (1) |
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62 | (1) |
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62 | (1) |
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62 | (1) |
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62 | (1) |
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5.4.2.7 Dibucaine (cinchocaine) |
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62 | (1) |
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62 | (1) |
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63 | (2) |
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Chapter 6 Nonopioid and adjuvant analgesic agents |
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65 | (26) |
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65 | (2) |
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6.1.1 Mechanism of action |
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65 | (1) |
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6.1.2 Clinical efficacy and use |
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66 | (1) |
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66 | (1) |
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6.2 Nonselective nonsteroidal antiinflammatory drugs |
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67 | (4) |
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6.2.1 Mechanism of action |
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67 | (1) |
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6.2.2 Clinical efficacy and use |
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68 | (1) |
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68 | (1) |
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69 | (1) |
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69 | (1) |
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6.2.3.3 Platelet function |
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70 | (1) |
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70 | (1) |
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70 | (1) |
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6.2.4 Precautions and contraindications |
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70 | (1) |
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6.3 COX-2 selective inhibitors (coxibs) |
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71 | (3) |
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6.3.1 Mechanism of action |
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72 | (1) |
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6.3.2 Clinical efficacy and use |
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72 | (1) |
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72 | (1) |
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6.3.3.1 Gastrointestinal, respiratory, and renal |
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72 | (1) |
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72 | (2) |
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6.4 NMDA receptor antagonists |
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74 | (3) |
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74 | (1) |
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6.4.1.1 Clinical efficacy and use |
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75 | (1) |
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76 | (1) |
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77 | (1) |
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77 | (1) |
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6.5 Alpha-2-adrenergic agonist drugs |
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77 | (2) |
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78 | (1) |
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78 | (1) |
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79 | (1) |
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6.6.1 Tricyclic antidepressant drugs |
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79 | (1) |
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79 | (1) |
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79 | (1) |
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6.6.2 Serotonin norepinephrine reuptake inhibitors |
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80 | (1) |
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80 | (3) |
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81 | (1) |
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6.7.1.1 Mechanism of action |
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81 | (1) |
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81 | (1) |
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6.7.1.3 Treatment of neuropathic pain |
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81 | (1) |
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6.7.1.4 Use in the perioperative setting |
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82 | (1) |
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82 | (1) |
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82 | (1) |
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83 | (1) |
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6.8 Membrane stabilizing drugs |
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83 | (1) |
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83 | (1) |
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83 | (1) |
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84 | (1) |
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84 | (1) |
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84 | (3) |
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85 | (1) |
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6.9.1.1 Clinical efficacy and use |
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85 | (1) |
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85 | (1) |
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86 | (1) |
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87 | (1) |
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87 | (4) |
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88 | (3) |
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Chapter 7 Systemic routes of opioid administration |
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91 | (24) |
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93 | (4) |
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7.1.1 Immediate-release and slow-release formulations |
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93 | (1) |
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7.1.2 Titration of oral immediate-release opioids |
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94 | (1) |
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94 | (1) |
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94 | (3) |
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97 | (1) |
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7.1.2.4 Selection of subsequent doses |
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97 | (1) |
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7.2 Subcutaneous and intramuscular |
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97 | (3) |
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7.2.1 Titration of intermittent SC or IM opioids |
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99 | (1) |
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99 | (1) |
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99 | (1) |
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7.2.1.3 Monitoring and selection of subsequent doses |
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100 | (1) |
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100 | (5) |
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7.3.1 Titration of intermittent IV opioids |
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102 | (1) |
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103 | (1) |
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103 | (1) |
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7.3.1.3 Monitoring and selection of subsequent doses |
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103 | (1) |
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7.3.1.4 Subsequent analgesic regimens |
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103 | (1) |
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7.3.2 Titration of continuous IV opioid in fusions |
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103 | (1) |
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103 | (2) |
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105 | (1) |
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7.3.2.3 Alterations of infusion rates |
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105 | (1) |
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105 | (1) |
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105 | (2) |
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106 | (1) |
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7.5.2 Buprenorphine patches |
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107 | (1) |
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107 | (8) |
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107 | (1) |
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7.6.2 Oral transmucosal (sublingual and buccal) |
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108 | (1) |
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109 | (1) |
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109 | (2) |
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Appendix 7.1 Example of a "standard order" form for intermittent PRN oral and SC opioid regimens |
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111 | (4) |
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Chapter 8 Patient-controlled analgesia |
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115 | (20) |
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115 | (2) |
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8.1.1 Electronic PCA pumps |
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115 | (2) |
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117 | (1) |
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117 | (1) |
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8.1.2 Disposable PCA devices |
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117 | (1) |
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8.2 Analgesic drugs used with PCA |
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117 | (1) |
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117 | (1) |
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118 | (1) |
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8.3 The PCA "prescription" |
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118 | (4) |
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118 | (1) |
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119 | (1) |
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120 | (1) |
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120 | (1) |
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8.3.5 Continuous (background) infusion |
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120 | (1) |
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121 | (1) |
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121 | (1) |
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8.4 Requirements for the safe management of PCA |
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122 | (2) |
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8.4.1 Suitable patient and patient education |
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122 | (1) |
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8.4.2 Nursing and medical staff education |
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122 | (1) |
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8.4.3 Standard orders and nursing procedure protocols |
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123 | (1) |
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123 | (1) |
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8.4.3.2 Nursing procedure protocols |
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124 | (1) |
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8.5 Management of inadequate analgesia |
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124 | (2) |
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8.5.1 Inadequate loading dose |
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124 | (1) |
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8.5.2 Inadequate bolus dose |
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124 | (1) |
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8.5.2.1 "Successful" and "unsuccessful" demands |
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125 | (1) |
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125 | (1) |
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126 | (3) |
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8.6.1 Side effects related to the opioid |
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126 | (1) |
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8.6.1.1 Opioid-induced ventilatory impairment |
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126 | (1) |
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126 | (1) |
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8.6.1.3 Nausea and vomiting |
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126 | (2) |
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8.6.1.4 Masking of postoperative or postinjury complications |
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128 | (1) |
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8.6.2 Complications related to equipment or human factors |
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128 | (1) |
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8.6.2.1 Equipment malfunction |
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128 | (1) |
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8.6.2.2 Operator-related errors |
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128 | (1) |
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8.6.2.3 Patient-related errors |
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128 | (1) |
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8.7 "Step-down" analgesia |
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129 | (1) |
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129 | (1) |
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8.8 Alternative systemic routes of PCA administration |
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129 | (6) |
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129 | (1) |
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130 | (1) |
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130 | (1) |
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8.8.4 Epidural and other regional PCA |
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130 | (1) |
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131 | (1) |
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Appendix 8.1 Example of a "standard order" form for PCA |
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132 | (3) |
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Chapter 9 Epidural and intrathecal analgesia |
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135 | (34) |
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136 | (1) |
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137 | (2) |
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9.2.1 Untrained nursing and medical staff |
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137 | (1) |
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137 | (1) |
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9.2.3 Contraindications to the placement of an epidural needle or catheter |
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138 | (1) |
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9.2.3.1 Local and systemic infection |
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138 | (1) |
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9.2.3.2 Central nervous system disease |
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138 | (1) |
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138 | (1) |
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9.2.3.4 Coagulation disorders or concurrent treatment with anticoagulant or antiplatelet medications |
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138 | (1) |
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9.2.3.5 Presence of a dural puncture |
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139 | (1) |
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9.3 Drugs used with epidural analgesia |
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139 | (9) |
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9.3.1 Local anesthetic drugs |
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139 | (1) |
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139 | (1) |
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139 | (1) |
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140 | (2) |
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142 | (1) |
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142 | (1) |
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143 | (1) |
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144 | (2) |
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9.3.3 Combinations of local anesthetics and opioids |
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146 | (1) |
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146 | (1) |
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9.3.4 Alpha-2 receptor agonists |
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147 | (1) |
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147 | (1) |
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147 | (1) |
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9.3.5 Other adjuvant drugs |
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147 | (1) |
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9.4 Requirements for the safe management of epidural analgesia |
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148 | (2) |
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9.4.1 Standard orders and nursing procedure protocols |
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148 | (1) |
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148 | (2) |
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9.4.1.2 Nursing procedure protocols |
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150 | (1) |
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9.5 Patient-controlled epidural analgesia |
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150 | (1) |
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9.6 Management of inadequate analgesia |
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150 | (2) |
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9.7 "Step-down" analgesia |
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152 | (1) |
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9.8 Complications and side effects of epidural analgesia |
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152 | (7) |
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9.8.1 Postdural puncture headache |
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152 | (3) |
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9.8.2 Nerve or spinal cord injury |
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155 | (1) |
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155 | (1) |
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9.8.3.1 Diagnosis and treatment |
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155 | (1) |
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156 | (1) |
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156 | (1) |
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9.8.4 Epidural space infection |
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156 | (1) |
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157 | (1) |
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157 | (1) |
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157 | (1) |
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158 | (1) |
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9.8.6 Problems related to equipment |
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158 | (1) |
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9.8.6.1 Epidural catheter or filter |
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158 | (1) |
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159 | (1) |
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9.8.7 Side effects related to drugs |
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159 | (1) |
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9.9 Concurrent antithrombotic or antiplatelet therapy |
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159 | (3) |
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160 | (1) |
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160 | (1) |
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9.9.2.1 Standard unfractionated heparin (intravenous) |
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160 | (1) |
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9.9.2.2 Standard unfractionated heparin (subcutaneous) |
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160 | (1) |
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9.9.2.3 Low molecular weight heparin |
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161 | (1) |
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9.9.3 Newer anticoagulants |
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161 | (1) |
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161 | (1) |
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162 | (1) |
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162 | (1) |
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9.9.4 Nonsteroidal antiinflammatory drugs and other antiplatelet agents |
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162 | (1) |
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9.9.4.1 Nonsteroidal antiinflammatory drugs |
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162 | (1) |
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9.9.4.2 Other antiplatelet drugs |
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162 | (1) |
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9.9.5 Thrombolytic and fibrinolytic therapy |
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162 | (1) |
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9.10 Intrathecal analgesia |
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162 | (7) |
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9.10.1 Drugs used for intrathecal analgesia |
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163 | (1) |
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163 | (1) |
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9.10.3 Possible side effects |
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163 | (1) |
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9.10.4 Management of inadequate analgesia |
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164 | (1) |
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164 | (2) |
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Appendix 9.1 Example of a "standard order" form for epidural and intrathecal analgesia |
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166 | (3) |
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Chapter 10 Other regional and local analgesia |
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169 | (14) |
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10.1 Continuous peripheral nerve blockade |
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169 | (7) |
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170 | (1) |
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170 | (1) |
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171 | (1) |
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171 | (1) |
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10.1.5 Drugs used with CPNB analgesia |
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171 | (1) |
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10.1.5.1 Local anesthetics |
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171 | (1) |
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172 | (1) |
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10.1.5.3 Clonidine and epinephrine |
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172 | (1) |
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172 | (1) |
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10.1.6 Requirements for the safe management of CPNB |
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172 | (1) |
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172 | (1) |
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173 | (1) |
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10.1.6.3 Monitoring and documentation requirements |
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173 | (1) |
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173 | (1) |
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10.1.6.5 Nursing procedure protocols |
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174 | (1) |
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10.1.7 Patient-controlled CPNB |
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174 | (1) |
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174 | (1) |
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10.1.9 Complications of CPNB |
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175 | (1) |
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10.1.9.1 Complications arising from the drugs used |
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175 | (1) |
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10.1.9.2 Neurological injury |
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175 | (1) |
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10.1.9.3 Complications arising from infection |
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175 | (1) |
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10.1.9.4 Complications arising from anticoagulation |
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175 | (1) |
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10.1.9.5 Other complications |
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176 | (1) |
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10.2 Intraarticular analgesia |
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176 | (1) |
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176 | (1) |
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176 | (7) |
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177 | (2) |
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Appendix 10.1 Example of a "standard order" form for continuous regional analgesia |
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179 | (4) |
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Chapter 11 Nonpharmacological therapies |
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183 | (4) |
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11.1 Psychological interventions |
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183 | (1) |
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183 | (1) |
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11.1.2 Relaxation and attentional strategies |
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183 | (1) |
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11.1.3 Cognitive behavioral interventions |
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184 | (1) |
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184 | (1) |
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11.2 Transcutaneous electrical nerve stimulation |
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184 | (1) |
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184 | (1) |
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11.4 Physical interventions |
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185 | (2) |
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185 | (2) |
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Chapter 12 Acute neuropathic and persistent postacute pain |
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187 | (14) |
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12.1 Pathophysiology of neuropathic pain |
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187 | (2) |
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12.2 Clinical features and diagnosis of neuropathic pain |
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189 | (1) |
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12.3 Acute neuropathic pain syndromes |
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189 | (2) |
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12.3.1 Postamputation pain syndrome |
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189 | (2) |
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12.3.2 Complex regional pain syndrome |
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191 | (1) |
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12.4 Treatment of acute neuropathic pain |
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191 | (4) |
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12.4.1 Pharmacological treatments |
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192 | (1) |
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12.4.1.1 Specific treatment of acute neuropathic pain states |
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192 | (1) |
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12.4.1.2 Treatment approaches to neuropathic pain in general |
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193 | (1) |
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12.4.1.3 Topical treatments |
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193 | (1) |
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12.4.2 Regional neural blockade |
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194 | (1) |
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12.4.3 Transcutaneous electrical nerve stimulation |
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194 | (1) |
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12.4.4 Treatment of postamputation pain syndromes |
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194 | (1) |
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12.5 Progression of acute to persistent pain |
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195 | (1) |
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12.6 Preventive analgesia |
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196 | (5) |
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197 | (4) |
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Chapter 13 Nonsurgical acute pain |
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201 | (8) |
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201 | (2) |
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201 | (1) |
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13.1.1.1 Initial pain relief |
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201 | (1) |
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13.1.1.2 "Background" analgesia |
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202 | (1) |
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13.1.1.3 Procedural analgesia |
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202 | (1) |
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13.1.2 Nonpharmacological |
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203 | (1) |
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203 | (1) |
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13.2.1 Management of pain associated with acute spinal cord injury |
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204 | (1) |
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13.3 Other specific conditions |
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204 | (5) |
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204 | (1) |
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13.3.1.1 Renal and biliary colic |
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204 | (1) |
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204 | (1) |
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204 | (1) |
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13.3.3 Sickle cell disease and hemophilia |
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|
205 | (1) |
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13.3.3.1 Sickle cell disease |
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206 | (1) |
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|
206 | (1) |
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13.3.4 Neurological disease |
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|
206 | (1) |
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207 | (1) |
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13.3.4.2 Guillain-Barre syndrome |
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|
207 | (1) |
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13.3.4.3 Multiple sclerosis |
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|
207 | (1) |
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|
208 | (1) |
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Chapter 14 More complex patients |
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|
209 | (30) |
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209 | (10) |
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14.1.1 Assessment of pain |
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|
210 | (1) |
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14.1.1.1 Perception of pain |
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|
210 | (1) |
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14.1.1.2 Reporting of pain |
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|
210 | (1) |
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14.1.1.3 Cognitive impairment |
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|
210 | (1) |
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14.1.1.4 Measurement of pain |
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|
211 | (1) |
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14.1.2 Changes in pharmacokinetics and pharmacodynamics |
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|
212 | (1) |
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14.1.2.1 Pharmacokinetics |
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|
212 | (1) |
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14.1.2.2 Pharmacodynamics |
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|
212 | (1) |
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|
212 | (1) |
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14.1.3.1 Opioids and tramadol |
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|
212 | (3) |
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14.1.3.2 Other analgesic and adjuvant drugs |
|
|
215 | (1) |
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14.1.4 Specific analgesic techniques |
|
|
215 | (1) |
|
14.1.4.1 Patient-controlled analgesia |
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|
215 | (3) |
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14.1.4.2 Epidural and intrathecal analgesia |
|
|
218 | (1) |
|
14.1.4.3 Other regional analgesia |
|
|
218 | (1) |
|
14.2 Opioid-tolerant patients |
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|
219 | (8) |
|
14.2.1 Opioid tolerance, hyperalgesia, dependence, and addiction |
|
|
219 | (1) |
|
14.2.1.1 Tolerance and opioid-induced hyperalgesia |
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|
219 | (1) |
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14.2.1.2 Physical dependence |
|
|
220 | (1) |
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|
221 | (1) |
|
14.2.3 Review prior to commencement of pain relief |
|
|
221 | (1) |
|
14.2.4 Effective analgesia |
|
|
222 | (1) |
|
14.2.4.1 Opioids and tramadol |
|
|
222 | (1) |
|
14.2.4.2 Attenuation of tolerance and hyperalgesia |
|
|
223 | (1) |
|
14.2.4.3 Other analgesic agents and techniques |
|
|
224 | (1) |
|
14.2.5 Specific analgesic techniques |
|
|
224 | (1) |
|
14.2.5.1 Patient-controlled analgesia |
|
|
224 | (2) |
|
14.2.5.2 Regional analgesia |
|
|
226 | (1) |
|
14.2.6 Prevention of withdrawal |
|
|
226 | (1) |
|
14.2.7 Involvement of multidisciplinary and other specialist teams |
|
|
226 | (1) |
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14.2.8 Discharge analgesia |
|
|
226 | (1) |
|
14.3 Patients with an addiction disorder |
|
|
227 | (4) |
|
14.3.1 Use of opioids in patients with a past addiction disorder |
|
|
228 | (1) |
|
14.3.2 Withdrawal from other drugs |
|
|
228 | (1) |
|
14.3.3 Management of aberrant drug-taking behaviors |
|
|
229 | (1) |
|
14.3.4 Drugs used in the treatment of opioid addiction |
|
|
229 | (1) |
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|
229 | (1) |
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|
230 | (1) |
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|
230 | (1) |
|
14.3.5 Discharge analgesia |
|
|
231 | (1) |
|
14.4 Patients with obstructive sleep apnea |
|
|
231 | (1) |
|
14.4.1 Opioid analgesia and patients with OSA |
|
|
231 | (1) |
|
14.5 Pregnant or lactating patients |
|
|
232 | (4) |
|
14.5.1 Analgesic use during pregnancy |
|
|
232 | (1) |
|
14.5.2 Analgesic use during lactation |
|
|
233 | (3) |
|
14.6 Patients with renal or hepatic impairment |
|
|
236 | (3) |
|
|
236 | (3) |
|
Chapter 15 Opioid analgesia after discharge from hospital |
|
|
239 | (10) |
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|
239 | (3) |
|
15.1.1 Adverse effects of opioids |
|
|
239 | (1) |
|
15.1.1.1 Opioid-related side effects |
|
|
239 | (1) |
|
15.1.1.2 Inadvertent initiation of long-term use |
|
|
240 | (1) |
|
15.1.1.3 Effect on driving ability |
|
|
240 | (1) |
|
15.1.2 Risk of diversion and harm |
|
|
241 | (1) |
|
15.1.2.1 Identification of the "at risk" patient |
|
|
241 | (1) |
|
15.2 Choice of discharge opioid regimen |
|
|
242 | (2) |
|
|
242 | (1) |
|
15.2.1.1 Opioid-tolerant patients |
|
|
243 | (1) |
|
15.2.2 Relevant legislation and regulations |
|
|
243 | (1) |
|
15.2.3 Duration of treatment |
|
|
243 | (1) |
|
15.3 Information for patients and treating doctors |
|
|
244 | (5) |
|
15.3.1 Patient information |
|
|
244 | (1) |
|
15.3.2 Information for the treating doctors |
|
|
245 | (1) |
|
|
245 | (4) |
|
Chapter 16 Self-assessment questions |
|
|
249 | (11) |
Answers |
|
260 | (1) |
Index |
|
261 | |