This new edition elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills.
Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin. The first half of the book is organized anatomically: tumors of the brain, spinal cord, leptomeninges, optic pathway, ocular choroid, and skull base. The second half covers primary CNS lymphoma, rare CNS tumors, metastatic brain disease, vascular conditions of the CNS, radiation-associated complications, and radiation modalities. This new edition is updated throughout and includes several new chapters, including: palliative radiation therapy for leptomeningeal disease, preoperative treatment for brain metastases, advanced neuroimaging for brain tumors, and MR-LINAC for brain tumors. Each chapter provides guidance on treatment field design, target delineation, and normal critical structure tolerance constraints in the context of the disease being treated. Learning objectives, case studies, and Maintenance of Certification Self-Assessment Continuing Medical Education-style questions and answers are incorporated throughout the book.
This is an ideal guide for radiation oncologists, residents, and fellows, but medical students may also find value in the text.
Section I: Brain Tumors: Benign.- Meningioma.- Pituitary Adenoma.-
Craniopharyngioma.- Vestibular Schwannoma.- Section II: Brain Tumors:
Malignant Gliomas.- Low-Grade Glioma.- High-Grade Glioma.- Section III:
Spine: Benign.- Schwannomas and Neurofibromas.- Spinal Meningioma.- Section
IV: Spine: Malignant.- Astrocytic Tumors of the Spinal Cord.- Spinal Cord
Ependymoma.- Section V: Spine: Metastatic.- Metastatic Epidural Spinal Cord
Compression: Conventional Radiotherapy.- Vertebreal Body Metastases.- Section
VI: Leptomeningeal Disease.- Evaluation and Workup of Leptomeningeal
Disease.- Palliative Radiation Therapy for Leptomeningeal Disease.- Section
VII: Optic Pathway Tumors.- Optic Pathway Gliomas.- Optic Nerve Sheath
Meningioma.- Section VIII: Ocular Oncology.- Uveal Melanoma.- Section IX:
Skull Base Tumor.- Skull Base Tumors.- Section X: Primary Central Nervous
System Lymphoma.- Primary Central Nervous System Lymphoma.- Section XI: Rare
Tumors.- Choroid Plexus Tumors.- Hemangiopericytoma.- Stereotactic
Radiosurgery for Hemangioblastomas.- NF2-Related Tumors and Malignant
Peripheral Nerve Sheath Tumors.- Germ Cell Tumors.- Pineal Region Tumors.-
Glomus Tumors.- Adult Medulloblastoma.- Intracranial Ependyoma.- Central
Neurocytoma.- Section XII: Metastatic Brain Disease.- Neurosurgical
Management of Single Brain Metastasis.- Multiple Brain Metastasis.-
Preoperative Treatment for Brain Metastases.- Postoperative Treatment for
Brain Metastasis.- Section XIII: Vascular Conditions of the CNS.- Vascular
Malformation.- Trigeminal Neuralgia.- Section XIV: Radiation Associated
Complications.- Brain Radionecrosis.- Spinal Cord Tolerance and Risk of
Radiation Myelopathy.- Radiation Optic Neuropathy.- Hypopituitarism.-
Neurocognitive Changes.- Cranial Nerve Palsies, Vascular Damage, and
Brainstem Injury.- Section XV: Radiation Modalities Applied to CNS Tumors.-
Advanced Neuroimaging for Brain Tumors.- 3-D Conformal Therapy and
Intensity-Modulated Radiation Therapy/Volumetric Modulated ARC Therapy.-
Linac-Based Stereotactic Radiosurgery and Hypofractionated Stereotactic
Radiotherapy.- Gamma Knife® Stereotactic Radiosurgery and Hypo-Fractionated
Stereotactic Radiotherapy.- Spinal Stereotactic Body Radiotherapy.- Proton
Beam Therapy (for CNS Tumors).- MR-LINAC for Brain Tumors.- Brachytherapy.-
Novel Systemic Therapies for Brain Metastases.
Eric L. Chang, MD, FASTRO, FACR, FARS
Professor and Chair
Department of Radiation Oncology
Keck School of Medicine of USC
Norris Cancer Hospital
Los Angeles, CA, USA
Adjunct Professor of Radiation Oncology
UT MD Anderson Cancer Center
Houston, TX, USA
Paul D. Brown, MD
Professor
Department of Radiation Oncology
Mayo Clinic
Rochester, MN, USA
Simon S. Lo, MB, ChB, FACR, FASTRO
Professor and Vice Chair for Strategic Planning
Director of Stereotactic Body Radiation Therapy
Professor of Neurological Surgery
Department of Radiation Oncology
University of Washington School of Medicine
Seattle, WA, USA
Arjun Sahgal, MD
Professor of Radiation Oncology, University of Toronto
Chief, Department of Radiation Oncology
Senior Scientist, Sunnybrook Research Institute
Sunnybrook Odette Cancer Centre
Toronto, ON, Canada
John H. Suh, MD, FASTRO
Professor and Chair
Department of Radiation Oncology
Cleveland Clinic Taussig Cancer Institute
Rose Ella Burkhardt Brain Tumor and Neuro-oncology Center
Cleveland, OH, USA
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