Advances in Immunology, Volume 149, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.
- Presents current developments and comprehensive reviews in immunology
- Provides the latest in a longstanding, respected serial on the subject matter
- Focuses on recent advances in the advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodies
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1 Thymoproteasome Optimizes Positive Selection Of Cd8+ T Cells Without Contribution Of Negative Selection |
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1 | (24) |
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2 | (1) |
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2 Overview of proteasomes |
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3 | (2) |
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3 Thymoproteasome for CD8 T cell generation |
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5 | (14) |
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19 | (1) |
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19 | (1) |
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19 | (6) |
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2 Modeling A Complex Disease: Multiple Sclerosis---Update 2020 |
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25 | (10) |
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1 Gray matter demyelination in multiple sclerosis |
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25 | (2) |
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2 The influence of the microbiome on CNS autoimmunity |
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27 | (2) |
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3 Identifying the pathogenic factor driving MS and EAE |
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29 | (2) |
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4 Perspective and conclusion |
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31 | (1) |
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31 | (4) |
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3 The Transcription Factors Gfi1 And Gfi1B As Modulators Of The Innate And Acquired Immune Response |
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35 | (60) |
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1 The SNAG domain transcription factors GFI1 and GFI1B |
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37 | (16) |
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2 GFI1 and GFI1B in thymic pre-T cell differentiation |
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53 | (7) |
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3 GFI1 in the activation and polarization of mature T cells and innate lymphoid cells |
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60 | (9) |
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4 B cell commitment, differentiation and activation |
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69 | (3) |
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5 GFI1 in innate immunity and the inflammatory response |
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72 | (8) |
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80 | (2) |
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82 | (1) |
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82 | (13) |
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4 Panorama Of Stepwise Involvement Of The Igh 3' Regulatory Region In Murine B Cells |
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95 | |
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1 Structure of the IgH 3' boundary and associated regulatory region |
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96 | (2) |
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2 Is the 3'RR involved in early B cell development? |
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98 | (1) |
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3 Involvement of the 3'RR in Ig μ heavy chain production and B cell receptor expression |
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99 | (2) |
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4 Individual 3'lgH enhancers control CSR by providing accessibility of acceptor switch regions |
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101 | (3) |
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5 Involvement of the quasi-palindromic structure in somatic hypermutation |
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104 | (2) |
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6 Plasma cell Ig heavy chain production depends on the full palindromic IgH 3'RR |
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106 | (1) |
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7 Concluding remarks: Panorama of IgH 3'RR stepwise activation |
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107 | (2) |
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8 Remaining 3'RR dark zones and future perspectives |
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109 | (1) |
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110 | (1) |
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110 | (1) |
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110 | |
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
