This comprehensive book captures and compiles new and current information on hematologic malignancies. New knowledge of cellular disease processes, molecular pathology, and cytogenetic, epigenetic and genomic changes has influenced the current outlook toward haematological malignancies. This recent and ongoing expansion of knowledge on malignant hematology has not previously been utilized to its full capacity due to its diffuse distribution scattered over the internet and research publications. This book is written by experts from the American and European continent, sharing their current thoughts and knowledge on the pathobiology of malignant haematological diseases of the blood, as well as current treatment strategies and future developments in the area of these haematological diseases.
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vii | |
| Acknowledgement |
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xi | |
| Preface |
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xiii | |
| Abbreviations |
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xv | |
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1 | (46) |
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1 Normal and Malignant Hematopoiesis |
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3 | (28) |
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31 | (16) |
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Part 2 Myeloid Malignancies |
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47 | (144) |
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3 Myeloproliferative Neoplasms |
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49 | (13) |
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4 Molecular Pathogenesis of BCR-ABL in Chronic Myeloid Leukemia |
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62 | (9) |
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5 Standard Management of Patients with Chronic Myeloid Leukemia |
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71 | (15) |
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6 The Molecular Biology of Acute Myeloid Leukemia |
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86 | (17) |
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103 | (24) |
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8 Acute Promyelocytic Leukemia |
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127 | (16) |
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9 A Pluralistic Approach to the Study of Myelodysplastic Syndromes: Evolving Pathology of the Seed via the Soil |
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143 | (10) |
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10 Myelodysplastic Syndrome: A Review of Current Care |
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153 | (19) |
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11 Supportive Care in Myelodysplastic Syndrome |
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172 | (19) |
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Part 3 Lymphoid Malignancies |
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191 | (124) |
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12 Molecular Biology of Chronic Lymphoproliferative Disorders |
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193 | (18) |
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13 Chronic Lymphocytic Leukemia |
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211 | (17) |
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14 Acute Lymphoblastic Leukemia |
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228 | (16) |
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15 Large Granular Lymphocyte Leukemia |
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244 | (9) |
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253 | (13) |
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17 Molecular Basis of B-cell Lymphomas |
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266 | (8) |
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274 | (22) |
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296 | (19) |
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Part 4 Plasma Cell Disorders |
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315 | (52) |
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20 Multiple Myeloma: Molecular Biology, Diagnosis and Treatment |
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317 | (25) |
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21 Waldenstrom's Macroglobulinemia |
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342 | (13) |
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22 Primary Systemic Amyloidosis (AL) |
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355 | (12) |
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Meletios Athanasios Dimopoulos |
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Part 5 Bone Marrow Transplantation and Quality of Life |
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367 | (32) |
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23 Advances in Allogeneic Hematopoietic Cell Transplantation: Progress in Transplantation Technology and Disease-Specific Outcomes |
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369 | (15) |
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24 Quality of Life after the Diagnosis of Hematological Malignancies |
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384 | (15) |
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| Index |
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399 | |
Hussain I. Saba, Department of Medicine, University of South Florida College of Medicine; James A. Haley Veterans Hospital; H. Lee Moffitt Cancer Center and Research Institute; , Tampa, FL, USA Ghulam Mufti, Department of Haematological Medicine, Guys and St. Thomass School of Medicine, Kings College Hospital, London, UK
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