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El. knyga: Advances in Metallodrugs: Preparation and Applications in Medicinal Chemistry

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  • Formatas: EPUB+DRM
  • Išleidimo metai: 10-Jun-2020
  • Leidėjas: Wiley-Scrivener
  • Kalba: eng
  • ISBN-13: 9781119641001
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Advances in Metallodrugs: Preparation and Applications in Medicinal ChemistryDidesnis paveikslėlis
  • Formatas: EPUB+DRM
  • Išleidimo metai: 10-Jun-2020
  • Leidėjas: Wiley-Scrivener
  • Kalba: eng
  • ISBN-13: 9781119641001
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"Over the past few decades, medicinal inorganic chemistry as an interdisciplinary sub-area of bioinorganic chemistry has received the growing attention of researchers in the search for promising antimicrobial, antimalarial, antiviral, and antitumor chemotherapeutic agents. An excellent compilation of reports on metal complexes has revealed the potency of metal complexes as better therapeutic agents. Metal-containing drugs have several promising advantages over organic ligands and have gained the trust ofresearches after the worldwide approval of the drug cisplatin. Their distinct mechanism of action makes them perfect candidates as alternatives to the conventional drugs to which resistance has already been shown. In this direction, a huge number of transition metal complexes have been synthesized and evaluated for their biological profiles"--

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Preface xiii
1 Metallodrugs in Medicine: Present, Past, and Future Prospects
1(40)
Imtiyaz Yousuf
Masrat Bashir
1.1 Introduction
2(4)
1.2 Therapeutic Metallodrugs
6(17)
1.2.1 Anticancer Metallodrugs
6(1)
1.2.1.1 Mechanism of Anticancer Action
7(8)
1.2.2 Antimicrobial and Antiviral Metallodrugs
15(1)
1.2.2.1 Antimicrobial Metallodrugs
15(1)
1.2.2.2 Antiviral Metallodrugs
16(1)
1.2.3 Radiopharmaceuticals and Radiodiagnostic Metallodrugs
17(2)
1.2.4 Anti-Diabetic Metallodrugs
19(3)
1.2.5 Catalytic Metallodrugs
22(1)
1.3 Future Prospects
23(2)
1.4 Conclusion
25(16)
References
26(15)
2 Chemotherapeutic Potential of Ruthenium Metal Complexes Incorporating Schiff Bases
41(30)
Manzoor Ahmad Malik
Parveez Gull
Ovas Ahmad Dar
Mohmmad Younus Wani
Md Ikbal Ahmed Talukdar
Athar Adil Hashmi
2.1 Introduction
42(1)
2.2 Schiff Base Complexes of Ruthenium as Anticancer Agents
43(20)
2.3 Conclusion
63(8)
References
64(7)
3 Role of Metallodrugs in Medicinal Inorganic Chemistry
71(44)
Mattish Kumar
Gyanendra Kumar
Arun Kant
Dhanraj T. Masram
3.1 Introduction
72(2)
3.2 Platinum Anticancer Drugs
74(8)
3.2.1 Nucleophilic Displacement Reactions in Complexes of Platinum
80(1)
3.2.2 Mode of the Interaction of Cisplatin Species With Nitrogen Donors of DNA Strand
80(2)
3.2.3 Systemic Toxicity of Cisplatin
82(1)
3.3 Copper-Based Anticancer Complexes
82(7)
3.3.1 Copper is Essential for Health and Nutrition
82(1)
3.3.2 Healthcare Applications of Copper
83(1)
3.3.3 Copper and Human Health Disorders
83(1)
3.3.3.1 Wilsons Disease (WD)
84(1)
3.3.3.2 Menkes' Disease
85(1)
3.3.4 Role of Copper Complexes as Potential Therapeutic Agents
85(1)
3.3.4.1 Thiosemicarbazones-Based Complexes
86(2)
3.3.4.2 Quinolones-Based Copper Complexes
88(1)
3.3.4.3 Naphthoquinones
88(1)
3.4 Zinc Anticancer Complexes
89(14)
3.4.1 Biologically Importance of Zinc
90(2)
3.4.2 Schiff Base Chemistry
92(1)
3.4.2.1 Schiff Base and Their Metal Complexes
92(1)
3.4.3 Zinc-Based Complexes
93(1)
3.4.4 Top Food Sources of Zinc
94(3)
3.4.5 Role of Zinc in Human Body
97(1)
3.4.6 Zinc as a Health Benefit
98(2)
3.4.7 Zinc in Alloy and Composites
100(1)
3.4.8 Zinc Supplementation as a Treatment
100(1)
3.4.8.1 Zinc Deficiency
101(1)
3.4.8.2 Zinc Toxicity
102(1)
3.4.8.3 Zinc and Viral Infections
102(1)
3.4.9 Gastrointestinal Effects
103(1)
3.5 Future Prospects of Metallodrugs
103(12)
References
104(11)
4 Ferrocene-Based Metallodrugs
115(22)
Hamza Shoukat
Ataf Ali Altaf
Amin Badshah
4.1 Introduction
115(2)
4.2 Ferrocene-Based Antimalarial Agents
117(1)
4.2.1 Mechanism of Action
118(1)
4.3 Ferrocene-Based Antibacterial and Antifungal Drugs
118(5)
4.3.1 Schiff Base Derived Ferrocene Conjugates as Antibacterial Agents
119(2)
4.3.2 Ferrocenyl Guanidines as Antibacterial and Antifungal Agents
121(1)
4.3.3 Sedaxicene as Antifungal Agents
122(1)
4.4 Ferrocene-Based Anti-Tumor and Anti-Cancerous Drugs
123(8)
4.4.1 Ferricenium Salts as Anti-Tumor Agents
124(1)
4.4.2 Ferrocenylalkylazoles Active Anti-Tumor Drugs
124(1)
4.4.3 Ferrocene Conjugated to Peptides for Lung Cancer
125(1)
4.4.4 Ferrocenylalkyl Nucleobases Potential Anti-Cancerous Drugs
126(1)
4.4.5 Ferrocenyl Sub-Ordinates of Illudin-M
126(1)
4.4.6 Ferrocenyl Derivatives of Retinoids Potential Anti-Tumor Drug
127(1)
4.4.7 Targeting Breast Cancer With Selective Ferrocene-Based Estrogen Receptor Modulators (SERM)
128(3)
4.5 Conclusion
131(1)
4.6 Future of Ferrocene-Based Drugs
131(6)
References
132(5)
5 Recent Advances in Cobalt Derived Complexes as Potential Therapeutic Agents
137(20)
Manzoor Ahmad Malik
Ovas Ahmad Dar
Athar Adil Hashmi
5.1 Introduction
137(1)
5.2 Cobalt Complexes as Potential Therapeutic Agents
138(15)
5.3 Conclusion
153(4)
References
154(3)
6 NO-, CO-, and H2S-Based Metallopharmaceuticals
157(46)
R. C. Maurya
J. M. Mir
6.1 Introduction
158(2)
6.2 Signaling Molecules: Concept of "Gasotransmitter"
160(7)
6.2.1 Therapeutic Applications of NO, CO, and H2S
162(1)
6.2.1.1 Exogenous NO Donating Molecules
163(4)
6.3 NO Donors Incorporated in Polymeric Matrices
167(3)
6.3.1 Metal Nitrosyl Complexes
168(1)
6.3.1.1 Sodium Nitroprusside (SNP)
168(2)
6.4 Dinitrosyl Iron Thiol Complexes (DNICs)
170(1)
6.5 Photoactive Transition Metal Nitrosyls as NO Donors
170(3)
6.6 Exogenous CO Donating Molecules
173(3)
6.7 H2S Donating Compounds
176(9)
6.7.1 H2S Gas: A Fast Delivering Compound
176(1)
6.7.2 Sulfide Salts: Fast Delivering H2S Compounds
177(1)
6.7.3 Synthetic Moieties
178(1)
6.7.3.1 Slow-Delivering H2S Compounds
178(1)
6.7.3.2 H2S-Releasing Composite Compounds
179(3)
6.7.4 Naturally Occurring Plant Derived Compounds
182(1)
6.7.4.1 Garlic
182(2)
6.7.4.2 Broccoli and Other Cruciferous Vegetables
184(1)
6.8 Concluding Remarks and Future Outlook
185(18)
References
186(17)
7 Platinum Complexes in Medicine and in the Treatment of Cancer
203(44)
Rakesh Kumar Ameta
Parth Malik
7.1 What is Cancer?
203(6)
7.1.1 Characteristic Features of Cancer Cells
205(1)
7.1.2 Definition of Anticancer Compound
206(1)
7.1.3 Anticancer Attributes of Pt Complexes
207(1)
7.1.4 Native State Behavior of Pt Complexes
208(1)
7.2 Compatibility of Pt Compounds in Cancer Treatment
209(5)
7.2.1 Significance of DNA as Primary Target
209(1)
7.2.2 Kinetics of DNA Binding Activities
210(1)
7.2.3 Structural and Regioselectivity of DNA Adducts
210(1)
7.2.4 Studies on Action Mechanism
211(3)
7.3 Pt Complexes as Anticancer Drugs
214(17)
7.3.1 DNA-Coordinating Pt(II) Complexes
214(5)
7.3.2 DNA-Covalently Binding Pt(II) Complexes
219(3)
7.3.3 Targeted Pt(II) Complexes
222(2)
7.3.4 Pt(IV) Prodrugs
224(1)
7.3.5 Multiple Action of Pt(IV) Prodrugs
225(3)
7.3.6 Targeted Pt(IV) Prodrugs
228(3)
7.3.7 Photodynamic Killing of Cancer Cell by Pt Complexes
231(1)
7.4 Conclusion
231(16)
Acknowledgments
232(1)
References
232(15)
8 Recent Advances in Gold Complexes as Anticancer Agents
247(26)
Mohammad Nadeem Lone
Zubaid-ul-khazir
Ghulam Nabi Yatoo
Javid A. Banday
Irshad A. Wani
8.1 Introduction
248(2)
8.2 Evolution of Metal Complexes as Anticancer Agents
250(1)
8.3 Gold Complexes
251(11)
8.3.1 Complexes with Nitrogen Donar Ligands
252(2)
8.3.2 Complexes with Sulphur Donar Ligands
254(1)
8.3.3 Complexes with Phosphorus Donar Ligands
255(1)
8.3.4 Complexes with Sulphur-Phosphorus Donar Ligands
256(3)
8.3.5 Organometallic Gold Complexes
259(1)
8.3.6 Miscellaneous
260(2)
8.4 Nano-Formulations of Gold Complexes
262(1)
8.5 Future Challenges and Perspectives
263(2)
8.6 Conclusion
265(8)
Acknowledgements
266(1)
References
266(7)
9 Recent Developments in Small Molecular HIV-1 and Hepatitis B Virus RNase H Inhibitors
273(20)
Fenju Wei
Dongwei Kang
Luis Menendez-Arias
Xinyong Liu
Peng Zhan
9.1 Introduction
273(3)
9.1.1 Activity and Function of HIV and HBV RNases H
274(1)
9.1.2 The Metal-Chelating RNase H Active Site
274(2)
9.2 RNase H Inhibitors and Strategies in the Discovery of Active Compounds
276(10)
9.2.1 High-Throughput Screening
276(2)
9.2.2 Design Based on Pharmacophore Models
278(1)
9.2.3 Novel Inhibitors Obtained by Using "Click Chemistry"
279(1)
9.2.4 Dual-Target Inhibitors Against HIV-1 Integrase (IN) and RNase H
280(2)
9.2.5 Inhibitors Obtained by Using Privileged Fragment-Based Libraries
282(1)
9.2.6 RNase H Inhibitors in Natural Products
283(1)
9.2.7 Drug Repurposing Based on Privileged Structures
284(2)
9.3 Conclusion
286(7)
References
287(6)
10 The Role of Metals and Metallodrugs in the Modulation of Angiogenesis
293(26)
Mehmet Varol
Tugba Oren Varol
10.1 Introduction
294(3)
10.2 Metallodrugs in Anticancer Therapy
297(3)
10.3 Angiogenesis as a Substantial Target of Tumorigenesis
300(2)
10.4 Metals and Metallodrugs in Angiogenesis
302(4)
10.5 Concluding Remarks and Future Prospects
306(13)
References
306(13)
11 Metal-Based Cellulose: An Attractive Approach Towards Biomedicine Applications
319(44)
Kulsoom Koser
Athar Adil Hashmi
11.1 Introduction
320(1)
11.2 History of Cellulose
320(1)
11.3 The Properties and Structure of Cellulose
321(1)
11.4 Modification of Cellulose
322(22)
11.4.1 Acid Hydrolysis
322(2)
11.4.2 Oxidation
324(2)
11.4.3 Esterification
326(5)
11.4.4 Amidation
331(2)
11.4.5 Carbamiation
333(3)
11.4.6 Etherification
336(3)
11.4.7 Nucleophilic Substitution
339(2)
11.4.8 Further Modification
341(3)
11.5 Present and Future Medical Applications of Cellulose as Well as Its Components
344(7)
11.5.1 Cellulose Used as Wound Dressing
344(1)
11.5.2 Dental Applications
345(1)
11.5.3 Engineering
346(2)
11.5.4 Controllable Drug Delivery System
348(1)
11.5.5 Blood Purification
348(2)
11.5.6 Wrapping Purpose
350(1)
11.5.7 Renal Failure
351(1)
11.6 Conclusion
351(12)
References
352(11)
12 Multifunctional Nanomedicine
363(40)
Nobel Tomar
Maroof A. Hashmi
Athar Adil Hashmi
12.1 Introduction
364(2)
12.2 Diagnostics and Imaging
366(3)
12.3 Drug Delivery and Therapy
369(16)
12.3.1 Drug Delivery by Organic Nanomaterials
369(1)
12.3.1.1 Liposomal Drug Delivery
369(2)
12.3.1.2 Polymeric Drug Delivery
371(2)
12.3.1.3 Proteins and Peptides for Drug Delivery
373(1)
12.3.2 Drug Delivery by Inorganic Nanomaterials
374(1)
12.3.2.1 Metal and Metal Oxides
374(1)
12.3.2.2 AuNPs
375(1)
12.3.2.3 Carbon-Based NPs
375(3)
12.3.2.4 Silicon-Based Nanostructures for Drug Delivery
378(1)
12.3.3 Photo Therapy
379(1)
12.3.3.1 Photodynamic Therapy
380(1)
12.3.3.2 Photothermal Therapy
381(2)
12.3.4 Radiation Therapy
383(1)
12.3.5 Neutron Capture Therapy
384(1)
12.4 Regenerative Medicine
385(1)
12.5 Future Prospects and Conclusion
386(17)
References
387(16)
Index 403
Shahid-ul-Islam is a Principal Project Scientist at the Indian Institute of Technology Delhi, where he works on the chemistry of metal-based natural dyes using advanced technologies. He received his PhD in Chemistry from Jamia Millia Islamia (A Central University), New Delhi, India, in 2017. He has to his credit several research journal publications, patents and books with the Wiley-Scrivener imprint.

Athar Adil Hashmi studied chemistry at Aligarh Muslim University, India and obtained his PhD in 1994. From 1990 to 2007 he held positions at the department of chemistry, Jamia Millia Islamia (Central University), New Delhi, India. Since April 2017 he is working as a visiting Professor at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. His work area includes organometallic chemistry, metal containing polymers and bio-inorganic chemistry. Along with his international publications, book chapters, he has guided 30 postgraduate projects and 13 PhD students.

Salman Ahmad Khan received his PhD in Organic Chemistry from the Jamia Millia Islamia (JMI) (A Central University), New Delhi, India, in 2007. Since 2009 he has been with the Department of Chemistry, King Abdulaziz University, Jeddah, Saudi Arabia, where he is an Associate Professor. His current research interests include Heterocyclic Chemistry, Chromones, Chalcones, Anthraquinones, Photophysical, Physicochemical, Multi steps reactions, one pot multi component synthesis and Nanotechnology. Dr. Salman is an active researcher and has published more than 100 research articles in various reputed international journals.
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