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Aging: The Longevity Dividend [Kietas viršelis]

Edited by , Edited by , Edited by
  • Formatas: Hardback, 256 pages, Illustrations
  • Išleidimo metai: 01-Dec-2015
  • Leidėjas: Cold Spring Harbor Laboratory Press,U.S.
  • ISBN-10: 1621820807
  • ISBN-13: 9781621820802
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 256 pages, Illustrations
  • Išleidimo metai: 01-Dec-2015
  • Leidėjas: Cold Spring Harbor Laboratory Press,U.S.
  • ISBN-10: 1621820807
  • ISBN-13: 9781621820802
Kitos knygos pagal šią temą:
"Aging affects us all and is characterized not only by increasing frailty but by increased susceptibility to conditions such as Alzheimer's, cardiovascular disease, and cancer. We are gaining an increasing understanding of the molecular mechanisms underlying aging, however, and uncovering clues to how life may be prolonged. This book examines the biological basis of aging and research into strategies that may extend lifespan"--

Aging affects us all and is characterized not only by increasing frailty but by increased susceptibility to conditions such as Alzheimer's, cardiovascular disease, and cancer. We are gaining an increasing understanding of the molecular mechanisms underlying aging, however, and uncovering clues to how life may be prolonged. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of aging and research into strategies that may extend lifespan. Contributors discuss:
- An Overview of the Theory of Aging
- DNA Damage, DNA Repair, Aging, and Neurodegeneration
- Articulating the Case for the Longevity Dividend
- The Translation of Aging Science into a Therapeutic Intervention
This volume also covers the economic promise of delayed aging, and examines whether the rate of human aging has already been modified. It is an indispensable reference for biologists, physicians, public health administrators, and others working in the field.
Foreword vii
Janko Nikolich-Zugich
Preface ix
Introduction
The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span
1(14)
Felipe Sierra
PART I BASIC MECHANISMS OF BIOLOGICAL AGING
The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging
15(10)
Nathan A. DeCarolis
Elizabeth D. Kirby
Tony Wyss-Coray
Theo D. Palmer
Biochemical Genetic Pathways that Modulate Aging in Multiple Species
25(26)
Alessandro Bitto
Adrienne M. Wang
Christopher F. Bennett
Matt Kaeberlein
DNA Damage, DNA Repair, Aging, and Neurodegeneration
51(18)
Scott Maynard
Evandro Fei Fang
Morten Scheibye-Knudsen
Deborah L. Croteau
Vilhelm A. Bohr
How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative
69(24)
Fuki M. Hisama
Junko Oshima
George M. Martin
Dissecting the Mechanisms Underlying Successful Human Health Span and Life Span
93(14)
Sofiya Milman
Nir Barzilai
The Companion Dog as a Model for the Longevity Dividend
107(14)
Kate E. Creevy
Steven N. Austad
Jessica M. Hoffman
Dan G. O'Neill
Daniel E.L. Promislow
PART II CLINICAL AND TRANSLATIONAL ASPECTS OF AGING
Translating the Science of Aging into Therapeutic Interventions
121(14)
James L. Kirkland
Interventions for Human Frailty: Physical Activity as a Model
135(14)
Linda P. Fried
The Aging Heart
149(16)
Ying Ann Chiao
Peter S. Rabinovitch
Inhibition of the Mechanistic Target of Rapamycin (mTOR)---Rapamycin and Beyond
165(14)
Dudley W. Lamming
Metformin: A Hopeful Promise in the Aging Research
179(12)
Marta G. Novelle
Ahmed Ali
Carlos Dieguez
Michel Bernier
Rafael de Cabo
PART III SOCIETAL IMPLICATIONS OF DELAYED AGING
Articulating the Case for the Longevity Dividend
191(6)
S. Jay Olshansky
The Economic Promise of Delayed Aging
197(12)
Dana Goldman
Past, Present, and Future of Healthy Life Expectancy
209(12)
Hiram Beltran-Sanchez
Samir Soneji
Eileen M. Crimmins
Has the Rate of Human Aging Already Been Modified?
221(18)
S. Jay Olshansky
Index 239