Preface |
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xv | |
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Part 1 Alginates---Introduction, Characterization and Properties |
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1 | (78) |
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1 Alginates: General Introduction and Properties |
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3 | (18) |
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4 | (1) |
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4 | (1) |
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4 | (2) |
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1.4 Alginates and Their Properties |
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6 | (5) |
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6 | (1) |
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1.4.1.1 Ionic Alginate Gels |
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6 | (2) |
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1.4.1.2 Alginic Acid Gels |
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8 | (1) |
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8 | (1) |
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1.4.3 Solubility and Viscosity |
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8 | (1) |
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1.4.4 Ionic Cross-Linking |
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9 | (1) |
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1.4.5 Chemical Properties |
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9 | (2) |
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11 | (1) |
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1.6 Biosynthesis of Bacterial Alginate |
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11 | (5) |
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1.6.1 Precursor Synthesis |
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12 | (1) |
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1.6.2 Polymerization and Cytoplasmic Membrane Transfer |
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13 | (2) |
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1.6.3 Periplasmic Transfer and Modification |
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15 | (1) |
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15 | (1) |
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1.6.3.2 Mannuronan C 5-Epimerases |
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16 | (1) |
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16 | (1) |
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1.6.5 Export through the Outer Membrane |
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16 | (1) |
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16 | (5) |
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17 | (1) |
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17 | (1) |
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17 | (4) |
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2 Alginates Production, Characterization and Modification |
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21 | (24) |
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22 | (2) |
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24 | (4) |
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2.2.1 Screening of Alginate-Producing Microbes |
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24 | (1) |
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2.2.2 Production of Alginate by Bacteria |
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25 | (1) |
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2.2.3 Production of Alginate by Pseudomonas |
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26 | (1) |
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2.2.4 Production of Alginate by Azotobacter spp. |
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26 | (1) |
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2.2.5 Influence of Medium Components |
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26 | (1) |
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2.2.5.1 Effect of Nutrients on Bacterial Alginate Production |
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26 | (1) |
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2.2.5.2 Effect of Phosphate on Bacterial Alginate Production |
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27 | (1) |
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2.2.5.3 Effect of Dissolved Oxygen on Bacterial Alginate Production |
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27 | (1) |
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2.2.5.4 Effect of Agitation in the Medium for the Production of Alginate |
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27 | (1) |
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2.2.6 Commercial Production of Alginate |
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28 | (1) |
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2.3 Characterization of Physicochemical Properties of Alginate |
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28 | (5) |
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2.3.1 Composition of Alginate Polymer Chains |
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29 | (2) |
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2.3.2 XRD, FTIR, and NMR Spectroscopy for Alginate Structure Analysis |
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31 | (1) |
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2.3.3 Rheology and Mechanical Characterization of Alginate Gels and Solutions |
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32 | (1) |
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2.4 Modification of Alginates |
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33 | (5) |
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2.4.1 Chemical Modification |
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33 | (1) |
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34 | (1) |
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34 | (1) |
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35 | (1) |
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2.4.5 Graft Copolymerization |
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35 | (1) |
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35 | (1) |
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2.4.7 Carbodiimide Coupling |
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36 | (1) |
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2.4.8 Covalent Cross-Linking |
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36 | (2) |
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38 | (1) |
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39 | (6) |
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39 | (6) |
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3 Alginate: Recent Progress and Technological Prospects |
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45 | (14) |
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45 | (1) |
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46 | (1) |
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47 | (1) |
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3.4 Characteristics of Alginate Salts |
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48 | (1) |
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48 | (2) |
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50 | (3) |
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53 | (1) |
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54 | (1) |
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54 | (1) |
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54 | (5) |
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55 | (1) |
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55 | (4) |
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4 Alginate Hydrogel and Aerogel |
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59 | (20) |
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59 | (1) |
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60 | (10) |
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4.2.1 Preparation of Alginate Hydrogels |
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61 | (1) |
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4.2.1.1 Ionic Cross-Linking |
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62 | (1) |
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4.2.1.2 Covalent Cross-Linking |
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62 | (1) |
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62 | (1) |
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4.2.1.4 Cell Cross-Linking |
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63 | (1) |
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4.2.2 Biomedical Applications |
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63 | (1) |
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4.2.2.1 Pharmaceutical Applications |
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63 | (5) |
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4.2.3 Tissue Regeneration with Protein and Cell Delivery |
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68 | (1) |
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68 | (1) |
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69 | (1) |
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69 | (1) |
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4.2.3.4 Muscle, Nerve, Pancreas, and Liver |
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70 | (1) |
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70 | (3) |
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4.3.1 Properties of Alginate Aerogels |
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71 | (1) |
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4.3.1.1 Bulk Density and Pore Volume |
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71 | (1) |
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4.3.1.2 Specific Surface Area |
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71 | (1) |
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71 | (1) |
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4.3.1.4 Thermal Conductivity and Absorption |
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72 | (1) |
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4.3.2 Preparative Methods |
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72 | (1) |
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73 | (6) |
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73 | (6) |
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Part 2 Alginates in Biomedical Applications |
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79 | (126) |
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5 Alginate in Biomedical Applications |
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81 | (14) |
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81 | (2) |
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5.2 Chemical Structure and Properties of Alginate |
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83 | (1) |
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5.3 Types of Interaction of Alginate |
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84 | (3) |
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5.4 Biomedical Application of Alginates |
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87 | (3) |
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5.5 Future Perspective of the Use and Biomedical Applications |
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90 | (5) |
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90 | (5) |
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6 Alginates in Pharmaceutical and Biomedical Application: A Critique |
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95 | (30) |
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95 | (1) |
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6.2 Structure of Alginate |
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96 | (1) |
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6.3 Different Types of Alginates Used in Pharmaceutical Industries |
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97 | (1) |
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6.4 Properties of Alginate |
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98 | (1) |
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6.5 Pathway for the Biosynthesis of Alginate |
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98 | (2) |
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6.6 Regulatory Consideration of Alginate |
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100 | (1) |
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100 | (14) |
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113 | (1) |
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114 | (11) |
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115 | (10) |
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7 Alginates in Evolution of Restorative Dentistry |
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125 | (16) |
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125 | (1) |
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7.2 Method of Alginate Extraction |
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126 | (2) |
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7.3 Evolution of Alginate in Restorative Dentistry |
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128 | (5) |
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7.3.1 Problems with Conventional Alginate |
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129 | (1) |
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7.3.2 Current Trends and Modification of Alginate |
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129 | (1) |
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7.3.2.1 Extended Pour Time Alginate |
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130 | (1) |
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7.3.2.2 Dust-Free Alginates |
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130 | (2) |
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7.3.2.3 Infection-Free Alginates |
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132 | (1) |
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7.3.2.4 High Viscosity Alginates |
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132 | (1) |
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7.3.2.5 Alginates in Two Pastes Form |
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133 | (1) |
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7.3.2.6 Tray Adhesive Alginates |
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133 | (1) |
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7.4 The Art of Impression Taking Using Alginates |
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133 | (5) |
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7.4.1 Selection of Impression Trays |
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134 | (1) |
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7.4.2 Mixing and Loading Alginates |
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135 | (1) |
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7.4.3 Preparation of the Oral Cavity before Impression Taking |
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135 | (1) |
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7.4.4 Impression Taking Using Alginate Material |
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136 | (1) |
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7.4.5 Removal and Inspection of Alginate Material |
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137 | (1) |
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7.4.6 Effects of Cast Production Techniques |
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137 | (1) |
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138 | (3) |
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138 | (3) |
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8 Alginates in Drug Delivery |
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141 | (12) |
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141 | (1) |
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8.2 Chemistry of Alginates |
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142 | (2) |
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8.2.1 Hydrogel Formation by Alginates |
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143 | (1) |
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8.2.1.1 Preparation of Hydrogel |
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143 | (1) |
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8.3 Pharmaceutical and Biomedical Chemistry of Alginates |
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144 | (5) |
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8.3.1 Factors Governing Drug Encapsulation and Drug Delivery Processes |
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145 | (1) |
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8.3.1.1 Delivery and Encapsulation of Small Drugs |
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145 | (3) |
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8.3.1.2 Macromolecular Drug Delivery by Alginates |
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148 | (1) |
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149 | (4) |
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149 | (1) |
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149 | (4) |
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153 | (26) |
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154 | (1) |
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9.2 Sources and Synthesis of Alginate |
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154 | (2) |
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9.3 Physicochemical Properties of the Alginate Biopolymer |
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156 | (1) |
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9.4 Biomedical Applications of Alginate |
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157 | (15) |
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9.4.1 Alginate in Wound Care |
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158 | (2) |
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9.4.1.1 Pure Alginate Polymer-Based Wound Dressing |
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160 | (1) |
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9.4.1.2 Intercellular Mediators Incorporated Alginate Polymer-Based Wound Dressing |
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160 | (1) |
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9.4.1.3 Zinc/Alginate- and Silver/Alginate-Based Wound Dressing |
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161 | (2) |
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9.4.1.4 Chitosan/Alginate- and Collagen/Alginate-Based Wound Dressing |
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163 | (1) |
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9.4.1.5 Alginate Fiber-Based Wound Dressing |
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163 | (4) |
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9.4.1.6 Alginate Hydrogel-Based Wound Dressing |
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167 | (5) |
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9.5 Opportunities and Future Thrust |
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172 | (7) |
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173 | (6) |
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10 Alginate-Based Biomaterials for Bio-Medical Applications |
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179 | (26) |
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180 | (1) |
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10.2 Alginate: General Properties |
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180 | (2) |
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10.2.1 Chemical Properties, Structure, and Characterization |
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181 | (1) |
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10.3 Extraction and Preparation |
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182 | (5) |
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10.3.1 Gelation and Cross-Linking of Alginate |
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183 | (1) |
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10.3.2 Ionic Cross-Linking |
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184 | (1) |
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184 | (1) |
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185 | (1) |
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10.3.5 Covalent Cross-Linking |
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185 | (1) |
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10.3.6 Large Bead Preparation |
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186 | (1) |
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10.3.7 Microbead Preparation |
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186 | (1) |
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187 | (1) |
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188 | (1) |
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10.6 Shape-Memory Alginate Scaffolds |
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188 | (1) |
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10.7 Biodegradation of Alginate |
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189 | (1) |
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10.8 Biomedical Application of Alginates |
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190 | (15) |
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10.8.1 Controlled Chemical and Protein Drug Delivery |
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190 | (3) |
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10.8.2 Wound/Injury Dressings |
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193 | (1) |
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194 | (1) |
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10.8.4 Tissue Regeneration |
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195 | (1) |
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196 | (9) |
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Part 3 Alginates in Food Industry |
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205 | (76) |
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11 Alginates for Food Packaging Applications |
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207 | (26) |
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207 | (1) |
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11.2 Biopolymer in Food Industry |
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208 | (1) |
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11.3 Alginates in Food Packaging |
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209 | (4) |
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11.4 Biosynthesis of Alginate |
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213 | (2) |
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11.5 Application of Alginate in Formation of Biofilm |
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215 | (2) |
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11.5.1 Preparation of Packaging Films |
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215 | (1) |
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11.5.2 Role of Alginate in Biofilm Formation |
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215 | (2) |
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11.6 Packaging Properties of Alginate |
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217 | (5) |
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11.6.1 Thermostability of Alginate Packaging |
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218 | (1) |
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218 | (1) |
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11.6.3 Water Vapor Permeability |
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218 | (1) |
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218 | (1) |
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11.6.5 Oxygen Permeability |
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219 | (1) |
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219 | (1) |
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11.6.7 Antimicrobial Activity |
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219 | (3) |
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11.7 Effect of Alginate on the Quality of Food |
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222 | (1) |
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11.8 Interaction between Food and Alginates |
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223 | (1) |
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11.9 Environmental Effects on Alginate Packaging |
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224 | (1) |
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224 | (1) |
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225 | (8) |
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226 | (7) |
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12 Potential Application of Alginates in the Beverage Industry |
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233 | (30) |
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233 | (1) |
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234 | (1) |
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12.3 Extraction of Alginates |
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235 | (1) |
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12.4 Physical, Chemical and Functional Properties of Alginate |
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236 | (5) |
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12.5 Uses as a Food Additive/Ingredient |
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241 | (4) |
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12.6 Alginate as Stabilizer |
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245 | (2) |
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12.7 As Encapsulating Wall Material |
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247 | (7) |
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12.7.1 Immobilization of Biocatalysts |
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249 | (1) |
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250 | (3) |
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12.7.3 Improvement of the Alginate Encapsulation: Prebiotics Addition |
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253 | (1) |
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254 | (9) |
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254 | (9) |
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13 Alginates in Comestibles |
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263 | (18) |
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264 | (1) |
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13.2 Alginates in Agricultural Marketing |
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265 | (1) |
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13.3 Use of Alginates in Food Industry |
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266 | (5) |
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13.3.1 Thickeners and Gelling Agents |
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267 | (1) |
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13.3.2 Stabilizers and Emulsifiers |
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268 | (1) |
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269 | (1) |
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269 | (1) |
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270 | (1) |
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13.4 Use of Alginates for Pets |
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271 | (1) |
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13.5 Effect of Dietary Alginates |
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271 | (1) |
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272 | (1) |
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272 | (9) |
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272 | (9) |
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Part 4 Alginates Future Prospects |
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281 | (32) |
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14 Alginates: Current Uses and Future Perspective |
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283 | (30) |
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284 | (1) |
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14.2 Sources of Alginate Synthesis |
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285 | (3) |
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285 | (2) |
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287 | (1) |
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14.3 Synthesis of Alginate |
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288 | (2) |
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14.3.1 Alginate Biosynthesis Gene |
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289 | (1) |
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14.4 Properties of Alginates |
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290 | (4) |
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290 | (1) |
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291 | (1) |
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291 | (1) |
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14.4.4 Ionic Binding Property |
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292 | (1) |
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14.4.5 Gel Formation Ability |
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293 | (1) |
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14.4.6 Biological Properties |
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293 | (1) |
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14.5 Application of Alginates |
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294 | (1) |
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14.6 Future Perspectives of Alginates |
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295 | (5) |
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14.6.1 3D-Based Cell Culture Systems |
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295 | (1) |
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296 | (1) |
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14.6.3 Cell-Based Microparticles |
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296 | (2) |
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14.6.4 Alginate Oligosaccharides |
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298 | (1) |
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299 | (1) |
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14.6.6 Nanoparticulate Systems |
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300 | (1) |
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300 | (13) |
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300 | (13) |
Index |
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313 | |