This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer"s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer"s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer"s disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia. Alzheimer"s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.
Chapter 1How does Alzheimer"s begin and who gets it?Chapter 2Forming memoriesChapter 3Masquerading as dementiachapter 4Alzheimer"s --then and nowChapter 5Unproven hypotheses on the cause of Alzheimer"sChapter 6Other hypotheses on the cause of Alzheimer"s diseaseChapter 7Alzheimer noiseChapter 8Social contract and Alzheimer"sChapter 9Genetics of Alzheimer"sChapter 10Powering the brainChapter 11Pharmaceuticals and Alzheimer"sChapter 12Alzheimer vascular risk factorsChapter 13The Good, The Bad and The Ugly of Advanced AgingChapter 14A Personal Account of How a Scientific HypothesisBlooms Into a Life of Its OwnChapter 15Clinical tools to detect and predict individuals at risk of Alzheimer"sChapter 16The turning point for Alzheimer"sChapter 17How poor brain blood flow promotes Alzheimer"s diseaseChapter 18Interventions that may increase cerebral blood flowChapter 19Great ExpectationsChapter 20A road to new
thinkingReferences
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1 How Does Alzheimer's Begin and Who Gets It? |
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1 | (20) |
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2 Storing and Keeping Memories |
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21 | (4) |
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3 Masquerading as Dementia |
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25 | (6) |
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4 Alzheimer's Then and Now |
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31 | (8) |
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5 Unproven Hypotheses on the Cause of Alzheimer's |
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39 | (10) |
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6 Other Hypotheses on the Cause of Alzheimer's Disease |
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49 | (12) |
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61 | (8) |
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8 The Social Contract and Alzheimer's |
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69 | (6) |
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9 Genetics of Alzheimer's Disease |
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75 | (10) |
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85 | (8) |
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11 Pharmaceuticals and Alzheimer's |
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93 | (6) |
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12 Conditions That Can Promote Alzheimer's |
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99 | (52) |
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13 The Good, the Bad, and the Ugly of Advanced Aging |
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151 | (18) |
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14 A Personal Account of How a Scientific Hypothesis Blooms into a Life of Its Own |
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169 | (16) |
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15 Clinical Tools to Detect and Predict Individuals at Risk of Alzheimer's |
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185 | (12) |
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16 The Turning Point for Alzheimer's |
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197 | (12) |
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17 How Poor Brain Blood Flow Promotes Alzheimer's Disease |
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209 | (8) |
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18 Interventions that May Increase Cerebral Blood Flow |
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217 | (12) |
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229 | (6) |
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20 A Road to New Thinking |
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235 | (6) |
| Index |
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241 | |
Jack C. de la Torre, MD, PhD Professor of Neuropsychology (Adjunct)
Department of Psychology
University of Texas at Austin,
1 University Station
Austin, Texas
Dr. Jack de la Torre is a leading authority in the field of Alzheimer's disease (AD). In 1993, he first advanced the concept of AD as a vascular disorder with neurodegenerative consequences in a series of basic and clinical papers that culminated in the CATCH (critically-attained threshold of cerebral hypoperfusion) vascular hypothesis of AD. The vascular hypothesis of AD has had a profound impact and influence on research studies involving epidemiology, neuroimaging, neuropathology and therapeutics that continue to clarify the pathophysiology and pathogenesis of Alzheimer dementia. Dr. de la Torre has edited or co-edited 10 volumes on the subject of vascular factors in AD and published over 200 peer reviewed papers on neurodegeneration, neuropathology and neurotransmission. He has held professorial appointments in the Departments of Neurosurgery at the University of Chicago, Northwestern University, University of Ottawa, and in Pathology at Case Western Reserve University. Dr. de la Torre continues his active research on Alzheimers disease as an Adjunct Professor in the Department of Psychology at the University of Texas at Austin.
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