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El. knyga: Apoptosis in Health and Disease

Edited by , Edited by (Wyeth Research, Collegeville, Pennsylvania, USA)
  • Formatas: 368 pages
  • Išleidimo metai: 15-Sep-2000
  • Leidėjas: Taylor & Francis Ltd
  • Kalba: eng
  • ISBN-13: 9781135286675
Kitos knygos pagal šią temą:
Apoptosis in Health and DiseaseDidesnis paveikslėlis
  • Formatas: 368 pages
  • Išleidimo metai: 15-Sep-2000
  • Leidėjas: Taylor & Francis Ltd
  • Kalba: eng
  • ISBN-13: 9781135286675
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The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation and organ remodelling. It is hoped that, with an increase in our understanding of the mechanisms controlling apoptosis, there will come the development of a new class of drugs which can pharmacologically manipulate apoptosis and thus provide a means to treat important diseases which currently pose problems to our society. Containing papers presented at the Eleventh SmithKline Beecham Pharmaceuticals United States Research Symposium and with contributions from leading researchers, Apoptosis in Health and Disease offers a comprehensive review of important developments and research in the field.
Preface to the Series ix Preface to the Volume xi Contributors xiii Caspase Activation in the Cardiomyocyte: A Drug Discovery Perspective 1(16) Lawrence C. Fritz Joe Wu Anu Srinivasan Kevin J. Tomaselli Robert C. Armstrong Apoptosis and Autoimmune Diseases 17(16) Peter M. Lydyard Pierre Y. Youinou David A. Isenberg Ischemic Neuronal Death is not by Classic Apoptosis: Are all DNA-ladders the Same? 33(14) John P. MacManus Ingrid Rasquinha The Role of Caspases in Apoptosis In Vivo Studied by Gene Targeting 47(14) Richard A. Flavell Keisuke Kuida Timothy S. Zheng Tarik F. Haydar Chia-Yi Kuan Michael S. Su Pasco Rakic Why Atherosclerotic Vessels Narrow and Re-narrow 61(24) Karen O. Yee Stephen M. Schwartz Death-associated Proteins: From Gene Identification to the Analysis of Their Apoptotic and Tumor-Suppressive Functions 85(18) Adi Kimchi Abortive Apoptosis as a Mechanism for Resistance to Cancer Therapy 103(12) Edward P. Gelmann Cai Bowen Kotohiko Kimura Apoptosis in Cardiac Diseases: New Opportunities for Novel Therapeutics for Heart Diseases 115(10) Giora Z. Feuerstein Pharmacological Regulation of Vascular Smooth Muscle Cell Apoptosis In Vivo 125(24) Denis deBlois Pierre Moreau Bun-Seng Tea Johanne Tremblay Pavel Hamet Pathways of Neuronal Apoptosis 149(16) David S. Park Caspase Activation Pathways in Neuronal Death in Stroke 165(8) Michael A. Moskowitz Turgay Dalkara The Role of Caspases in Cell Death After Brain Ischemia 173(10) Julie A. Ellison James J. Velier Giora Z. Feuerstein Yeast as a Model Organism for Studying Apoptosis 183(12) Jason J. Kang Hossein Askari David J. Hall Mary-Ann Bjornsti Regulation of Programmed Cell Death and Viral Pathogenesis by the Bcl-2 Protein Family and Caspases 195(20) J. Marie Hardwick Jennifer Lewis Shifa Zou Emily H.-Y. Cheng David G. Kirsch David S. Bellows Nelson Chau George A. Oyler Kazuyoshi Ueno Jun Zhang Rollie J. Clem Death Paradigms in Cellular Hypoxia 215(30) Pothana Saikumar Zheng Dong Michael Denton Joel M. Weinberg M.A. Venkatachalam Index 245
Robert R. Ruffolo Jr., Frank Walsh
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