This is an overview of the advantages and disadvantages of the different methods currently available for the assessment of cell proliferation. Researchers involved with each method critically review the techniques and discuss how their particular techniques may be applied to clinical material.
Regulation of the eukaryotic cell cycle; growth factors, oncogenes and
tumour suppressor genes; the kinetic organization of tissues; basic methods
for assessing cellular proliferation; mitoses counting; flow cytometry;
measurement of cell proliferation using bromodeosyuridine; the application of
immunohistochemistry in assessment of cellular proliferation; nucleolar
organizer regions; clinical aspects of assessing cell proliferation; cell
proliferation and the principles of cancer chemotherapy.
