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Basic & Applied Concepts of Blood Banking and Transfusion Practices 3rd Revised edition [Minkštas viršelis]

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  • Formatas: Paperback / softback, 408 pages, aukštis x plotis: 276x216 mm, Approx. 216 illustrations (176 in full color)
  • Išleidimo metai: 25-Oct-2012
  • Leidėjas: Mosby
  • ISBN-10: 0323086632
  • ISBN-13: 9780323086639
Kitos knygos pagal šią temą:
  • Formatas: Paperback / softback, 408 pages, aukštis x plotis: 276x216 mm, Approx. 216 illustrations (176 in full color)
  • Išleidimo metai: 25-Oct-2012
  • Leidėjas: Mosby
  • ISBN-10: 0323086632
  • ISBN-13: 9780323086639
Kitos knygos pagal šią temą:
Using an easy-to-understand writing style, this text integrates immunohematology theory and application to provide you with the knowledge and skills you need to be successful in blood banking. Problem-solving exercises and case studies help you develop a solid understanding of all areas of blood banking. Learning objectives begin each chapter. Illustrated blood group boxes throughout chapter 6, Other Blood Group Systems, give the ISBT symbol, number, and the clinical significance of the antibodies at a glance. Margin notes and definitions in each chapter highlight important material and offer additional explanations. Chapter summaries recap the most important points of the chapter. Study questions at the end of each chapter provide an opportunity for review. Critical thinking exercises with case studies help you apply what you have learned in the chapter. UPDATED! Information and photos on automation include equipment actually used in the lab. Flow charts showing antibody detection and identification help you detect and identify antibodies. Advanced topics on Transplantation and Cellular Therapy, the HLA System, Molecular Techniques and Applications, Automation, Electronic Crossmatching, and Therapeutic Apheresis make the text relevant for 4-year MLS programs.
PART I FOUNDATIONS: BASIC SCIENCES AND REAGENTS
Chapter 1 Immunology: Basic Principles and Applications in the Blood Bank
1(27)
Section 1 Characteristics Associated With Antigen-Antibody Reactions
2(8)
General Properties of Antigens
2(1)
General Properties of Antibodies
3(1)
Molecular Structure
3(2)
Fab and Fc Regions
5(1)
Comparison of IgM and IgG Antibodies
5(1)
IgM Antibodies
6(1)
IgG Antibodies
7(1)
Primary and Secondary Immune Response
7(1)
Antigen-Antibody Reactions
8(1)
Properties That Influence Binding
8(2)
Section 2 Characteristics Associated With Red Cell Antigen-Antibody Reactions
10(9)
Red Cell Antigens
10(2)
Red Cell Antibodies
12(1)
Immunohematology: Antigen-Antibody Reactions In Vivo
12(1)
Transfusion, Pregnancy, and the Immune Response
12(1)
Complement Proteins
12(2)
Clearance of Antigen-Antibody Complexes
14(1)
Immunohematology: Antigen-Antibody Reactions In Vitro
14(1)
Overview of Agglutination
14(1)
Sensitization Stage or Antibody Binding to Red Cells
14(1)
Factors Influencing First Stage of Agglutination
15(1)
Lattice-Formation Stage or Cell-Cell Interactions
16(1)
Factors Influencing Second Stage of Agglutination
16(1)
Grading Agglutination Reactions
17(1)
Hemolysis as an Indicator of Antigen-Antibody Reactions
18(1)
Section 3 Human Leukocyte Antigen (Hla) System And Platelet Immunology
19(9)
Human Leukocyte Antigens
19(1)
Testing Applications in the Clinical Laboratory
19(1)
Inheritance and Nomenclature of HLA
19(2)
Testing and Identification of HLA and Antibodies
21(1)
Hematopoietic Progenitor Cell Transplants
22(1)
Graft-versus-Host Disease
23(1)
Platelet Antigens
23(5)
Chapter 2 Blood Banking Reagents: Overview and Applications
28(31)
Section 1 Introduction To Routine Testing In Immunohematology
29(2)
Sources of Antigen for Testing
29(1)
Sources of Antibody for Testing
30(1)
Routine Testing Procedures in the Immunohematology Laboratory
30(1)
Section 2 Introduction To Blood Banking Reagents
31(1)
Regulation of Reagent Manufacture
31(1)
Reagent Quality Control
32(1)
Section 3 Commercial Antibody Reagents
32(6)
Polyclonal versus Monoclonal Antibody Products
32(1)
Polyclonal Antibody Reagents
33(1)
Monoclonal Antibody Reagents
33(1)
Monoclonal and Polyclonal Antibody Reagents
34(1)
Reagents for ABO Antigen Typing
34(2)
Reagents for D Antigen Typing
36(1)
Low-Protein Reagent Control
37(1)
Section 4 Reagent Red Cells
38(2)
A1 and B Red Cells for ABO Serum Testing
38(1)
Screening Cells
39(1)
Antibody Identification Panel Cells
40(1)
Section 5 Antiglobulin Test And Reagents
40(7)
Principles of Antiglobulin Test
40(2)
Direct Antiglobulin Test
42(1)
Indirect Antiglobulin Test
43(1)
Sources of Error in Antiglobulin Testing
43(1)
Antiglobulin Reagents
44(1)
Polyspecific Antihuman Globulin Reagents
45(1)
Monospecific Antihuman Globulin Reagents
45(1)
IgG-Sensitized Red Cells
46(1)
Section 6 Principles Of Antibody Potentiators And Lectins
47(2)
Low-Ionic-Strength Saline (LISS)
47(1)
Polyethylene Glycol
48(1)
Enzymes
48(1)
Bovine Serum Albumin
48(1)
Lectins
49(1)
Section 7 Other Methods Of Detecting Antigen-Antibody Reactions
49(10)
Gel Technology Method
49(1)
Microplate Testing Methods
50(2)
Solid-Phase Red Cell Adherence Methods
52(7)
Chapter 3 Genetic Principles in Blood Banking
59(18)
Section 1 Blood Group Cenetics
60(7)
Genetic Terminology
60(1)
Phenotype versus Genotype
61(1)
Punnett Square
61(1)
Genes, Alleles, and Polymorphism
61(1)
Inheritance Patterns
62(1)
Silent Genes
63(1)
Mendelian Principles
63(1)
Chromosomal Assignment
64(1)
Heterozygosity and Homozygosity
64(1)
Genetic Interaction
65(1)
Linkage and Haplotypes
65(1)
Crossing Over
66(1)
Section 2 Populatoin Genetics
67(2)
Combined Phenotype Calculations
67(1)
Gene Frequencies
68(1)
Relationship Testing
68(1)
Section 3 Molecular Genetics
69(8)
Application of Molecular Genetics to Blood Banking
69(1)
Polymerase Chain Reaction
70(1)
Polymerase Chain Reaction-Based Human Leukocyte Antigen Typing Procedures
70(2)
Molecular Testing Applications in Red Cell Typing
72(1)
Polymerase Chain Reaction-Based Red Cell Typing Procedures
72(5)
PART II OVERVIEW OF THE MAJOR BLOOD GROUPS
Chapter 4 ABO and H Blood Group Systems and Secretor Status
77(30)
Section 1 Historical Overview Of Abo Blood Group System
79(1)
Section 2 Abo And H Blood Group System Antigens
80(6)
General Characteristics of ABO Antigens
80(1)
Inheritance and Development of A, B, and H Antigens
81(1)
Common Structure for A, B, and H Antigens
82(1)
Development of H Antigen
82(1)
Development of A and B Antigens
82(2)
ABO Subgroups
84(1)
Comparison of A1 and A2 Phenotypes
84(1)
Additional Subgroups of A and B
85(1)
Importance of Subgroup Identification in Donor Testing
86(1)
Section 3 Genetic Features Of Abo Blood Group System
86(2)
Section 4 Abo Blood Groups System Antibodes
88(1)
General Characteristics of Human Anti-A and Anti-B
88(1)
Immunoglobulin Class
88(1)
Hemolytic Properties and Clinical Significance
88(1)
In Vitro Serologic Reactions
89(1)
Human Anti-A,B from Group O Individuals
89(1)
Anti-A1
89(1)
Section 5 Abo Blood Group System And Transfusion
89(2)
Routine ABO Phenotyping
89(1)
Selection of ABO-Compatible Red Blood Cells and Plasma Products for Transfusion
90(1)
Section 6 Recognition And Resolution Of Abo Discrepancies
91(9)
Technical Considerations in ABO Phenotyping
91(1)
Sample-Related ABO Discrepancies
92(1)
ABO Discrepancies Associated with Red Cell Testing
92(4)
ABO Discrepancies Associated with Serum or Plasma Testing
96(4)
Section 7 Special Topics Related To Abo And H Blood Group Systems
100(7)
Classic Bombay Phenotype
100(1)
Secretor Status
101(6)
Chapter 5 Rh Blood Group System
107(19)
Section 1 Historical Overview Of The Discovery Of The D Antigen
108(1)
Section 2 Genetics, Biochemistry, And Terminology
108(4)
Fisher-Race: CDE Terminology
110(1)
Wiener: Rh-Hr Terminology
110(1)
Rosenfield: Numeric Terminology
111(1)
International Society of Blood Transfusion: Standardized Numeric Terminology
111(1)
Determining the Genotype from the Phenotype
111(1)
Section 3 Antigens Of The Rh Blood Group System
112(7)
D Antigen
112(1)
Weak D
112(3)
Weak D: Genetic
115(1)
Weak D: Position Effect
115(1)
Weak D: Partial D
115(1)
Significance of Testing for Weak D
116(1)
Other Rh Blood Group System Antigens
117(1)
Compound Antigens
117(1)
G Antigens
118(1)
Unusual Phenotypes
118(1)
D-Deletion Phenotype
118(1)
Rhnull Phenotype
119(1)
Rhmod Phenotype
119(1)
Section 4 Rh Antibodies
119(1)
General Characteristics
119(1)
Clinical Considerations
119(1)
Transfusion Reactions
119(1)
Hemolytic Disease of the Fetus and Newborn
120(1)
Section 5 Lw Blodd Group System
120(6)
Relationship to the Rh Blood Group System
120(6)
Chapter 6 Other Blood Group Systems
126(32)
Section 1 Why Study Other Blood Group Systems?
127(2)
Organization of
Chapter
127(2)
Section 2 Kell Blood Group System
129(3)
Characteristics and Biochemistry of Kell Antigens
129(1)
Kell Antigens Facts
129(1)
Biochemistry of Kell Antigens
129(1)
Immunogenicity of Kell Antigens
130(1)
K0 or Kellnull Phenotype
130(1)
Genetics of Kell Blood Group System
131(1)
Characteristics of Kell Antibodies
131(1)
Section 3 Kx Blood Group System
132(2)
KX Antigen and Its Relationship to Kell Blood Group System
132(1)
McLeod Phenotype
132(1)
McLeod Syndrome
133(1)
Section 4 Duffy Blood Group System
134(2)
Characteristics and Biochemistry of Duffy Antigens
134(1)
Duffy Antigens Facts
134(1)
Biochemistry of Duffy Antigens
134(1)
Genetics of Duffy Blood Group System
135(1)
Characteristics of Duffy Antibodies
135(1)
Duffy System and Malaria
136(1)
Section 5 Kidd Blood Group System
136(2)
Characteristics and Biochemistry of Kidd Antigens
136(1)
Kidd Antigens Facts
136(1)
Biochemistry of Kidd Antigens
136(1)
Genetics of Kidd Blood Group System
137(1)
Characteristics of Kidd Antibodies
137(1)
Section 6 Lutheran Blood Group System
138(2)
Characteristics And Biochemistry of Lutheran Antigens
138(1)
Lutheran Antigens Facts
138(1)
Biochemistry of Lutheran Antigens
139(1)
Genetics of Lutheran Blood Group System
139(1)
Characteristics of Lutheran Antibodies
139(1)
Anti-Lua
139(1)
Anti-Lub
139(1)
Section 7 Lewis Blood Group System
140(2)
Characteristics and Biochemistry of Lewis Antigens
140(1)
Lewis Antigens Facts
140(1)
Biochemistry of Lewis Antigens
140(1)
Inheritance of Lewis System Antigens
141(1)
Characteristics of Lewis Antibodies
142(1)
Serologic Characteristics
142(1)
Section 8 I Blood Group System And I Antigen
142(2)
I and i Antigens Facts
143(1)
Biochemistry of I and i Antigens
143(1)
Serologic Characteristics of Autoanti-I
143(1)
Disease Association
144(1)
Section 9 P1 Pk Blood Group System, Globoside Blood Group System, And Globoside Blood Group Collection
144(3)
P1 Antigen
144(1)
P Antigen
144(1)
P1PK and GLOB Blood Group System Antigens Facts
144(1)
Biochemistry
145(1)
P1PK and GLOB Blood Group System Antibodies
146(1)
Anti-P1
146(1)
Autoanti-P
146(1)
Anti-PP1Pk
147(1)
Section 10 Mns Blood Group System
147(3)
M and N Antigens
147(1)
S and s Antigens
148(1)
Genetics and Biochemistry
148(1)
GPA: M and N Antigens
148(1)
GPB: S, s, and U Antigens
148(1)
Antibodies of MNS Blood Group System
148(1)
Anti-M
149(1)
Anti-N
150(1)
Anti-S, Anti-s, and Anti-U
150(1)
Section 11 Miscellaneous Blood Group Systems
150(8)
PART III ESSENTIALS OF PRETRANSFUSION TESTING
Chapter 7 Antibody Detection and Identification
158(30)
Section 1 Antibody Detection
159(3)
Antibody Screen
159(1)
Autocontrol and Direct Antiglobulin Test
160(1)
Potentiators
161(1)
Patient History
161(1)
Section 2 Antibody Identification
162(12)
Initial Panel
162(1)
Panel Interpretation: Single Antibody Specificity
163(2)
Autocontrol
165(1)
Phases
165(1)
Reaction Strength
165(1)
Ruling Out
165(1)
Matching the Pattern
166(1)
Rule of Three
166(1)
Patient's Phenotype
166(1)
Multiple Antibodies
166(2)
Multiple Antibody Resolution
168(1)
Additional Techniques
168(1)
Antibodies to High-Frequency Antigens
169(1)
Additional Testing
170(1)
High-Titer, Low-Avidity Antibodies
170(1)
Antibodies to Low-Frequency Antigens
171(1)
Enhancing Weak IgG Antibodies
171(1)
Cold Alloantibodies
172(2)
Section 3 Autoantibodies
174(14)
Cold Autoantibodies
174(1)
Specificity
175(1)
Avoiding Cold Autoantibody Reactivity
176(1)
Adsorption Techniques
177(1)
Warm Autoantibodies
177(1)
Specificity
178(1)
Elution
178(2)
Adsorption
180(8)
Chapter 8 Compatibility Testing
188(20)
Section 1 Princeples Of The Crossmatch
190(4)
What Is a Crossmatch?
190(1)
Purposes of Crossmatch Testing
191(1)
Standards and Regulations Governing the Crossmatch
191(1)
Crossmatch Procedures
191(1)
Serologic Crossmatch
192(1)
Computer Crossmatch
192(1)
Limitations of Crossmatch Testing
193(1)
Problem Solving Incompatible Crossmatches
194(1)
Section 2 Principles Of Comaptibility Testing
194(5)
Overview of Steps in Compatibility Testing
194(1)
Recipient Blood Sample
194(2)
Comparison with Previous Records
196(1)
Repeat Testing of Donor Blood
196(1)
Pretransfusion Testing on Recipient Sample
197(1)
Tagging, Inspecting, Issuing, and Transfusing Blood Products
198(1)
Section 3 Special Topics
199(9)
Urgent Requirement for Blood and Blood Components
199(2)
Massive Transfusion
201(1)
Maximum Surgical Blood Order Schedule
201(1)
Type and Screen Protocols
201(1)
Crossmatching Autologous Blood
202(1)
Crossmatching of Infants Younger than 4 Months Old
202(1)
Pretransfusion Testing for Non-Red Blood Cell Products
203(5)
Chapter 9 Blood Bank Automation for Transfusion Services
208(18)
Section 1 Introduction To Automation In Immunohematology
208(3)
Forces Driving the Change to Automation
209(1)
Benefits and Barriers of Automated Instruments
209(1)
Potential Benefits
209(1)
Potential Challenges
210(1)
Characteristics of an Ideal Instrument for the Blood Bank
211(1)
Section 2 Selection Of Automation To Meet Laboratory Needs
211(2)
Vendor Assessment
211(1)
Base Technology Assessment
212(1)
Instrument Assessment
212(1)
Section 3 Automated Testing Systems
213(13)
Automated Systems for Solid Phase Red Cell Adherence Assays
213(1)
Hemagglutination Assays
214(1)
Solid Phase Red Cell Adherence Assays
215(1)
SolidscreenR II Technology
216(1)
ErytypeR S Technology
217(3)
Automated System for Gel Technology Assays
220(6)
PART IV CLINICAL CONSIDERATIONS IN IMMUNOHEMATOLOGY
Chapter 10 Adverse Complications of Transfusions
226(20)
Section 1 Overview Of Adverse Reactions To Transfusion
227(1)
Hemovigilance Model
227(1)
Recognition of a Transfusion Reaction
227(1)
Section 2 Categories Of Transfusion Reactions
228(10)
Hemolytic Transfusion Reaction
228(1)
Acute Hemolytic Transfusion Reaction
228(2)
Delayed Hemolytic Reaction
230(1)
Non-Immune-Mediated Mechanisms of Red Cell Destruction
231(1)
Delayed Serologic Transfusion Reactions
232(1)
Febrile Nonhemolytic Transfusion Reactions
233(1)
Allergic and Anaphylactic Transfusion Reactions
234(1)
Transfusion-Related Acute Lung Injury
234(1)
Transfusion-Associated Graft-versus-Host Disease
235(1)
Bacterial Contamination of Blood Products
236(1)
Transfusion-Associated Circulatory Overload
237(1)
Transfusion Hemosiderosis
237(1)
Citrate Toxicity
237(1)
Posttransfusion Purpura
238(1)
Section 3 Evaluation And Reporting A Transfusion Reaction
238(8)
Initiating a Transfusion Reaction Investigation
238(2)
Additional Laboratory Testing in a Transfusion Reaction
240(1)
Records and Reporting of Transfusion Reactions and Fatalities
241(1)
Hemovigilance Component
241(1)
Records
241(1)
FDA Reportable Fatalities
241(5)
Chapter 11 Hemolytic Disease of the Fetus and Newborn
246(21)
Section 1 Etiology Of Hemolytic Disease Of The Fetus And Newborn
247(1)
Section 2 Overview Of Hemolytic Disease Of The Fetus And Newborn
247(3)
Rh Hemolytic Disease of the Fetus and Newborn
248(1)
ABO Hemolytic Disease of the Fetus and Newborn
249(1)
Alloantibodies Causing Hemolytic Disease of the Fetus and Newborn Other than Anti-D
249(1)
Section 3 Prediction Of Hemolytic Disease Of The Fetus And Newborn
250(3)
Maternal History
250(1)
Antibody Titration
250(1)
Ultrasound Techniques
251(1)
Amniocentesis
252(1)
Cordocentesis
252(1)
Fetal Genotyping
253(1)
Section 4 Postpartum Testing
253(2)
Postpartum Testing of Infants and Mothers
254(1)
D Testing
254(1)
ABO Testing
255(1)
Direct Antiglobulin Test
255(1)
Intrauterine Transfusions
255(1)
Section 5 Prevention Of Hemolytic Disease Of The Fetus And Newborn
255(3)
Antepartum Administration of Rh Immune Globulin
256(1)
Postpartum Administration of Rh Immune Globulin
256(1)
Screening for Fetomaternal Hemorrhage
257(1)
Quantifying Fetomatemal Hemorrhage
258(1)
Section 6 Treatment Of Hemolytic Disease Of The Fetus And Newborn
258(9)
In Utero Treatment
258(1)
Postpartum Treatment
259(1)
Phototherapy
259(1)
Exchange Transfusion
259(1)
Selection of Blood and Compatibility Testing for Exchange Transfusion
260(7)
PART V BLOOD COLLECTION AND TESTING
Chapter 12 Donor Selection and Phlebotomy
267(19)
Section 1 Donor Screening
268(8)
Registration
268(1)
Educational Materials
268(2)
Health History Interview
270(1)
Questions for Protection of the Donor
270(2)
Questions for Protection of the Recipient
272(3)
Physical Examination
275(1)
General Appearance
275(1)
Hemoglobin or Hematocrit Determination
275(1)
Temperature
275(1)
Blood Pressure
275(1)
Pulse
275(1)
Weight
275(1)
Informed Consent
276(1)
Section 2 Phlebotomy
276(3)
Identification
276(1)
Bag Labeling
276(1)
Arm Preparation and Venipuncture
277(1)
Adverse Donor Reactions
277(1)
Postdonation Instructions and Care
277(2)
Section 3 Special Blood Collection
279(7)
Autologous Donations
279(1)
Preoperative Collection
279(1)
Normovolemic Hemodilution
280(1)
Blood Recovery
280(1)
Directed Donations
280(1)
Apheresis
281(1)
Therapeutic Phlebotomy
281(5)
Chapter 13 Testing of Donor Blood
286(18)
Section 1 Overview Of Donor Blood Testing
286(1)
Required Testing on Allogeneic and Autologous Donor Blood
287(1)
Section 2 Immunohematologic Testing Of Donor Units
287(1)
ABO and D Phenotype
287(1)
Antibody Screen
288(1)
Section 3 Infectious Disease Testing Of Donor Units
288(16)
Serologic Tests for Syphilis
288(1)
Rapid Plasma Reagin Test
288(1)
Hemagglutination Test for Treponema pallidum Antibodies
289(1)
Confirmatory Testing for Syphilis
289(1)
Principles of Viral Marker Testing
289(1)
Enzyme-Linked Immunosorbent Assay
289(2)
Nucleic Acid Testing
291(1)
Chemiluminescence
291(1)
Controls
291(1)
Sensitivity and Specificity
292(1)
Viral Hepatitis
292(1)
Hepatitis Viruses
292(2)
Hepatitis Tests
294(1)
Human Retroviruses
295(1)
Human Immunodeficiency Virus Types 1 and 2
296(1)
Nucleic Acid Testing for Ribonucleic Acid of Human Immunodeficiency Virus Type 1
297(1)
Human T-Lymphotropic Virus Types I and II
297(1)
Western Blotting
297(1)
West Nile Virus
298(1)
Recipient Tracing (Look-Back)
299(1)
Additional Tests Performed on Donor Blood
299(1)
Cytomegalovirus
299(1)
Chagas Disease
299(1)
Testing for Bacterial Contamination of Blood Components
300(4)
PART VI BLOOD COMPONENT PREPARATION AND TRANSFUSION THERAPY
Chapter 14 Blood Component Preparation and Therapy
304(25)
Section 1 Blood Collection And Storage
305(4)
Storage Lesion
306(1)
Types of Anticoagulant-Preservative Solutions
307(1)
Additive Solutions
307(1)
Rejuvenation Solution
308(1)
Section 2 Blood Component Preparation
309(12)
Whole Blood
311(1)
Indications for Use
311(1)
Red Blood Cell Components
311(1)
Indications for Use
311(1)
Red Blood Cells Leukocytes Reduced
312(1)
Apheresis Red Blood Cells
313(1)
Frozen Red Blood Cells
314(1)
Deglycerolized Red Blood Cells
314(1)
Washed Red Blood Cells
315(1)
Red Blood Cells Irradiated
315(1)
Platelet Components
316(1)
Indications for Use
316(1)
Platelets
317(1)
Pooled Platelets
317(1)
Apheresis Platelets
317(1)
Platelets Leukocytes Reduced
318(1)
Plasma Components
318(1)
Fresh Frozen Plasma, Plasma Frozen within 24 Hours of Phlebotomy
318(1)
Cryoprecipitated Antihemophilic Factor
319(2)
Apheresis Granulocytes
321(1)
Section 3 Distribution And Administration
321(8)
Labeling
321(2)
Storage and Transportation
323(1)
Transportation of Blood Components
323(1)
Administration of Blood Components
324(5)
Chapter 15 Transfusion Therapy in Selected Patients
329(16)
Section 1 Transfusion Practices
329(12)
Urgent and Massive Transfusion
329(1)
Cardiac Surgery
330(1)
Neonatal and Pediatric Transfusion Issues
331(1)
Transplantation
332(1)
Organ Transplants
333(1)
Hematopoietic Progenitor Cell Transplantation
333(2)
Therapeutic Apheresis
335(1)
Oncology
336(1)
Chronic Renal Disease
337(1)
Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura
338(1)
Anemias Requiring Transfusion Support
339(1)
Sickle Cell Anemia
339(1)
Thalassemia
339(1)
Immune Hemolytic Anemias
340(1)
Hemostatic Disorders
340(1)
Section 2 Alternatives To Transfusion
341(4)
PART VII QUALITY AND SAFETY ISSUES
Chapter 16 Quality Assurance and Regulation of the Blood Industry and Safety Issues in the Blood Bank
345(20)
Section 1 Regulatory And Accrediting Agencies For Quality And Safety
346(2)
Food and Drug Administration
346(1)
AABB
347(1)
Other Safety Regulations
347(1)
Occupational Safety and Health Act
347(1)
Environmental Protection Agency
347(1)
Section 2 Quality Assurance And Good Manufacturing Practices
348(8)
Quality Assurance
348(1)
Quality Assurance Department
348(1)
Good Manufacturing Practices
348(1)
Components of a Quality Assurance Program
348(1)
Records and Documents
348(3)
Standard Operating Procedures
351(1)
Change Control
352(1)
Personnel Qualifications
352(2)
Supplier Qualification
354(1)
Error Management
354(1)
Validation
355(1)
Facilities and Equipment
355(1)
Proficiency Testing
355(1)
Label Control
356(1)
Section 3 Safety
356(9)
Standard versus Universal Precautions
356(1)
Blood Bank Safety Program
356(1)
Physical Space, Safety Equipment, Protective Devices, and Warning Signs
357(2)
Decontamination
359(1)
Chemical Storage and Hazards
359(1)
Radiation Safety
359(1)
Biohazardous Wastes
359(1)
Storage and Transportation of Blood and Blood Components
360(1)
Personal Injury and Reporting
360(1)
Employee Education
360(5)
Appendix A Answers To Study Questions 365(2)
Glossary 367(6)
Index 373