The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy. As previously, a multi-national authorship includes some of the top radiation oncologists, biologists, and physicists from North America and Europe, who highlight the core principles of radiobiology.
The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy.
Preface
About the editors
List of contributors
Glossary
1. Introduction: The significance of radiobiology and radiotherapy for cancer
treatment.
2. Irradiation-induced damage and the DNA damage response.
3. Cell
death after irradiation how, when and why cells die.
4. Quantifying cell
kill and cell survival.
5. Radiation dose-response relationships.
6. Linear
energy transfer and relative biological effectiveness.
7. Physics of
radiation therapy for the radiobiologist.
8. Tumour growth and response to
radiation.
9. Fractionation: The Linear-Quadratic approach.
10. The
linear-quadratic approach in clinical practice.
11. Modified fractionation.
12. Early effects in epithelial tissues, the role of stem cells and time
factors.
13. The dose-rate effect.
14. Pathogenesis of late normal tissue
effects.
15. Volume effects, regional responses, and risk models.
16.
Biological modifiers of normal tissue effects.
17. The oxygen effect and
therapeutic approaches to tumour hypoxia.
18. The tumour microenvironment and
cellular hypoxia responses.
19. Combined radiotherapy and chemotherapy from
the perspective of the Radiation Oncologist.
20. Molecular targeted agents
for enhancing tumour response.
21. Biological individualisation of
radiotherapy.
22. Molecular image guided radiotherapy.
23. Retreatment
tolerance of normal tissues.
24. Cancer stem cells in radiotherapy.
25.
Hadron therapy: The clinical aspects.
26. Radiation and the immune system.
27. Second cancers after radiotherapy.
Index
Michael C. Joiner, PhD, is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at Wayne State University, Detroit, Michigan, USA.
Albert J. van der Kogel, PhD, is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at the University of Wisconsin, Madison, Wisconsin, USA.
