Contributors |
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xv | |
Editor's biography |
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xix | |
Preface |
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xxi | |
Acknowledgment |
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xxiii | |
1 Best practices for supervised machine learning when examining biomarkers in clinical populations |
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1 | (1) |
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2 | (3) |
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3 Statistical assumptions |
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5 | (3) |
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8 | (1) |
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5 Choosing parsimonious models |
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9 | (2) |
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6 Reduction of data dimensionality |
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11 | (4) |
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12 | (1) |
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12 | (1) |
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6.3 Principal component analysis |
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13 | (1) |
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6.4 Linear discriminant analysis |
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14 | (1) |
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15 | (4) |
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19 | (4) |
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23 | (1) |
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23 | (1) |
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9.2 Data reduction and scaling |
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23 | (1) |
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23 | (1) |
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24 | (1) |
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10 Supervised machine learning classifiers |
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24 | (2) |
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11 Deep learning and artificial intelligence |
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26 | (2) |
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12 Limitations and future directions |
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28 | (1) |
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28 | (1) |
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29 | (6) |
2 Big data in personalized healthcare |
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35 | (1) |
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2 Characteristics, methods, and software platforms of big data |
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36 | (3) |
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3 Big data in the healthcare area |
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39 | (3) |
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4 Big data and big data analytics in personalized healthcare |
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42 | (4) |
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46 | (1) |
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46 | (1) |
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46 | (5) |
3 Longitudinal data analysis: The multiple indicators growth curve model approach |
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51 | (2) |
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2 Multivariate dimension reduction techniques: Principal component analysis and factor analysis |
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53 | (5) |
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2.1 Principal component analysis |
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54 | (1) |
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55 | (2) |
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2.3 Factor analysis and principal component analysis for multiple indicator growth curve models |
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57 | (1) |
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3 Longitudinal measurement invariance |
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58 | (2) |
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4 Multiple indicators growth curve model |
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60 | (4) |
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61 | (2) |
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4.2 Specification details |
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63 | (1) |
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5 Steps in fitting an MILCM |
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64 | (2) |
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66 | (3) |
4 Challenges and solutions for big data in personalized healthcare |
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69 | (2) |
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71 | (6) |
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2.1 Interoperability and reusability |
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71 | (1) |
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2.2 Standards for clinical data |
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72 | (2) |
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2.3 Standards for -omics data |
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74 | (1) |
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2.4 Standards for imaging data |
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75 | (1) |
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2.5 Standards for biosample data |
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76 | (1) |
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3 Data sharing and integration |
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77 | (7) |
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77 | (1) |
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3.2 Support for data sharing |
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78 | (1) |
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3.3 Data sharing initiatives |
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79 | (2) |
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81 | (3) |
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84 | (3) |
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84 | (1) |
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85 | (1) |
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4.3 Privacy and ethics in industry |
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85 | (2) |
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87 | (1) |
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5.1 Need for more training |
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87 | (1) |
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5.2 Training data science to medical students |
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87 | (1) |
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5.3 Available courses in Clinical Data Science |
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88 | (1) |
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88 | (1) |
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Competing interest statement |
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89 | (1) |
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90 | (5) |
5 Data linkages in epidemiology |
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95 | (1) |
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2 Linking local and national routinely-collected data |
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96 | (3) |
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2.1 Development of diagnostic algorithms: Structured data |
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98 | (1) |
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3 Linking routinely- and non-routinely-collected data |
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99 | (1) |
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4 Linking structured and unstructured routinely-collected data |
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100 | (9) |
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4.1 CRIS and CRATE databases |
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101 | (5) |
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4.2 Development of diagnostic algorithms: Unstructured data |
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106 | (3) |
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109 | (2) |
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111 | (8) |
6 Neutrosophic rule-based classification system and its medical applications |
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119 | (3) |
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122 | (4) |
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2.1 Neutrosophic logic and neutrosophic set |
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122 | (1) |
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2.2 Neutrosophic rule-based classification system |
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123 | (3) |
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3 NRCS medical applications |
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126 | (7) |
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3.1 Neutrosophic rule-based prediction system for toxicity effects assessment of biotransformed hepatic drugs |
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126 | (3) |
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3.2 A predictive model for diabetics using NRCS |
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129 | (1) |
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3.3 A predictive model for seminal quality using NRCS |
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130 | (3) |
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4 Conclusions and future work |
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133 | (1) |
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133 | (4) |
7 From complex to neural networks |
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1 Big data and MRI analyses |
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137 | (4) |
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2 Modeling purposes: Complex networks |
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141 | (4) |
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145 | (5) |
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4 A multiplex model to diagnose neurodegenerative diseases and anomalous aging |
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150 | (2) |
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152 | (3) |
8 The use of Big Data in Psychiatry-The role of administrative databases |
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155 | (1) |
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2 Big Data, administrative databases, and mental health |
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156 | (1) |
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3 Pros and cons of administrative databases research in mental health |
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157 | (5) |
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162 | (1) |
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163 | (4) |
9 Predicting the emergence of novel psychoactive substances with big data |
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167 | (2) |
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2 Internet search queries as data |
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169 | (2) |
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171 | (1) |
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172 | (2) |
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5 Discussion and conclusion |
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174 | (3) |
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177 | (4) |
10 Hippocampus segmentation in MR images: Multiatlas methods and deep learning methods |
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181 | (3) |
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2 Patch-based multiatlas labeling for Hippocampus segmentation |
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184 | (10) |
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2.1 Weighted voting label fusion |
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185 | (2) |
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2.2 Local learning-based label fusion |
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187 | (1) |
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2.3 Supervised metric learning for label fusion |
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188 | (2) |
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2.4 An evaluation of different patch-based multiatlas labeling methods |
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190 | (4) |
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3 Deep learning-based methods for Hippocampus segmentation |
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194 | (16) |
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3.1 Multiatlas-based deep learning method for hippocampus segmentation |
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196 | (9) |
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3.2 End-to-end dilated residual dense U-net for hippocampus segmentation |
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205 | (5) |
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210 | (1) |
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211 | (1) |
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212 | (5) |
11 A scalable medication intake monitoring system |
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Diane Myung-Kyung Woodbridge |
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217 | (1) |
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218 | (2) |
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220 | (3) |
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3.1 Smartwatch application |
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221 | (1) |
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222 | (1) |
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222 | (1) |
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3.4 Distributed data processing |
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223 | (1) |
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223 | (5) |
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4.1 Distributed preprocessing |
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224 | (2) |
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4.2 Distributed AutoML and machine learning |
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226 | (2) |
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228 | (8) |
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228 | (3) |
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231 | (5) |
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236 | (2) |
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238 | (1) |
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238 | (3) |
12 Evaluating cascade prediction via different embedding techniques for disease mitigation |
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241 | (2) |
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243 | (2) |
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245 | (8) |
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245 | (1) |
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3.2 Generating graph embeddings |
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245 | (4) |
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249 | (4) |
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253 | (1) |
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253 | (2) |
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4.1 Cascade prediction using MLP |
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253 | (1) |
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4.2 Cascade prediction using LSTM |
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253 | (2) |
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255 | (1) |
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5 Discussion and conclusions |
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255 | (4) |
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259 | (1) |
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259 | (4) |
13 A two-stage classification framework for epileptic seizure prediction using EEG wavelet-based features |
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263 | (2) |
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265 | (7) |
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265 | (1) |
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2.2 Two-stage zero-crossings wavelet-based framework |
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266 | (5) |
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2.3 Comparative analysis methods |
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271 | (1) |
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272 | (11) |
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3.1 Stage 1: Interictal and preictal binary classification |
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272 | (5) |
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3.2 Stage 2: Preictal classification into early and late stages |
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277 | (6) |
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283 | (1) |
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284 | (1) |
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285 | (1) |
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285 | (2) |
14 Visual neuroscience in the age of big data and artificial intelligence |
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1 Confining the problem space |
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287 | (1) |
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288 | (1) |
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3 Understanding vision-What do we seek to reveal? |
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288 | (5) |
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3.1 The first generation of neural network models |
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290 | (1) |
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3.2 Next generation of neural network models |
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291 | (1) |
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3.3 Experiments to falsify and improve models |
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292 | (1) |
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4 How to evaluate the current models of vision? |
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293 | (4) |
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293 | (4) |
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297 | (1) |
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5 The vision community is coming together to combine data and models |
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297 | (4) |
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5.1 Allen brain observatory |
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299 | (1) |
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299 | (1) |
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5.3 The Algonauts project |
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300 | (1) |
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301 | (1) |
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301 | (4) |
15 Application of big data and artificial intelligence approaches in diagnosis and treatment of neuropsychiatric diseases |
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305 | (2) |
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307 | (3) |
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307 | (1) |
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308 | (1) |
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308 | (1) |
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309 | (1) |
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2.5 Wearable equipment data |
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309 | (1) |
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310 | (1) |
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311 | (6) |
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311 | (1) |
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312 | (4) |
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316 | (1) |
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5 Challenges and promising solutions |
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317 | (3) |
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5.1 Privacy and security of patient information |
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317 | (2) |
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319 | (1) |
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5.3 Storage and analysis capabilities |
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319 | (1) |
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5.4 Lack of specialized personnel |
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320 | (1) |
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320 | (1) |
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321 | (4) |
16 Harnessing big data to strengthen evidence-informed precise public health response |
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325 | (1) |
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2 Global burden of disease |
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326 | (2) |
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2.1 Noncommunicable diseases |
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327 | (1) |
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327 | (1) |
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3 Health systems and public health system |
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328 | (4) |
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3.1 Public health surveillance system |
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329 | (3) |
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4 Big data in precision public health |
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332 | (1) |
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333 | (2) |
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5.1 Noncommunicable diseases |
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333 | (1) |
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5.2 Infectious disease: COVID-19 |
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334 | (1) |
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335 | (4) |
17 How big data analytics is changing the face of precision medicine in women's health |
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339 | (2) |
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2 The role of big data and deep learning in personalized medicine to empower women's health |
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341 | (1) |
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342 | (5) |
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3.1 Advanced data analytics on skin conditions from genotype to phenotype |
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342 | (2) |
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3.2 Big data platform to use machine learning on EHR data for personalized medicine in heart failure survival analysis and patient similarity |
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344 | (2) |
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3.3 Large-scale labeling of free-text pathology report for deep learning to improve women's health in breast cancer |
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346 | (1) |
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347 | (1) |
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348 | (1) |
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348 | (1) |
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348 | (3) |
Index |
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351 | |