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El. knyga: Biointeractions of Nanomaterials

Edited by (University of South Florida College of Pharmacy, Tampa, USA), Edited by (University of South Florida College of Pharmacy, Tampa, USA)
  • Formatas: 480 pages
  • Išleidimo metai: 29-Jul-2014
  • Leidėjas: CRC Press Inc
  • Kalba: eng
  • ISBN-13: 9781466582392
  • Formatas: 480 pages
  • Išleidimo metai: 29-Jul-2014
  • Leidėjas: CRC Press Inc
  • Kalba: eng
  • ISBN-13: 9781466582392

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"The purpose of this book is to focus on the biointeraction of nanomaterials, an area that has not been previously addressed in detail. It also covers various techniques and tests that have been developed to evaluate the toxicity of materials at the nanolevel. The interactions of nanomaterials and nanosystems within biosystems are a concern for the scientific community. This book is targeted toward academic researchers as well as industry members who are involved in the development of nanosystems. Many graduate schools have initiated courses in nanotechnology and applications. This book will be a great resource for students as well as professors. Additionally, this will be a useful tool for industrial scientists investigating technology to update their nanotoxicology and nano-safety understanding. The objective of the book is to address issues related to toxicity and safety of nanomaterials and nanosystems. It also covers the interactions of these in biological systems, various tools and methods used toevaluate the toxicity and safety issues. The volume comprises 20 chapters written by leading scientists in the field of nanotechnology. Chapter 1 covers the challenges and solutions of bio interactions of nanomaterials. This is followed by three chaptersthat address the assessment and characterization of nanosystems in the bio-environment"--Provided by publisher.

Researchers in pharmacy and other physical and biological sciences review the science on toxicity and safety of nanomaterials and nanosystems, their interactions in biological systems, and various tools and methods used to evaluate toxicity and safety issues. Among the topics are nanoparticle exposures in occupational environments, biosensing devices for assessing the toxicity of nanomaterials, the nanotoxicity of polymeric and solid lipid nanoparticles, toxicogenomic approaches to understanding the toxicity of nanoparticles, regulatory implications of nanotechnology, interactions of polysaccharide-coated nanoparticles with proteins, and the immunotoxicity of carbon nanoparticles. Annotation ©2014 Ringgold, Inc., Portland, OR (protoview.com)

An examination of the widespread application of nano materials in biology, medicine, and pharmaceuticals and the accompanying safety concerns, Bio-interactions of Nano Materials addresses the issues related to toxicity and safety of nano materials and nano systems. It covers the interactions in biological systems and presents various tools and methods used to evaluate the nano toxicity and nano safety issues.

Written by leading scientists, the book focuses on the bio-interaction of nano materials, covering various techniques and tests which have been developed to evaluate the toxicity of materials at the nano level. The book highlights the challenges of bio-interactions of nano materials and possible solutions to those challenges. It addresses the assessment and characterization of nano systems in bio-environments, toxicity and bio-sensing devices for toxicity assessment, carbon nano tubes and pulmonary toxicity, and nano toxicity of solid lipid nanoparticles. It also discusses nano safety concerns and solutions, including the effects of nano particles on different organs and regulatory implications of nano materials.

These particles may be used to encapsulate drugs, recognize biological markers, or visualize body tissues among many other possibilities, all enabling their widespread application in biology, medicine, and pharmaceutics. Indeed, these nano materials may have beneficial effects that have not even been imagined. This book gives you an understanding of the safety issues, how to assess for them, and how to mitigate them to move forward in research and development of new applications for nano materials.

Foreword ix
Preface xi
Editors xiii
Contributors xv
Chapter 1 Introduction---Biointeractions of Nanomaterials: Challenges and Solutions
1(48)
Vijaykumar B. Sutariya
Vrinda Pathak
Ana Groshev
Mahavir B. Chougule
Sachin Naik
Deepa Patel
Yashwant Pathak
Chapter 2 Nanoparticle Exposures in Occupational Environments
49(24)
Li-Hao Young
Ying-Fang Wang
Ching-Hwa Chen
Chun-Wan Chen
Perng-Jy Tsai
Chapter 3 Physicochemical Characterization-Dependent Toxicity of Nanoparticles
73(30)
Jigar N. Shah
Ankur P. Shah
Hiral J. Shah
Vijaykumar B. Sutariya
Chapter 4 Cytotoxicity of Stimuli-Responsive Nanomaterials: Predicting Clinical Viability through Robust Biocompatibility Profiles
103(14)
Daniel Wehrung
Moses O. Oyewumi
Chapter 5 Biosensing Devices for Toxicity Assessment of Nanomaterials
117(14)
Evangelia Hondroulis
Pratik Shah
Xuena Zhu
Chen-Thong Li
Chapter 6 Carbon Nanotubes and Pulmonary Toxicity
131(10)
Malay K. Das
Charles Preuss
Chapter 7 Nanotoxicity of Polymeric and Solid Lipid Nanoparticles
141(18)
Dev Prasad
Harsh Chauhan
Chapter 8 Analytical Characterization of Nanomaterials in Biological Matrices for Hazard Assessment
159(16)
Mingsheng Xu
Daisuke Fujita
Huanxing Su
Hongzheng Chen
Nobutaka Hanagata
Chapter 9 Nanoparticles and Human Health: A Review of Epidemiological Studies
175(34)
Vijaykumar B. Sutariya
Ana Groshev
Vivek Dave
Hardeep Saluja
Deepak Bhatia
Prabodh Sadana
Yashwant Pathak
Chapter 10 Toxicogenomic Approaches to Understanding the Toxicity of Nanoparticles
209(16)
Qiwen Shi
Mahavir B. Chougule
Vijaykumar B. Sutariya
Deepak Bhatia
Chapter 11 Nanomaterial-Based Gene and Drug Delivery: Pulmonary Toxicity Considerations
225(24)
Mahavir B. Chougule
Rakesh K. Tekade
Peter R. Hoffmann
Deepak Bhatia
Vijaykumar B. Sutariya
Yashwant Pathak
Chapter 12 Cardiovascular Toxicity of Nanomaterials
249(10)
Saijie Zhu
Minghuang Hong
Chapter 13 Toxicity of Nanomaterials on the Gastrointestinal Tract
259(26)
Jayvadan Patel
Vibha Champavat
Chapter 14 Toxicity of Nanomaterials on the Liver, Kidney, and Spleen
285(30)
Jayvadan Patel
Anita Patel
Chapter 15 Regulatory Implications of Nanotechnology
315(32)
Lynn L. Bergeson
Michael F. Cole
Chapter 16 Ocular Toxicity of Nanoparticles
347(6)
Aditya Grover
Anjali Hirani
Yong Woo Lee
Vijaykumar B. Sutariya
Yashwant Pathak
Chapter 17 Genotoxicity of Nanoparticles
353(12)
Amaya Azqueta
Leire Arbillaga
Adela Lopez de Cerain
Chapter 18 Interactions of Polysaccharide-Coated Nanoparticles with Proteins
365(18)
Christine Vauthier
Chapter 19 Models for Risk Assessments of Nanoparticles
383(42)
Sanjay Dey
Bhaskar Mazumder
Yaswant Pathak
Chapter 20 Immunotoxicity of Carbon Nanoparticles
425(18)
Paulami Pal
Bhaskar Mazumder
Yaswant Pathak
Index 443
Vijaykumar B. Sutariya, Yashwant Pathak