Atnaujinkite slapukų nuostatas

El. knyga: Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell, and Tissue Responses

Edited by , Edited by
  • Formatas: PDF+DRM
  • Išleidimo metai: 26-Jun-2009
  • Leidėjas: Springer-Verlag New York Inc.
  • Kalba: eng
  • ISBN-13: 9780387981611
Kitos knygos pagal šią temą:
  • Formatas: PDF+DRM
  • Išleidimo metai: 26-Jun-2009
  • Leidėjas: Springer-Verlag New York Inc.
  • Kalba: eng
  • ISBN-13: 9780387981611
Kitos knygos pagal šią temą:

DRM apribojimai

  • Kopijuoti:

    neleidžiama

  • Spausdinti:

    neleidžiama

  • El. knygos naudojimas:

    Skaitmeninių teisių valdymas (DRM)
    Leidykla pateikė šią knygą šifruota forma, o tai reiškia, kad norint ją atrakinti ir perskaityti reikia įdiegti nemokamą programinę įrangą. Norint skaityti šią el. knygą, turite susikurti Adobe ID . Daugiau informacijos  čia. El. knygą galima atsisiųsti į 6 įrenginius (vienas vartotojas su tuo pačiu Adobe ID).

    Reikalinga programinė įranga
    Norint skaityti šią el. knygą mobiliajame įrenginyje (telefone ar planšetiniame kompiuteryje), turite įdiegti šią nemokamą programėlę: PocketBook Reader (iOS / Android)

    Norint skaityti šią el. knygą asmeniniame arba „Mac“ kompiuteryje, Jums reikalinga  Adobe Digital Editions “ (tai nemokama programa, specialiai sukurta el. knygoms. Tai nėra tas pats, kas „Adobe Reader“, kurią tikriausiai jau turite savo kompiuteryje.)

    Negalite skaityti šios el. knygos naudodami „Amazon Kindle“.

Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.
Protein Adsorption to Biomatrials
David Richard Schmidt
Heather Waldeck
Weiyuan John Kao
Introduction
2(1)
Fundamentals of Protein Adsorption
2(9)
General Concepts
2(1)
Protein Properties
3(4)
Surface Properties
7(3)
Environmental Effects
10(1)
Adsorption of Serum Proteins
10(1)
Techniques for the Study of Protein Adsorption
11(4)
Established Techniques for the Study of Protein Adsorption
11(2)
Emerging Techniques for the Study of Protein Adsorption
13(2)
Recent Advances in Protein Adsorption
15(2)
Protein Adsorption to Nanomaterials
15(1)
Manipulating Protein Adsorption
16(1)
Current Limitations and Potential Future Opportunities
17(3)
References
17(3)
Investigating Protein Adsorption via Spectroscopic Ellipsometry
Maria F. Mora
Jennifer L. Wehmeyer
Ron Synowicki
Carlos D. Garcia
Introduction
20(1)
Ellipsometry
21(1)
Optical Models Used to Interpret Ellipsometric Results
22(2)
Instrument Considerations
24(2)
Material Surface Preparation
26(1)
Typical Protein Adsorption Experiment Followed by Ellipsometry
26(2)
Ellipsometric Determination of the Adsorption of Proteins to Nanomaterials
28(5)
Adsorption of BSA to Nanostructured TiO2
28(3)
Adsorption of Proteins to Carbon Nanotubes: Biosensing Applications
31(2)
Innovative Applications
33(1)
Conclusions
34(10)
References
35(9)
Atomic Force Microscopy Methods for Characterizing Protein Interactions with Microphase-Separated Polyurethane Biomaterials
Li-Chong Xu
Pranav Soman
Ashiish Agnihotri
Christopher A. Siedlecki
Introduction
44(3)
Surface Microphase Separation Structures of PU Materials
47(3)
Microphase Structure of PU Under Ambient Environments
47(1)
Microphase Structure of PU Under Aqueous Buffer Conditions
48(1)
Micromechanical Analysis of PU Materials by AFM Indentation
49(1)
Protein Interactions with Hydrophobic and Hydrophilic Surfaces
50(6)
Time-Dependent Conformational Changes in Fibrinogen Measured by AFM
51(1)
Effects of Surface Wettability and Contact Time on Protein Adhesion to Materials
52(2)
Dynamic Force Microscopy Studies of Fibrinogen-Material Surface Interactions
54(2)
Recognition of Proteins on Material Surfaces by AFM
56(2)
Immunological Recognition of Protein with Polyclonal Antibodies by AFM Force Mode
56(1)
Immunological Nanogold Labeling Technique
57(1)
Measuring the Functional Activity of Adsorbed Fibrinogen
58(1)
Measuring Protein Adsorption on PU Surfaces at the Molecular Scale
59(2)
Microphase Separation Structure Affects Protein Adsorption
59(1)
Soft Segment Chemistry and Hard Segment Content of PUs Affect Fibriongen Adsorption/Bioactivity and Platelet Adhesion
60(1)
Summary
61(9)
References
63(7)
Molecular Simulation of Protein-Surface Interactions
Robert A. Latour
Introduction
70(1)
Fundamentals of Protein Structure and Protein-Surface Interactions
71(3)
Molecular Simulation Methods
74(17)
Overview
74(1)
Molecular Simulation of Protein-Surface Interactions
75(7)
Representation of Solvation Effects for Protein-Surface Interactions
82(4)
Statistical Sampling Considerations for Protein-Surface Interactions
86(5)
Future Directions
91(1)
Concluding Remarks
91(7)
References
92(6)
Biomolecule-Nanomaterial Interactions: Effect on Biomolecule Structure, Function, and Stability
Ravindra C. Pangule
Shyam Sundhar Bale
Dhiral A. Shah
Amit Joshi
Prashanth Asuri
Jonathan S. Dordick
Ravi S. Kane
Introduction
98(1)
Structure and Function of Proteins on Carbon Nanotubes
99(3)
Enhanced Protein Stability on Nanomaterials
102(3)
Functional Materials
105(7)
Polymer---Nanotube---Enzyme Composites for Antifouling Applications
105(1)
Nanotube-Assisted Protein Deactivation
106(2)
Protein-Mediated Formation of Nanotube---Nanoparticle Hybrid Materials
108(1)
Nanotube-Directed Interfacial Biocatalysis
108(2)
Solubilization of SWNTs Using Proteins
110(1)
DNA Degradation by MWNT-DNAzyme Hybrids
110(2)
Conclusion and Future Directions
112(4)
References
113(3)
Phage Display as a Strategy for Designing Organic/Inorganic Biomaterials
Sharon Segvich
David H. Kohn
Introduction: Biomaterials Development and the Need for More Robust Approaches to Control Protein, Cell, and Tissue Responses
116(2)
Peptide---Biomaterial Interaction
118(1)
Phage Display as a Selection Technique
119(4)
Computational Analysis Tools
122(1)
Characterization Techniques
123(1)
Phage Display on Apatite-Based Mineral
123(2)
Phage Display on Cells and the Role of Dual-Functioning Peptides
125(2)
Advancing Phage Display in Biomaterials Research - Summary
127(7)
References
127(7)
Extracellular Matrix-Derived Lignds for Selective Integrin Binding to Control Cell Function
Timothy A. Petrie
Andres J. Garcia
Extracellular Matrix: Composition and Role
134(1)
Cell-ECM Adhesive Interactions: Integrins as Pivotal Linkers
135(3)
Engineering Biomaterial Surface Properties for Integrin Binding
138(2)
Modulating Cellular Response to Biomaterial Surfaces Through ECM-Mimetic Surface Modification Strategies
140(9)
General ECM Surface Modifications to Regulate Integrin-Mediated Cell Function
140(2)
Small Biomimetic Peptide Surface Strategies
142(2)
Multiple-Motif Integrin-Specific Ligands
144(1)
FN-Derived Highly Selective Integrin Ligands
145(2)
Collagen-Mimetic Integrin-Specific Ligands
147(1)
FN-Derived Integrin Ligands to Direct Matrix Assembly
148(1)
Advanced ECM-Mimetic Surface Strategies: Multivalent, Clustered Integrin Ligands
149(2)
Summary
151(7)
References
151(7)
Ligand-Functionalized Biomaterial Surfaces: Controlled Regulation of Signaling Pathways to Direct Stem Cell Differentiation
Myung Hee Kim
Krishnendu Roy
Introduction
158(1)
Notch Signaling Pathway
158(9)
Biological Strategy for Inducing Notch Signaling In Vitro: Notch Ligand-Transfected Stromal Cells for T-Cell Differentiation
159(3)
Ligand Presentation Through the Cell Surface Is Not Necessary for Notch Signaling: Immobilization of Notch Ligand on Synthetic Surfaces for Notch Signal Activation
162(2)
Method to Scale-Up Notch Signaling and Mimic Cell-Cell Interactions: Microbead-Based Notch Signaling for T-Cell Differentiation
164(3)
Other Signal Transduction Pathways
167(2)
Sonic Hedgehog Signaling
167(1)
Fibronectin-Immobilized Biomaterial Surface to Induce Mesenchymal Stem Cell Differentiation and HSC Expansion
168(1)
Conclusions
169(5)
References
170(4)
Growth Factors on Biomaterial Scaffolds
Yoshihiro Ito
Introduction
174(1)
Mechanisms of Action of Growth Factors on Cells
174(2)
Immobilized Growth Factors
176(5)
Effects of Immobilized Growth Factors on Cell Function
181(6)
High Local Concentration of Growth Factors and Multivalency
182(2)
Inhibition of Growth Factor Downregulation
184(1)
Other Pertinent Mechanisms
185(2)
Biomaterial Design Using Immobilized Growth Factors
187(5)
Methods for Growth Factor Immobilization
187(1)
Spacer Insertion and Surface Stiffness
188(1)
Micropatterning
188(1)
Coimmobilization
189(1)
Engineering of Proteins for Immobilization
190(2)
Conclusions
192(8)
References
192(8)
Cell and Tissue Interactions with Materials: The Role of Growth Factors
Christopher C. Gibson
David A. Puleo
Rena Bizios
Introduction
200(1)
Growth Factors in Vascular Network Formation and Repair
201(5)
Vascular Endothelial Growth Factor (VEGF)
202(1)
Fibroblast Growth Factor (FGF)
203(1)
Platelet-Derived Growth Factor (PDGF)
204(1)
Transforming Growth Factor-β (TGF-β)
204(1)
Growth Factors in the Wound-Healing Process of Vascular Tissue
205(1)
Growth Factors in Select Pathological Conditions Pertinent to Vascularization
206(1)
Growth Factors in Bone Development and Repair
206(4)
Bone Development
206(1)
Bone Morphogenetic Protein
207(1)
Fibroblast Growth Factor (FGF)
208(1)
Insulin-Like Growth Facctor (IGF)
208(1)
Platelet-Derived Growth Factor (PDGF)
208(1)
Transforming Growth Factor-β (TGF-β)
208(1)
Growth Factors in the Wound-Healing Process of Bone
209(1)
Future Directions in Growth Factor Research
210(1)
Applications of Growth Factors to Biomaterials
210(7)
Modes of Growth Factor Delivery from Biomaterials
211(2)
Combined Delivery of Growth Factors
213(2)
Combined Angiogenic/Osteogenic Growth Factor Delivery
215(1)
Sequential Delivery of Growth Factors
216(1)
State of the Art Summary and Future Dirctions
217(9)
References
218(8)
In Vitro and In Vivo Monocyte, Macrophage, Foreign Body Giant Cell, and Lymphocyte Interactions with Biomaterials
James M. Anderson
Introduction
226(2)
Monocytes, Macrophages, and FBGCs
228(6)
Protein Adsorption on Biomaterial Surfaces
228(1)
Monocyte/Macrophage Migration and Adhesion
228(3)
Macrophage Fusion/FBGC Formation
231(1)
FBGC Phenotype
231(1)
Consequences of FBGC Formation on Biomaterial Surfaces
232(2)
Paracrine Interactions Between Macrophages/FBGCs and Inflammatory/Wound-Healing Cells
234(4)
Macrophage/FBGC and Cytokines
234(3)
Lymphocyte/Macrophage Interactions
237(1)
Conclusions and Perspectives
238(8)
References
238(8)
Development and Differentiation of Neural Stem and Progenitor Cells on Synthetic and Biologically Based Surfaces
Erin N. Boote Jones
Donald S. Sakaguchi
Surya K. Mallapragada
Introduction
246(1)
Neural Stem and Progenitor Cells
247(2)
Synthetic Material Surfaces
249(4)
Nonbiodegradable Substrates
249(2)
Biodegradable Polymer Substrates
251(2)
Biologically Derived Surfaces
253(6)
Poly(L-lysine)-Based Substrates
253(1)
Laminin-Based Substrates
254(2)
Fibrin and Collagen
256(1)
Chitosan
257(1)
Polysaccharides from Other Sources
258(1)
Conclusion
259(5)
References
260(4)
Toward Osteogenic Differentiation of Marrow Stromal Cells and In Vitro Production of Mineralized Extracellular Matrix onto Natural Scaffolds
Ana M. Martins
Catarina M. Alves
Rui L. Reis
Antonios G. Mikos
F. Kurtis Kasper
Introduction
264(1)
Scaffolds of Natural Origin - Polysaccharides
265(3)
Chitosan
266(1)
Starch
267(1)
Alginate
268(1)
CaP Biomimetic Coatings
268(3)
Osteoconductivity
269(1)
Osteoinductivity
270(1)
Incorporation of Biomolecules into CaP Biomimetic Coatings
270(1)
Osteogenic Differentiation of Marrow Stromal Cells and Mineralized ECM Production In Vitro
271(3)
BMSCs Versus MSCs
271(1)
Osteogenic Differentiation
272(1)
Bone-Specific Matrix Proteins
273(1)
Summary
274(10)
References
275(9)
Biomimetic Nanophase Materials to Promote New Tissue Formation for Tissue-Engineering Applications
Xiaohua Liu
Lan O. Smith
Peter X. Ma
Introduction
284(1)
Fabrication of Biomimetic Scaffolds with Nanoscale Architecture
284(4)
Nanofibrous Polymeric Scaffolds
285(1)
Nanophase Ceramic Scaffolds
286(1)
Nanocomposite Scaffolds
286(2)
Surface Modification of Nanofibrous Scaffolds
288(4)
Surface-Modification Methods for Scaffolds
289(1)
Surface Engineering of Nanofibrous Scaffolds Using Self-Assembly Techniques
289(2)
Porogen-Induced Surface Modification for Nanofibrous Scaffolds
291(1)
Effects of the Nanoarchitecture of Scaffolds on Cell Function and New Tissue Formation
292(2)
Protein Adsorption
292(1)
Cell Attachment
293(1)
Cell Differentiation and Tissue Formation
293(1)
Conclusion
294(4)
References
294(4)
Photofunctionalization of Materials to Promote Protein and Cell Interactions for Tissue-Engineering Applications
Shalu Suri
Ankur Singh
Christine E. Schmidt
Introduction
298(1)
Mechanisms of Photofunctionalization
298(3)
Photoinitiators
299(2)
Photosensitizers
301(1)
Photoinitiators in Biomaterials and Tissue Engineering
301(2)
Strategies to Fabricate Photofunctionalized Materials for Biomedical Applications
303(6)
Photopolymerized Biomaterial Scaffolds
303(2)
Photografting
305(2)
Advanced Methods
307(2)
Photofunctionalized Materials to Promote Cell Interactions for Tissue-Engineering Applications
309(5)
Bone and Cartilage Tissue Engineering
310(3)
Neural Tissue Engineering
313(1)
Conclusions
314(6)
References
315(5)
Hydrogel Nanocomposites in Biology and Medicine: Applications and Interactions
Nitin S. Satarkar
Ashley M. Hawkins
J. Zach Hilt
Introduction
320(1)
Hydrogel Nanocomposites for Drug-Delivery Applications
321(6)
Hydrogel Nanocomposites for Remote-Controlled Drug Release
322(3)
Hydrogel-Clay Nanocomposits for Enhanced Drug-Release Profile
325(2)
Hydrogel Nanocomposites for Tissue-Engineering Applications
327(7)
Hydrogel Nanocomposites for Bone Tissue Engineering
327(4)
Hydrogel Nanocomposites for Articular Cartilage Tissue Engineering
331(1)
Hydrogel Nanocomposites for Cornea Applications
332(1)
Hydrogel Nanocomposites for Cell Adhesion Applications
332(2)
Hydrogel Nanocomposites for Other Therapeutic Applications
334(3)
Antimicrobial Applications
334(2)
Thermal Therapy Applications
336(1)
Hydrogel Nanocomposites and Biological Interactions
337(1)
Concluding Remarks
338(6)
References
339(5)
Protein and Cell Interactions with Nanophase Biomaterrials
Courtney M. Creecy
David A. Puleo
Rena Bizios
Introduction
344(1)
Protein Interactions with Nanophase Materials
344(3)
Protein Adsorption
345(2)
Cell Interactions with Nanophase Materials
347(4)
Adhesion of Bone Cells on Nanophase Materials
348(1)
Mechanism of Cell Adhesion on Nanophase Materials
349(1)
Other Functions of Bone Cells on Nanophase Materials
350(1)
Adhesion and Function of Other Cells on Nanophase Materials
350(1)
Concluding Remarks
351(5)
References
352(4)
Inflammatory Response to Implanted Nanostructured Materials
Kristy M. Ainslie
Rahul G. Thakar
Daniel A. Bernards
Tejal A. Desai
Introduction
356(1)
Fabrication Techniques
357(3)
Nanofibers
357(1)
Electrochemical Methods
357(1)
Lithographic Techniques
358(1)
Molding and Embossing
359(1)
Immune Response to Implanted Nanostructured Materials
360(8)
Inflammatory Response to Biomaterials
360(3)
Acute Inflammation and Encapsulation in Response to Nanostructured Biomaterials
363(5)
Concluding Remarks
368(6)
References
369(5)
Collagen I-Coated Titanium Surfaces for Bone Implantation
Marco Morra
Clara Cassinelli
Giovanna Cascardo
Daniele Bollati
Introduction
374(1)
Literature Reports Regarding Collagen-Coated Ti Surfaces
375(6)
In Vitro Studies of Collagen-Coated Ti Surfaces
375(4)
In Vivo Studies on Collagen-Coated Ti Surfaces
379(2)
Design of Collagen-Coated Biomaterial Surfaces
381(12)
Collagen Coatings on Ti Implants: Relevant Parameters
381(8)
Collagen Coating of Ti Implants: Summary
389(4)
Conclusions
393(5)
References
394(4)
Prevention of Postsurgical Adhesions: A Biomaterials Perspective
John M. Medley
Thomas D. Dziubla
Introduction
398(1)
Postsurgical Adhesion (PSA) Formation
398(2)
Methods of PSA Prevention and Control
400(6)
Modification of Surgical Technique
400(1)
Pharmaceutical Interventions
401(1)
Liquid Instillates
402(2)
Adhesion Barriers
404(2)
PSA Evaluation Methods
406(6)
Conclusion
412(5)
References
413(4)
Index 417
Rena Bizios received a B.S. (Cum Laude) degree in Chemical Engineering from the University of Massachusetts, a M.S. degree in Chemical Engineering from the California Institute of Technology, and a Ph.D. degree in Biomedical Engineering from the Massachusetts Institute of Technology. From 1981-2005, she was a member of the faculty in the Department of Biomedical Engineering at Rensselaer Polytechnic Institute, Troy, NY. She is now a Peter T. Flawn Professor in the Department of Biomedical Engineering at the University of Texas at San Antonio (UTSA), San Antonio, TX. During her career, Dr. Bizios has taught various undergraduate and graduate fundamental engineering and biomedical engineering courses as well as developed new courses for biomedical engineering curricula. She has mentored many graduate students, post-doctoral fellows and junior faculty. Most of her former doctoral students are now pursuing academic careers at various universities in the United States.









Her research interests include cellular and tissue engineering, tissue regeneration, biomaterials (including nanostructured ones) and biocompatibility. She has co-authored a textbook (entitled An Introduction to Tissue-Biomaterial Interactions) and authored/co-authored over 95 scientific publications and book chapters. She has given numerous presentations at scientific conferences and invited seminars/lectures in academic institutions and industry. She has also organized and/or co-chaired numerous symposia and sessions at national/international conferences.









Dr. Bizios is a member of many professional societies. She has been an active participant (including elected officer positions) in the Society for Biomaterials, the Biomedical Engineering Society, and the American Institute of Chemical Engineers. She is a member of the editorial board of the Journal of Biomedical Materials Research. She has participated in various (and chaired some) NIH Study Sections, NSF Review Panels, and similar national-level review committees. She has also served on numerous departmental, School/College of Engineering and Institute/University committees at Rensselaer and now at UTSA.









Dr. Bizios received the Outstanding Alumna in Engineering Award of the Society of Women Engineers, College of Engineering, University of Massachusetts, Amherst, MA (1985), the Rensselaer Alumni Association Teaching Award, Rensselaer Polytechnic Institute (1997), and the Clemson Award for Contributions to the Scientific Literature of Biomaterials from the Society for Biomaterials (1998). She was Jubileums Professor at Chalmers University of Technology, Göteborg, Sweden (fall of 2002), Chercheur Associé (spring of 2003) and Directeur de Recherche Associé, Centre National de la Recherche Scientifique, Faculté de Médicine Saint-Louis Lariboisiére, Université Paris VII, Paris, France (fall of 2005). She is Fellow of the American Institute for Medical and Biological Engineering (AIMBE), International Fellow of Biomaterials Science and Engineering of the International Union of Societies for Biomaterials Sciences and Engineering, and Fellow of the Society of Biomedical Engineering (BMES).









David A. Puleo received B.S. and Ph.D. degrees in Biomedical Engineering from Rensselaer Polytechnic Institute. In 1991, he joined the University of Kentucky as a junior faculty member to establish a track in biomaterials in the Center for Biomedical Engineering. In addition to being promoted through the ranks to Professor, he served as Director of Graduate Studies and currently is Director of the Center, overseeing all administrative and educational matters. He also holds an appointment in the Center for Oral Health Research in the College of Dentistry. Dr. Puleo has developed and teaches courses ranging from introductory biomaterials to advanced offerings on events at the tissue-implant interface. He has taughtundergraduates, graduates, orthopedic surgery residents, and post-graduate dental students.









Dr. Puleos research interests focus on applying understanding of cell-biomaterial interactions to develop materials and surface modification strategies for the purpose of manipulating cellular responses at the tissue-implant interface. He is active in a variety of professional organizations, including the Society For Biomaterials, Biomedical Engineering Society, and the International and American Associations for Dental Research. He is an Assistant Editor for the Journal of Biomedical Materials Research Part B (Applied Biomaterials) and on the editorial board of Journal of Biomedical Materials Research Part A. He has served on and chaired numerous review panels centered on biomaterials and tissue engineering at NIH and NSF and has reviewed for several other domestic and foreign organizations. Dr. Puleo received a Research Initiation Award from the National Science Foundation, was awarded the Bourses de stage de recherche scientifique of the Programme québécois de bourses d'excellence administered through the Ministčre de l'Éducation of the Gouvernement du Québec. He is also coauthor of Introduction to Tissue-Biomaterial Interactions, a textbook written specifically for undergraduates and first semester graduate students transitioning into the field of biomaterials