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Biology of Disease [Minkštas viršelis]

4.27/5 (29 ratings by Goodreads)
(Manchester Metropolitan University, UK), (University of Leeds, UK), (Manchester Metropolitan University, UK),
  • Formatas: Paperback / softback, 608 pages, aukštis x plotis: 276x212 mm, weight: 1220 g, 473 Illustrations, black and white
  • Išleidimo metai: 26-Oct-2006
  • Leidėjas: Nelson Thornes Ltd
  • ISBN-10: 0748772103
  • ISBN-13: 9780748772100
Kitos knygos pagal šią temą:
Biology of DiseaseDidesnis paveikslėlis
  • Formatas: Paperback / softback, 608 pages, aukštis x plotis: 276x212 mm, weight: 1220 g, 473 Illustrations, black and white
  • Išleidimo metai: 26-Oct-2006
  • Leidėjas: Nelson Thornes Ltd
  • ISBN-10: 0748772103
  • ISBN-13: 9780748772100
Kitos knygos pagal šią temą:
Kitos knygos iš šio išskirtinio pasiūlymo: Taylor & Francis siūlomos knygos ISE (International Student Edition) kainomis
Pastovi nuoroda: https://www.kriso.lt/db/9780748772100.html
Raktažodžiai:
Aimed at first- and second-year students in biomedical science programs, this volume describes the biology of a number of human disorders and diseases. Real clinical cases are used to illustrate the concepts discussed, and each of 18 chapters concludes with some questions and suggestions for further reading. Sample topics include infectious diseases, the immune system, endocrine disorders, toxicology, and genetic diseases. The editors are affiliated with Manchester Metropolitan U., UK. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)

Biology of Disease describes the biology of many of the human disorders and disease that are encountered in a clinical setting. It is designed for first and second year students in biomedical science programs and will also be a highly effective reference for health science professionals as well as being valuable to students beginning medical school. Real cases are used to illustrate the importance of biology in understanding the causes of diseases, as well as in diagnosis and therapy.

Recenzijos

"Overall, the book is an excellent introduction to the subject of pathology, disease and laboratory diagnostics, which would be ideal for undergraduate students on biomedical science and related degrees." - Biochemistry and Molecular Biology Education, 2007 "When you first pick up this book and peruse the pages it is immediately encouraging. The presentation and production values are very good, the diagrams and photographs look professional and it is a substantial volume, all of which suggests a worthwhile textbook."

"I would have welcomed this book when I started out in the laboratory, as the books at that time were less welcoming and somewhat drier to read. I recommend this book to students and tutors as a text for any course on the biology of disease." British Journal of Biomedical Science, Volume 64, Number 1, 2007

"Overall, the book is an excellent introduction to the subject of pathology, disease and laboratory diagnostics, which would be ideal for undergraduate students on biomedical science and related degrees." Biochemistry and Molecular Biology Education, 2007

"an excellent introduction to the subject of pathology, disease and laboratory diagnostics, which would be ideal for undergraduate students on biomedical science and related degrees."

Biochemistry and Molecular Biology Education

Preface xvii
Glossary xix
The Nature and Investigation of Diseases
1(24)
Introduction
1(1)
Characteristic Features of Diseases
2(4)
Etiology
2(1)
Pathogenesis
3(1)
Manifestations of Diseases
4(1)
Outcome of a Disease
5(1)
Classification of Diseases
6(1)
Epidemiology of Disease
7(1)
Investigating Diseases
8(1)
Types of Pathology Laboratories
9(1)
Role of Hospital Laboratory Tests
10(4)
Hospital Laboratory Tests
14(2)
Evaluation of Laboratory Tests
16(1)
Reference Ranges
17(1)
Quality of Test Results and Clinical Auditing
18(3)
Summary
21(4)
Further Reading
22(3)
Pathogens and Virulence
25(16)
Introduction
25(1)
Types of Pathogens
26(7)
Prions
26(1)
Viruses
27(3)
Bacteria
30(1)
Protozoa, Fungi and Helminths
30(1)
Arthropods and Vertebrates
31(2)
Virulence Factors
33(4)
Defensive Virulence Factors
33(1)
Offensive Virulence Factors
34(3)
Course of Infection
37(1)
Summary
38(3)
Further Reading
39(2)
Infectious Diseases and Treatments
41(32)
Introduction
41(1)
Infections of the Skin
42(1)
Infections of the Eyes, Ears and Central Nervous System
42(2)
Infections of the Respiratory System
44(2)
Infections of the Gastrointestinal Tract
46(2)
Infections of the Urogenital System
48(5)
Sepsis and Systemic Infections
53(1)
Investigating Infectious Diseases
54(5)
Culture
54(1)
Serological Tests
55(1)
Biochemical and Molecular Biological Techniques
56(3)
Preventing Infectious Diseases
59(1)
Controlling the Spread of Pathogens
60(1)
Treatment of Infectious Diseases
60(9)
Antiviral Drugs
60(1)
Antibacterial Drugs
61(3)
Antifungal, Antiprotozoal and Antihelminthic Drugs
64(2)
Combination Therapy
66(1)
Surgery
66(3)
Summary
69(4)
Further Reading
70(3)
The Immune System
73(26)
Introduction
73(1)
Types of Immune Defense
74(1)
Nonspecific Defenses
74(5)
Interferons
74(1)
Complement
75(1)
Nonspecific Cells
75(2)
Mononuclear Leukocytes
77(1)
Inflammation and the Acute Phase Response
77(2)
Specific Immune Responses
79(7)
Roles of Humoral and Cell-Mediated Immunity
80(1)
Humoral Immunity
80(5)
Cell-Mediated Immunity
85(1)
Small Lymphocytes
86(1)
Production of a Specific Immune Response
87(8)
Humoral Immunity
89(6)
Summary
95(4)
Further Reading
97(2)
Disorders of the Immune System
99(28)
Introduction
99(1)
Immunodeficiency Diseases
100(10)
Primary Immunodeficiency Disease
100(10)
Autoimmune Disorders
110(8)
Classification of Autoimmune Disorders
110(1)
Autoimmune Disorders Affecting Endocrine Glands
111(2)
Antiglomerular Basement Membrane Disease
113(1)
Myasthenia Gravis
114(1)
Rheumatoid Arthritis
115(1)
Systemic Lupus Erythematosus
116(2)
Immunological Hypersensitivity
118(5)
Type I Hypersensitivity
118(3)
Type II Hypersensitivity
121(1)
Type III Hypersensitivity
121(1)
Type IV Delayed Type Hypersensitivity
122(1)
Summary
123(4)
Further Reading
125(2)
Transfusion and Transplantation
127(30)
Introduction
127(1)
Blood and Blood Products for Transfusion
128(1)
The Discovery of the Blood Group Systems
129(3)
The ABO Blood Group System (ISBT 001)
132(3)
The Antigens of the ABO System
133(1)
Antibodies of the ABO Blood Group System
134(1)
Consequences of ABO Incompatible Transfusions
134(1)
The Rh Blood Group System (ISBT 004)
135(3)
Hemolytic Disease of the Newborn
136(2)
Other Blood Group Systems
138(1)
Laboratory Determination of Blood Groups
139(1)
Role of Complement in Transfusion Reactions
140(1)
Hazards of Transfusion
141(2)
Transfusion Related Acute Lung Injury
142(1)
Iron Overload
142(1)
Alloimmunization
142(1)
Graft versus Host Disease
143(1)
Infections
143(1)
Screening of Blood Donors
143(2)
Transplantation of Solid Tissues and Organs
145(2)
Immunological Rejection of Transplants
145(1)
Causes of Graft Rejection
146(1)
The HLA System
147(3)
HLA Typing
148(2)
Immunosuppression
150(2)
Hemopoietic Stem Cell Transplantation
152(2)
Bone Marrow Transplantation
152(1)
Peripheral Blood Stem Cell Transplantation
153(1)
Umbilical Cord Stem Cell Transplantation
153(1)
Identification of Hemopoietic Stem Cells
153(1)
Summary
154(3)
Further Reading
155(2)
Disorders of the Endocrine System
157(46)
Introduction
157(2)
Hormone Production
159(3)
Mechanisms of Hormonal Action
162(2)
Causes of Endocrine Disorders
164(1)
The Pituitary Gland
165(4)
Disorders of Pituitary Function
167(2)
Growth Hormone Disorders
169(3)
Diagnosis and Treatment of Growth Hormone Disorders
171(1)
Thyroid Hormone Disorders
172(5)
Diagnosis and Treatment of Thyroid Disorders
174(3)
Regulation of Blood Glucose
177(6)
Diabetes Mellitus
178(3)
Hypoglycemia
181(2)
Disorders of the Adrenal Cortex
183(5)
Addison's Disease
184(1)
Cushing's Syndrome
185(1)
Congenital Adrenal Hyperplasia
186(1)
Conn's Syndrome
187(1)
Reproductive Hormones
188(10)
Disorders of Sex Hormones
194(4)
Summary
198(5)
Further Reading
200(3)
Disorders of Water, Electrolytes and Urate Balances
203(22)
Introduction
203(1)
Kidneys
204(4)
Renal Function Tests
206(1)
Renal Failure
206(2)
Disorders of Water Homeostasis
208(2)
Disorders of Na+ Homeostasis
210(1)
Disorders of K+ Homeostasis
211(1)
Disorders of Ca2+ Homeostasis
212(4)
Disorders of Phosphate Homeostasis
216(2)
Disorders of Mg2+ Homeostasis
218(1)
Disorders of Urate Metabolism
219(3)
Summary
222(3)
Further Reading
223(2)
Disorders of Acid-Base Balance
225(14)
Introduction
225(1)
The Production and Transport of Carbon Dioxide
226(1)
Buffering and the Excretion of H+
227(3)
Types of Acid-Base Disorders
230(3)
Metabolic Acid--Base Disorders
230(1)
Respiratory Acid--Base Disorders
231(1)
Mixed Acid--Base Disorders
232(1)
Investigating Acid--Base Disorders
233(3)
Summary
236(3)
Further Reading
237(2)
Diet and Disease
239(38)
Introduction
239(1)
Diet and Nutrition
240(12)
Nutrients and Energy
240(1)
Carbohydrates
241(1)
Lipids
241(3)
Proteins
244(1)
Water
244(1)
Vitamins
245(5)
Minerals and Trace Elements
250(2)
Nutritional Disorders
252(14)
Protein-Energy Malnutrition
252(2)
Obesity
254(4)
Anorexia Nervosa and Bulimia Nervosa
258(1)
Disorders of Vitamin Nutrition
259(4)
Nutritional Disorders of Minerals and Trace Elements
263(3)
Investigating Nutritional Disorders
266(5)
Protein-Energy Malnutrition
267(1)
Obesity
267(1)
Anorexia Nervosa and Bulimia Nervosa
267(1)
Vitamins
268(2)
Minerals and Trace Elements
270(1)
General Management of Nutritional Disorders
271(2)
Summary
273(4)
Further Reading
276(1)
Disorders of the Gastrointestinal Tract, Pancreas, Liver and Gall Bladder
277(38)
Introduction
277(1)
The Gastrointestinal Tract and its Accessory Organs
278(3)
Digestion
281(8)
Mouth
282(1)
Stomach
283(2)
Small Intestine
285(4)
Absorption of the Products of Digestion
289(6)
Activities of the Large Intestine
295(1)
The Small Intestine and Homeostasis
295(1)
Hormonal Control of GIT Secretions
296(1)
Disorders of the GIT and Accessory Organs
297(15)
Disorders of the Exocrine Pancreas
297(1)
Disorders of the Liver, Gall Bladder and Bile Duct
298(4)
Disorders of the Stomach
302(4)
Disorders of the Small Intestine
306(5)
Disorders of the Large Intestine
311(1)
Summary
312(3)
Further Reading
313(2)
Toxicology
315(30)
Introduction
315(1)
Drug Action, Metabolism, Distribution and Excretion
316(2)
Physiological Detoxification Mechanisms
318(3)
Symptomatic Poisoning
321(1)
Common Poisons
321(20)
Paracetamol
321(4)
Aspirin
325(2)
Ethanol
327(4)
Methanol
331(1)
Ethylene Glycol
331(1)
Barbiturates
332(1)
Carbon Monoxide
333(1)
Paraquat
334(1)
Metals
335(6)
Summary
341(4)
Further Reading
342(3)
Disorders of the Blood
345(34)
Introduction
345(1)
Blood Cells and Platelets
346(3)
Hemoglobins
349(3)
Key Properties of Hemoglobin
350(1)
Embryonic and Fetal Hemoglobins
351(1)
Hemostasis and Blood Clotting
352(4)
The Intrinsic Pathway
353(1)
The Extrinsic Pathway
354(1)
Common Final Pathway
355(1)
Prevention of Clotting
355(1)
Dissolution of Clots
356(1)
Anemias
356(5)
Microcytic Anemias
357(2)
Macrocytic Anemia
359(2)
Hemoglobinopathies
361(7)
Sickle Cell Anemia
362(3)
The Thalassemias
365(3)
Glucose 6-Phosphate Dehydrogenase Deficiency (G6PD)
368(2)
Favism
369(1)
Clinical Aspects of Clotting
370(2)
Vitamin K and Anticoagulants
370(1)
Hemophilia
371(1)
Thrombocytopenia and Thrombocytosis
372(3)
Summary
375(4)
Further Reading
377(2)
Disorders of the Cardiovascular System
379(36)
Introduction
379(1)
The Heart and Circulatory Systems
380(3)
Blood Vessels
383(3)
Arteries
384(2)
Veins
386(1)
Capillaries
386(1)
Blood Pressure
386(3)
Investigating Cardiac Function in Health and Disease
389(3)
The Electrocardiogram (ECG)
389(2)
Echocardiography
391(1)
Cardiac Catheterization (Angiography)
391(1)
Angiography and Radiographic Visualization
391(1)
Exercise Stress Test
391(1)
Endocarditis
392(1)
Abnormal Heart Rhythms
392(3)
Atrial Fibrillation and Flutter
393(1)
Ventricular Tachycardia
393(1)
Ventricular Fibrillation
394(1)
Heart Block
394(1)
Cardic Failure
395(1)
Investigation
395(1)
Treatment
395(1)
Chronic Heart Failure
396(1)
Acute Heart Failure
396(1)
Ischemic Heart Disease
396(1)
Cardiomyopathies
397(2)
Dilated Congestive Cardiomyopathy
397(1)
Hypertrophic Cardiomyopathy
398(1)
Restrictive Cardiomyopathy
398(1)
Heart Valve Disorders
399(1)
Heart Tumors
399(1)
Atherosclerosis or Arteriosclerosis
400(4)
Angina
400(2)
Cholesterol and Lipoproteins
402(2)
Myocardial Infarction
404(2)
Plasma Enzymes in Myocardial Infarction
405(1)
Treatment
405(1)
Coronary Bypass Surgery
405(1)
Pericardial Diseases
406(1)
Disorders of Arteries and Veins
407(3)
Peripheral Arterial Disease
407(1)
Aneurysms
407(1)
Aortic Dissection
407(1)
Stroke
408(1)
Varicose Veins
409(1)
Deep Vein Thrombosis
409(1)
Clinical Problems Associated with Blood Pressure
410(2)
Low Blood Pressure (Hypotension)
410(1)
Shock
410(1)
High Blood Pressure (Hypertension)
411(1)
Summary
412(3)
Further Reading
414(1)
Genetic Diseases
415(34)
Introduction
415(1)
Genetics and DNA
416(1)
DNA Replication and the Cell Cycle
417(4)
Mitosis and Meiosis
418(3)
Genotype and Phenotype
421(1)
Inheritance and Mutations
421(3)
Sex-linked Genetic Diseases
423(1)
Inherited Gene Disorders
424(4)
Consequences of an Enzyme Deficiency
424(4)
National Screening Programs for Inherited Diseases
428(1)
Chromosomes and the Human Karyotype
428(4)
Fragile Sites
430(2)
Chromosomal Mutations or Aberrations
432(5)
Deletions
433(1)
Duplications
434(1)
Inversions
435(1)
Translocations
435(2)
Variations in Chromosome Numbers
437(4)
Aneuploidy
437(3)
Euploidy
440(1)
Detecting, Diagnosing and Screening Human Genetics Diseases
441(4)
Detection of Hereditary Diseases
442(3)
Summary
445(4)
Further Reading
446(3)
Membrane, Organelle and Cytoskeletal Disorders
449(26)
Introduction
449(1)
Nucleus and Nucleocytoplasmic Transport
450(3)
Clinical Aspects of Nucleocytoplasmic Transport
453(1)
Plasma Membrane Disorders
453(3)
Cystic Fibrosis
454(2)
Mitochondrial Disorders
456(5)
Causes of Mitochondrial Disorders
457(3)
Diagnosis and Treatment of Mitochondrial Disorders
460(1)
Peroxisomal Disorders
461(2)
Diagnosis and Treatment of Peroxisomal Disorders
462(1)
Lysosomal Disorders
463(2)
Diagnosis and Treatment of Lysosomal Storage Disorders
465(1)
Cytoskeletal Disorders
465(6)
Muscular Dystrophies
467(3)
Hereditary Elliptocytosis and Spherocytosis
470(1)
Summary
471(4)
Further Reading
473(2)
Cancer
475(40)
Introduction
475(1)
Classification of Cancer Types
476(1)
Epidemiology of Cancer
476(2)
Molecular Biology of Cancer
478(2)
Oncogenes
478(1)
Tumor Suppressor Genes
479(1)
Causes of Cancer
480(7)
Inherited Cancers
480(1)
Chromosomes and Cancer
481(1)
Chemical Carcinogens
482(2)
Diet and Cancer
484(1)
Radiation and Cancer
485(1)
Viruses and Cancer
486(1)
General Diagnosis of Cancer
487(5)
Clinical Tests for Cancer
487(5)
General Treatment of Cancer
492(6)
Chemotherapy
493(4)
Radiation Therapy
497(1)
Immunotherapy
497(1)
Specific Types of Cancers
498(13)
Lung Cancer
498(2)
Breast Cancer
500(2)
Prostate Cancer
502(3)
Colorectal Cancer
505(2)
Leukemias
507(4)
Summary
511(4)
Further Reading
512(3)
Aging and Disease
515(16)
Introduction
515(1)
Aging of Cells, Tissues, Organs and Systems
516(3)
Cells
516(1)
Tissues
516(1)
Organs
516(1)
Systems
517(2)
Causes of Aging
519(3)
`Wear and Tear' Theories
519(2)
Genome-Based Theories
521(1)
Age-Related Diseases
522(5)
Cancer
522(1)
Cardiovascular Disease
522(1)
Diabetes Mellitus Type 2
523(1)
Cataracts
523(1)
Arthritis
523(1)
Parkinson's Disease
523(4)
Calorie Restriction and Aging
527(1)
Investigations and Management of the Elderly
527(1)
Summary
528(3)
Further Reading
529(2)
Case Study Discussions
531(10)
Chapter 1
531(1)
Chapter 2
531(1)
Chapter 3
531(1)
Chapter 4
532(1)
Chapter 5
532(1)
Chapter 6
533(1)
Chapter 7
533(1)
Chapter 8
534(1)
Chapter 9
535(1)
Chapter 10
535(1)
Chapter 11
536(1)
Chapter 12
537(1)
Chapter 13
537(1)
Chapter 14
538(1)
Chapter 15
538(1)
Chapter 16
539(1)
Chapter 17
539(1)
Chapter 18
540(1)
Answers to Questions
541(10)
Chapter 1
541(1)
Chapter 2
541(1)
Chapter 3
542(1)
Chapter 4
542(1)
Chapter 5
543(1)
Chapter 6
543(1)
Chapter 7
543(1)
Chapter 8
544(1)
Chapter 9
545(1)
Chapter 10
545(1)
Chapter 11
546(1)
Chapter 12
546(1)
Chapter 13
547(1)
Chapter 14
548(1)
Chapter 15
548(1)
Chapter 16
549(1)
Chapter 17
549(1)
Chapter 18
550(1)
Index 551
Nessar Ahmed, Maureen Dawson,

and Chris Smith all teach the biomedical science course at Manchester Metropolitan University. The course is accredited by the Institute of Biomedical Science and the Health Professions Council. Ed Wood

has many years teaching experience in the biological sciences at the University of Leeds