The 46 paper provide perspectives from a wide range of disciplines on the multifunctional adhesive protein, vitronectin, and related compounds, which together with the associated cell surface adhesion receptors, underlie the cellular communication necessary for development, proliferation, pericellular proteolysis, humoral defense mechanisms, and tumor metastasis in all biological systems. The overall topics include vitronectin structure, biosynthesis, processing, and distribution; receptors and adhesive interactions; alterations in the extracellular matrix; and immune defense and microorganisms. Reproduced from typescripts. Annotation copyright Book News, Inc. Portland, Or.
Part 1 Vitronectin Structure, Biosynthesis, Processing and Distribution:
Vitronectins: From vertebrates to invertebrates (M. Hayashi). Purification of
stabilised native vitronectin (I. Hayashi, D.F Mosher). Multimeric
vitronectin: Structure and function (S. Hess et al). Vitronectin-integrin
interactions: Analysis by site-directed mutations (R.C. Cherny, P.
Thiagarajan). A comparison of vitronectin and megakaryocyte stimulating
factor (D.M. Merberg et al). Binding domain P-endorphin and vitronectin (S.
Wohner et al). Primary structure of vitronectins and homology with other
proteins (H.J. Ehrlich et al). Distribution of vitronection (R. Seiffert,
T.J. Podor, D.J. Loskutoff). Vitronectin expression in human germ cell
tumours and normal mouse development (S. Cooper et al). Vitronectin
association with skin (K. Dahlback). The distribution of vitronectin in
resting and thrombin stimulated platelets. An ultra-immunocytochemical study
(E. Morgenstern, K.T. Preissner). Metabolism of vitronectin complexes (H.C.
de Boer, Ph. de Groot, K.T. Preissner). Receptor mediated endocytosis of
vitronectin by fibroblast monolayers (P.J. McKeown-Longo, T.S. Panetti). Part
2 Vitronectin Receptors and Adhesive Interactions: Platelets, extracellular
matrix and integrins (J.J. Sixma, H.K. Nieuwenhuis, Ph.G. de Groot).
Megakaryocyte specific expression of the allb integrin (G. Marguerie, G.
Uzan). Vitronectin receptors in melanoma tumour growth and metastasis (B.
Felding-Habermann et al). Peptide and non-peptide antagonists of 0 3
integrins (B. Steiner, W.C. Kouns, T. Weller). Tyrosine phosphorylation of a
38 kDa protein upon interaction of urokinase-type plasminogen activator
(u-PA) with its cellular receptor (I. Dumler, T Petri, W.-D. Schleuning).
Part 3 Extracellular Matrix Interactions and Alterations: Drosophila
development and cellular adhesion (J.H. Fessler et al). Episialin modulate
cell-cell adhesion, promotes invasion in matrigel and inhibits cytolysis by
cytotoxic effector cells (J. Hilkens et al.). Molecular organisation and
antiproliferative activity of arterial tissue heparan sulfate proteoglycans
(E. Buddecke et al). Thrombin interaction with the vascular system (R.
Bar-Shavit et al.). Vitronectin in inflammatory conditions: Localisation in
rheumatoid arthritic synovia (B.R. Tomasini-Johansson). Tenascin and
DSD-Iproteoglycan: Extracellular matrix components involved in neural pattern
formation and remodelling (A. Faissner et al). Part 4 Immune Defense and
Micro-Organisms. Lymphocyte medicated cytotoxicity (E.R. Podack). Structure
and function of CD59 (P.J. Sims). (Part contents).
