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Biomedical Engineering Challenges: A Chemical Engineering Insight [Kietas viršelis]

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  • Formatas: Hardback, 256 pages, aukštis x plotis x storis: 231x155x18 mm, weight: 499 g
  • Išleidimo metai: 18-Apr-2018
  • Leidėjas: John Wiley & Sons Inc
  • ISBN-10: 1119296048
  • ISBN-13: 9781119296041
Kitos knygos pagal šią temą:
Biomedical Engineering Challenges: A Chemical Engineering InsightDidesnis paveikslėlis
  • Formatas: Hardback, 256 pages, aukštis x plotis x storis: 231x155x18 mm, weight: 499 g
  • Išleidimo metai: 18-Apr-2018
  • Leidėjas: John Wiley & Sons Inc
  • ISBN-10: 1119296048
  • ISBN-13: 9781119296041
Kitos knygos pagal šią temą:
Pastovi nuoroda: https://www.kriso.lt/db/9781119296041.html
Raktažodžiai:

An important resource that puts the focus on the chemical engineering aspects of biomedical engineering

In the past 50 years remarkable achievements have been advanced in the fields of biomedical and chemical engineering. With contributions from leading chemical engineers, Biomedical Engineering Challenges reviews the recent research and discovery that sits at the interface of engineering and biology. The authors explore the principles and practices that are applied to the ever-expanding array of such new areas as gene-therapy delivery, biosensor design, and the development of improved therapeutic compounds, imaging agents, and drug delivery vehicles.

Filled with illustrative case studies, this important resource examines such important work as methods of growing human cells and tissues outside the body in order to repair or replace damaged tissues. In addition, the text covers a range of topics including the challenges faced with developing artificial lungs, kidneys, and livers; advances in 3D cell culture systems; and chemical reaction methodologies for biomedical imagining analysis. This vital resource:

  • Covers interdisciplinary research at the interface between chemical engineering, biology, and chemistry
  • Provides a series of valuable case studies describing current themes in biomedical engineering
  • Explores chemical engineering principles such as mass transfer, bioreactor technologies as applied to problems such as cell culture, tissue engineering, and biomedical imaging

Written from the point of view of chemical engineers, this authoritative guide offers a broad-ranging but concise overview of research at the interface of chemical engineering and biology.

List of Contributors
xi
Preface xiii
1 Introduction
1(8)
Luigi Marrelli
References
6(3)
2 Artificial Kidney: The New Challenge
9(18)
Pasquale Berloco
Simone Novelli
Renzo Pretagostini
2.1 Introduction
9(2)
2.2 Kidney Transplantation Statistics
11(1)
2.3 Transplantation Costs
12(1)
2.4 Post-Transplant Costs
12(1)
2.5 Renal Replacement Devices
13(3)
2.6 Implantable Artificial Kidney: Prototype Developments
16(1)
2.7 Kidney Tissue Engineering
17(3)
2.8 Next Steps
20(1)
2.9 Conclusion
21(6)
List of Acronyms
22(1)
References
23(4)
3 Current Status and New Challenges of the Artificial Liver
27(28)
Hiroshi Mizumoto
Nana Shirakigawa
Hiroyuki Ijima
3.1 Introduction
27(1)
3.2 Non-Biological Artificial Liver
28(7)
3.2.1 Classification and Clinical Study
29(1)
3.2.2 PE and HDF
29(1)
3.2.2.1 High-Volume Therapeutic PE
29(1)
3.2.2.2 High-Flow Dialysate Continuous HDF
29(1)
3.2.2.3 PE with Online HDF
30(1)
3.2.3 Blood Purification with Albumin Dialysis
30(1)
3.2.3.1 Single-Pass Albumin Dialysis
30(1)
3.2.3.2 Molecular Adsorbent Recirculating System
31(1)
3.2.3.3 Fractionated Plasma Separation and Adsorption (PrometheusTM)
32(1)
3.2.3.4 Hepa Wash
32(1)
3.2.4 Selective Plasma Filtration Therapy
32(1)
3.2.4.1 Biologic-Detoxifilter/Plasma Filter
32(1)
3.2.4.2 Selective Plasma-Exchange Therapy
32(1)
3.2.4.3 Plasma Filtration with Dialysis
33(1)
3.2.5 Clinical Observations of Various Combinations
33(2)
3.3 Bioartificial Liver
35(5)
3.3.1 Bioartificial Liver Support System
35(2)
3.3.2 Cell Source for BAL
37(3)
3.4 New Stream for Artificial Liver
40(3)
3.4.1 Tissue Engineering for Liver Construction
40(1)
3.4.2 Whole Organ Engineering for the Transplantable Artificial Liver
41(2)
3.5 Conclusion and Future Trends
43(12)
List of Acronyms
44(1)
References
45(10)
4 A Chemical Engineering Perspective on Blood Oxygenators
55(20)
Luisa Di Paola
4.1 Introduction
55(2)
4.2 A Historical Note
57(3)
4.3 Chemical Engineering Principles in Blood Oxygenators
60(5)
4.4 Chemical Engineering Process Analogues of ECMO Systems
65(2)
4.5 New Challenges
67(2)
4.6 Conclusion
69(6)
List of Symbols
69(1)
References
69(6)
5 Model Predictive Control for the Artificial Pancreas
75(22)
M. Capocelli
L. De Santis
A. Maurizi
P. Pozzilli
Vincenzo Piemonte
5.1 Introduction
75(3)
5.2 Phenomenological Models
78(7)
5.2.1 Background and Two-Compartmental Models
78(1)
5.2.2 Three-Compartment Models
79(6)
5.3 Black-Block Approach
85(5)
5.4 Conclusions
90(7)
Nomenclature
91(1)
References
92(5)
6 Multiscale Synthetic Biology: From Molecules to Ecosystems
97(22)
Luisa Di Paola
Alessandro Giuliani
6.1 Introduction: An Historical-Epistemological Perspective
97(2)
6.2 Applications
99(12)
6.2.1 Protein Synthetic Biology
99(9)
6.2.2 Tissue Engineering and Artificial Organs
108(1)
6.2.3 Biotechnology and Ecology Applications
109(2)
6.3 Conclusions
111(8)
List of Symbols
112(1)
References
112(7)
7 Chemical Reaction Engineering Methodologies for Biomedical Imaging Analysis
119(26)
Masahiro Kawahara
7.1 Introduction
119(1)
7.2 Magnetic Resonance Imaging (MRI)
119(4)
7.2.1 1H-MRI
120(1)
7.2.2 19F-MRI
121(1)
7.2.3 MRI using Magnetization Transfer
122(1)
7.3 Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT)
123(3)
7.3.1 PET
123(2)
7.3.2 SPECT
125(1)
7.4 Fluorescence Imaging
126(5)
7.4.1 Fluorescent Proteins
126(2)
7.4.2 Small Organic Fluorophores
128(3)
7.5 Conclusion
131(14)
List of Abbreviations
131(1)
References
132(13)
8 Noninvasive and Label-Free Characterization of Cells for Tissue Engineering Purposes
145(30)
Shunsuke Tomita
8.1 Introduction
145(1)
8.2 Multivariate Analyses
146(3)
8.2.1 Principal Component Analysis (PCA)
147(1)
8.2.2 Linear Discriminant Analysis (LDA)
148(1)
8.2.3 Hierarchical Clustering Analysis (HCA)
148(1)
8.2.4 Other Multivariate Analyses
149(1)
8.3 Vibrational Spectroscopic Features
149(3)
8.3.1 Cell Characterization Based on Whole-Cell Analysis by Raman Spectroscopy
152(1)
8.3.2 Cell Characterization Based on Subcellular Analysis by Raman Spectroscopy
153(4)
8.3.3 Raman-Based Cell Characterization Toward Biomedical Applications
157(3)
8.4 Morphological Features
160(105)
8.4.1 Cell Characterization Based on Unstained Microscopic Images of Single Cells
160(2)
8.4.2 Cell Characterization Based on Unstained Microscopic Images of Cell Populations
162(3)
8.5 Secreted Molecule Features
165(1)
8.5.1 Cell Characterization Based on Response Signatures
165(2)
8.6 Conclusion and Outlook
167(8)
List of Acronyms
168(1)
References
168(7)
9 TMS-EEG: Methods and Challenges in the Analysis of Brain Connectivity
175(24)
Elisa Kallioniemi
Mervi Kononen
Sara Maatta
9.1 Introduction
175(6)
9.1.1 Transcranial Magnetic Stimulation
175(1)
9.1.2 Electroencephalography
176(2)
9.1.3 Combined TMS and Electroencephalography
178(1)
9.1.4 Data Acquisition
178(2)
9.1.5 Artifacts and Their Prevention
180(1)
9.2 Signal Processing Methods
181(3)
9.2.1 Preprocessing
181(1)
9.2.2 Connectivity Analysis Methods in TMS-EEG
182(1)
9.2.3 Time Domain Methods
183(1)
9.2.4 Frequency Domain Methods
183(1)
9.3 TMS-EEG Applications in Studies of Connectivity
184(5)
9.3.1 General Aspects
184(1)
9.3.2 TMS-Evoked Potentials (TEPs)
185(1)
9.3.3 TMS-Induced Oscillations
186(1)
9.3.4 Clinical Perspectives
187(1)
9.3.4.1 Alzheimer's Disease
187(1)
9.3.4.2 Schizophrenia
188(1)
9.3.4.3 Disorders of Consciousness
189(1)
9.4 Conclusions and Future Trends
189(10)
List of Acronyms
190(1)
References
190(9)
10 Thermal Treatments of Tumors: Principles and Methods
199(30)
P. Saccomandi
E. Schena
M. Diana
J. Marescaux
G. Costamagna
10.1 Introduction
199(1)
10.2 Effects of Temperature on Living Tissue
199(4)
10.2.1 Hyperthermal Tissue Destruction
200(2)
10.2.2 Cold Temperature for Tissue Destruction
202(1)
10.3 Physical Principles of Thermal Treatments
203(6)
10.3.1 Hyperthermal Treatments
203(1)
10.3.1.1 High-Intensity Focused Ultrasound Ablation
203(1)
10.3.1.2 Radiofrequency Ablation (RFA)
204(1)
10.3.1.3 Microwave Ablation (MWA)
205(1)
10.3.1.4 Laser Ablation (LA)
206(1)
10.3.2 Cryoablation
207(2)
10.4 Mathematical Modeling of Thermal Therapies
209(2)
10.5 Temperature Monitoring During Thermal Treatments
211(7)
10.5.1 Invasive (Contact) Thermometric Techniques
212(3)
10.5.2 Non-Invasive (Contactless) Thermometric Techniques
215(3)
10.6 Conclusions
218(11)
List of Acronyms
219(1)
List of Symbols
219(1)
References
220(9)
Index 229
Vincenzo Piemonte is Associate Professor at University Campus Biomedico of Rome, Faculty of Engineering, Italy. His research activity is primarily focused on the study of Transport phenomena in the artificial and bioartificial organs; new biotreatment technology platform for the elimination of toxic pollutants from water and soil.

Angelo Basile is Senior Researcher at the Institute on Membrane Technology of the Italian National Research Council (ITM-CNR), Rende, Italy. His research activity is primarily focused on membrane applications in several fields.

Taichi Ito is Associate Professor at the University of Tokyo, School of Medicine and Engineering, Japan. His research activity is primarily focused on the study of biomimetic membranes; anti-peritoneal barrier membranes; hemostats; artificial oxygen carriers; scaffolds for tissue engineering and hydrogels for drug delivery of anti-cancer drugs.

Luigi Marrelli is Full professor of Chemical Reactors and of Applied Thermodynamics at University Campus Biomedico of Rome, Faculty of Engineering, Italy. His main research activity deals with thermodynamics of fluid phase equilibria and with kinetics of chemical and biochemical reactions. Some of the results obtained have been applied in the field of artificial and bio-artificial organs.