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El. knyga: Biopsy Pathology in Colorectal Disease, 2Ed

(University of Southampton, UK), ,
  • Formatas: 400 pages
  • Išleidimo metai: 24-Nov-2006
  • Leidėjas: Hodder Arnold
  • Kalba: eng
  • ISBN-13: 9781444113563
Kitos knygos pagal šią temą:
  • Formatas: 400 pages
  • Išleidimo metai: 24-Nov-2006
  • Leidėjas: Hodder Arnold
  • Kalba: eng
  • ISBN-13: 9781444113563
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Biopsy Pathology in Colorectal Disease shows how the practising pathologist can extract the maximum of diagnostic value from biopsies of the colon, rectum and anus. With the advances in colonoscopic mucosal biopsy techniques these are amongst the most frequently encountered specimens in hospital histopathology departments. This new edition provides practising pathologists and those in allied disciplines with a thorough guide to the diagnosis of colorectal conditions, both common and rare, and offers expert guidance in the handling of biopsy specimens.

The most valuable information for diagnostic interpretation of the various types of inflammatory disease is presented clearly and succinctly, minimizing the use of non-diagnostic terms such as non-specific colitis. Optimal ways of handling and examining polyps, the assessment of biopsies in motility disorders and the interpretation of biopsies of anal lesions are described. A rational classification and practical approach to dysplasia is presented.

The early chapters describe how to recognize the many different features, both normal and abnormal, which can be regarded as signposts to diagnosis. The significance of these diagnostic signposts is briefly described and cross referenced to later chapters, in which the histological features of the specific diseases are covered in greater depth.

Recenzijos

"This book fulfils the needs of all clinicians and pathologists having to deal with various colorectal conditions, both common and rare, that are looking for an expert guidance for the diagnosis."

Dr P Kitsanta, ACP News

"This book is a must-keep and a worthy successor to the first edition ... One would hope that all surgical pathologists, whether practitioner or academic, residents or fellows, would read this superb publication."

Gregory Y. Lauwers, Archives of Pathology and Laboratory Medicine

Preface xi
Acknowledgements xiii
Introduction
1(4)
The clinician's role
1(1)
The pathologist's report
2(1)
Research and development
3(2)
References
3(2)
Normal features
5(9)
Normal mucosal architecture
5(1)
The normal epithelium
5(4)
The lamina propria
9(1)
The muscularis mucosae
10(1)
The submucosa
11(3)
References
11(3)
Assessment of abnormalities: diagnostic signposts
14(42)
Introduction
15(1)
The lumen
15(1)
Surface epithelium
16(2)
Intercryptal erosion
18(1)
Subepithelial zone
18(1)
Mucosal crypt architecture
19(10)
Crypt epithelium
29(4)
Lamina propria - cells
33(11)
Lamina propria - matrix
44(5)
Muscularis mucosae
49(1)
Submucosa
50(2)
Vasculature
52(1)
Nerves
53(1)
Pigment deposition
53(3)
References
53(3)
Infective colitis
56(34)
Introduction
56(1)
Acute bacterial diarrhoeas/infective colitis and proctitis
57(8)
Enterocolitic syndromes
65(1)
Sexually transmitted diseases
66(3)
Intestinal spirochaetosis
69(1)
Viral causes of colitis
70(4)
Protozoal infection
74(3)
Helminths
77(2)
Nematodes
79(3)
Fungal infection
82(8)
References
82(8)
Ulcerative colitis
90(23)
Introduction
90(1)
The biopsy for diagnosis
91(10)
The equivocal biopsy
101(1)
Sequential biopsies
101(1)
Colonoscopic biopsy
102(4)
Inflammatory polyps ('pseudopolyps')
106(1)
Fulminant acute colitis (toxic dilatation)
106(1)
Follicular proctitis
107(1)
Conclusions
107(6)
References
107(6)
Crohn's disease
113(11)
Introduction
113(1)
Making the diagnosis
113(1)
Histopathology
114(4)
Differential diagnosis
118(1)
Disease activity
119(1)
Indicators of prognosis
120(1)
Colonoscopic biopsy in Crohn's disease
120(1)
Complications
121(1)
Conclusions
121(3)
References
121(3)
Ileoanal pouch pathology
124(9)
Introduction: clinical indications for pouch surgery
124(1)
Normal adaptive changes: ileal mucosa vs. residual rectal cuff mucosa
124(1)
Inflammation and pouchitis
125(1)
Risk factors for pouchitis
126(2)
Pre-pouch ileitis
128(1)
Differential diagnosis of pouchitis
128(2)
Neoplasia
130(3)
References
131(2)
Pseudomembranous colitis
133(13)
Introduction: pseudomembranous colitis, antibiotic-associated colitis and diarrhoea
133(1)
The biopsy diagnosis
134(6)
Problems in the differential diagnosis
140(1)
Clostridium difficile and its toxin
140(2)
The pathologist's role in the diagnosis of pseudomembranous colitis
142(1)
Conclusions
142(4)
References
142(4)
Microscopic colitis -- collagenous colitis, lymphocytic colitis and their variants
146(22)
Introduction
146(1)
Terminology
147(1)
The biopsy diagnosis
148(13)
Aetiology and pathogenesis
161(1)
Course and therapy
162(1)
Conclusions
163(5)
References
163(5)
Ischaemic colitis
168(14)
Introduction
168(1)
Anatomical considerations
168(1)
Precipitating causes
169(2)
Natural history of ischaemic bowel disease
171(1)
Endoscopic features
171(1)
Biopsy appearances
172(3)
Difficulties with diagnosis
175(1)
Vasculitis
176(1)
Necrotizing colitis syndromes
177(5)
References
177(5)
Iatrogenic disease
182(20)
Radiation colitis
182(2)
Barium granuloma
184(1)
Oleogranuloma
184(1)
Drug-associated colitis
185(6)
Diversion proctocolitis
191(1)
Graft-versus-host disease
192(2)
Neutropenic colitis
194(1)
Colitis caused by bowel preparation and instrumentation
194(1)
Anastomotic ulceration
195(1)
Melanosis coli and laxative abuse
195(7)
References
196(6)
The differential diagnosis of inflammatory bowel disease
202(31)
General principles
203(1)
Significance of the normal biopsy
203(1)
Minor abnormalities
204(5)
Major disease entities: ulcerative colitis vs. Crohn's disease vs. infection
209(3)
Other forms of colitis
212(7)
The terminal ileal biopsy
219(5)
Backwash ileitis and ileal complications of ulcerative colitis
224(1)
Ileal nodular lymphoid hyperplasia
225(1)
Conclusions
226(7)
References
226(7)
Disorders of motility
233(15)
Introduction
233(1)
The normal innervation
233(2)
Congenital megacolon: neuronal dysplasias, including Hirschsprung's disease
235(7)
Idiopathic megacolon of childhood
242(1)
Acquired megacolon
242(2)
Features associated with megacolon
244(4)
References
246(2)
Neoplasia in the colon and rectum and its classification
248(3)
Definitions
248(3)
References
250(1)
Polyps
251(41)
Definition
251(1)
Handling
251(1)
Classification
252(1)
Aberrant crypt foci
252(1)
Adenomatous polyps
253(7)
Serrated polyps
260(4)
Juvenile polyps
264(2)
Peutz-Jeghers polyps
266(2)
Inflammatory polyps
268(3)
Mucosal prolapse syndrome, including inflammatory cap polyp and inflammatory myoglandular polyp
271(4)
The Cronkhite--Canada syndrome
275(1)
Problems in the diagnosis of mucosal polyps: differential diagnosis
275(1)
Lymphoid polyps
276(1)
Leiomyomatous polyps
277(1)
Lipomatous polyps
278(1)
Vascular hamartoma
279(1)
Neurofibroma
279(1)
Ganglioneuroma
279(3)
Cowden's (multiple hamartoma) syndrome
282(1)
Granular cell tumour
282(1)
Heterotopic gastric mucosa
282(2)
Colonoscopic polypectomy
284(1)
The reporting of polyps
285(7)
References
286(6)
The diagnosis of malignancy
292(9)
Introduction
292(1)
Overdiagnosis of malignancy
293(1)
The stroma of invasive adenocarcinoma
293(2)
Focal carcinoma in adenomatous polyps ('malignant polyps')
295(3)
Decisions when reporting biopsies of neoplastic tissue
298(3)
References
300(1)
Dysplasia in inflammatory bowel disease
301(29)
Introduction
301(1)
Definitions
302(1)
Patients at risk and cancer incidence
303(2)
The reliability of dysplasia in cancer surveillance
305(1)
The macroscopic lesion in dysplasia
306(1)
Histological recognition and classification of dysplasia
307(9)
Observer variation
316(1)
Other stains and methodologies
316(1)
Molecular investigations
317(1)
Implication of the pathologist's report
317(2)
The sporadic adenoma and dysplasia-associated lesion or mass in ulcerative colitis
319(4)
Failure to find a lesion following recommendation for surgery
323(7)
References
323(7)
Malignant tumours
330(21)
Carcinoma
330(7)
Endocrine cell (carcinoid) tumours
337(3)
Lymphoma and leukaemia
340(2)
Mesenchymal tumours
342(3)
Metastatic tumours
345(6)
References
347(4)
Anal biopsy
351(26)
Introduction
351(1)
Inflammatory lesions
352(9)
Tumours of the anal canal
361(7)
Lesions of perianal skin
368(9)
References
374(3)
Miscellaneous conditions
377(18)
Angiodysplasia and other primary vascular lesions
377(3)
Cystic pneumatosis (pneumatosis cystoides intestinalis, pneumatosis coli)
380(1)
Malakoplakia
380(1)
Chronic granulomatous disease of childhood
381(1)
Whipple's disease
382(1)
Sarcoidosis
382(1)
Ceroid lipofuscinosis (including Batten's disease)
383(1)
Amyloidosis
383(2)
Cronkhite-Canada syndrome
385(1)
Mucoviscidosis (cystic fibrosis)
386(1)
Colitis cystica profunda
386(1)
Endometriosis
387(1)
Primary immunodeficiency syndromes
387(1)
Irritable bowel syndrome
388(1)
Brown bowel syndrome
389(6)
References
389(6)
Index 395


Ian Talbot is a consulting pathologist at St. Marks and Northwick Park Hospitals and Professor of Histopatholgy at Imperial College Faculty of Medicine. Ashley Price is a consulting pathologist at Northwick Park and St Marks Hospitals and Professor of Gastrointestinal Pathology at Imperial College Faculty of Medicine. Manuel Salto-Tellez is Associate Professor at the Department of Pathology, Yong Loo Lin School of Medicine, at the National University of Singapore and Senior Consultant Pathologist at the National University Hospital in Singapore.