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El. knyga: Boorman's Pathology of the Rat: Reference and Atlas

Edited by (National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA), Edited by (Wil Research, North Carolina, USA), Edited by (National Institute of Environmental Health Sciences, Resear), Edited by , Edited by , Edited by , Edited by (Pathologist, Covance, Inc, VA, USA)
  • Formatas: EPUB+DRM
  • Išleidimo metai: 01-Dec-2017
  • Leidėjas: Academic Press Inc
  • Kalba: eng
  • ISBN-13: 9780123914897
Kitos knygos pagal šią temą:
Boorman's Pathology of the Rat: Reference and AtlasDidesnis paveikslėlis
  • Formatas: EPUB+DRM
  • Išleidimo metai: 01-Dec-2017
  • Leidėjas: Academic Press Inc
  • Kalba: eng
  • ISBN-13: 9780123914897
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Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues to be the most comprehensive pathology reference and standard on rat strains. It is a vital resource for researchers across science and medicine using rat models in the laboratory, offering an added emphasis on the Sprague-Dawley and Wistar rat strains that is inline with current research across academia, government, and industry.In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database.With updated references and photographs, as well as coverage of all rat strains, this book is the standard in the field, invaluable to toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to promulgation of meaningful regulations.Contains full, four color photographs from the NTP archive and database and coverage of all rat strainsOrgan-by-organ and system-by-system approach that provides a standard diagnostic criteria, and basic content on histology and histological changesIncludes comprehensive and detailed background incidence data Presents detailed descriptive content regarding changes in rat models during research

Daugiau informacijos

Through an emphasis on the Sprague-Dawley and Wistar rat strains, this book presents a comprehensive pathology reference
List of Contributors xv
Preface xvii
Acknowledgements to Contributors of the First Edition xix
1 Introduction
Andrew W. Suttie
2 Introduction to First Edition
Gary A. Boorman
Michael R. Elwell
Scot L. Eustis
Joel R. Leininger
Bibliography
4(3)
3 The History of the Rat
John R. Foster
Denzil Frost
1 Introduction
7(1)
2 Origin
7(2)
2.1 Wistar Strains
8(1)
2.2 F344 Strain
9(1)
2.3 Sprague-Dawley Strain
9(1)
3 Use of the Rat Strains in Chronic Carcinogenicity Studies
9(2)
3.1 Wistar Strains
9(1)
3.2 F344 Strain
10(1)
3.3 Sprague-Dawley Strain
11(1)
4 Comparison of the Rat Strains for Early Onset of Neoplasms
11(1)
Synonyms
12(1)
Bibliography
12(3)
Section I Digestive System
4 Oral Cavity, Teeth and Gingiva
Joel R. Leininger
Melissa Schutten
1 Normal Oral Cavity
15(1)
1.1 Anatomy
15(1)
1.2 Histology
15(1)
1.3 Physiology
16(1)
2 Congenital Anomalies
16(1)
3 Degenerative Lesions
17(1)
3.1 Oral Cavity
17(1)
4 Inflammatory and Vascular Lesions
17(1)
4.1 Oral Cavity
17(1)
5 Hyperplastic and Neoplastic Lesions
17(1)
5.1 Oral Cavity
17(1)
6 Toxicologic Lesions
18(2)
6.1 Oral Cavity
18(2)
Bibliography
20(3)
5 Salivary Glands
Suzanne Botts
Joel R. Leininger
1 Introduction
23(1)
2 Normal Salivary Glands
23(3)
2.1 Embryology and Perinatal Development
23(1)
2.2 Anatomy and Histology
23(3)
2.3 Physiology
26(1)
3 Congenital Lesions
26(1)
4 Degenerative Lesions
26(2)
5 Inflammatory and Vascular Lesions
28(1)
6 Hyperplastic and Neoplastic Lesions
28(4)
6.1 Basophilic Hypertrophic Foci
28(1)
6.2 Adenoma
29(1)
6.3 Adenocarcinoma
29(1)
6.4 Squamous Cell Carcinoma
30(1)
6.5 Mesenchymal Neoplasms
31(1)
7 Toxicologic Lesions
32(1)
Further Reading
33(2)
6 Esophagus and Stomach
Takeki Uehara
Susan A. Elmore
Kathleen A. Szabo
1 Introduction
35(1)
2 Normal Upper Digestive Tract
35(3)
2.1 Embryology
35(1)
2.2 Anatomy
36(1)
2.3 Histology
36(2)
2.4 Physiology
38(1)
3 Congenital Anomalies
38(1)
4 Degenerative Lesions
39(1)
4.1 Esophagus
39(1)
4.2 Stomach
39(1)
5 Inflammatory and Vascular Lesions
40(1)
5.1 Esophagus
40(1)
5.2 Stomach
40(1)
6 Hyperplastic and Neoplastic Lesions
41(5)
6.1 Esophagus
41(1)
6.2 Stomach
41(5)
7 Miscellaneous Lesions
46(1)
8 Toxicologic Lesions
46(2)
8.1 Esophagus
46(1)
8.2 Stomach
46(2)
Bibliography
48(3)
7 Small and Large Intestine
Shunji Nakatsuji
Kathleen A. Szabo
Susan A. Elmore
1 Introduction
51(1)
2 Normal Intestine
51(4)
2.1 Embryology
51(1)
2.2 Anatomy and Histology
52(2)
2.3 Physiology
54(1)
3 Congenital Anomalies
55(1)
4 Degenerative Lesions
55(1)
5 Inflammatory and Vascular Lesions
56(1)
6 Hyperplastic and Neoplastic Lesions
57(6)
6.1 Hyperplasia
57(1)
6.2 Neoplastic Lesions
58(5)
7 Miscellaneous Lesions
63(1)
8 Toxicologic Lesions
64(4)
Bibliography
68(3)
8 Peritoneum, Retroperitoneum, Mesentery, and Abdominal Cavity
Bevin Zimmerman
1 Introduction
71(1)
2 Normal Peritoneum
71(1)
2.1 Embryology
71(1)
2.2 Anatomy and Histology
71(1)
3 Congenital Anomalies
72(1)
4 Degenerative Lesions
72(1)
5 Inflammatory and Vascular Lesions
73(1)
6 Hyperplastic and Neoplastic Lesions
73(3)
7 Miscellaneous Lesions
76(1)
8 Toxicologic Lesions
76(1)
Bibliography
76(5)
Section II Liver and Exocrine Pancreas
9 Liver
John R. Foster
1 Introduction
81(1)
2 Normal Liver
81(4)
2.1 Embryology
81(1)
2.2 Anatomy
82(2)
2.3 Histology
84(1)
2.4 Physiology
85(1)
3 Congenital Lesions
85(1)
4 Degenerative Lesions
86(3)
4.1 Lipidosis/Steatosis/Fatty Accumulation
86(1)
4.2 Necrosis and Apoptosis
87(2)
4.3 Cystic Degeneration/Spongiosis Hepatis
89(1)
4.4 Peribiliary Fibrosis
89(1)
4.5 Hepatic Cysts (Biliary)
89(1)
5 Inflammatory and Vascular Lesions
89(2)
5.1 Inflammatory Lesions
89(1)
5.2 Angiectasis (Telangiectasis, Peliosis Hepatis)
90(1)
6 Hyperplastic and Neoplastic Lesions
91(10)
6.1 Hepatocellular Lesions
91(4)
6.2 Biliary Lesions
95(2)
6.3 Miscellaneous Lesions
97(4)
7 Miscellaneous Lesions
101(4)
7.1 Polyploidy
101(1)
7.2 Inclusions
102(2)
7.3 Extramedullary Hematopoiesis
104(1)
Acknowledgments
105(1)
Bibliography
105(2)
10 Exocrine Pancreas
Andrew W. Suttie
Regis Masson
Melissa Schutten
10.1 Introduction
107(1)
10.2 Normal Exocrine Pancreas
107(3)
10.2.1 Embryology
107(1)
10.2.2 Anatomy
108(1)
10.2.3 Histology
108(1)
10.2.4 Physiology
109(1)
10.3 Congenital Lesions
110(1)
10.4 Degenerative Lesions
110(3)
10.4.1 Hydropic Degeneration, Fatty Degeneration, and Autophagocytosis (Apoptosis)
110(1)
10.4.2 Necrosis
111(1)
10.4.3 Atrophy
111(1)
10.4.4 Lipomatosis
112(1)
10.4.5 Peri-Islet Fibrosis and Hemosiderosis
112(1)
10.5 Inflammatory and Vascular Lesions
113(1)
10.6 Hyperplastic and Neoplastic Lesions
113(4)
10.6.1 Acinar Cell Hyperplasia
114(1)
10.6.2 Acinar Cell Adenoma
115(1)
10.6.3 Acinar Cell Carcinoma
115(1)
10.6.4 Mixed Acinar-Islet Cell Adenoma
116(1)
10.7 Miscellaneous Lesions
117(1)
10.7.1 Basophilic Cytoplasmic Change
117(1)
10.7.2 Hepatocyte Metaplasia
117(1)
10.8 Toxicologic Lesions
118(2)
Bibliography
120(5)
Section III Urinary Tract
11 Kidney
John Curtis Seely
Gordon C. Hard
Brad Blankenship
1 Introduction
125(1)
2 Normal Kidney
126(8)
2.1 Embryology
126(1)
2.2 Anatomy
127(1)
2.3 Histology
127(6)
2.4 Physiology
133(1)
3 Congenital Lesions
134(1)
4 Degenerative Lesions
135(6)
4.1 Chronic Progressive Nephropathy
135(2)
4.2 Acute Tubule Necrosis
137(1)
4.3 Degenerative Changes
138(3)
5 Inflammatory and Vascular Lesions
141(3)
6 Hyperplastic and Neoplastic Lesions
144(11)
6.1 Renal Tubule Epithelium
144(5)
6.2 Other Neoplasms
149(4)
6.3 Renal Pelvic Urothelium
153(2)
7 Miscellaneous Changes
155(1)
8 Artifacts
155(1)
9 Toxicologic Lesions
156(6)
9.1 General Considerations
156(1)
9.2 Glomerular Toxicity
157(1)
9.3 Tubule Toxicity
157(2)
9.4 Papillary Toxicity
159(1)
9.5 Vascular Lesions
160(1)
9.6 Specific Forms of Nephrotoxicity
160(2)
9.7 Experimentally Induced Renal Carcinogenesis
162(1)
Bibliography
162(5)
12 Urinary Bladder, Ureter, and Urethra
Micheal P. Jokinen
John Curtis Seely
1 Introduction
167(1)
2 Normal Urinary Pathway
167(5)
2.1 Embryology
167(1)
2.2 Anatomy and Histology
168(3)
2.3 Physiology
171(1)
3 Congenital Lesions
172(1)
4 Inflammatory Lesions
172(1)
5 Hyperplastic and Neoplastic Lesions
173(9)
5.1 Urothelial Hyperplasia and Metaplasia
173(3)
5.2 Urothelial Neoplasms
176(6)
6 Miscellaneous
182(3)
6.1 Urolithiasis
182(1)
6.2 Trichosomoides crassicauda (Bladder Threadworm)
183(1)
6.3 Angiectasis
184(1)
6.4 Artifacts
184(1)
6.5 Diverticuli
185(1)
7 Toxicologic Lesions
185(1)
8 Experimentally Induced Urinary Bladder Carcinogenesis
185(1)
Bibliography
186(5)
Section IV Nervous System and Special Sense Organs
13 Brain
Alys Bradley
Lise Bertrand
Deepa B. Rao
D. Greg Hall
Alok K. Sharma
1 Introduction
191(7)
1.1 Embryology
194(2)
1.2 Anatomy
196(2)
2 Congenital Lesions
198(1)
3 Degenerative Lesions
198(5)
3.1 Artifacts
198(1)
3.2 Basophilic Bodies/Mineralization
199(1)
3.3 Osseous Metaplasia
199(1)
3.4 Neuronal Vacuolation
199(1)
3.5 Neuronal Degeneration and Necrosis
200(1)
3.6 Neuronal Pigmentation
200(1)
3.7 Gliosis
201(1)
3.8 Degenerative Changes Affecting Axons and Myelin Within the CNS
201(1)
3.9 Neuronal Chromatolysis
202(1)
3.10 Malacia
202(1)
3.11 Inflammatory and Vascular Lesions
202(1)
4 Hyperplastic Lesions
203(1)
4.1 Granular Cell Hyperplasia
203(1)
5 Neoplastic Lesions
204(7)
5.1 Neuronal Tumors
205(1)
5.2 Glial Tumors
205(3)
5.3 Meningeal Tumors
208(3)
6 Toxicologic Lesions
211(2)
6.1 Primary Toxic Damage to Neurons (Toxic Neuronopathies)
212(1)
6.2 Primary Damage to Axons (Toxic Axonopathies)
212(1)
6.3 Primary Damage to Myelin (Toxic Myelinopathies)
212(1)
6.4 Toxic Damage to Astrocytes
213(1)
6.5 Toxic Damage to Microglia
213(1)
6.6 Miscellaneous Toxic Lesions
213(1)
Bibliography
213(4)
14 The Spinal Cord and Peripheral Nervous System
Alys Bradley
Aude Roulois
Jenny McKay
Nicola Parry
Gary Boorman
1 Spinal Cord and Peripheral Nerves
217(12)
1.1 Introduction
217(1)
1.2 Embryology and Anatomy
218(2)
1.3 Sampling and Histology
220(2)
1.4 Congenital Lesions
222(1)
1.5 Degenerative Lesions
223(1)
1.6 Inflammatory and Vascular Lesions
224(1)
1.7 Hyperplastic and Neoplastic Lesions
225(4)
2 Artifacts
229(2)
3 Toxicologic Lesions
231(4)
3.1 Primary Damage to Perikarya of Peripheral Neurons
231(2)
3.2 Primary Damage to Axons of Peripheral Neurons
233(1)
3.3 Primary Damage to Myelin Sheaths or Schwann Cells
234(1)
3.4 Induced Neoplastic Lesions
235(1)
4 Animal Models of Peripheral Neuropathies
235(1)
References
236(5)
15 Ears and Pinna
241(11)
Katsuhiko Yoshitomi
Phaedra Cole
1 Introduction
241(1)
2 Normal Ear and Pinna
241(3)
2.1 Embryology
241(1)
2.2 Anatomy and Histology
241(3)
2.3 Function
244(1)
3 Congenital Lesions
244(1)
4 Degenerative Lesions
244(1)
5 Inflammatory and Vascular Lesions
244(2)
5.1 External Ear
244(1)
5.2 Middle Far
245(1)
5.3 Auditory Tube
246(1)
5.4 Inner Far
246(1)
6 Hyperplastic and Neoplastic Lesions
246(1)
6.1 Hyperplasia
246(1)
6.2 Neoplasia
246(1)
7 Neural Crest Neoplasm of the Pinna
247(1)
8 Miscellaneous Lesions
248(1)
8.1 External Ear
248(1)
9 Toxicologic Lesions
248(1)
Bibliography
249(3)
16 Eye and Associated Glands
Dale G. Dunn
Julia F.M. Baker
Steven D. Sorden
1 Introduction
252(1)
2 Normal Eye and Associated Glands
252(8)
2.1 Embryology
252(1)
2.2 Anatomy and Histology
253(4)
2.3 Physiology
257(3)
3 Congenital Lesions
260(1)
4 Degenerative Lesions
261(5)
4.1 Eye
261(4)
4.2 Adnexa
265(1)
5 Inflammatory and Vascular Lesions
266(1)
5.1 Eye
266(1)
5.2 Adnexa
267(1)
6 Hyperplastic and Neoplastic Lesions
267(4)
6.1 Eye
268(1)
6.2 Harderian Gland
269(1)
6.3 Lacrimal Gland
270(1)
6.4 Optic Nerve
270(1)
7 Miscellaneous Lesions
271(1)
7.1 Eye
271(1)
7.2 Adnexa
271(1)
8 Toxicologic Lesions
272(2)
8.1 Eye
272(2)
8.2 Adnexa
274(1)
Bibliography
274(7)
Section V Musculoskeletal System
17 Skeletal Muscle
Stacey L. Fossey
D. Greg Hall
Joel R. Leininger
1 Introduction
281(1)
2 Normal Skeletal Muscle
281(4)
2.1 Embryology
281(1)
2.2 Anatomy
282(1)
2.3 Histologic and Ultrastructural Features
282(3)
2.4 Physiology
285(1)
3 Congenital Anomalies
285(1)
4 Degenerative Lesions
285(3)
4.1 Atrophy
285(1)
4.2 Hypertrophy
285(1)
4.3 Degeneration and Necrosis
286(1)
4.4 Regeneration
286(1)
4.5 Hormonal Disorders
287(1)
4.6 Nutritional Disorders
288(1)
5 Parasitic, Inflammatory, and Vascular Lesions
288(1)
6 Hyperplastic and Neoplastic Lesions
288(1)
7 Miscellaneous
289(1)
7.1 Hind Leg Myopathy of Aging Rats
289(1)
7.2 Other
289(1)
8 Toxicologic Lesions
290(2)
Acknowledgments
292(1)
Bibliography
292(7)
18 Bones, Joints, and Synovia
Stacey L. Fossey
John L. Vahle
Joel R. Leininger
1 Introduction
299(1)
2 Normal Bones, Joints, and Synovia
299(5)
2.1 Embryology
299(1)
2.2 Anatomy
300(1)
2.3 Histology
300(3)
2.4 Evaluation Methods
303(1)
2.5 Physiology
304(1)
3 Non-proliferative Lesions
304(7)
3.1 Congenital Lesions
304(1)
3.2 Disturbances of Growth or Metabolism
305(2)
3.3 Necrosis
307(1)
3.4 Fracture and Callus Formation
307(1)
3.5 Increased Physeal Thickness and/or Physeal Dysplasia
308(1)
3.6 Decreased Physeal Thickness
308(1)
3.7 Degenerative Joint Disease
309(1)
3.8 Chondromucinous Degeneration
310(1)
3.9 Inflammation
310(1)
3.10 Reactive New Bone Formation
310(1)
4 Hyperplastic and Neoplastic Lesions
311(3)
4.1 Hyperplastic Bone Lesions
311(1)
4.2 Hyperplastic Synovial Lesions
311(1)
4.3 Bone Neoplasms
311(2)
4.4 Cartilage Neoplasms
313(1)
Bibliography
314(9)
Section VI Integumentary System
19 The Skin and Subcutis
Jyoji Yamate
1 Introduction
323(1)
2 Normal Skin and Subcutis
324(3)
2.1 Embryology
324(1)
2.2 Anatomy and Histology
324(2)
2.3 Physiology
326(1)
3 Infectious Diseases
327(1)
4 Congenital Lesions
327(1)
5 Non-neoplastic Lesions
327(4)
5.1 Atrophy
327(1)
5.2 Epidermal Degeneration
328(1)
5.3 Dermal Degeneration
329(1)
5.4 Erosion and Ulceration
329(1)
5.5 Tissue Necrosis and Apoptosis
329(1)
5.6 Inflammatory Lesion
330(1)
6 Hyperplastic and Neoplastic Lesions
331(10)
6.1 Hyperplasia
331(1)
6.2 Epithelial Neoplasms
332(4)
6.3 Mesodermal Non-Neoplastic Proliferative and Neoplasmic Lesions
336(4)
6.4 Neurogenic Neoplasms
340(1)
6.5 Other Neoplasms
341(1)
7 Toxicologic Lesions
341(2)
7.1 Non-Neoplastic Lesions
341(1)
7.2 Neoplastic Lesions
342(1)
Bibliography
343(4)
20 Specialized Sebaceous Glands-Zymbal's Gland, Preputial Gland, Clitoral Gland, and Perianal Gland
Katsuhiko Yoshizawa
1 Introduction
347(1)
2 Normal Specialized Sebaceous Gland
347(4)
2.1 Embryology
347(1)
2.2 Anatomy and Histology
348(2)
2.3 Physiology
350(1)
3 Congenital Lesions
351(1)
4 Degenerative Lesions
351(1)
5 Inflammatory Lesions
352(1)
6 Growth Disturbances (Non-Neoplastic)
352(2)
7 Growth Disturbances (Neoplastic)
354(5)
7.1 Zymbal's Gland
354(2)
7.2 Preputial and Clitoral Glands
356(3)
7.3 Perianal (Circumanal) Glands
359(1)
8 Toxicologic Lesions
359(4)
Acknowledgments
363(1)
Bibliography
363(6)
Section VII Mammary Gland
21 Mammary Gland
Johnnie J. Eighmy
Alok K. Sharma
Pamela E. Blackshear
1 Introduction
369(1)
2 Normal Mammary Gland
369(3)
2.1 Embryology and Development
369(2)
2.2 Anatomy
371(1)
2.3 Histology
371(1)
3 Congenital Lesions
372(1)
4 Degenerative Lesions
372(2)
5 Inflammatory and Vascular Lesions
374(1)
6 Hyperplastic and Neoplastic Lesions
374(8)
6.1 Lobular or Lobuloalveolar Hyperplasia
375(1)
6.2 Focal Hyperplasia with Cellular Atypia (Atypical Hyperplasia)
375(1)
6.3 Fibroadenoma
376(3)
6.4 Adenoma
379(1)
6.5 Adenolipoma
380(1)
6.6 Adenocarcinoma
380(2)
6.7 Carcinosarcoma
382(1)
7 Miscellaneous Lesions
382(1)
8 Toxicologic Lesions
383(4)
Bibliography
387(4)
Section VIII Respiratory Tract
22 Nose, Larynx, and Trachea
Ronald A. Herbert
Kyathanahalli S. Janardhan
Arun R. Pandiri
Mark F. Cesta
Rodney A. Miller
1 Introduction
391(1)
2 Normal Upper Respiratory Tract
392(10)
2.1 Embryology
392(1)
2.2 Anatomy and Histology
392(9)
2.3 Physiology
401(1)
3 Congenital Lesions
402(1)
4 Degenerative, Regenerative, and Adaptive Lesions
402(9)
4.1 Nasal Cavity
402(8)
4.2 Larynx and Trachea
410(1)
5 Inflammatory and Vascular Lesions
411(4)
6 Hyperplastic and Neoplastic Lesions
415(11)
6.1 Nasal Cavity
416(6)
6.2 Larynx and Trachea
422(4)
7 Miscellaneous
426(2)
7.1 Nasal Cavity
426(2)
8 Toxicologic Lesions
428(3)
8.1 Nasal Passages and Associated Structures
429(1)
8.2 Larynx
430(1)
8.3 Trachea
431(1)
9 Molecular Pathology of the Upper Respiratory Tract
431(2)
9.1 Alterations in Gene Expression
431(1)
9.2 Alterations in Protein Expression
432(1)
9.3 DNA Adducts and Mutations in Nasal Tumors
432(1)
References
433(2)
Further Reading-Molecular pathology
435(2)
23 Lung, Pleura, and Mediastinum
Ronald A. Herbert
Kyathanahalli S. Janardhan
Arun R. Pandiri
Mark F. Cesta
Vivian Chen
Rodney A. Miller
1 Introduction
437(1)
2 Normal Lung
438(5)
2.1 Embryology
438(1)
2.2 Anatomy
439(1)
2.3 Histology
440(3)
2.4 Physiology
443(1)
3 Congenital Lesions
443(1)
4 Infectious Diseases
444(2)
4.1 Mycoplasma pulmonis
444(1)
4.2 Cilia-Associated Respiratory Bacillus (CAR Bacillus)
444(1)
4.3 Corynebacterium kutscheri
444(1)
4.4 Pneumocystis carinii
445(1)
4.5 Rat Coronavirus
445(1)
4.6 Sendai Virus
445(1)
4.7 Rat Polyomavirus
446(1)
5 Nonproliferative, Degenerative, and Vascular Lesions
446(2)
5.1 Degeneration and Necrosis
446(1)
5.2 Fibrosis
446(1)
5.3 Alveolar Proteinosis (Lipoproteinosis)
446(1)
5.4 Alveolar Histiocytosis (Infiltrate Cellular, Histiocyte)
447(1)
5.5 Mineral
448(1)
5.6 Pigments
448(1)
5.7 Inflammatory Lesions
448(1)
6 Nonneoplastic and Neoplastic Proliferative Lesions
448(11)
6.1 Regenerative Hyperplasia
449(1)
6.2 Primary Hyperplasia of the Alveolar Epithelium
450(1)
6.3 Bronchial Hyperplasia
451(1)
6.4 Mesothelial Hyperplasia
451(1)
6.5 Alveolar/Bronchiolar Adenoma and Carcinoma
452(3)
6.6 Bronchial Adenoma and Carcinoma
455(1)
6.7 Squamous Cell Carcinoma
455(1)
6.8 Cystic Keratinizing Epithelioma
456(1)
6.9 Sarcoma
457(1)
6.10 Malignant Mesothelioma
457(1)
6.11 Mediastinal Neoplasms
458(1)
6.12 Metastatic Neoplasms
458(1)
7 Miscellaneous Lesions
459(1)
7.1 Gavage-Related Lesions
459(1)
7.2 Hair Embolism
459(1)
7.3 Cartilaginous Metaplasia
460(1)
7.4 Osseous Metaplasia
460(1)
7.5 Goblet Cell Metaplasia
460(1)
8 Toxicologic Lesions
460(3)
8.1 Toxicity of Particles
460(1)
8.2 Toxicity of Gases
461(1)
8.3 Toxicity of Chemicals Administered Systemically
462(1)
8.4 Carcinogenesis
462(1)
References
463(7)
Section IX Immune System
24 Spleen, Lymph Nodes, and Thymus
Marlon C. Rebelatto
1 Spleen
470(1)
1.1 Introduction
470(1)
2 Normal Spleen
470(1)
2.1 Embryology
470(1)
3 Anatomy and Histology
470(1)
4 Function
471(1)
5 Congenital Lesions
472(1)
6 Degenerative Lesions
472(1)
Atrophy
472(1)
Pigment
472(1)
6.1 Fibrosis
473(1)
7 Inflammatory and Vascular Lesions
473(1)
8 Hyperplastic and Neoplastic Lesions
474(3)
8.1 Hyperplasia
474(1)
9 Neoplasia
475(1)
9.1 Large Granular Lymphocyte Leukemia
475(2)
10 Lymphoma and Other Hematopoietic Neoplasms
477(1)
11 Mesenchymal Neoplasms
477(2)
11.1 Fibroma and Fibrosarcoma
478(1)
11.2 Leiomyoma and Leiomyosarcoma
478(1)
11.3 Hemangioma and Hemangiosarcoma
478(1)
11.4 Osteosarcoma
478(1)
11.5 Undifferentiated Sarcoma
479(1)
11.6 Malignant Schwannoma
479(1)
12 Other Neoplasms
479(1)
13 Miscellaneous
480(1)
14 Toxicologic Lesions
480(1)
15 Lymph Nodes
480(1)
15.1 Introduction
480(1)
16 Normal Lymph Nodes
481(1)
16.1 Embryology
481(1)
16.2 Anatomy and Histology
481(1)
17 Congenital Lesions
482(1)
18 Degenerative Lesions
482(1)
19 Inflammatory and Vascular Lesions
483(1)
20 Hyperplastic and Neoplastic Lesions
484(1)
20.1 Hyperplasia
484(1)
20.2 Neoplasia
484(1)
21 Toxicologic Lesions
485(1)
22 Thymus
485(1)
22.1 Introduction
485(1)
23 Normal Thymus
485(1)
23.1 Embryology
485(1)
23.2 Anatomy and Histology
485(1)
23.3 Function
486(1)
24 Congenital Lesions
486(1)
25 Degenerative Lesions
486(2)
26 Inflammatory and Vascular Lesions
488(1)
27 Hyperplastic and Neoplastic Lesions
488(1)
27.1 Hyperplasia
488(1)
28 Neoplasia
488(1)
28.1 Thymoma
488(1)
29 Thymic Lymphoma
489(1)
30 Toxicologic Lesions
489(2)
References
491(4)
Section X Bone Marrow
25 Bone Marrow
Michelle C. Cora
Ken Latimer
Gregory S. Travlos
1 Introduction
495(1)
2 Normal Bone Marrow
496(6)
2.1 Ontogeny
496(1)
2.2 Structure and Function
497(3)
2.3 Hematopoiesis and the Hematopoietic Cells
500(1)
2.4 The Myeloid: Erythroid Ratio
501(1)
3 Disturbances in Hematopoietic Cell Growth
502(7)
3.1 Increased Cell Numbers
503(3)
3.2 Decreased Cell Numbers
506(3)
3.3 Dyshematopoiesis
509(1)
4 Alterations of Bone Marrow Stromal Cells
509(3)
4.1 Fibrosis
509(1)
4.2 Reactive Increases in Macrophages
510(1)
4.3 Focal Lipomatosis
511(1)
4.4 Miscellaneous
512(1)
5 Degenerative Changes
512(3)
5.1 Necrosis
512(1)
5.2 Thrombosis
512(2)
5.3 Gelatinous Transformation of Bone Marrow
514(1)
5.4 Inflammation
514(1)
5.5 Neoplasia
515(1)
6 Miscellaneous
515(2)
6.1 Angiectasis
515(1)
6.2 Iron Pigmentation
516(1)
Bibliography
517(6)
Section XI Female Reproductive Tract
26 Ovary
Justin D. Vidal
Darlene Dixon
1 Introduction
523(1)
2 Normal Ovary
523(1)
2.1 Embryology
523(1)
2.2 Anatomy and Histology
524(1)
2.3 Physiology
524(1)
3 Congenital Lesions
524(1)
4 Nonproliferative Lesions
524(4)
4.1 Atrophy
524(1)
4.2 Decreased Number/Absence of Corpora Lutea
525(1)
4.3 Increased Size/Number of Corpora Lutea
525(1)
4.4 Degeneration Within Corpora Lutea
526(1)
4.5 Follicular Atresia
526(1)
4.6 Cysts
526(1)
4.7 Other Degenerative Lesions
527(1)
5 Hyperplastic and Neoplastic Lesions
528(3)
5.1 Hyperplastic Lesions
528(1)
5.2 Neoplasia
529(1)
5.3 Benign and Malignant Granulosa Cell Tumors
529(2)
6 Toxicologic Lesions
531(3)
Bibliography
534(3)
27 Oviduct, Uterus, and Vagina
Darlene Dixon
Justin D. Vidal
Joel R. Leininger
Micheal P. Jokinen
1 Introduction
537(1)
2 Normal Tubular Genital Organs
537(3)
2.1 Embryology
537(1)
2.2 Anatomy
538(1)
2.3 Histology
539(1)
2.4 Physiology
540(1)
3 Congenital Lesions
540(1)
4 Aging Lesions
541(1)
5 Inflammatory and Vascular Lesions
541(1)
6 Nonproliferative Lesions
541(2)
6.1 Atrophy
541(1)
6.2 Hypertrophy
542(1)
6.3 Cysts
542(1)
6.4 Dilation
542(1)
6.5 Prolapse
543(1)
6.6 Adenomyosis
543(1)
7 Hyperplastic and Neoplastic Lesions
543(9)
7.1 Oviduct
543(1)
7.2 Uterus
544(7)
7.3 Vagina and Cervix
551(1)
8 Toxicologic Lesions
552(2)
Acknowledgments
554(3)
Bibliography
557(6)
Section XII Male Reproductive System
28 Testis and Epididymis
Katharine M. Whitney
Andrew Suttie
1 Introduction
563(1)
2 Normal Testis and Epididymis
563(5)
2.1 Embryology
563(1)
2.2 Postnatal Development
564(1)
2.3 Anatomy and Histology
564(3)
2.4 Physiology
567(1)
3 Congenital Lesions
568(1)
4 Degenerative Lesions
568(1)
5 Inflammatory and Vascular Lesions
569(1)
6 Hyperplastic and Neoplastic Lesions
570(2)
6.1 Hyperplasia and Adenoma of Interstitial Cells
570(1)
6.2 Mesothelioma
571(1)
6.3 Rete Testis Neoplasms
571(1)
6.4 Other Neoplasms
571(1)
7 Miscellaneous
572(1)
8 Toxicologic Lesions
572(4)
Bibliography
576(3)
29 Male Accessory Sex Glands
Katharine M. Whitney
1 Introduction
579(1)
2 Normal Male Sex Glands and Organs
579(5)
2.1 Embryology
579(1)
2.2 Structure
580(4)
3 Congenital Lesions
584(1)
4 Degenerative Lesions
584(1)
5 Inflammatory and Vascular Lesions
584(1)
6 Hyperplastic and Neoplastic Lesions
584(1)
7 Toxicologic Lesions
585(2)
Bibliography
587(4)
Section XIII Circulatory System
30 Cardiovascular System
Alys Bradley
Pierluigi Fant
Silvia Guionaud
Michael Boyle
Roger Alison
Adam Hargreaves
1 Introduction
591(2)
1.1 Embryology
592(1)
2 Congenital Lesions
593(1)
2.1 Interventricular Septal Defect
594(1)
2.2 Hamartomas of Blood Vessels
594(1)
2.3 Patent Ductus Arteriosus
594(1)
2.4 Right-Sided Aortic Arch
594(1)
3 Degenerative Lesions
594(3)
3.1 Vascular Ectasia/Angiectasis
594(1)
3.2 Arteriosclerosis
594(1)
3.3 Focal Loss of Internal Elastic Lamina
594(1)
3.4 Intimal Proliferation
594(1)
3.5 Medial Degeneration
595(1)
3.6 Hypertrophy
595(1)
3.7 Myocardial Degeneration
595(1)
3.8 Spontaneous Cardiomyopathy
595(1)
3.9 Mineralization (Calcification)
595(2)
3.10 Thrombosis and Aneurysms
597(1)
4 Inflammatory Lesions
597(2)
5 Hyperplastic Lesions
599(1)
5.1 Endocardial Hyperplasia
599(1)
5.2 Myocardial Hyperplasia
599(1)
5.3 Proliferation and Hyperplasia of Blood Vessels
600(1)
6 Neoplastic Lesions
600(3)
6.1 Blood Vessels
600(1)
6.2 Heart
601(2)
6.3 Metastatic Neoplasms
603(1)
6.4 Artefacts
603(1)
7 Toxicologic Lesions
603(9)
7.1 Cardiotoxicity
603(1)
7.2 Myocardial Degeneration and Necrosis
603(4)
7.3 Biomarkers of Cardiotoxicity
607(1)
7.4 Cardiac Weight Changes, Hypertrophy, and Atrophy
608(2)
7.5 Submicroscopic ("Occult") Cardiotoxicity
610(1)
7.6 Chemically Induced Cardiac Thrombosis
611(1)
7.7 Valve Lesions
611(1)
7.8 Neoplasia
612(1)
8 Induced Lesions In Blood Vessels
612(6)
8.1 Vasculitis
613(2)
8.2 Immune-Mediated Vasculitis
615(1)
8.3 Hypertrophy, Hyperplasia, and Fibrosis
616(1)
8.4 Plexiform Vasculopathy
616(1)
8.5 Aneurysms
616(1)
8.6 Induced Degenerative Changes
617(1)
8.7 Induced Neoplasia
617(1)
8.8 Infusion Studies
617(1)
Bibliography
618(13)
Section XIV Endocrine System
31 Pituitary Gland
Amera K. Remick
Danielle L. Brown
1 Introduction
631(1)
2 Normal Pituitary Gland
631(4)
2.1 Embryology
631(2)
2.2 Anatomy
633(1)
2.3 Histology
634(1)
2.4 Physiology
635(1)
3 Congenital Lesions
635(1)
4 Degenerative Lesions
636(2)
5 Inflammatory and Vascular Lesions
638(1)
6 Hyperplastic and Neoplastic Lesions
638(6)
6.1 Pars Distal is
638(5)
6.2 Pars Intermedia
643(1)
6.3 Pars Nervosa
643(1)
6.4 Miscellaneous Neoplasms
644(1)
7 Miscellaneous Lesions
644(1)
8 Toxicologic Lesions
645(1)
Bibliography
645(4)
32 Adrenal Gland
Andrew W. Suttie
Catherine Sutcliffe
1 Introduction
649(1)
2 Normal Adrenal Gland
649(3)
2.1 Embryology
649(1)
2.2 Anatomy
650(1)
2.3 Histology
650(1)
2.4 Physiology
651(1)
3 Congenital Lesions
652(1)
3.1 Accessory (Adreno) Cortical Tissue
652(1)
3.2 Agenesis
653(1)
4 Degenerative Lesions
653(2)
4.1 Atrophy
653(1)
4.2 Cortical Vacuolation (Fatty Change)
653(1)
4.3 Cystic Degeneration
654(1)
4.4 Mineralization
654(1)
4.5 Lipofuscin (Gerold)
654(1)
4.6 Necrosis
654(1)
4.7 Diffuse Lipid Depletion
655(1)
4.8 Extracapsular Cortical Tissue
655(1)
5 Inflammatory and Vascular Lesions
655(1)
6 Hyperplastic and Neoplastic Lesions
655(9)
6.1 Adrenal Cortex
655(4)
6.2 Adrenal Medulla
659(5)
7 Miscellaneous Lesions
664(1)
7.1 Osseous Metaplasia
664(1)
7.2 Amyloidosis
664(1)
8 Toxicologic Lesions
664(2)
8.1 Cortex
664(2)
8.2 Adrenal Medulla
666(1)
Bibliography
666(3)
33 Thyroid Gland
Mark G. Mense
Gary A. Boorman
1 Introduction
669(1)
2 Normal Thyroid Gland
669(3)
2.1 Embryology
669(1)
2.2 Anatomy
670(1)
2.3 Histology
670(1)
2.4 Physiology
671(1)
3 Congenital Anomalies
672(1)
4 Degenerative Lesions
673(1)
5 Inflammatory and Vascular Lesions
673(1)
6 Hyperplastic and Neoplastic Lesions
674(9)
6.1 Follicular Epithelium
674(5)
6.2 C Cells (Parafollicular Cells)
679(4)
7 Miscellaneous Lesions
683(1)
8 Toxicologic Lesions
683(1)
References
684(3)
34 Parathyroid Gland
Mark G. Mense
Thomas J. Rosol
1 Introduction
687(1)
2 Normal Parathyroid Gland
687(1)
2.1 Embryology
687(1)
2.2 Histology
687(1)
2.3 Physiology
688(1)
3 Congenital Lesions
688(1)
4 Degenerative Lesions
688(1)
5 Inflammatory and Vascular Lesions
689(1)
6 Hyperplasia and Neoplastic Lesions
689(3)
6.1 Hyperplasia
689(1)
6.2 Adenoma
690(1)
6.3 Carcinoma
691(1)
7 Miscellaneous
692(1)
8 Toxicologic Lesions
692(1)
Bibliography
692(3)
35 Endocrine Pancreas
Mark G. Mense
Thomas J. Rosol
1 Introduction
695(1)
2 Normal Endocrine Pancreas
695(2)
2.1 Embryology
695(1)
2.2 Anatomy and Histology
695(2)
2.3 Pathophysiology
697(1)
3 Congenital Lesions
697(1)
4 Degenerative Lesions
697(1)
5 Inflammatory and Vascular Lesions
698(1)
6 Hyperplastic and Neoplastic Lesions
698(3)
6.1 Islet Cell Hyperplasia
698(1)
6.2 Islet Cell Regeneration
699(1)
6.3 Islet Cell Adenoma
699(1)
6.4 Islet Cell Carcinoma
700(1)
6.5 Mixed Acinar-Islet Cell Adenoma
701(1)
7 Hepatocyte Metaplasia
701(1)
8 Toxicologic Lesions
702(1)
Bibliography
703(2)
Index 705
Andrew W. Suttie, BVSc, PhD, DACVP, Pathologist/Manager, Pathology, Covance, Inc..He is a Member of the Working group in Male Reproductive area for INHAND Nomenclature for the Society of Toxicologic Pathology, Diplomat, American College of Veterinary Pathologists, 2004 and Diplomat, Royal College of Pathologists, Veterinary Pathology, 2000, Member, Society of Toxicologic Pathologists and British Society of Toxicologic Pathologists, Active speaker at international society meetings and symposiums. Gary A. Boorman works at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Joel R. Leininger works at the Wil Research, North Carolina, USA. Scot L. Eustis works at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Michael R. Elwell works at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. William F. MacKenzie works at the Experimental Pathology Laboratories, Research Triangle Park, North Carolina, USA. Dr. Bradley has been with Charles River since 1998 where she is the senior director of pathology. In this capacity she leads a team of veterinary pathologists and pathology analysts. She has specialist interest and provides consultancy services in neuropathology, non-human primate pathology, medical devices, and cellular therapy products (human and animal stem cells). She is an experienced study pathologist for acute, long term reproductive toxicology, tumorigenicity, oncogenicity, microautoradiography, target animal safety and carcinogenicity studies. She has authored over 700 GLP or GMP compliant toxicological peer reviewed pathology and photomicroscopy reports. She is the GLP and GMP Study Director as well as the Quality Control Manager for GMP pathology services.
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