Contains 191 papers contributed primarily by surgical, radiation, and medical oncologists to assure a multidisciplinary approach to each disease. Gynecologic, urologic, orthopedic, and otolaryngologic surgical oncologists have contributed in their specialty areas. Psycho-oncology, nursing oncology, and rehabilitation medicine are all represented, and pathology and the imaging specialties are specifically included as individual contributions and as parts of the chapters on various diseases. Volume one begins with the biology, etiology, and epidemiology of cancer, then covers the principles of imaging, endocrine and gene therapy, chemotherapy, and each oncologic discipline. Volume two presents specific neoplasms and complications. Annotation c. by Book News, Inc., Portland, Or.
Preface v(2) Contributors vii VOLUME ONE SECTION I CANCER BIOLOGY 3(204) 1 Cell Proliferation and Differentiation 3(16) Howard J. Fingert, M.D. Judith Campisi, Ph.D. Arthur B. Pardee, Ph.D. 2 Molecular Biology 19(22) Barrett J. Rollins, M.D., Ph.D. Charles D. Stiles, Ph.D. 3 Growth Factors 41(24) Paolo Fedi, M.D., Ph.D. Steven R. Tronick, Ph.D. Stuart A. Aaronson, M.D. 4 Signal Transduction in Cancer 65(20) Yusuf A. Hannun, M.D. 5 Oncogenes 85(12) Steven A. Schichman, M.D., Ph.D. Carlo H. Croce, M.D. 6 Tumor Suppressor and DNA Repair Gene Defects in Human Cancer 97(22) Eric R. Fearon, M.D., Ph.D. Bert Vogelstein, M.D.
7. Recurring Chromosome Rearrangements in Human Cancer 119(24) Olufunmilayo I. Olopade, M.D. Janet D. Rowley, M.D., D.Sc.
8. Biochemistry of Cancer 143(22) Edward Bresnick, Ph.D.
9. Invasion and Metastasis 165(16) Lance A. Liotta, M.D., Ph.D. Elise C. Kohn, M.D.
10. Tumor Angiogenesis 181(26) Judah Folkman, M.D. SECTION II TUMOR IMMUNOLOGY 207(38)
11. Tumor Immunology 207(38) Robert C. Bast, Jr., M.D. Gordon B. Mills, M.D., Ph.D. Spencer Gibson, Ph.D. Cinda M. Boyer, Ph.D. SECTION III CANCER ETIOLOGY 245(156)
12. Genetic Predisposition to Cancer 245(16) Bruce A. J. Ponder, Ph.D., F.R.C.P.
13. Chemical Carcinogenesis 261(16) Ainsley Weston, Ph.D. Curtis C. Harris, M.D.
14. Hormones and the Etiology of Cancer 277(16) Brian E. Henderson, M.D. Leslie Bernstein, Ph.D. Ronald K. Ross, M.D.
15. Ionizing Radiation 293(14) John B. Little, M.D.
16. Ultraviolet Radiation Carcinogenesis 307(12) James E. Cleaver, Ph.D. David L. Mitchell, Ph.D.
17. Carcinogenesis from Low-Frequency Electromagnetic Fields 319(6) Cesare Maltoni, M.D. Morando Soffritti, M.D.
18. Physical Carcinogens 325(8) Cesare Maltoni, M.D. Franco Minardi, M.D.
19. Trauma and Inflammation 333(4) John F. Gaeta, M.D.
20. RNA Tumor Viruses 337(18) Howard A. Fine, M.D. Joseph G. Sodroski, M.D.
21. Herpesviruses 355(10) Jeffrey I. Cohen, M.D.
22. Papillomaviruses and Cervical Neoplasia 365(10) Catherine M. McLachlin, M.D., F.R.C.P.C. Christopher P. Crum, M.D.
23. Hepatitis Viruses 375(14) Max W. Sung, M.D. Swan N. Thung, M.D. George Acs, M.D., Ph.D.
24. Parasites 389(12) Piero Mustacchi, M.D. SECTION IV CANCER EPIDEMIOLOGY 401(22)
25. Cancer Epidemiology 401(22) Frederick P. Li, M.D. Arlene F. Kantor, Dr. P.H. SECTION V THEORY AND PRACTICE OF CLINICAL TRIALS 423(24)
26. Theory and Practice of Clinical Trials 423(24) Marvin Zelen, Ph.D. SECTION VI CANCER PREVENTION 447(64)
27. Prevention of Tobacco-Related Cancers 447(18) Paul F. Engstrom, M.D. Elizabeth A. Rosvold, M.D. Neal R. Boyd, Jr., Ed.D, M.S.P.H., C. Tracy Orleans, Ph.D.
28. Nutrition in the Etiology and Prevention of Cancer 465(30) Steven K. Clinton, M.D., Ph.D. Edward Giovannucci, M.D., D.P.H.
29. Chemoprevention of Cancer 495(16) Michael B. Sporn, M.D. Scott M. Lippman, M.D., F.A.C.P. SECTION VII CANCER SCREENING AND EARLY DETECTION 511(22)
30. Cancer Screening and Early Detection 511(22) Charles R. Smart, M.D. Curtis P. Mettlin, Ph.D. Laszlo Tabar, M.D. Harmon J. Eyre, MD SECTION VIII PRINCIPLES OF CANCER PATHOLOGY 533(26)
31. Principles of Cancer Pathology 533(26) James L. Connolly, M.D. Stuart J. Schnitt, M.D. Helen H. Wang, M.D. Dr. P.H. Ann M. Dvorak, M.D. Harold F. Dvorak, M.D. SECTION IX PRINCIPLES OF IMAGING 559(56)
32. Introduction 559(4) Richard J. Steckel, M.D.
33. Imaging Cancer of Unknown Primary Site 563(4) A. Robert Kagan, M.D. Richard J. Steckel, M.D.
34. Imaging Neoplasms of the Head, Neck and Central Nervous System 567(6) Robert Lufkin, M.D.
35. Imaging Neoplasms of the Thorax 573(6) Poonam V. Batra, M.D., F.C.C.P., F.A.C.R.
36. Imaging Neoplasms of the Abdomen and Pelvis 579(6) Robert A. Halvorsen, Jr., M.D. William M. Thompson, M.D.
37. Cross-Sectional Imaging of Musculoskeletal Neoplasms 585(4) Leanne L. Seeger, M.D.
38. Imaging the Breast 589(8) Lawrence W. Bassett, M.D.
39. Ultrasound in Cancer Medicine 597(6) Edward G. Grant, M.D.
40. Radionuclide Imaging in Cancer Medicine 603(8) Randall A. Hawkins, M.D., Ph.D.
41. Perspectives in Imaging 611(4) Richard J. Steckel, M.D. SECTION X INTERVENTIONAL RADIOLOGY 615(16)
42. Interventional Radiology 615(16) Sidney Wallace, M.D. Chusilp Charnsangavej, M.D. C. Humberto Carrasco, M.D. SECTION XI ENDOSCOPY 631(20)
43. Gastrointestinal Endoscopy 631(14) J. Mark Lawson, M.D., F.A.C.P., F.A.C.G. John Baillie, M.B., Ch.B., F.R.C.P.
44. Bronchoscopy 645(6) Victor F. Tapson, M.D. William J. Fulkerson, Jr., M.D. SECTION XII PRINCIPLES OF SURGICAL ONCOLOGY 651(46)
45. Principles of Surgical Oncology 651(14) Donald L. Morton, M.D. Ralph C. Jones, Lt. Cdr., M.C., U.S.N.
46. Vascular Access in Cancer Patients 665(10) Michail Shafir, M.D.
47. Minimally Invasive Surgery 675(22) Michael Edye, M.B., B.S. Barry Salky, M.D., F.A.C.S. Steven M. Keller, M.D. T. Scott Jennings, M.D. Peter R. Dottino, M.D. Nelson N. Stone, M.D. SECTION XIII PRINCIPLES OF RADIATION ONCOLOGY 697(58)
48. Biological and Physical Basis of Radiation Oncology 697(30) Ralph R. Weichselbaum, M.D. George Chen, M.D. Dennis E. Hallahan, M.D.
49. Principles of Hyperthermia 727(12) Daniel S. Kapp, Ph.D., M.D. George M. Hahn, Ph.D. Robert W. Carlson, M.D.
50. Photodynamic Therapy of Cancer 739(16) Tayyaba Hasan, Ph.D. John A. Parrish, M.D. SECTION XIV PRINCIPLES OF MEDICAL ONCOLOGY 755(14)
51. Principles of Medical Oncology 755(14) James F. Holland, M.D. Emil Frei III, M.D. Donald W. Kufe, M.D. Robert C. Bast, Jr., M.D. SECTION XV PRINCIPLES OF CHEMOTHERAPY 769(138)
52. Cytokinetics 769(30) Antonella Surbone, M.D. Teresa Ann Gilewski, M.D. Larry Norton, M.D.
53. Drug Resistance and Its Clinical Circumvention 799(18) Charles S. Morrow, M.D., Ph.D. Kenneth H. Cowan, M.D., Ph.D.
54. Combination Chemotherapy, Dose, and Schedule 817(22) Emil Frei III, M.D. Karen H. Antman, M.D.
55. Regional Chemotherapy 839(16) Stephen B. Howell, M.D.
56. Animal Models in Drug Development 855(14) Samir N. Khleif, M.D. Gregory A. Curt, M.D.
57. In Vitro and In Vivo Predictive Tests 869(6) Axel-R. Hanauske, M.D., Ph.D. Daniel D. Von Hoff, M.D., F.A.C.P.
58. Pharmacology 875(16) Mark J. Ratain, M.D. William Plunkett, Ph.D.
59. Toxicology by Organ System 891(16) Michael R. Grever, M.D. Charles K. Grieshaber, Ph.D. SECTION XVI CHEMOTHERAPEUTIC AGENTS 907(142)
60. Folate Antagonists 907(16) Joseph R. Bertino, M.D. Barton A. Kamen, M.D., Ph.D. Antonella Romanini, M.D.
61. Pyrimidine and Purine Antimetabolites 923(26) Giuseppe Pizzorno, Ph.D., Pharm.D. Yung-Chi Cheng, Ph.D. Robert E. Handschumacher, Ph.D.
62. Alkylating Agents and Platinum Antitumor Compounds 949(28) O. Michael Colvin, M.D.
63. Anthracyclines and DNA Intercalators 977(12) Charles Myers, M.D.
64. Epipodophyllotoxins 989(8) Antoinette J. Wozniak, M.D. Warren E. Ross, M.D.
65. DNA Topoisomerase I Inhibitors 997(8) Robert Silber, M.D.
66. Anticancer Drugs From Plants: Vinca Alkaloids and Taxanes 1005(22) William T. Beck, Ph.D. Carol E. Cass, Ph.D. Peter J. Houghton, Ph.D.
67. Asparaginase 1027(10) Joanne Kurtzberg, M.D.
68. Antitumor Activity of Polyanions 1037(12) Charles Myers, M.D. SECTION XVII PRINCIPLES OF ENDOCRINE THERAPY 1049(120)
69. Steroid Hormone Binding and Hormone Receptors 1049(12) Elwood V. Jensen, M.D. Eugene R. DeSombre, Ph.D.
70. Hormone Physiology and Endocrine Ablation 1061(6) B. J. Kennedy, M.D.
71. Hypothalamic and Other Peptide Hormones 1067(20) Andrew V. Schally, Ph.D., D.Sci., M.D.h.c. Ana Maria Comaru-Schally, M.D., M.S.
72. Corticosteroids 1087(16) Robert A. Schwartzman, Ph.D. John A. Cidlowski, M.D., M.S.
73. Estrogens and Antiestrogens 1103(10) V. Craig Jordan, Ph.D., D.Sc.
74. Clinical Use of Aromatase Inhibitors in Breast Carcinoma 1113(12) Harold A. Harvey, M.D. Andrea Manni, M.D.
75. Progestins 1125(8) Kenneth S. McCarty, Jr., M.D., Ph.D. Kenneth S. McCarty, Sr., Ph.D.
76. Androgens and Antiandrogens 1133(16) Nicholas Bruchovsky, M.D., Ph.D., F.R.C.P.
77. Paraneoplastic Syndromes 1149(20) William D. Odell, M.D., Ph.D., M.A.C.P. SECTION XVIII PRINCIPLES OF BIOTHERAPEUTICS 1169(96)
78. Immunostimulants 1169(10) Robert C. Bast, Jr., M.D. Donald L. Morton, M.D.
79. Active Specific Immunotherapy with Vaccines 1179(20) Mepur H. Ravindranath, Ph.D. Donald L. Morton, M.D.
80. Interferons 1199(14) Ernest C. Borden, M.D.
81. Cytokines: Biology and Applications in Cancer Medicine 1213(14) David R. Parkinson, M.D. Elizabeth A. Grimm, Ph.D.
82. Hematopoietic Growth Factors 1227(18) George D. Demetri, M.D.
83. Monoclonal Serotherapy 1245(20) Robert C. Bast, Jr., M.D. Michael R. Zalutsky, Ph.D. Arthur Edward Frankel, M.D. SECTION XIX PRINCIPLES OF GENE THERAPY 1265(14)
84. Cancer Gene Therapy 1265(14) Howard A. Fine, M.D. Donald W. Kufe, M.D. SECTION XX PRINCIPLES OF BONE MARROW TRANSPLANTATION 1279(48)
85. Autologous Bone Marrow Transplantation 1279(16) William P. Peters, M.D., Ph.D.
86. Allogeneic Transplantation 1295(32) Richard J. OReilly, M.D. Esperanza B. Papadopoulos, M.D. SECTION XXI PRINCIPLES OF PSYCHO-ONCOLOGY 1327(20)
87. Principles of Psycho-Oncology 1327(20) Jimmie C. Holland, M.D. SECTION XXII PRINCIPLES OF ONCOLOGY NURSING 1347(24)
88. Principles of Oncology Nursing 1347(24) Connie Henke Yarbro, R.N., B.S.N. SECTION XXIII PRINCIPLES OF REHABILITATION MEDICINE 1371(24)
89. Principles of Cancer Rehabilitation Medicine 1371(24) Kristjan T. Ragnarsson, M.D. SECTION XXIV PRINCIPLES OF MULTIDISCIPLINARY MANAGEMENT 1395(10)
90. Principles of Multidisciplinary Management 1395(10) James F. Holland, M.D. Emil Frei III, M.D. Donald W. Kufe, M.D. Robert C. Bast, Jr., M.D. Donald L. Morton, M.D. Ralph R. Weichselbaum, M.D. SECTION XXV PRINCIPLES OF SOCIETAL ONCOLOGY 1405(66)
91. Ethical Aspects of Caring for Patients with Cancer 1405(18) Ezekiel J. Emanuel, M.D., Ph.D. Frederic C. Kass, M.D., J.D.
92. Legal Aspects of Cancer 1423(12) Joseph M. Taraska, J.D.
93. Government and Cancer Medicine 1435(12) John E. Ultmann, M.D. Marguerite Donoghue, R.N., M.N. Terry L. Lierman
94. Clinical Oncology in a Reforming Health Care Environment 1447(4) Martin N. Raber, M.D. Joseph S. Bailes, M.D., F.A.C.P.
95. Outcomes Assessment 1451(8) Jane Weeks, M.D., M.Sc.
96. Questionable Cancer Therapies 1459(12) Stephen Barrett, M.D. Victor D. Herbert, M.D., J.D. SECTION XXVI NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM 1471(46)
97. Neoplasms of the Central Nervous System 1471(46) Michael D. Prados, M.D., J.D. Charles B. Wilson, M.D., J.D. SECTION XXVII NEOPLASMS OF THE EYE 1517(22)
98. Neoplasms of the Eye 1517(22) David H. Abramson, M.D. Ira J. Dunkel, M.D. Beryl McCormick, M.D. SECTION XXVIII NEOPLASMS OF THE ENDOCRINE GLANDS 1539(106)
99. Pituitary Neoplasms 1539(12) Charles B. Wilson, M.D. Thomas Mindermann, M.D.
100. Neoplasms of the Thyroid 1551(12) Blake Cady, M.D. Arturo R. Rolla, M.D.
101. Neoplasms of the Adrenal Cortex 1563(8) Mary R. Flack, M.D. George P. Chrousos, M.D.
102. Neoplasms of the Neuroendocrine System 1571(34) Li-Teh Wu, M.D. A. Philippe Chahinian, M.D. Stephen B. Baylin, M.D. Norman W. Thompson, M.D., Ph.D. Steven D. Averbuch, M.D.
103. Neoplasms of the Gastroenteropancreatic Endocrine System 1605(36) Arthur I. Vinik, M.D., Ph.D., F.C.P., F.A.C.P. Roger R. Perry, M.D., F.A.C.S.
104. Pass through to the Gonads 1641(4) James F. Holland, M.D. Emil Frei III, M.D. Robert C. Bast, Jr., M.D. Donald W. Kufe, M.D. Donald L. Morton, M.D. Ralph R. Weichselbaum, M.D. SECTION XXIX NEOPLASMS OF THE HEAD AND NECK 1645
105. Head and Neck Cancer 1645(66) Gary L. Clayman, D.D.S. Scott M. Lippman, M.D., F.A.C.P. George E. Laramore, M.D., Ph.D. Waun Ki Hong, M.D.
106. Odontogenic Tumors 1711 George T. Gallagher, D.M.D., D.M.Sc. Gerald Shklar, D.D.S., M.S.
