"Carbon monoxide, one of the smallest organic natural molecules, is widely known for its toxicity. Formation of CO via incomplete combustion is a major contributing factor to accidental or intentional CO poisoning, leading to severe health consequences or death. In addition, CO is a by-product of tobacco smoking, and has been associated with some of the harmful effects of smoking. However, less known and probably far more important is the recognition of the essential physiological roles of CO as a signaling molecule in mammals. Against over more than a century of negative connotation, the last few decades have proven that CO possesses a multitude of physiological roles and therapeutic functions including regulation of the immune response, cellular proliferation, and control of cell survival. This concept is supported by the discovery that CO is produced by all cells and more so under conditions of stress. This book comprehensively summarizes key aspects of CO's endogenous roles, therapeutic functions, and challenges that we face in its development as a therapeutic agent. We hope this preface will provide a thread for reading this book and a birds-eye view of the landscape for understanding this field, and more importantly lay out the challenges ahead in understanding the detailed mechanisms of action of CO and in its development as a therapeutic agent. We have divided the book into four sections that provide a framework for the reader to follow the evolution of CO from an accepted poison to a bioactive molecule that may offer enormous clinical benefits"--
CARBON MONOXIDE IN DRUG DISCOVERY An insightful reference for the latest physiological and therapeutic studies of carbon monoxide
In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials.
Organized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes.
The editors of Carbon Monoxide in Drug Discovery have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from:
- A thorough introduction to the background and physiological actions of carbon monoxide, including endogenous CO production in sickness and in health
- Comprehensive explorations of CO delivery forms, including non-carrier formulations, metal-carbonyl complexes, and organic CO donors
- Practical discussions of carbon monoxide sensing and scavenging, including fluorescent probes for intracellular carbon monoxide detection
- In-depth examinations of the therapeutic applications of CO, including CO in solid organ transplantation
Perfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential is also an invaluable resource for industrial scientists in these areas.
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