This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.
Part I. Pathophysiology, Molecular Biology, and Clinical Management of
Cardiac Repolarization.- 1. Physiology and Molecular biology of Cardiac Ion
Channels and Ventricular Repolarization.- 2. Cardiac Repolarization and the
Autonomic Nervous System.- 3. Role of Repolarization Remodeling in Organic
Heart Disease.- 4. Stem Cells in Study and Treatment of Cardiac
Repolarization.- 5. Racial and Gender Differences in Cardiac Repolarization
and Arrhythmogenesis.- 6. ECG-derived Evaluation of Cardiac
Repolarization.- Part II. Pathophysiology, Molecular Biology, and Clinical
Management of Long QT Syndromes.- 7. Physiology and Molecular Biology of
Congenital Long QT Syndrome (LQTS).- 8. Pharmacotherapeutics and Clinical
Management of Congenital LQTS.- 9. Drug-induced LQTS.- 10. Arrhythmogenic
Mechanism of TdP in LQTS.- 11. Pathogenesis of Autoimmune-associated
LQTS.- 12. Role of inflammation andAutoimmune Disease in LQTS.- 13. Future of
Genetic Therapy of Congenital LQTS.- Part III. Pathophysiology, Molecular
Biology, and Clinical Management of Early Repolarization Syndromes.- 14.
Genetics, Molecular biology, and Emerging Concepts of Early Repolarization
Syndrome (ERS).- 15. Electrocardiographic J-wave and Cardiovascular Risk in
the General Population.- 16. Benign Versus Malignant Early Repolarization
Patterns.- 17. Genetics, Molecular Biology, and Management of Brugada
Syndrome.- Part IV. Pathophysiology and Clinical Management of Special
Cardiac Repolarization Syndromes.- 18. Genetics, Molecular Biology, and
Management of Short QT Syndrome.- 19. Pathophysiology of Repolarization
Alternans.- 20. Microvolt T-wave Alternans: Pathophysiology and Clinical
Aspects.- 21. Atrial Repolarization and Arrhythmogenesis: Basic and Clinical
Aspects.
Nabil El-Sherif, MDProfessor of Medicine & Physiology, State University of New York Medical CenterChief, Cardiology Division, NY Harbor VA Healthcare System, Brooklyn, NYDistinguished Scientist of the American College of Cardiology
