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El. knyga: Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop

  • Formatas: 122 pages
  • Išleidimo metai: 26-Jul-2019
  • Leidėjas: National Academies Press
  • Kalba: eng
  • ISBN-13: 9780309488549
Kitos knygos pagal šią temą:
  • Formatas: 122 pages
  • Išleidimo metai: 26-Jul-2019
  • Leidėjas: National Academies Press
  • Kalba: eng
  • ISBN-13: 9780309488549
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The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management.





To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

Table of Contents



Front Matter 1 Introduction 2 Context for the Use of Marmosets as Animal Models 3 Ethical Considerations 4 Current Research Applications 5 Marmoset Genomics and Genetic Diversity 6 Marmoset Supply and Availability 7 Marmoset Care and Management 8 Final Remarks Appendix A: Workshop Agenda Appendix B: Professional Biosketches
1 Introduction
1(4)
Workshop Statement of Task
2(3)
2 Context for the Use of Marmosets as Animal Models
5(6)
History
5(1)
Current Use and Key Advantages
6(2)
Key Challenges
8(1)
References
9(2)
3 Ethical Considerations
11(12)
Theoretical Considerations
11(5)
Practical Considerations
16(2)
Discussion
18(3)
References
21(2)
4 Current Research Applications
23(18)
Neuroscience
23(8)
Aging
31(2)
Infectious Disease
33(3)
Gene Editing and Transgenic Animals
36(2)
Discussion
38(1)
References
38(3)
5 Marmoset Genomics and Genetic Diversity
41(10)
Characterizing the Marmoset Genome
41(3)
Genetic Diversity in Marmosets
44(5)
References
49(2)
6 Marmoset Supply and Availability
51(10)
Marmosets in the Wild
51(3)
Breeding and Transportation
54(4)
References
58(3)
7 Marmoset Care and Management
61(24)
Routine Care
61(3)
Diet
64(4)
Habits and Environment
68(1)
Reproduction
69(3)
Disease Prevention and Management
72(5)
Pain Prevention and Management
77(3)
Discussion
80(1)
Suggested Reading
80(5)
8 Final Remarks
85(2)
Appendixes
A Workshop Agenda 87(8)
B Professional Biosketches 95