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El. knyga: Chiral Separations: Methods and Protocols

  • Formatas: PDF+DRM
  • Serija: Methods in Molecular Biology 970
  • Išleidimo metai: 04-Jan-2013
  • Leidėjas: Humana Press Inc.
  • Kalba: eng
  • ISBN-13: 9781627032636
Kitos knygos pagal šią temą:
  • Formatas: PDF+DRM
  • Serija: Methods in Molecular Biology 970
  • Išleidimo metai: 04-Jan-2013
  • Leidėjas: Humana Press Inc.
  • Kalba: eng
  • ISBN-13: 9781627032636
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Detailing current methodology, this book examines important analytical techniques in chiral separation sciences. It includes step-by-step, readily reproducible laboratory protocols and troubleshooting tips.

There is a demand for analytical methods that are able to discriminate between enantiomers in order to analyze the enantiomeric purity of compounds from natural or chemical sources not only in pharmaceutical sciences but in any field on bioactive compounds including chemistry, biology, biochemistry, forensic, and environmental sciences and many others. The second edition of Chiral Separations: Methods and Protocols, expands upon the previous edition with current methodology, providing an overview and especially practically oriented applications of the most important analytical techniques in chiral separation sciences. New chapters on analytical separation sciences by chromatographic and electrophoretic techniques have been added as has simulated moving bed chromatography as a preparative method. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chiral Separations: Methods and Protocols, Second Edition is helpful for analytical chemists working on stereochemical problems in fields or pharmacy, chemistry, biochemistry, food chemistry, molecular biology, forensics, environmental sciences or cosmetics in academia, government or industry.

Recenzijos

From the reviews of the second edition:

The second edition of Chiral Separations: Methods and Protocols discusses almost every kind of chiral separation method, with the emphasis on fundamental research and experimental design. it is a very useful book for scientists and students involved in the enantioseparation field, and scientists involved in R & D areas such as drug development and environmental monitoring can also benefit from this monograph. It is expected that this book will definitely promote research in chirality-related fields. (Huwei Liu, Analytical and Bioanalytical Chemistry, Vol. 406, 2014)

The book provides an overview and practically oriented applications of the most important analytical techniques in chiral separations. the chapters include introductions, lists of necessary materials and reagents, step-by-step laboratory protocols, and troubleshooting tips. Pharmacists, biochemists, chemists, food chemists, molecular biologists, and forensic and environmental scientists will find this book extremely useful. (Omer Iqbal, Doodys Book Reviews, August, 2013)

Preface ix
Contributors xv
1 Chiral Recognition in Separation Science: An Overview
1(28)
Gerhard K.E. Scriba
2 Enantioseparations by Thin-Layer Chromatography
29(16)
Massimo Del Bubba
Leonardo Checchini
Alessandra Cincinelli
Luciano Lepri
3 Gas-Chromatographic Enantioseparation of Unfunctionalized Chiral Hydrocarbons: An Overview
45(24)
Volker Schurig
Diana Kreidler
4 HPLC Enantioseparation on Cyclodextrin-Based Chiral Stationary Phases
69(12)
Yong Wang
Siu Choon Ng
5 Enantioseparations by High-Performance Liquid Chromatography Using Polysaccharide-Based Chiral Stationary Phases: An Overview
81(32)
Bezhan Chankvetadze
6 Common Screening Approaches for Efficient Analytical Method Development in LC and SFC on Columns Packed with Immobilized Polysaccharide-Derived Chiral Stationary Phases
113(14)
Pilar Franco
Tong Zhang
7 Chiral Separations by HPLC on Immobilized Polysaccharide Chiral Stationary Phases
127(10)
Imran Ali
Zeid A. AL-Othman
Hassan Y. Aboul-Enein
8 Enantioseparations by High-Performance Liquid Chromatography Using Macrocyclic Glycopeptide-Based Chiral Stationary Phases: An Overview
137(28)
Istvan Ilisz
Anita Aranyi
Zoltan Pataj
Antal Peter
9 Enantioseparations of Primary Amino Compounds by High-Performance Liquid Chromatography Using Chiral Crown Ether-Based Chiral Stationary Phase
165(12)
Myung Ho Hyun
10 Screening of Pirkle-Type Chiral Stationary Phases for HPLC Enantioseparations
177(14)
Gregory K. Webster
Ted J. Szczerba
11 Enantioseparations by High-Performance Liquid Chromatography Based on Chiral Ligand-Exchange
191(18)
Benedetto Natalini
Roccaldo Sardella
Federica Ianni
12 Enantioseparations by High-Performance Liquid Chromatography Using Molecularly Imprinted Polymers
209(12)
David A. Spivak
13 Chiral Mobile Phase Additives in HPLC Enantioseparations
221(12)
Lushan Yu
Shengjia Wang
Su Zeng
14 Chiral Benzofurazan-Derived Derivatization Reagents for Indirect Enantioseparations by HPLC
233(16)
Toshimasa Toyo'oka
15 Separation of Racemic 1-(9-Anthryl)-2,2,2-trifluoroethanol by Sub-/Supercritical Fluid Chromatography
249(8)
Xiqin Yang
Leo Hsu
Gerald Terfloth
16 Chiral Separations by Simulated Moving Bed Method Using Polysaccharide-Based Chiral Stationary Phases
257(14)
Toshiharu Minoda
17 Enantioseparations by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors
271(18)
Gerhard K.E. Scriba
Pavel Jac
18 Application of Dual Cyclodextrin Systems in Capillary Electrophoresis Enantioseparations
289(8)
Anne-Catherine Servais
Marianne Fillet
19 Enantioseparations in Nonaqueous Capillary Electrophoresis Using Charged Cyclodextrins
297(10)
Anne-Catherine Servais
Marianne Fillet
20 Use of Macrocyclic Antibiotics as the Chiral Selectors in Capillary Electrophoresis
307(12)
Chengke Li
Jingwu Kang
21 Application of Polymeric Surfactants in Chiral Micellar Electrokinetic Chromatography (CMEKC) and CMEKC Coupled to Mass Spectrometry
319(30)
Jun He
Shahab A. Shamsi
22 Cyclodextrin-modified Micellar Electrokinetic Chromatography for Enantioseparations
349(14)
Wan Aini Wan Ibrahim
Dadan Hermawan
Mohd Marsin Sanagi
23 Cyclodextrin-Mediated Enantioseparation in Microemulsion Electrokinetic Chromatography
363(14)
Claudia Borst
Ulrike Holzgrabe
24 Chiral Separations by Capillary Electrophoresis Using Proteins as Chiral Selectors
377(16)
Jun Haginaka
25 Enantioseparation by Chiral Ligand-Exchange Capillary Electrophoresis
393(16)
Yi Chen
Lijuan Song
26 Experimental Design Methodologies in the Optimization of Chiral CE or CEC Separations: An Overview
409(20)
Bieke Dejaegher
Debby Mangelings
Yvan Vander Heyden
27 Chiral Capillary Electrophoresis-Mass Spectrometry
429(14)
Elena Dominguez-Vega
Antonio L. Crego
Maria Luisa Marina
28 Application of Chiral Ligand-Exchange Stationary Phases in Capillary Electrochromatography
443(14)
Martin G. Schmid
29 Polysaccharide-Derived Chiral Stationary Phases in Capillary Electrochromatography Enantioseparations
457(12)
Zhenbin Zhang
Hanfa Zou
Junjie Ou
30 Open Tubular Molecular Imprinted Phases in Chiral Capillary Electrochromatography
469(20)
Won Jo Cheong
Song Hee Yang
31 Enantioseparations in Capillary Electrochromatography Using Sulfated Poly β-Cyclodextrin-Modified Silica-Based Monolith as Stationary Phase
489(16)
Ruijuan Yuan
Guosheng Ding
32 Cyclodextrin-Mediated Enantioseparations by Capillary Electrochromatography
505(20)
Dorothee Wistuba
Volker Schurig
Index 525