Focuses on techniques to diagnose precise defects in genetically unstable, evolving leukemic populations of neoplastic hematopoietic cells, highlighting findings on the molecular biology and clinical behavior of chronic myelogenous leukemia (CML). Covering the identification and characterization of the BCR-ABL chimeric gene, the reference reviews data for therapy of CML and discusses molecular details of v-abl and ber-abl oncogenes; the evolution and functional consequences of the ber-abl oncogene as studied by retroviral infection or plasmic transfection; studies of CML biology in short- and long-term culture systems; the current status of biological therapy, chemotherapy, and bone marrow transplantation; and the potential application of molecular and biological approaches to therapy for CML. Annotation copyright Book News, Inc. Portland, Or.
Focuses on techniques to diagnose precise defects in genetically unstable, evolving leukemic populations of neoplastic hematopoietic cells, highlighting findings on the molecular biology and clinical behavior of chronic myelogenous leukemia (CML). Covering the identification and characterization of
