The Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy. This second edition of Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers a thorough, timely discussion of ethical issues raised by the latest genetic and genomic technologies applied in human reproductive and prenatal medicine, providing practical recommendations, guidelines, and algorithms to support ethical clinical practice. Here, international experts consider the ethics of technologies from preconception carrier screening to genetic engineering, CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction, and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Throughout the book, contributors adopt a global, holistic perspective on applied challenges and the moral questions around the implementation of genetic reproductive technologies. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors, and graduate and medical students.This fully updated second edition examines new developments in the field, tackling ethical aspects of organoid development, recent advances in pharmacogenomics, direct-to-consumer genetic testing, and genetic engineering.
- Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive geneticsContains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology
- Discusses preconception carrier screening, genetic engineering, and the use of CRISPR gene editing, mitochondrial gene replacement therapy, and ethical issues, among others
- Considers ethical aspects of recent advances and new technologies in the field, from organoid development to pharmacogenomics and direct-to-consumer genetic testing
Recenzijos
*4 stars* This timely and expansive second edition assembles an international group of bioethicists and scientists to describe and consider how recent technologies and approaches impact human and prenatal medicine. This book adds new chapters to the previous edition (2018) to provide a more comprehensive discussion of current ethical issues in medical and prenatal genetics The purpose of this edition is to address the ethical issues raised by the newest techniques and most recent advances in prenatal and reproductive medicine. This book is timely and does an excellent job of providing guidelines and recommendations for ethical clinical practice. This book will be a valuable resource for medical practitioners, undergraduate and medical students, clinical researchers, genetic counselors, regulators, and lawmakers. The chapters are detailed and scholarly but are written in a manner accessible to an audience with a wide range of expertise in the specifics of the subject matter. --©Doodys Review Service, 2024, Mark F. Sanders, PhD (UC Davis College of Biological Sciences)
1. Genomic Editing: From Human Health to the "Perfect Child"
2. Ethics of Mitochondrial Gene Replacement Therapy
3. Reproductive Technologies Used by Same Gender Couples
4. Ethical Issues Raised by Multiparents
5. Revisiting the Nondirective Principle of Genetic Counseling in Prenatal Screening
6. Sex Selection, Gender Selection, and Sexism
7. The Impact of Big Data on Beginning of Life Issues
8. The Moral Status of the Embryo From the Standpoint of Social Perceptions
9. Fetal Reduction
10. Stem Cell Therapies for Neurodegenerative Disorders. An Ethical Analysis
11. Predictive Genetic Testing in Multifactorial Disorders
12. Whole-Genome Sequencing as a Method of Prenatal Genetic Diagnosis
13. Noninvasive Prenatal Genetic Diagnosis
14. Prenatal Testing in Low-Risk Populations: A US Perspective
15. Using Genetics for Enhancement (Liberal Eugenics)
16. Should Incidental Findings Arising From Prenatal Testing be Reported Indiscriminately to Patients?
17. Third Party Sharing of Genetic Information
18. Cerebral and non-cerebral organoids
19. Pharmacogenomics
20. Genetic methods of moral and intellectual enhancement
21. Direct to consumer genetic testing
Sorin Hostiuc, MD, PhD, is Professor in the Department of Legal Medicine and Bioethics at Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, and Senior Physician at the National Institute of Legal Medicine, Bucharest, Romania. Dr. Hostiuc has written extensively on topics such as informed consent, research ethics, history of medical ethics, and reproductive ethics, with more than 200 published articles in The Lancet, New England Journal of Medicine, PLOS ONE, Journal of Translational Medicine, and Frontiers in Neuroscience, among other journals. He has also published four monographs in Romanian dealing with bioethical issues: A Treaty of Medical and Dental Bioethics, Ethics of Scientific Research, Ethics of Scientific Publishing, and Informed Consent as well as a book about the history of informed consent in Europe. Dr. Hostiuc received his PhD in medicine and MD from Carol Davila University of Medicine and Pharmacy.
Daugiau apie elektronines knygas