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Clinical Hematology: Theory & Procedures 6th edition [Kietas viršelis]

  • Formatas: Hardback, 752 pages, weight: 2177 g
  • Išleidimo metai: 23-Mar-2017
  • Leidėjas: Jones and Bartlett Publishers, Inc
  • ISBN-10: 1496332288
  • ISBN-13: 9781496332288
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 752 pages, weight: 2177 g
  • Išleidimo metai: 23-Mar-2017
  • Leidėjas: Jones and Bartlett Publishers, Inc
  • ISBN-10: 1496332288
  • ISBN-13: 9781496332288
Kitos knygos pagal šią temą:
Designed to help students develop the professional entry-level competencies they need for certification and career success, this 6th edition of Clinical Hematology strengthens the pedagogy that set the quality benchmark  for hematology  and includes the current, competency-based content needed by MLT and MLS students.
 
In addition to state-of-the-art content, many, fully developed case studies with critical thinking discussion questions, and a strong emphasis on emerging  molecular diagnostics and genomic medicine, the 6th edition encompasses the professional knowledge guidelines recommended by ASCLS Entry Level and Professional Body of Knowledge competencies in hematology, hemostasis and coagulation, and molecular applications.
Throughout the text, a logical eight-part organization, clear explanations, and multiple learning tools help students master the theory underlying clinical hematology and the procedures used to diagnose and treat disorders of the blood and bone marrow.
  • Expanded coverage of Next Generation Sequencing (NGS) in the Molecular Techniques chapter reflects the importance of molecular diagnostics and genomic medicine in today's medical laboratories.
  • Numerous Clinical Case Studies with critical thinking group discussion questions link concepts and procedures to laboratory practice.
  • Two dedicated chapters provide step-by-step procedure instructions, enabling students to confidently perform important clinical procedures.
  • Learning Outcomes and Review questions— now identified as core and advanced content—clarify what MLT and MLS students should know upon successful completion of each chapter.
  • More algorithms and other student desired visual learning formats (figures, tables and boxes) clarify key points.
  • In-text learning aids (Learning Outcomes, Chapter Highlights and Review Questions) organized by major topic to facilitate concept mastery.
  • A streamlined Phlebotomy chapter focuses on the newest content with additional information moved online for easy access.
  • Bulleted Chapter Highlights facilitate quick review of each chapter’s material.
  • Key Terms italicized in the text and defined in the glossary help students master the vocabulary of hematology.
  • Certification-style Review Questions help students assess their knowledge as they advance through each chapter.
  • Updated full-color images offer a visual guide to the concepts and procedures presented in the text.
  • Updated references reflect the latest research in the field.


Designed to help students develop the professional entry-level competencies they need for certification and career success, this 6th edition of Clinical Hematology strengthens the pedagogy that set the quality benchmark  for hematology  and includes the current, competency-based content needed by MLT and MLS students.
 
In addition to state-of-the-art content, many, fully developed case studies with critical thinking discussion questions, and a strong emphasis on emerging  molecular diagnostics and genomic medicine, the 6th edition encompasses the professional knowledge guidelines recommended by ASCLS Entry Level and Professional Body of Knowledge competencies in hematology, hemostasis and coagulation, and molecular applications.
Throughout the text, a logical eight-part organization, clear explanations, and multiple learning tools help students master the theory underlying clinical hematology and the procedures used to diagnose and treat disorders of the blood and bone marrow.
About the Author v
Preface vii
PART ONE Hematology Basics
1(80)
1 Safety Practices and Quality in the Hematology Laboratory
1(24)
An Overview of the Hematology Laboratory
2(1)
Patient Safety
2(1)
Safety in the Hematology Laboratory
2(4)
Safe Work Practices and Protective Techniques for Infection Control
6(5)
Quality Assessment in the Hematology Laboratory
11(4)
Quality Control in the Hematology Laboratory
15(10)
Chapter Highlights
20(1)
Review Questions
21(2)
References
23(1)
Bibliography
23(2)
2 Principles of Blood Collection
25(33)
Quality in Blood Collection
26(1)
Safe Blood Collection Equipment
27(3)
Safe Blood Collection Equipment
30(28)
Chapter Highlights
51(3)
Review Questions
54(2)
Case Studies
56(1)
References
56(1)
Bibliography
57(1)
Internet sites
57(1)
3 Cellular Morphology and Foundations of Genetic Hematopoietic Disorders
58(23)
Cellular Ultrastructure and Organization
59(1)
Cellular Membranes
59(3)
Cytoplasmic Organelles and Metabolites
62(6)
Apoptosis
68(13)
Chapter Highlights
75(1)
Review Questions
76(3)
Bibliography
79(2)
PART TWO Hematopoiesis and Cellular Maturation
81(128)
4 Hematopoiesis
81(23)
Ontogeny of Hematopoiesis
82(1)
Hematopoietic Organs and Tissues
83(4)
Secondary Lymphoid Tissues
87(2)
Cellular Elements of Bone Marrow
89(1)
Human Stem Cells
89(3)
Cytokines
92(2)
Examination of Maturing Blood Cells
94(4)
Mature Blood Cells in Peripheral Blood
98(6)
Chapter Highlights
99(1)
Review Questions
100(3)
Bibliography
103(1)
5 Erythrocytes: Erythropoiesis, Maturation, Membrane Characteristics, and Metabolic Activities
104(15)
Erythropoiesis
104(7)
Disorders Related to Erythrocyte Maturation and Production
111(1)
Membrane Characteristics and Metabolic Activities of Erythrocytes
112(7)
Chapter Highlights
115(1)
Case Study
116(1)
Review Questions
116(2)
Bibliography
118(1)
6 Erythrocytes: Hemoglobin
119(22)
Characteristics of Hemoglobin
120(1)
Hemoglobin Function
120(1)
Oxygen Dissociation and Alterations
121(1)
Carbon Dioxide Transport
122(1)
Biosynthesis of Hemoglobin
123(4)
Disorders Related to Hemoglobin Biosynthesis
127(1)
Ontogeny of Hemoglobin
128(1)
Variant Forms of Normal Hemoglobin
129(1)
Abnormal Hemoglobin Molecules
129(1)
Analysis of Hemoglobin
130(1)
Catabolism of Erythrocytes
131(10)
Chapter Highlights
133(3)
Case Studies
136(1)
Review Questions
137(3)
Bibliography
140(1)
7 Erythrocytes: Morphology and Inclusions
141(22)
Erythrocytes: Normal and Abnormal
142(1)
Types of Variations in Erythrocyte Size
142(1)
Kinds of Variations in Erythrocyte Shape
143(6)
Alterations in Erythrocyte Color
149(1)
Varieties of Erythrocyte Inclusions
150(2)
Alterations in Erythrocyte Distribution
152(1)
Parasitic Inclusions in Erythrocytes
152(11)
Chapter Highlights
157(1)
Case Studies
158(1)
Review Questions
159(3)
Bibliography
162(1)
8 Leukocytes: The Granulocytic and Monocytic Series
163(25)
Introduction
164(1)
Granulocytic Series: Production of Neutrophils, Eosinophils, and Basophils
164(1)
Granulocyte Sites of Development and Maturation
165(1)
Distribution of Neutrophils, Eosinophils, and Basophils
165(1)
Normal Maturational Characteristics of Granulocytes
166(3)
Leukocyte Surface Markers
169(1)
The Monocytic-Macrophage Series
169(3)
Normal Reference Ranges and Variations
172(1)
Abnormalities in Granulocytic Reference Ranges
173(1)
Functional Properties of Monocytes/Macrophages
174(1)
Phagocytosis
175(13)
Chapter Highlights
180(3)
Case Study
183(1)
Review Questions
183(3)
Bibliography
186(2)
9 Leukocytes: Lymphocytes and Plasma Cells
188(21)
Anatomical Origin and Development of Lymphocytes
189(4)
Morphological Characteristics of Normal Lymphocytes
193(4)
Characteristics of Lymphocytes
197(4)
T Lymphocytes, B Lymphocytes, and Plasma Cell Kinetics
201(1)
Plasma Cell Development and Maturation
202(7)
Chapter Highlights
204(1)
Review Questions
205(3)
Bibliography
208(1)
PART THREE Hematology Laboratory Assessments
209(30)
10 Basic Laboratory Assessment of Erythrocytes, Leukocytes, and Platelets
209(21)
The Complete Blood Count
210(1)
Quantitative Assessment of Erythrocytes
211(5)
Quantitative Assessment of Leukocytes
216(1)
Other Leukocyte-Related Assessments
217(1)
Quantitative Assessment of Platelets
218(1)
Peripheral Blood Film Evaluation
219(1)
Semiquantitative Grading of Erythrocyte Morphology
220(1)
Semiquantitative Assessment of Leukocytes
220(1)
Semiquantitative Assessment of Platelets
220(1)
Leukocyte Differential Count
221(9)
Chapter Highlights'
223(3)
Review Questions
226(3)
Bibliography
229(1)
11 Classification and Laboratory Assessment of Anemias
230(9)
Overview of Anemia
230(1)
Development of Anemia
230(1)
Clinical Signs and Symptoms of Anemia
231(1)
Classification of Anemias
231(2)
Laboratory Assessment of Anemias
233(6)
Chapter Highlights
235(1)
Review Questions
236(1)
Bibliography
237(2)
PART FOUR Erythrocyte Disorders
239(96)
12 Acute and Chronic Blood Loss Anemia and Anemias Associated with Systemic Disorders
239(4)
Acute Blood Loss Anemia
239(1)
Chronic Blood Loss Anemia
240(3)
Chapter Highlights
241(1)
Case Studies
241(1)
Review Questions
242(1)
Bibliography
242(1)
13 Bone Marrow Failure Syndromes
243(14)
Bone Marrow Failure Syndromes
244(1)
Acquired Aplastic Anemia
244(4)
Constitutional Bone Marrow Failure Syndromes Associated with Aplastic Anemia
248(1)
Bone Marrow Failures Involving a Single-Cell Lineage
249(3)
Congenital Amegakaryocytic Thrombocytopenia
252(5)
Chapter Highlights
253(1)
Case Studies
254(1)
Review Questions
255(1)
Bibliography
255(2)
14 Disorders of Iron Metabolism and Heme Synthesis
257(23)
Iron Deficiency and Iron Overload
258(1)
Iron Deficiency and Iron Deficiency Anemia
258(1)
Iron Deficiency Anemia
258(7)
Anemia of Inflammation or Anemia of Chronic Disorders/Diseases
265(3)
Disorders Related to Hemoglobin Biosynthesis: Sideroblastic Anemia
268(2)
Disorders Related to Hemoglobin Biosynthesis: Hereditary Hemochromatosis
270(1)
Disorders Related to Hemoglobin Biosynthesis: Heme (Porphyrin) Synthesis
271(1)
Disorders Related to Hemoglobin Biosynthesis: Disorders of Globulin Synthesis
272(8)
Chapter Highlights
272(2)
Case Studies
274(2)
Review Questions
276(3)
Bibliography
279(1)
15 Macrocytic and Megaloblastic Anemias
280(12)
Macrocytic Anemias
280(1)
Megaloblastic Anemias
281(1)
Pernicious Anemia
282(5)
Folic Acid Deficiency Anemia
287(5)
Chapter Highlights
288(1)
Case Study
289(1)
Review Questions
290(1)
Bibliography
291(1)
16 Hemolytic Anemias
292(21)
Hemolytic Anemias
292(1)
The Role of Complement in Hemolytic Anemia
293(13)
Complement-Mediated Disease
306(7)
Chapter Highlights
308(1)
Case Studies
308(2)
Review Questions
310(2)
Bibliography
312(1)
17 Hemoglobinopathies and Thalassemias
313(22)
Hemoglobin Defects
314(1)
Sickle Cell Disease
315(6)
Sickle Cell Syndromes: Pathogenesis and New Approaches
321(2)
Thalassemia
323(4)
Other Hemoglobinopathies
327(1)
Hereditary Persistence of Fetal Hemoglobin
328(7)
Chapter Highlights
329(1)
Case Studies
330(2)
Review Questions
332(2)
Bibliography
334(1)
PART FIVE Nonmalignant Leukocyte Disorders
335(36)
18 Disorders of Granulocytes and Monocytes
335(19)
Granulopoietic Alterations: Quantitative Disorders
336(3)
Morphological Abnormalities of Mature Granulocytes
339(3)
Inherited Functional Abnormalities
342(1)
Granulopoietic Alterations: Qualitative Disorders
343(1)
Monocyte-Macrophage Disorders
344(10)
Chapter Highlights
346(1)
Case Studies
347(3)
Review Questions
350(3)
Bibliography
353(1)
19 Disorders of Lymphocytes
354(17)
Characteristics of Lymphocytes
354(1)
Lymphocytosis
355(1)
Disorders Associated with Lymphocytosis
356(6)
Lymphocytopenia
362(1)
Immune Disorders Associated with Lymphocytopenia
362(9)
Chapter Highlights
367(1)
Case Studies
367(2)
Review Questions
369(1)
Bibliography
370(1)
PART SIX Neoplastic Disorders
371(118)
20 Characteristics of Leukemias, Lymphomas, and Myelomas
371(10)
Comparison of Leukemias, Lymphomas, and Myelomas
372(1)
Forms of Leukemia
372(1)
Classifications of Leukemias
372(1)
Prognosis and Treatment
373(1)
Factors Related to the Occurrence of Leukemia
373(4)
Demographic Distribution of Leukemia and Lymphomas
377(1)
Leukemia Vaccines
378(3)
Chapter Highlights
378(1)
Review Questions
379(1)
Bibliography
380(1)
21 Acute Leukemias
381(34)
General Characteristics of Acute Leukemias
382(2)
Acute Myeloid Leukemias
384(3)
Prognosis of AML
387(8)
Treatment Options
395(3)
Acute Lymphoblastic Leukemia
398(4)
Prognosis of ALL
402(1)
Life-Threatening Emergencies
403(1)
Future Trends: Vaccines
404(11)
Chapter Highlights
405(2)
Case Studies
407(3)
Review Questions
410(3)
Bibliography
413(2)
22 Lymphoid and Plasma Cell Neoplasms
415(34)
Leukemias versus Lymphomas
416(1)
Chronic Lymphocytosis
416(7)
T-Cell and NK-Cell Neoplasms
423(3)
Lymphomas
426(6)
Hodgkin Disease
432(2)
Plasma Cell Dyscrasias
434(5)
Immune Approaches
439(1)
Waldenstrom Primary Macroglobulinemia (Lymphoplasmacytic Lymphoma)
440(9)
Chapter Highlights
441(2)
Case Studies
443(2)
Review Questions
445(2)
Bibliography
447(2)
23 Myeloproliferative Neoplasms
449(26)
General Characteristics of Myeloproliferative Neoplasms
450(1)
Chronic Myelogenous Leukemia
451(8)
Polycythemia Vera, Essential Thrombocytosis (Essential Thrombocythemia), and Primary Myelofibrosis
459(1)
Polycythemia Vera
460(3)
Primary Myelofibrosis
463(3)
Essential Thrombocytosis/Essential Thrombocythemia
466(2)
Mastocytosis
468(1)
Myeloproliferative Neoplasm, Unclassifiable (MPN-U)
468(7)
Chapter Highlights
468(1)
Case Studies
469(2)
Review Questions
471(3)
Bibliography
474(1)
24 Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms
475(14)
General Characteristics of Myelodysplastic Syndrome and Myelodysplastic/Myeloproliferative Neoplasms
476(1)
Myelodysplastic Syndromes
476(5)
Relationship of Cytogenetics to Prognosis
481(1)
Treatment Strategies
481(1)
Myelodysplastic Syndromes/Myeloproliferative Neoplasms (MDS/MPN)
482(7)
Chapter Highlights
484(1)
Case Studies
485(1)
Review Questions
486(1)
Bibliography
487(2)
PART SEVEN Principles and Disorders of Hemostasis and Thrombosis
489(94)
25 Principles of Hemostasis and Thrombosis: Vasculature and Platelets
489(15)
Overview of Hemostasis and Thrombosis
490(1)
Blood Vasculature: Structure and Function
490(1)
Vasculature Physiology
491(1)
Thrombopoiesis
492(4)
Cell-Based Mechanism of Hemostasis: Platelet Function
496(8)
Chapter Highlights
500(1)
Review Questions
501(2)
Bibliography
503(1)
26 Disorders of Primary Hemostasis and Thrombosis Vasculature and Platelets
504(22)
Vascular Abnormalities
504(5)
Quantitative Platelet Disorders
509(7)
Qualitative Characteristics of Platelets: Thrombocytopathy/Thrombocythemia
516(10)
Chapter Highlights
522(1)
Case Study
523(1)
Review Questions
524(1)
Bibliography
524(2)
27 Principles of Hemostasis and Thrombosis: Blood Coagulation Factors and Natural Coagulant Systems
526(24)
Blood Coagulation Factors
526(15)
Normal Protective Mechanisms against Thrombosis
541(4)
Modern View of Hemostasis
545(5)
Chapter Highlights
545(1)
Review Questions
546(2)
Bibliography
548(2)
28 Disorders of Hemostasis and Thrombosis: Blood Coagulation Factors, Hypercoagulable State, and Anticoagulant Therapy
550(33)
Introduction
550(1)
Defective Production
551(8)
Disorders of Destruction and Consumption
559(4)
The Hypercoagulable (Thrombophilia)
563(11)
Anticoagulant Therapy
574(9)
Chapter Highlights
577(2)
Case Studies
579(1)
Review Questions
580(1)
Bibliography
581(2)
PART EIGHT Fundamentals of Hematological Analysis
583(120)
29 Body Fluid Analysis
583(35)
Introduction
584(1)
Cerebrospinal Fluid
585(7)
Pleural, Peritoneal, and Pericardial Fluids
592(26)
Chapter Highlights
610(1)
Case Studies
611(1)
Review Questions
611(6)
Bibliography
617(1)
30 Instrumentation in Hematology
618(35)
Instrumental Principles
619(5)
Whole Blood Cell Analysis
624(3)
Analysis of Instrumental Data Output
627(4)
Laser Technology
631(3)
Applications of Flow Cytometry
634(4)
Digital Microscopy
638(1)
Instruments in Coagulation Studies
639(14)
Chapter Highlights
641(2)
Case Studies
643(7)
Review Questions
650(2)
Bibliography
652(1)
31 Molecular Diagnostic Techniques and Applications
653(17)
The Human Genome Project
653(1)
Molecular Techniques in Hematology
654(1)
Molecular Genetics in Hematology
655(15)
Chapter Summary
666(1)
Review Questions
667(1)
Bibliography
668(2)
32 Laboratory Manual: Manual Procedures in Hematology
670(33)
Procedural Format
670(33)
Review Questions
699(4)
APPENDICES
A Answers to Review Questions
703(5)
B Frequently Used Abbreviations
708(1)
C Safety Data Sheets
709(5)
D Tube Guide BD
714(2)
E Tube Guide Greiner
716(2)
F Interleukins
718(4)
G The Microscope
722(2)
H Quick References
724(3)
Glossary 727(16)
Index 743