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Clinical Immunology: Principles and Practice 4th Revised edition [Kietas viršelis]

  • Formatas: Hardback, 1323 pages, aukštis x plotis: 219x276 mm, Approx. 652 illustrations (559 in full color)
  • Išleidimo metai: 19-Dec-2012
  • Leidėjas: W B Saunders Co Ltd
  • ISBN-10: 0723436916
  • ISBN-13: 9780723436911
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 1323 pages, aukštis x plotis: 219x276 mm, Approx. 652 illustrations (559 in full color)
  • Išleidimo metai: 19-Dec-2012
  • Leidėjas: W B Saunders Co Ltd
  • ISBN-10: 0723436916
  • ISBN-13: 9780723436911
Kitos knygos pagal šią temą:
Written and edited by international leaders in the field, this book has, through two best-selling editions, been the place to turn for authoritative answers to your toughest challenges in clinical immunology. Now in full color and one single volume, the 3rd Edition brings you the very latest immunology knowledge - so you can offer your patients the best possible care. The user-friendly book and the fully searchable companion web site give you two ways to find the answers you need quickly...and regular online updates keep you absolutely current.Leading international experts equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems.A highly clinical focus and an extremely practical organization expedite access to the answers you need in your daily practice.Cutting-edge coverage of the human genome project, immune-modifier drugs, and many other vital updates keeps you at the forefront of your field.A new organization places scientific and clinical material side by side, to simplify your research and highlight the clinical relevance of the topics covered.A multimedia format allows you to find information conveniently, both inside the exceptionally user-friendly book and at the fully searchable companion web site.Regular updates online ensure that youll always have the latest knowledge at your fingertips.Includes many new and improved illustrations and four color design.Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued. Offer your patients the best possible care with clear, reliable guidance from one of the most respected and trusted resources in immunology. Authoritative answers from internationally renowned leaders in the field equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems.Depend on authoritative information from leading experts in the field who equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. Focus on the information thats most relevant to your daily practice through a highly clinical focus and an extremely practical organization that expedites access to the answers you need. Stay at the forefront of your field with cutting-edge coverage of the human genome project, immune-modifier drugs, and many other vital. Catch a glimpse of the future. On the Horizon boxes and discussion of translational research at the end of many chapters summarize especially promising research and development over the next 5 - 10 years. Keep current with the latest knowledge and evidence-based practices. Comprehensive updates throughout include up-to-the-minute information on topics like atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity.Find information quickly thanks to a user-friendly format, featuring new color-coded Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles boxes that signpost critical information.Access the fully searchable text online at expertconsult.com, along with regular updates, downloadable images, and Board review questions ideal for certification and recertification preparation. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
List of contributors
xi
Preface to the first edition xxiii
Preface to the fourth edition xxv
Dedication xxvii
PART ONE Principles of immune response
1 The human immune response
3(13)
Robert R. Rich
2 Organization of the immune system
16(19)
Dorothy E. Lewis
Gregory R. Harriman
Sarah E. Blutt
3 Innate immunity
35(12)
Douglas R. McDonald
Ofer Levy
4 Antigen receptor genes, gene products, and co-receptors
47(21)
Harry W. Schroeder, Jr.
John B. Imboden
Raul M. Torres
5 The major histocompatibility complex
68(9)
Robert J. Winchester
6 Antigens and antigen presentation
77(13)
John R. Rodgers
Robert R. Rich
7 B-cell development and differentiation
90(12)
Harry W. Schroeder, Jr.
Andreas Radbruch
Claudia Berek
8 T-cell development
102(6)
Louise Swainson
Stephanie C. De Barros
Marco Craveiro
Valerie S. Zimmermann
Naomi Taylor
9 Cytokines and cytokine receptors
108(28)
John J. O'Shea
Massimo Gadina
Richard Siegel
10 Chemokines and chemokine receptors
136(13)
Philip M. Murphy
11 Lymphocyte adhesion and trafficking
149(11)
Sirpa Jalkanen
Marko Salmi
12 T-cell activation and tolerance
160(12)
Erik J. Peterson
Jonathan S. Maltzman
Gary A. Koretzky
13 Programmed cell death in lymphocytes and associated disorders
172(11)
Helen C. Su
Andrew L. Snow
Michael J. Lenardo
PART TWO Host defense mechanisms and inflammation
14 Immunoglobulin function
183(10)
Neil S. Greenspan
Lisa A. Cavacini
15 Regulatory T cells
193(10)
Shimon Sakaguchi
Kajsa Wing
Makoto Miyara
16 Helper T-cell subsets and control of the inflammatory response
203(12)
Todd N. Eagar
Stephen D. Miller
17 Cytotoxic T lymphocytes and natural killer cells
215(13)
Stephen L. Nutt
Sebastian Carotta
Axel Kallies
Gabrielle T. Belz
18 Host defenses in the skin
228(11)
Hui Xu
Laura Timares
Craig A. Elmets
19 Host defenses at mucosal surfaces
239(13)
Kohtaro Fujihashi
Prosper N. Boyaka
Jerry R. McGhee
20 Complement in host deficiencies and diseases
252(18)
Terry W. Du Clos
Carolyn Mold
21 Phagocyte deficiencies
270(14)
Gulbu Uzel
Steven M. Holland
22 Mast cells, basophils, and mastocytosis
284(14)
Martin Metz
Knut Brockow
Dean D. Metcalfe
Stephen J. Galli
23 Eosinophils and eosinophilia
298(15)
Anna Kovalszki
Javed Sheikh
Peter F. Weller
PART THREE Host defenses to infectious agents
24 Host defenses to extracellular bacteria
313(11)
David S. Stephens
William M. Shafer
25 Host defenses to intracellular bacteria
324(14)
Stephen T. Reece
Stefan H.E. Kaufmann
26 Host defenses to spirochetes
338(8)
Chris M. Olson, Jr.
Erol Fikrig
Juan Anguita
27 Host defenses to viruses
346(10)
Scott N. Mueller
Barry T. Rouse
28 Host defenses to protozoa
356(11)
Peter C. Melby
Gregory M. Anstead
29 Host defenses to helminths
367(14)
Subash Babu
Thomas B. Nutman
PART FOUR Immunologic deficiencies
30 Approach to the evaluation of the immunodeficient patient
381(10)
Javier Chinen
Mary E. Paul
William T. Shearer
31 Infections in the immunocompromised host
391(14)
Jennifer Cuellar-Rodriguez
Alexandra F. Freeman
32 Maturing of the fetal and neonatal immune system
405(9)
David B. Lewis
33 Aging and the immune system
414(7)
Jorg J. Goronzy
Cornelia M. Weyand
34 Primary antibody deficiencies
421(16)
Harry W. Schroeder, Jr.
Ewa Szymanska-Mroczek
35 Primary T-cell immunodeficiencies
437(17)
Chaim M. Roifman
Eyal Grunebaum
36 Inherited disorders of IFN-γ-, IFN-α/β/λ-, and NF-KB-mediated immunity
454(11)
Capucine Picard
Anne Puel
Jacinta Bustamante
Emmanuelle Jouanguy
Shen-Ying Zhang
Stephanie Dupuis-Boisson
Jean-Laurent Casanova
37 HIV infection and acquired immunodeficiency syndrome
465(15)
Susan L. Gillespie
Mary E. Paul
Javier Chinen
William T. Shearer
38 External factors inducing immune deficiency
480(11)
Javier Chinen
William T. Shearer
PART FIVE Allergic diseases
39 Immunological mechanisms of airway diseases and pathways to therapy
491(15)
David B. Corry
Farrah Kheradmand
Amber Luong
Lavannya Pandit
40 Urticaria, angioedema, and anaphylaxis
506(16)
Elena Borzova
Clive E.H. Grattan
41 Allergic reactions to stinging and biting insects
522(9)
Ulrich R. Muller
Gabrielle Haeberli
Arthur Helbling
42 Atopic and contact dermatitis
531(12)
Thomas Bieber
Caroline Jagobi
43 Food allergy
543(7)
Barbara Bohle
44 Eosinophil-associated gastrointestinal disorders
550(8)
Petr L. Hruz
Alex Straumann
45 Allergic disorders of the eye
558(6)
Virginia L. Calder
Melanie Hingorani
Sue L. Lightman
46 Drug hypersensitivity
564(14)
Werner J. Pichler
47 Occupational asthma
578(9)
Jean-Luc Malo
PART SIX Systemic immune diseases
48 Mechanisms of autoimmunity
587(8)
Tricia Cottrell
Antony Rosen
49 Interface of autoimmunity and immunodeficiency
595(8)
Magda Carneiro-Sampaio
Antonio Coutinho
50 Systemic lupus erythematosus
603(18)
Cynthia Aranow
Betty Diamond
Meggan Mackay
51 Rheumatoid arthritis
621(16)
Andrew P. Cope
52 Juvenile idiopathic arthritis
637(11)
Randy Q. Cron
Peter Weiser
Timothy Beukelman
53 Sjogren's syndrome
648(8)
Gabor Illei
Sarfaraz A. Hasni
Ilias Alevizos
54 Scleroderma-systemic sclerosis
656(11)
John Varga
Fredrick M. Wigley
55 Inflammatory muscle diseases
667(9)
Lisa Christopher-Stine
Sabiha Khan
56 Spondyloarthritis
676(17)
John D. Reveille
57 Small and medium vessel primary vasculitis
693(23)
John H. Stone
58 Large-vessel vasculitides
716(12)
Cornelia M. Weyand
Jorg J. Goronzy
59 Systemic autoinflammatory syndromes
728(12)
Jeroen C.H. van der Hilst
Jos W.M. van der Meer
Anna Simon
60 Antiphospholipid syndrome
740(9)
Doruk Erkan
Michael D. Lockshin
PART SEVEN Organ-specific inflammatory disease
61 Immunohematologic disorders
749(11)
Pierre Noel
62 Bullous diseases of the skin and mucous membranes
760(15)
Khaled M. Hassan
Russell P. Hall
63 Immunology of psoriasis
775(7)
Cristina Albanesi
64 Myasthenia gravis
782(11)
Arnold I. Levinson
65 Multiple sclerosis
793(8)
Tanuja Chitnis
Samia J. Khoury
66 Autoimmune peripheral neuropathies
801(11)
Marinos C. Dalakas
67 Immunologic renal diseases
812(16)
James E. Balow
Monique E. Cho
Meryl Waldman
Howard A. Austin
68 Inflammation and atherothrombosis
828(9)
Prediman K. Shah
69 Autoimmune thyroid diseases
837(10)
Anna L. Mitchell
Simon H.S. Pearce
70 Diabetes and related autoimmune diseases
847(13)
George S. Eisenbarth
71 Immunologic lung diseases
860(14)
Andrew P. Fontenot
Philip L. Simonian
72 Sarcoidosis
874(11)
David R. Moller
73 Immunologic ocular disease
885(11)
James T. Rosenbaum
Justine R. Smith
74 Immunologic diseases of the gastrointestinal tract
896(14)
Peter J. Mannon
75 Inflammatory hepatobiliary diseases
910(15)
Carlo Selmi
Michael P. Manns
M. Eric Gershwin
PART EIGHT Immunology of neoplasia
76 Principles of tumor immunology
925(10)
Theresa L. Whiteside
Bruce W.S. Robinson
Carl H. June
Michael T. Lotze
77 Tumor immunotherapy
935(11)
Michael T. Lotze
Bruce W.S. Robinson
Carl H. June
Theresa L. Whiteside
78 Lymphoid leukemias
946(16)
Moshe E. Gatt
Dina Ben-Yehuda
Shai Izraeli
79 Lymphomas
962(13)
Stefania Pittaluga
Elaine S. Jaffe
80 Monoclonal gammopathies
975(14)
Robert A. Kyle
Angela Dispenzieri
PART NINE Transplantation
81 Concepts and challenges in organ transplantation: rejection, immunosuppression, and tolerance
989(18)
Kathryn Wood
Sushma Shankar
Shruti Mittal
82 Stem cell transplantation and immune reconstitution in immunodeficiency
1007(13)
Luigi D. Notarangelo
Sung-Yun Pai
83 Hematopoietic stem cell transplantation for malignant diseases
1020(12)
Scott D. Rowley
Thea Friedman
Robert Korngold
84 Thymic reconstitution
1032(9)
Mary Louise Markert
Blythe H. Devlin
Elizabeth A. McCarthy
PART TEN Prevention and therapy of immunologic diseases
85 Immunoglobulin therapy: replacement and immunomodulation
1041(13)
Mark C. Ballow
86 Gene therapy
1054(12)
Christine Rivat
Adrian J. Thrasher
H. Bobby Gaspar
87 Glucocorticoids
1066(11)
Frank Buttgereit
Markus J.H. Seibel
Johannes W.J. Bijlsma
88 Immunomodulating pharmaceuticals
1077(8)
Gideon P. Smith
Edwin S.L. Chan
89 Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders
1085(10)
Arian Laurence
Kamran Ghoreschi
Mary Byrne
John J. O'Shea
90 Vaccines
1095(27)
Alan R. Shaw
Mark B. Feinberg
91 Immunotherapy of allergic disease
1122(9)
Anthony J. Frew
92 Biologic modifiers of inflammatory diseases
1131(14)
Pim Jetanalin
Susan J. Lee
Arthur Kavanaugh
PART ELEVEN Diagnostic immunology
93 Assessment of proteins of the immune system
1145(15)
Roshini Sarah Abraham
David R. Barnidge
Ian R. Lanza
94 Flow cytometry
1160(12)
Thomas A. Fleisher
Joao B. Oliveira
95 Assessment of functional immune responses
1172(11)
Jack J.H. Bleesing
Joao B. Oliveira
96 Assessment of neutrophil function
1183(9)
Douglas B. Kuhns
97 Assessment of human allergic diseases
1192(10)
Robert G. Hamilton
98 Molecular methods
1202(13)
John W. Belmont
Luis M. Franco
Appendices
A1 Selected CD molecules and their characteristics
1215(6)
Thomas A. Fleisher
A2 Laboratory reference values
1221(3)
Thomas A. Fleisher
A3 Chemokines
1224(3)
Harry W. Schroeder, Jr.
A4 Cytokines
1227(5)
Robert R. Rich
A5 Vaccine schedules
1232(3)
Robert R. Rich
Index 1235