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Clinical Immunology: Principles and Practice 5th edition [Kietas viršelis]

(Professor of Medicine and Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA), , , , (Adjunct Professor of Pediatrics, USUHA, Chief, Department of Laboratory Medicine, NIH Clinical Center, National Inst),
  • Formatas: Hardback, 1392 pages, weight: 4090 g, Approx. 650 illustrations (560 in full color); Illustrations
  • Išleidimo metai: 21-Mar-2018
  • Leidėjas: Elsevier Health Sciences
  • ISBN-10: 0702068969
  • ISBN-13: 9780702068966
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 1392 pages, weight: 4090 g, Approx. 650 illustrations (560 in full color); Illustrations
  • Išleidimo metai: 21-Mar-2018
  • Leidėjas: Elsevier Health Sciences
  • ISBN-10: 0702068969
  • ISBN-13: 9780702068966
Kitos knygos pagal šią temą:
Keep abreast of the latest advances in this complex field with the 5th Edition of Clinical Immunology: Principles and Practice. This substantially revised edition by Drs. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., Anthony J. Frew, and Cornelia M. Weyand, offers authoritative guidance from some of the most respected global leaders in immunology, helping you navigate todays latest knowledge and evidence-based practices that result in improved patient care. This trusted resource features sweeping content updates, rewritten chapters, a highly clinical perspective, and an easy-to-use organization designed to enhance your diagnosis and management skills in daily practice.User-friendly format features color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.Includes new chapters on the Microbiota in Immunity and Inflammation, Immune Responses to Fungi, and Genetics and Genomics of Immune Response. Features extensive revisions to many chapters, including the Major Histocompatibility Complex, Multiple Sclerosis, Diabetes and Related Autoimmune Diseases, Biologic Modifiers of Inflammation and Tumor Immunotherapy. Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics. Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more. Summarizes promising research and development anticipated over the next 5-10 years with On the Horizon boxes and discussion of translational research. Includes new multiple choice questions in every chapter online, ideal for allergists and rheumatologists seeking certification or recertification in these subspecialties. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Recenzijos

"This book is fairly unique in this field in that it provides a comprehensive picture of both basic immunology and the immune system in human health and disease. "

-Christopher M Snyder, PhD (Thomas Jefferson University) Doodys Review Score: 92-4 Stars!

Preface to the First Edition vi
Preface to the Fifth Edition viii
List of Contributors
ix
Dedication xviii
PART ONE Principles of Immune Response
1 The Human Immune Response
3(16)
Robert R. Rich
David D. Chaplin
2 Organization of the Immune System
19(20)
Dorothy E. Lewis
Sarah E. Blutt
3 Innate Immunity
39(16)
Douglas R. McDonald
Ofer Levy
4 Antigen Receptor Genes, Gene Products, and Coreceptors
55(24)
Harry W. Schroeder, Jr.
John B. Imboden
Raul M. Torres
5 The Major Histocompatibility Complex
79(14)
Dimitrios S. Monos
Robert J. Winchester
6 Overview of T-Cell Recognition: Making Pathogens Visible to the Immune System
93(14)
Andrea J. Sant
7 B-Cell Development and Differentiation
107(12)
Harry W. Schroeder, Jr.
Andreas Radbruch
Claudia Berek
8 T-Cell Development
119(8)
Laurie E. Harrington
9 Cytokines and Cytokine Receptors
127(30)
John J. O'Shea
Massimo Gadina
Richard M. Siegel
10 Chemokines and Chemokine Receptors
157(14)
Philip M. Murphy
11 Lymphocyte Adhesion and Trafficking
171(12)
Sirpa Jalkanen
Marko Salmi
12 T-Cell Activation and Tolerance
183(14)
Erik J. Peterson
Jonathan S. Maltzman
13 Regulated Necrosis and Its Immunogenicity
197(10)
Wulf Tonnus
Andreas Linkermann
14 The Microbiota in Immunity and Inflammation
207(16)
Craig L. Maynard
PART TWO Host Defense Mechanisms and Inflammation
15 Immunoglobulin Function
223(12)
Neil S. Greenspan
Lisa A. Cavacini
16 Helper T-Cell Subsets and Control of the Inflammatory Response
235(12)
Todd N. Eagar
Stephen D. Miller
17 Cytotoxic T Lymphocytes and Natural Killer Cells
247(14)
Stephen L. Nutt
Nicholas D. Huntington
18 Regulatory Immune Cells
261(12)
James B. Wing
Shimon Sakaguchi
19 Host Defenses in Skin
273(12)
Hui Xu
Laura Timares
Craig A. Elmets
20 Host Defenses at Mucosal Surfaces
285(14)
Prosper N. Boyaka
Kohtaro Fujihashi
21 The Human Complement System: Basic Concepts and Clinical Relevance
299(20)
John P. Atkinson
Terry W. Du Clos
Carolyn Mold
Hrishikesh Kulkarni
Dennis Hourcade
Xiaobo Wu
22 Phagocyte Deficiencies
319(16)
Steven M. Holland
Gulbu Uzel
23 Mast Cells, Basophils, and Mastocytosis
335(14)
Joshua Boyce
Laura Fanning
24 Eosinophils and Eosinophilia
349(16)
Anna Kovalszki
Peter F. Weller
PART THREE Host Defenses to Infectious Agents
25 Host Defenses to Viruses
365(10)
Barry T. Rouse
Scott N. Mueller
26 Host Defenses to Intracellular Bacteria
375(16)
Stephen T. Reece
Stefan H.E. Kaufmann
27 Host Defenses to Extracellular Bacteria
391(12)
Marcos C. Schechter
Sarah W. Satola
David S. Stephens
28 Host Defenses to Spirochetes
403(10)
Nicolas Navasa
Erol Fikrig
Juan Anguita
29 Host Defenses to Fungal Pathogens
413(12)
Allison K. Lord
Jatin M. Vyas
30 Host Defenses to Protozoa
425(12)
Peter C. Melby
Robin Stephens
Sara M. Dann
31 Immune Responses to Helminth Infection
437(14)
Subash Babu
Thomas B. Nutman
PART FOUR Immunological Deficiencies
32 Approach to the Evaluation of the Patient With Suspected Immunodeficiency
451(12)
Javier Chinen
Mary E. Paul
William T. Shearer
33 Human Genomics in Immunology
463(8)
Robert L. Nussbaum
Jennifer M. Puck
34 Primary Antibody Deficiencies
471(18)
Tracy Hwangpo
Harry W. Schroeder, Jr.
35 Primary T-Cell Immunodeficiencies
489(20)
Chaim M. Roifman
36 Immunodeficiencies at the Interface of Innate and Adaptive Immunity
509(14)
Jacinta Bustamante
Shen-Ying Zhang
Bertrand Boisson
Michael Ciancanelli
Emmanuelle Jouanguy
Stephanie Dupuis-Boisson
Anne Puel
Capucine Picard
Jean-Laurent Casanova
37 Infections in the Immunocompromised Host
523(12)
Alexandra F. Freeman
Jennifer M. Cuellar-Rodriguez
38 Immune Deficiencies at the Extremes of Age
535(10)
Jorg J. Goronzy
Claire E. Gustafson
Cornelia M. Weyand
39 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
545(16)
Susan L. Gillespie
Javier Chinen
Mary E. Paul
William T. Shearer
40 Autoantibody-Mediated Phenocopies of Primary Immunodeficiency Diseases
561(10)
Sarthak Gupta
Sarah K. Browne
PART FIVE Allergic Diseases
41 Immunological Mechanisms of Airway Diseases and Pathways to Therapy
571(14)
David B. Corry
Farrah Kheradmand
Amber Luong
Lavannya Pandit
42 Urticaria, Angioedema, and Anaphylaxis
585(16)
Clive E.M. Grattan
Elena Borzova
43 Allergic Reactions to Stinging and Biting Insects
601(10)
Arthur Helbling
Ulrich R. Muller
44 Atopic and Contact Dermatitis
611(14)
Mark Boguniewicz
Luz Fonacier
Donald Y.M. Leung
45 Food Allergy
625(8)
J. Andrew Bird
Stacie Jones
Wesley Burks
46 Eosinophil-Associated Gastrointestinal Disorders
633(8)
Alex Straumann
47 Allergic Disorders of the Eye
641(8)
Virginia L. Calder
Amirah Mohd-Zaki
Valerie Saw
48 Drug Hypersensitivity
649(20)
Mariana Castells
Rafael Bonamichi-Santos
49 Occupational Respiratory Allergies
669(8)
Catherine Lemiere
James G. Martin
PART SIX Systemic Immune Diseases
50 Mechanisms of Autoimmunity
677(8)
Brendan Antiochos
Antony Rosen
51 Systemic Lupus Erythematosus
685(20)
Cynthia Aranow
Betty Diamond
Meggan Mackay
52 Rheumatoid Arthritis
705(18)
Andrew P. Cope
53 Juvenile Idiopathic Arthritis
723(12)
Randy Q. Cron
Peter Weiser
Timothy Beukelman
54 Sjogren Syndrome
735(8)
Sarfaraz A. Hasni
Leyla Y. Teos
Ilias Alevizos
55 Scleroderma---Systemic Sclerosis
743(14)
John Varga
Fredrick M. Wigley
56 Inflammatory Muscle Diseases
757(12)
Arash H. Lahouti
Lisa Christopher-Stine
57 Spondylarthritis
769(20)
John D. Reveille
58 Small- and Medium-Vessel Primary Vasculitis
789(20)
Raashid Ahmed Luqmani
Ana Agueda
Lorraine O'Neill
59 Large-Vessel Vasculitides
809(16)
Cornelia M. Weyand
60 Systemic Autoinflammatory Syndromes
825(10)
Catharina M. Mulders-Manders
Jeroen C.H. van der Hilst
Jos W.M. van der Meer
Anna Simon
61 Antiphospholipid Syndrome
835(10)
Thomas L. Ortel
Doruk Erkan
Michael D. Lockshin
PART SEVEN Organ-Specific Inflammatory Disease
62 Immunohematological Disorders
845(12)
Jay N. Lozier
Pierre Noel
63 Bullous Diseases of the Skin and Mucous Membranes
857(14)
Adela Rambi G. Cardones
Russell P. Hall
64 Immunology of Psoriasis
871(8)
Cristina Albanesi
65 Myasthenia Gravis
879(12)
Arnold I. Levinson
66 Multiple Sclerosis
891(12)
Benjamin M. Segal
67 Autoimmune Peripheral Neuropathies
903(14)
Marinos C. Dalakas
68 Immunological Renal Diseases
917(18)
Meryl Waldman
Howard A. Austin
James E. Balow
69 Inflammation and Atherothrombosis
935(12)
Giovanna Liuzzo
Daniela Pedicino
Davide Flego
Filippo Crea
70 Autoimmune Thyroid Diseases
947(10)
Anna L. Mitchell
Simon H.S. Pearce
71 Type 1 Diabetes
957(10)
Leonard C. Harrison
72 Immunological Lung Diseases
967(14)
Joyce S. Lee
Andrew P. Fontenot
73 Sarcoidosis
981(12)
Edward S. Chen
David R. Moller
74 Immunological Ocular Disease
993(12)
James T. Rosenbaum
Phoebe Lin
75 Immunological Diseases of the Gastrointestinal Tract
1005(16)
Peter J. Mannon
76 Inflammatory Hepatobiliary Diseases
1021(12)
Carlo Selmi
Michael P. Manns
M. Eric Gershwin
PART EIGHT Immunology of Neoplasia
77 Immunotherapy of Cancer
1033(16)
Anu Sharma
Matthew Campbell
Cassian Yee
Sangeeta Goswami
Padmanee Sharma
78 Lymphoid Leukemias
1049(16)
Moshe E. Gatt
Shai Izraeli
79 Lymphomas
1065(14)
Stefania Pittaluga
Tapan Bhavsar
Elaine S. Jaffe
80 Monoclonal Gammopathies
1079(18)
Kazunori Murata
Samuel McCash
C. Ola Landgren
PART NINE Transplantation
81 Concepts and Challenges in Organ Transplantation: Rejection, Immunosuppression, and Tolerance
1097(18)
Kathryn J. Wood
Sushma Shankar
Joanna Hester
Fadi Issa
82 Immune Reconstitution Therapy for Immunodeficiency
1115(14)
Luigi D. Notarangelo
Sung-Yun Pai
83 Hematopoietic Stem Cell Transplantation for Malignant Diseases
1129(14)
Pashna N. Munshi
Scott D. Rowley
Robert Korngold
PART TEN Prevention and Therapy of Immunological Diseases
84 Immunoglobulin Therapy: Replacement and Immunomodulation
1143(12)
Mark C. Ballow
85 Gene Therapy for Primary Immune Deficiency Diseases
1155(10)
Caroline Y. Kuo
Donald B. Kohn
86 Glucocorticoids
1165(12)
Anthony J. Frew
87 Immunomodulating Pharmaceuticals
1177(8)
Gideon P. Smith
Edwin S.L. Chan
88 Protein Kinase Antagonists in Therapy of Immunological and Inflammatory Diseases
1185(12)
Arian Laurence
Massimo Gadina
John J. O'Shea
89 Biological Modifiers of Inflammatory Diseases
1197(14)
W. Winn Chatham
90 Vaccines
1211(16)
Sarah Kabbani
Mark J. Mulligan
91 Immunotherapy of Allergic Disease
1227(12)
Anthony J. Frew
PART ELEVEN Diagnostic Immunology
92 Flow Cytometry
1239(14)
Sergio D. Hosenzweig
93 Assessment of Functional Immune Responses in Lymphocytes
1253(20)
Roshini Sarah Abraham
94 Assessment of Neutrophil Function
1273(10)
Debra Long Priel
Douglas B. Kuhns
95 Assessment of Human Allergic Diseases
1283(14)
Robert G. Hamilton
96 Molecular Methods
1297(14)
John W. Belmont
Appendices
A1 Selected CD Molecules and Their Characteristics
1311(6)
Thomas A. Fleisher
A2 Laboratory Reference Values
1317(2)
Thomas A. Fleisher
Index 1319