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Color Atlas of Clinical Hematology: Expert Consult - Online and Print 4th Revised edition [Multiple-component retail product]

  • Formatas: Multiple-component retail product, 544 pages, aukštis x plotis: 152x229 mm, Approx. 2700 illustrations (2100 in full color), Contains 1 Hardback and 1 Digital online
  • Išleidimo metai: 01-Sep-2009
  • Leidėjas: Mosby
  • ISBN-10: 0323044530
  • ISBN-13: 9780323044530
Kitos knygos pagal šią temą:
  • Formatas: Multiple-component retail product, 544 pages, aukštis x plotis: 152x229 mm, Approx. 2700 illustrations (2100 in full color), Contains 1 Hardback and 1 Digital online
  • Išleidimo metai: 01-Sep-2009
  • Leidėjas: Mosby
  • ISBN-10: 0323044530
  • ISBN-13: 9780323044530
Kitos knygos pagal šią temą:
A. Victor Hoffbrand (emeritus, Royal Free Hospital, UK) and John E. Pettit (U. of Otago Medical School, New Zealand) have been joined by a third author, Paresh Vyas (John Radcliffe Hospital, UK), for the fourth edition of a text that saw its previous edition only two years ago in 2008 (the first was published in 2000). The growing use of molecular genetics for diagnosis and increased understanding of the molecular basis of hematological diseases are reflected in the World Health Organization's classifications, and this new information is incorporated in this updated text. Four chapters introduce cell machinery, the cellular basis of hematopoiesis, and growth factors. Subsequent chapters devoted to the various classifications of blood disorders discuss pathogenesis and clinical, morphologic, and investigational aspects, with the support of 2,700 images, 2,100 in color. Online access to the contents is included with purchase of the printed volume. Annotation ©2010 Book News, Inc., Portland, OR (booknews.com)

The completely revised fourth edition of the Color Atlas of Clinical Hematology gives you the most comprehensive, authoritative, up-to-date visual assistance you'll find in any hematology atlas. It vividly depicts the pathogenesis, clinical, morphologic, and investigational aspects of the full range of blood disorders you'll see in everyday practice to help you diagnose virtually anything.

  • Helps you solve difficult diagnostic challenges using highly illustrated, full-color guidance to the recognition of signs in blood cells.
  • Shows complex principles more clearly with explanatory illustrations and tables.
  • Explores the pathogenesis, clinical, morphologic, and investigational aspects of blood disease with extensive coverage of the pathologic anatomy of common clinical entities.
  • Provides quick and easy reference of key diagnostic issues in a comprehensive yet concise format.


  • Illustrates diagnosis for even the most difficult blood disorders with over 2700 images-2100 in full color.
  • Includes comprehensive coverage of all hematologic disorders including those newly recognized and the latest molecular techniques.
  • Demonstrates how the science impacts prognosis and therapy through new illustrations that highlight the pathologic and clinical features.
  • Includes and illustrates WHO (2008) Classification of Hematologic Malignancies.
  • Provides Expert Consult functionality so you can access the Image Bank online from any internet connection.


Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Cell Machinery
1(22)
Molecular and Cellular Biology of the Cell
1(1)
Compartmentalization of the Cell
1(1)
The Nucleus
1(4)
Gene Transcription and mRNA Translation: The Production and Journey of mRNA
5(4)
DNA Mutations Can Alter Protein Synthesis by a Number of Mechanisms
9(1)
Transcriptional Control of Gene Expression
9(4)
CIS-Elements and Transcription Factors
10(1)
Chromatin and Epigenetic Control of Gene Expression
11(2)
Transcription Factors, Control of Gene Expression, and Lineage Commitment
13(1)
Micro-RNAs
14(1)
DNA Replication and Telomeres
14(2)
Mutations and How They Result in Disease
16(2)
Cell Cycle
18(1)
Apoptosis
19(2)
Organelles in Cells
21(1)
Mitochondria
21(1)
Lysosomes
21(1)
Protein Ubiquitination
22(1)
Cellular Basis of Hematopoiesis
23(8)
Road Maps of Hematopoiesis: Cellular Pathways as HSCs Differentiate into Terminally Mature Cells
24(3)
Transcriptional Control of Hematopoiesis
27(1)
The Hematopoietic Niche
28(3)
Growth Factors
31(12)
Signaling at Different Stages of Hematopoiesis
31(5)
Cytokine Receptors
36(1)
Signaling Pathways Downstream of Receptors
36(5)
WNT Pathway
36(1)
Cytokine Signaling Pathways
37(1)
The RASIMAPK Kinase Pathway
38(1)
PI-3 Kinase Pathway
39(1)
JAK-Stat Pathway
39(2)
Mutations in Signaling Components Leading to Clonal Hematologic Disorders
41(2)
Maturation of Blood Cells and Their Examination in Peripheral Blood and Bone Marrow
43(32)
Examination of Peripheral Blood and the Bone Marrow
44(2)
Erythroid Cells in the Bone Marrow and Peripheral Blood
46(3)
Megakaryocyte and Platelet Production
49(1)
Granulopoiesis and Monocyte Production
50(7)
Neutrophils (Polymorphs)
52(5)
Mononuclear Phagocytic System
57(1)
Reticuloendothelial System
57(2)
Lymphokines, Monokines, Chemokines
59(3)
Interleukin-1
59(1)
Interleukin-2
59(1)
Interleukin-4
59(1)
Interleukin-6
59(1)
Interleukin-7
59(2)
Interleukin-9
61(1)
Interleukin-10, 12, and 15
61(1)
Interleukin-11
61(1)
Chemokines
61(1)
Lymphocytes and Plasma Cells
62(7)
T Cells
62(3)
B Cells
65(2)
Natural Killer Cells
67(2)
Lymphocyte Proliferation and Differentiation
69(3)
Somatic Hypermutation in Normal B Cells
72(1)
Lymphocyte Circulation
72(1)
Mesenchymal Cells
72(3)
Hypochromic Anemias
75(18)
Iron Metabolism
75(1)
Iron Absorption
76(1)
Hepcidin
76(1)
Iron Homeostasis
77(1)
Iron-Deficiency Anemia
77(7)
Blood and Bone Marrow Appearances
79(1)
Causes of Iron Deficiency
80(4)
Sideroblastic Anemia
84(6)
Alcohol
90(1)
Lead Poisoning
90(1)
Differential Diagnosis of Hypochromic Microcytic Anemias
91(2)
The Porphyrias and Iron Overload
93(6)
Congenital Erythropoietic Porphyria
93(1)
Congenital Erythropoietic Protoporphyria
94(1)
Iron Overload
94(5)
Primary (Genetic) Hemochromatosis
94(3)
Rare Causes of Iron Overload
97(1)
Hereditary Hyperferritinemia with Autosomal Dominant Congenital Cataract Syndrome
98(1)
Megaloblastic Anemias
99(16)
Clinical Features
100(8)
Blood Count and Blood Film Appearances
103(2)
Bone Marrow Appearances
105(3)
Causes of Megaloblastic Anemia
108(6)
Vitamin B12 Deficiency
108(2)
Folate Deficiency
110(2)
Abnormalities of Vitamin B12 or Folate Metabolism
112(1)
Other Causes
113(1)
Treatment of Megaloblastic Anemia
114(1)
Causes of Macrocytosis Other Than Megaloblastic Anemia
114(1)
Hemolytic Anemias
115(18)
Hereditary Hemolytic Anemia
117(8)
Normal Red Cell Membrane
117(1)
Red Cell Blood Group Antigens
118(1)
Hereditary Spherocytosis
118(2)
Hereditary Elliptocytosis
120(1)
Normal Red Cell Metabolism
121(1)
Glucose-6-Phosphate Dehydrogenase Deficiency
122(2)
Pyruvate Kinase Deficiency
124(1)
Pyrimidine 5-Nucleotidase Deficiency
124(1)
Acquired Hemolytic Anemia
125(8)
Autoimmune Hemolytic Anemias
125(1)
Evans Syndrome
126(1)
Drug-Induced Immune Hemolytic Anemia
126(1)
Isoimmune Hemolytic Anemia
126(1)
Red Cell Fragmentation Syndromes
127(1)
Secondary Hemolytic Anemias
128(1)
Paroxysmal Nocturnal Hemoglobinuria
128(3)
Other Hemolytic Anemias
131(2)
Genetic Disorders of Hemoglobin
133(26)
Thalassemia
133(26)
β-Thalassemia Major
136(8)
β-Thalassemia Intermedia
144(1)
β-Thalassemia Trait
145(1)
β-Thalassemia with a Dominant Phenotype
145(1)
Antenatal Diagnosis
146(2)
α-Thalassemia
148(1)
X-Linked α-Thalassemia and Mental Retardation Syndrome
149(1)
Structural Hemoglobin Variants
149(1)
Sickle Cell Anemia
149(7)
Other Structural Hemoglobin Defects
156(1)
F-Cells
156(1)
Methemoglobinemia
157(2)
Benign Disorders of Phagocytes
159(14)
Hereditary Variation in White Cell Morphology
159(3)
Pelger-Huet Anomaly
159(1)
May-Hegglin Anomaly
159(1)
Chediak-Higashi Syndrome
159(1)
Alder's (Alder-Reilly) Anomaly
159(1)
Mucopolysaccharidoses VI and VII
160(1)
Dorfman-Chanarin Syndrome
160(1)
Lysinuric Protein Intolerance
160(1)
Disorders of Phagocytic Function
161(1)
Leukocytosis
162(3)
Neutrophil Leukocytosis (Neutrophilia)
162(1)
Hyperthermia
162(2)
Eosinophil Leukocytosis (Eosinophilia)
164(1)
Monocytosis and Basophil Leukocytosis
164(1)
Leukemoid Reaction
165(1)
Leukoerythroblastic Reaction
165(1)
Neutropenia
166(1)
Severe Congenital Neutropenia (Kostmann's Syndrome)
166(1)
Clinical and Bone Marrow Findings
166(1)
Myelokathexis
166(2)
Whim Syndrome
168(1)
Lysosornal Storage Diseases
168(5)
Gaucher's Disease
168(2)
Niemann-Pick Disease
170(1)
Sea-Blue Histiocyte Syndrome
171(2)
Benign Disorders of Lymphocytes
173(18)
Lymphocytosis
173(3)
Infectious Mononucleosis
173(3)
Lymphadenopathy
176(5)
Kikuchi's Disease
180(1)
Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) (See
Chapter 16)
180(1)
Primary Immunodeficiency Disorders
181(2)
Acquired Immunodeficiency Syndrome
183(7)
Autoimmune Lymphoproliferative Syndrome
190(1)
Acute Leukemias
191(42)
Clinical Features
194(6)
Microscopic Appearances
200(14)
Acute Myeloid Leukemia
200(6)
Rare Types of Acute Myeloid Leukemia
206(4)
Congenital Acute Leukemia
210(1)
Acute Leukemia and Down Syndrome
210(1)
Acute Lymphoblastic Leukemia
210(3)
Acute Mixed Cell Leukemia
213(1)
Cytochemistry
214(2)
Immunology
216(2)
Cytogenetics
218(4)
Fluorescent in Situ Hybridization
222(2)
Molecular Studies
224(2)
Gene Arrays
226(2)
Minimal Residual Disease
228(5)
Chronic Myeloid Leukemias and Myelomonocytic/Myeloproliferative Disorders
233(14)
Chronic Myeloid Leukemia (BCR Rearrangement Positive)
233(9)
Clinical Features
234(4)
Accelerated Phase
238(2)
Blast Transformation
240(1)
Treatment
241(1)
Philadelphia-Negative Chronic Myeloid Leukemia
242(1)
Chronic Neutrophilic Leukemia
242(1)
Chronic Eosinophilic Leukemia
242(1)
Chronic Myelomonocytic Leukemia
243(1)
Juvenile Myelomonocytic Leukemia
244(3)
Noonan Syndrome
245(1)
Neurofibromatosis I
246(1)
Refractory Anemia with Ringed Sideroblasts Associated with Marked Thrombocytosis (RARS-T)
246(1)
Myelodysplastic Syndromes
247(10)
Monosomy 7 Syndrome of Childhood
255(2)
Myeloproliferative Disorders
257(26)
Polycythemia Vera
259(4)
Primary Congenital Polycythemia
263(1)
Essential Thrombocythemia
263(4)
Myelofibrosis
267(8)
Leukemic Transformation of Polycythemia Vera and Myelofibrosis
275(1)
Myeloproliferative Disorder Unclassifiable
275(1)
Mast Cell Disease
276(7)
Cutaneous Mastocytosis
276(1)
Systemic Mastocytosis
277(3)
Mast Cell Leukemia
280(1)
Mast Cell Sarcoma
281(1)
Extracutaneous Mastocytoma
282(1)
Prognosis
282(1)
Histiocytic Disorders
283(16)
Introduction
283(1)
Hemophagocytic Syndrome
283(3)
Xanthogranuloma
286(1)
Rosai-Dorfman Disease
287(1)
Histiocytic and Dendritic Cell Neoplasms
287(1)
Histiocytic Sarcoma
288(1)
Langerhans Cell Histiocytosis
289(4)
Langerhans Cell Sarcoma
293(1)
Interdigitating Dendritic Cell Sarcoma
294(1)
Follicular Dendritic Cell Sarcoma
294(1)
Indeterminate Dendritic Cell Tumor
294(2)
Fibroblastic Reticular Cell Tumor
296(1)
Blastic Plasmacytoid Dendritic Cell Neoplasm
296(1)
Disseminated Juvenile Xanthogranuloma
296(3)
Aplastic and Dyserythropoietic Anemias
299(12)
Aplastic Anemia
299(6)
Inherited Aplastic Anemia
300(5)
Red Cell Aplasia
305(2)
Congenital Dyserythropoietic Anemias
307(4)
Chronic Lymphoid Leukemias
311(16)
Chronic B-Cell Leukemias
311(11)
Chronic Lymphocytic Leukemia
311(8)
Prolymphocytic Leukemia
319(1)
Hairy Cell Leukemia
319(3)
Leukemia/Lymphoma Syndromes
322(1)
Chronic T-Cell Leukemias
322(5)
T-Cell Prolymphocytic Leukemia
322(1)
Large Granular Lymphocytic Leukemia
323(2)
Adult T-Cell Leukemia/Lymphoma
325(2)
Non-Hodgkin Lymphomas: Mature B-Cell Neoplasms
327(34)
Introduction
327(1)
Geographic Variation
328(1)
Chromosome Abnormalities
328(1)
Mature B-Cell Neoplasms
329(7)
Clinical Features and Diagnosis
332(2)
Imaging
334(1)
Diagnosis
335(1)
Small Lymphocytic Lymphoma
336(1)
Splenic Marginal Zone Lymphoma
337(1)
Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia
338(2)
Hyperviscosity Syndrome
340(1)
Extranodal Marginal Zone B-Cell Lymphoma of Mucosa Associated Lymphoid Tissue (Malt) Lymphoma
341(2)
Nodal Marginal Zone B-Cell Lymphoma
343(1)
Follicular Lymphoma
343(3)
Primary Cutaneous Follicle Center Lymphoma
346(1)
Mantle Cell Lymphoma
346(3)
Diffuse Large B-Cell Lymphoma
349(4)
T-Cell-Rich Diffuse Large B-Cell Lymphoma
353(1)
Lymphomatoid Granulomatosis
353(1)
Primary Mediastinal (Thymic) Large B-Cell Lymphoma
354(1)
Intravascular Large B-Cell Lymphoma
354(1)
Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
355(1)
ALK-Positive Diffuse Large B-Cell Lymphoma
355(1)
Plasmablastic Lymphoma
356(1)
Primary Effusion Lymphoma
357(1)
Large B-Cell Lymphoma Arising in HHV8 Associated Multicentric Castleman's Disease
357(1)
Burkitt's Lymphoma
358(1)
Paraneoplastic Pemphigus
358(3)
Peripheral T-Cell Disorders
361(18)
Mature T-Cell and Natural Killer-Cell Neoplasms
361(1)
Primary Cutaneous T-Cell Lymphomas
361(1)
Mycosis Fungoides
361(2)
Sezary Syndrome
363(1)
Primary Cutaneous Anaplastic T-Cell Lymphoma
364(1)
Lymphomatoid Papulosis
365(1)
Subcutaneous Panniculitis-Like NK-/T-Cell Lymphoma
365(1)
Cutaneous γδT-Cell Lymphoma
366(1)
Primary Cutaneous Aggressive Epidermotrophic CD8 + T-Cell Lymphoma (Provisional Category)
367(1)
Primary Cutaneous Small/Medium CD4 + T-Cell Lymphoma (Provisional Category)
367(1)
Primary Cutaneous Peripheral T-Cell Lymphoma Unspecified
368(1)
Extranodal NK-/T-Cell Lymphoma, Nasal Type
368(1)
Hydroa Vacciniforme-Like T-Cell Lymphoma
369(1)
Intestinal and/or Enteropathy-Associated T-Cell Lymphoma
370(1)
Hepatosplenic T-Cell Lymphoma
371(1)
Angioimmunoblastic Lymphadenopathy
372(1)
Anaplastic Large Cell Lymphoma: ALK Positive
373(2)
Anaplastic Large Cell Lymphoma: ALK Negative
375(1)
Peripheral T-Cell Lymphoma, Unspecified
375(2)
Systemic EBV + T-Cell Lymphoproliferative Disease of Childhood
377(2)
Hodgkin Lymphoma
379(16)
Presentation and Evolution
379(2)
Histology
381(1)
The Hodgkin Reed-Sternberg Cell
381(1)
Classification of Hodgkin Lymphoma
382(4)
Nodular Sclerosing Hodgkin Lymphoma
382(1)
Mixed Cellularity Hodgkin Lymphoma
383(1)
Lymphocyte-Rich Classic Hodgkin Lymphoma
384(1)
Lymphocyte-Depleted Hodgkin Lymphoma
384(1)
Nodular Lymphocyte-Predominant Hodgkin Lymphoma
384(2)
Staging Techniques
386(7)
Prognostic Factors
393(2)
Myeloma and Related Conditions
395(18)
Plasma Cell Myeloma
395(13)
Plasma Cell Leukemia
405(1)
Prognosis
406(1)
Treatment
406(1)
Monocional Immunoglobulin Deposition Diseases (MIDDs)
407(1)
Primary Amyloidosis
407(1)
Other Plasma Cell Tumors
408(1)
Solitary Plasmacytoma of Bone
408(1)
Extraosseous (Extramedullary) Plasmacytoma
409(1)
Hyperviscosity Syndrome
409(1)
Other Causes of Serum M-Proteins
410(3)
Monoclonal Gammopathy of Uncertain Significance (MGUS)
410(1)
Cryoglobulinemia
411(1)
Heavy Chain Diseases
411(2)
Tissue Typing and Stem Cell Transplantation
413(16)
Human Leukocyte Antigen System
413(5)
Human Leukocyte Antigen Nomenclature
414(1)
Typing of Human Leukocyte Antigens
414(4)
Other Human Leukocyte Antigens
418(1)
Stem Cell Transplantation
418(11)
Nonmyeloablative (``Mini'') Transplants
422(1)
Donor Leukocytes
422(1)
Complications of Stem Cell Transplants
422(2)
Graft-Versus-Host Disease
424(2)
Post-Transplant Lymphoproliferative Disorders
426(3)
Vascular and Platelet Bleeding Disorders
429(16)
Vascular Bleeding Disorders
431(6)
Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Syndrome)
431(1)
Ehlers-Danlos Syndrome
432(1)
Senile Purpura
432(1)
Scurvy
432(1)
Purpura Associated with Abnormal Proteins
432(1)
Allergic Purpuras
433(2)
Purpura Associated with Infection
435(2)
Platelet Bleeding Disorders
437(4)
Thrombocytopenia
437(1)
Immune Thrombocytopenic Purpuro
438(1)
Drug-Induced Immune Thrombocytopenia
439(1)
Disseminated Intravascular Coagulation, Thrombotic Thrombocytopenic Purpuro, and Hemolytic-Uremic Syndrome
440(1)
Disorders of Platelet Function
441(4)
Hereditary Disorders
441(2)
Acquired Disorders
443(2)
The Inherited and Acquired Coagulation Disorders
445(16)
The Coagulation Pathway
445(1)
Hereditary Coagulation Disorders
446(10)
Hemophilia
446(9)
Von Willebrand's Disease
455(1)
Other Hereditary Coagulation Disorders
456(1)
Acquired Coagulation Disorders
456(5)
Liver Disease
457(1)
Overdosage with Anticoagulants
457(1)
Disseminated Intravascular Coagulation
458(1)
Acquired Coagulation Factor Inhibitor
458(2)
Thromboelastometry and Thromboelastography
460(1)
Thrombosis
461(16)
Atherothrombosis
461(1)
Venous Thrombosis
462(1)
Thrombophilia
462(3)
Factor V Leiden
463(1)
Protein C Deficiency
464(1)
Protein S Deficiency
465(1)
Antithrombin Deficiency
465(1)
Hyperhomocysteinemia
465(1)
Hyperprothrombinemia
465(1)
Other Disorders
465(1)
Acquired Risk Factors for Venous Thrombosis
465(1)
Antiphospholipid Syndrome
466(1)
Diagnosis of Venous Thrombosis
466(1)
Clinical Probability Assessment
466(1)
D-Dimer Assay
466(1)
Ultrasound and Radiologic Imaging
466(2)
Diagnosis of Pulmonary Embolus
468(401)
Clinical Assessment
468(1)
Antiplatelet Drugs
469(1)
Aspirin
469(1)
Dipyridamole (Persantin)
469(1)
Sulfinpyrazone
469(1)
Ticiopidine
469(1)
Clopidogrel
469(1)
Glycoprotein IIb/IIIa Inhibitors
469(1)
Prostacyclin
469(1)
Anticoagulant Therapy
470(3)
Heparin
470(1)
Warfarin
471(1)
Factor Xa Inhibitors
471(1)
Direct Thrombin Inhibitors
472(1)
Fibrinolytic Agents
473(1)
Postthrombotic Syndrome
473(4)
Secondary Anemia and Bone Marrow in Nonhematopoietic Disorders
477(24)
Anemia of Chronic Disorders
477(1)
Malignant Diseases (Other Than Leukemias, Lymphomas, and Histiocytic/Myeloproliferative Disorders)
478(7)
Rheumatoid Arthritis and Other Connective Tissue Diseases
485(1)
Renal Failure
486(1)
Liver Disease
487(1)
Hypothyroidism
487(1)
Infections
488(2)
Bacterial Infections
488(1)
Viral Infections
489(1)
Parasitic Infections Diagnosed in Blood
490(1)
Marrow Involvement in Other Infections
490(1)
Granulomatous Inflammation
490(1)
Sarcoidosis
491(1)
Other Granulomas
491(1)
Amyloidosis
491(4)
Osteopetrosis (Albers-Schonberg or Marble Bone Disease)
495(2)
Paget's Disease of Bone (Osteitis Deformans)
497(1)
Anorexia Nervosa
498(1)
Cystinosis
499(1)
Primary Oxaluria
499(2)
Parasitic Disorders
501(8)
Malaria
501(5)
Effects of Malaria on Various Organs
504(1)
Comparative Methods for Malaria Diagnosis
505(1)
Toxoplasmosis
506(1)
Babesiosis
506(1)
Trypanosomiasis
506(1)
Bancroftian Filariasis
507(1)
Loiasis
507(1)
Bartonellosis
508(1)
Relapsing Fever
508(1)
Blood Transfusion
509(10)
Red Cell Antigens
509(1)
Red Cell Antibodies
510(1)
ABO System
510(1)
Rh System
511(1)
Blood Grouping and Cross-Matching
511(1)
Red Cell Components
511(1)
Clinical Blood Transfusion
512(1)
Complications of Blood Transfusion
512(5)
Infections
513(2)
Iron Overload
515(1)
Transfusion-Related Acute Lung Injury
516(1)
Graft-Versus-Host Disease
517(1)
Other Blood Components
517(2)
Platelet Concentrates
517(1)
Leukocytes
517(1)
Fresh Frozen Plasma
517(1)
Plasma Derivatives
518(1)
Index 519