List of Contributors. Preface. Part 1: INTRODUCTION. 1 History of
Hemophilia (Caroline Cromwell and Louis Aledort). 2 Hemophilia Care in the
Modern World (Christine A. Lee). 3 Comprehensive Care Model in Hemophilia
(Prasad Mathew). Part 2: GENERAL TOPICS. 4 When Should We Switch From
On-Demand to Prophylaxis Regimen? (Jose A. Aznar, Andres Moret, Lydia
Abad-Franch, Ana Rosa Cid, Saturnino Haya and Felipe Querol). 5 Prophylaxis
in Children (M. Manco-Johnson). 6 Prophylaxis in Adults with Hemophilia
(Victor Jimenez -Yuste, Emerito-Carlos Rodriguez-Merchan, Maria-Teresa
Alvarez-Roman, Monica Martin -Salces). 7 The Economics of Prophylaxis: Does
Prophylaxis with Clotting Factor Represent Value for Money? (Alec Miners). 8
The Transition of Care for the Young Adult Hemophilia Patient (Pia Petrini).
9 Perinatal Clinical Care and Molecular Diagnosis in Hemophilia (Carmen
Altisent and Francisco Vidal). 10 Managing the Mature Person with Hemophilia
(Savita Rangarajan and Thynn Thynn Yee). 11 Quality of Life in Hemophilia
(Eduardo Remor). Part 3: INHIBITORS. 12 Immunology of Inhibitor Development
(Birgit M Reipert, Christoph J Hofbauer, Katharina N Steinitz, Hans-Peter
Schwarz, FM Horling). 13 Epidemiology of Inhibitors (Johanna G. Van der Bom)
14 Early Tolerisation to Minimise Inhibitors in PUPS with Hemophilia A
(Gunter Auerswald and Karin Kurnik). 15 Prediction of Inhibitors in Severe
Hemophilia (H. Marijke van den Berg and Kathelijn Fischer). 16 Genetic basis
for Inhibitor Development (Johannes Oldenburg and Anna Pavlova). 17
Non-Genetic Risk Factors for Inhibitor Development (Lisa N. Boggio and Mindy
L. Simpson). Part 4: INHIBITOR TREATMENT. 18 Immune Tolerance Induction
Programmes (Jan Blatny and Prasad Mathew). 19 Prophylaxis in Hemophilia A
Patients with Inhibitors (Leonard A. Valentino and Guy Young). 20 Treatment
of Bleeding in FVIII Inhibitor Patients (Paul Giangrande and Jerome Teitel).
21 Discordancy of By-Passing Therapy (Jan Astermark). Part 5: JOINT HEALTH
AND DISEASE. 22 Experimental Studies on Hemarthrosis, Synovitis and
Arthropathy (Leonard A. Valentino and Narine Hakobyan). 23 Assessment of
Joint Involvement in Hemophilia (Erik Berntorp). 24 Imaging of the Hemophilic
Joint (Carmen Martin-Hervasand Emerito-Carlos Rodriguez-Merchan). 25 Initial
and Advanced Stages of Hemophilic Arthropathy, and Other Musculo-Skeletal
Problems: the Role of Orthopedic Surgery (Emerito-Carlos Rodriguez-Merchan,
VictorJimenez -Yuste and Nicholas J. Goddard). 26 Perioperative
Thromboprophylaxis for Persons with Hemophilia Undergoing Orthopaedic Surgery
(Gerry Dolan, Donna M. Dimichele and Emerito-Carlos Rodriguez-Merchan). Part
6: NEW DEVELOPMENTS. 27 New Technologies for the Pharmacokinetic Improvement
of Coagulation Factor Proteins (Leonard A. Valentino). 28 Current and Future
Approaches to Gene Therapy in Patients with Hemophilia (Maria-Teresa Alvarez-
Roman, Monica Martin-Salces, Victor Jimenez -Yuste and Emerito-Carlos
Rodriguez-Merchan). 29 New Developments in Hemophilic Arthropathy
(Emerito-Carlos Rodriguez-Merchan and Leonard A. Valentino). 30 Physiotherapy
Evaluation and Intervention in the Acute Hemarthrosis: Challenging the
Paradigm (Nichan Zourikian and Angela L. Forsyth). 31 Laboratory Assays to
Predict Response to Bypassing Agents (Benny Sorensen and Claude Negrier). 32
Combination/Sequential Use of Bypassing Agents (Alessandro Gringeri). Index.
