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Current Trends and Future Developments on (Bio-) Membranes: Membrane Applications in Artificial Organs and Tissue Engineering [Minkštas viršelis]

Edited by (Senior Researcher, Institute of Membrane Technology, Italian National Research Council, ITM-CNR, University of Calabria, Rende, Italy), Edited by , Edited by (University of Rome La Sapienza”), Edited by (Professor, Universitą Campus Bio-Medico di Roma, Department of )
  • Formatas: Paperback / softback, 258 pages, aukštis x plotis: 235x191 mm, weight: 550 g
  • Išleidimo metai: 11-Oct-2019
  • Leidėjas: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128142251
  • ISBN-13: 9780128142257
Kitos knygos pagal šią temą:
  • Formatas: Paperback / softback, 258 pages, aukštis x plotis: 235x191 mm, weight: 550 g
  • Išleidimo metai: 11-Oct-2019
  • Leidėjas: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128142251
  • ISBN-13: 9780128142257
Kitos knygos pagal šią temą:

Current Trends and Future Developments on (Bio-) Membranes: Membrane Applications in Artificial Organs and Tissue Engineering reports on membrane applications in the field of biomedical engineering, ranging from artificial organs, to tissue engineering. The book offers a comprehensive review of all the current scientific developments and various applications of membranes in this area. It is a key reference text for R&D managers in industry who are interested in the development of artificial and bioartificial organs, as well as academic researchers and postgraduate students working in the wider area of artificial organs and tissue engineering.

  • Describes numerous bioartificial organ configurations and their relationships to membranes
  • Includes new innovations and solutions in the development of artificial organs with membrane components
  • Describes various membrane fabrication techniques for tissue engineering
Contributors ix
Preface xi
Chapter 1 Artificial kidney: A chemical engineering challenge
1(20)
Luisa Di Paola
1 Introduction
1(3)
2 Historical perspective
4(2)
3 Transport properties of membranes for artificial kidney
6(2)
4 Compartmental modeling for artificial kidney
8(3)
5 Membrane modules for renal replacement therapy
11(1)
6 Water quality management in artificial kidney
12(1)
7 The future of renal replacement therapy: Bioartificial kidney and implantable artificial kidney
13(2)
8 Conclusions and future trends
15(6)
References
18(3)
Chapter 2 Membrane application for liver support devices
21(24)
Simone Novelli
Cornelius Engelman
Vincenzo Piemonte
1 Introduction
21(1)
2 Liver support devices
22(1)
3 Development of blood purification systems
23(3)
4 Artificial devices
26(8)
4.1 Hemofiltration
26(1)
4.2 Hemoperfusion
26(1)
4.3 Reactors with immobilized enzymes
27(1)
4.4 Plasma exchange
27(1)
4.5 Hemodiafiltration
27(1)
4.6 Plasma exchange and continuous hemodiafiltration
28(1)
4.7 Molecular therapy of the absorbent recirculation system
28(4)
4.8 Prometheus
32(2)
5 Bioartificial devices
34(3)
5.1 Cellular sources
35(1)
5.2 Types of hepatocyte culture systems
36(1)
5.3 Types of bioreactor
36(1)
6 Tissue engineering
37(5)
6.1 Implantable engineered tissue for humanized mouse models
38(2)
6.2 Implantable therapeutic engineered liver tissue
40(1)
6.3 Design criteria for implantable systems
40(1)
6.4 Natural scaffold chemistry and modifications
40(2)
7 Conclusion and future trends
42(3)
References
42(3)
Chapter 3 Membrane bioreactors for (bio-)artificial lung
45(32)
M. Pflaum
A. Silva Peredo
D. Dipresa
A. De
S. Korossis
1 Introduction
45(1)
2 Milestones in ECMO development to date
46(4)
3 Limitations of ECMO/ECLS
50(2)
4 Computational fluid dynamics for the optimization of the oxygenator design
52(1)
5 Surface treatments for improving the hemocompatibility of blood contacting surfaces in ECMO circuits
53(4)
6 Biohybrid/bioartificial approaches
57(4)
7 Wearable or implantable artificial lung
61(2)
8 The implantable artificial lung
63(1)
9 The development of microfluidic artificial lungs
64(2)
10 Tissue engineered lungs
66(1)
11 Conclusions and future trends
67(10)
References
68(9)
Chapter 4 Membrane bioreactors for bio-artificial pancreas
77(32)
Rachid Jellali
Amal Essaouiba
Eric Leclerc
Cecile Legallais
1 Introduction: The pancreas
77(4)
1.1 Anatomy and physiology
77(1)
1.2 Mechanisms of glycemic regulation
78(1)
1.3 Physiopathology and treatment
79(2)
2 The concept of bioartificial pancreas
81(2)
3 Overview of the specificities of currently developed BAP
83(11)
3.1 Number and potential sources of pancreatic islets
84(3)
3.2 Mass transfer issues in BAP and implantation site
87(7)
4 Porous scaffolds---Membranes
94(1)
5 Conclusions and future trends
95(14)
References
100(9)
Chapter 5 Membrane devices for blood separation and purification
109(18)
Simone Novelli
Renzo Pretagostini
Vincenzo Piemonte
1 Introduction
109(2)
2 Requirements for an effective apheresis
111(2)
3 Main differences between centrifugation and filtration systems
113(3)
3.1 Centrifugal systems
114(1)
3.2 Membrane systems
114(1)
3.3 Mixed systems: Membranes and centrifuges
115(1)
4 Discontinuous and continuous flow systems
116(1)
5 Apheresis techniques
116(6)
5.1 Plasma exchange
116(2)
5.2 Semiselective plasmas (plasma separation through secondary membranes, or double filtration or cascade filtration)
118(1)
5.3 Selective plasma tracking (selective absorption)
118(2)
5.4 Apheresis of lipidic proteins
120(1)
5.5 Cytoapheresis
120(1)
5.6 Therapeutic cytoapheresis
120(2)
6 Donations of autologous or allogeneic blood components
122(1)
7 Conclusion and future trends
123(4)
References
125(2)
Chapter 6 Numerical prediction of blood damage in membrane-based biomedical assist devices
127(30)
Flavia Vitale
Luca Turchetti
1 Introduction
127(2)
2 Properties of red blood cells
129(6)
2.1 Red blood cell structure
129(3)
2.2 Mechanical properties
132(3)
3 Phenomenology of hemolysis and blood damage
135(2)
4 Quantification of blood damage
137(1)
5 Experimental data on blood damage
138(3)
6 Current modeling approaches for blood damage prediction
141(10)
6.1 Stress-based models
142(1)
6.2 Limitations of empirical stress-based models
143(4)
6.3 Strain-based models
147(4)
7 Conclusions and future trends
151(6)
References
153(3)
Further reading
156(1)
Chapter 7 Membrane scaffolds for 3D cell culture
157(34)
Vera Guduric
Mathilde Fenelon
Jean-Christophe Fricain
Sylvain Catros
1 Membrane scaffolds for tissue engineering applications
157(4)
1.1 Tissue engineering principles
157(1)
1.2 Application of tissue engineering methods for 3D cell culture
157(1)
1.3 Prerequisites of membranes for 3D cell culture
158(1)
1.4 Biomaterials for membranes fabrication
159(2)
2 Methods of membranes fabrication
161(11)
2.1 Conventional techniques
161(4)
2.2 Biofabrication methods for membranes in tissue engineering
165(7)
3 Use of membranes for cell culture in tissue engineering
172(9)
3.1 Limits of conventional tissue engineering
173(1)
3.2 Layer-by-layer bioassembly of cellularized membranes for tissue engineering
174(7)
4 Conclusions and future trends
181(10)
References
184(7)
Chapter 8 Artificial oxygen carriers
191(24)
Katja B. Ferenz
1 Introduction
191(3)
1.1 Oxygen is both: A blessing and a curse
191(3)
2 The role of AOCs in the context of artificial organs and tissue engineering
194(4)
2.1 Why has evolution developed such strategies?
195(3)
3 Relevant types of AOCs
198(10)
3.1 Hemoglobin-based AOCs
198(5)
3.2 Perfluorocarbon-based AOCs
203(5)
4 Conclusions and future trends
208(7)
Conflict of interest
209(1)
References
209(6)
Chapter 9 Membrane bioreactors for digestive system to study drugs absorption and bioavailability
215(22)
Pompa Marcello
Mauro Capocelli
Vincenzo Piemonte
1 Introduction
215(3)
2 Anatomy of the GI tract
218(3)
3 Physiology of the GI tract
221(2)
3.1 Stomach
221(1)
3.2 Duodenum
222(1)
3.3 Jejunum
222(1)
3.4 Ileum and colon
222(1)
4 Modeling of drugs' absorption and bioavailability
223(7)
4.1 Single and two-compartment models
223(1)
4.2 Five-compartments model
224(6)
5 Model simulations
230(4)
6 Conclusion and future trends
234(3)
References
236(1)
Index 237
Angelo Basile, a Chemical Engineer, is a senior Researcher at the ITM-CNR where is responsible of the research related to both the ultra-pure hydrogen production and CO2 capture using Pd-based Membrane Reactors. Basile is also Editor associate of the Int. J. Hydrogen Energy and Editor-in-chief of the Int. J. Membrane Science & Technol. and Editor-in-chief of Membrane Processes (Applications), a section of the international journal Membranes: Basile also prepared 42 special issues on membrane science and technology for many international journals (IJHE, Chem Eng. J., Cat. Today, etc.). He participated to and was/is responsible of many national and international projects on membrane reactors and membrane science. Basile served as Director of the ITM-CNR during the period Dec. 2008 May 2009. In the last years, he was tutor of 30 Thesis for master and Ph.D. students at the Chemical Engineering Department of the University of Calabria (Italy). From 2014, Basile is Full Professor of Chemical Engineering Processes. Maria Cristina Annesini is full professor of Chemical Engineering Fundamentals at the Faculty of Engineering of Rome University La Sapienza” where now she teaches Transport Phenomena and Chemical reactors for undergraduate and graduate students respectively. Her research activity is supported by over 150 scientific works; in the biotechnological and biomedical fields, she studied phase equilibrium thermodynamics of complex mixtures involved in biotechnological processes, drug controlled release and enzymatic processes in liposomes, bioreaction engineering (in particular, two-pahse sequenting batch reators for xenobiotics removal), artificial organ engineering. In the last field, she studied the physico-chemical phenomena involved in artificial liver devices, based on albumin-bound toxin removal by adsorption or albumin dialysis, and proposed mathematical models to engineer” the artificial device or to model the artificial device-patient system. She also active in studying transport phenomena in membrane reactors, for hydrogen separation in reforming processes Vincenzo Piemonte is an associate professor at the University Campus Bio-medico” of Rome (academic courses: Artificial Organs Engineering, Biorefinery Fundamentals, Chemical Engineering Principles, Bioreactors) and an Adjunct Professor at the Department of Chemical Engineering of the University La Sapienza” of Rome (academic course: Artificial Organs Engineering). His research activity is primarily focused on the study of Transport phenomena in the artificial and bioartificial organs; new biotreatment technology platform for the elimination of toxic pollutants from water and soil; Life Cycle Assessment (LCA) of petroleum-based plastics and bio-based plastics; extraction of valuable substances (polyphenols, tannins) from natural matrices; hydrogen production by membrane reactors for water gas shift reaction; concentrated Solar Power Plant integrated with membrane steam reforming reactor for the production of hydrogen and hydro-methane. He has about 120 publications on chemical thermodynamics, kinetics, biomedical devices modeling, Bioreactors, LCA studies. Catherine Charcosset got her PhD from Compičgne University (France) and then spent 2 years as a postdoctoral fellow at MIT (Boston, USA). She was appointed research scientist at CNRS (Centre National de la Recherche Scientifique, France) first as a junior and then as a senior scientist. Her field of research concerns membrane and membrane processes, especially in biotechnology and pharmaceutics as well as for drinking water treatment. Catherine Charcosset has been (or is) responsible for several national and international projects on membrane and membrane processes. She has supervised 15 PhD students and 20 Master students and has published over 100 papers and chapters in international journals and books, and 3 patents. She is the author of one book Membrane Processes in Biotechnology and Pharmaceutics” published by Elsevier in 2012. She is co-editor with Angelo Basile of another book Integrated Membrane Systems and Processes” published by Wiley in 2016.