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El. knyga: Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies

Edited by (Hematopathologist, Bioreference Laboratories, Elmwood Park, NJ, USA; Regional Cancer Care Associates, Hackensack, NJ, USA)
  • Formatas: 336 pages
  • Išleidimo metai: 01-Aug-2008
  • Leidėjas: CRC Press
  • Kalba: eng
  • ISBN-13: 9780203091555
Kitos knygos pagal šią temą:
Cytogenetics, FISH and Molecular Testing in Hematologic MalignanciesDidesnis paveikslėlis
  • Formatas: 336 pages
  • Išleidimo metai: 01-Aug-2008
  • Leidėjas: CRC Press
  • Kalba: eng
  • ISBN-13: 9780203091555
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Cytogenetics, fluorescence in situ hybridization (FISH) and molecular tests, especially polymerase chain reaction (PCR), play an important role in the management of patients with hematologic malignancies by helping to establish the diagnosis, as well as predict prognosis, response to treatment and disease progression. Chromosomal and molecular abnormalities provide the most reliable criteria for classification of hematopoietic tumors and often comprise the basis for targeted therapy.

Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies, provides a review of chromosomal and molecular changes in hematologic malignancies and correlates the karyotypic and genetic abnormalities with morphology, immunophenotype and clinical data. With over 180 figures and diagnostic algorithms, this text is essential reading for all pathologists, hematopathologists, hematologic oncologists, cytogenetists, cytogenetic technologists and cell biologists.

Recenzijos

"The intent of the author was to provide a helpful tool in diagnosing hematologic malignancies, as well as predicting prognosis, response to treatment, and disease progression. The author has reached his goals.This book will be useful primarily for practicing hematopathologists. Hematopathology fellows and pathology residents rotating in hematopathology, molecular genetics, and cytogenetics will also find it useful. In addition, it can be useful to practicing oncologists, hematology/oncology fellows, and residents in internal medicine.I would recommend it to anyone interested in hematologic malignancies." Anamarija Morovic, MD (University of Cincinnati College of Medicine), Doodys Reviews

Preface vii
Acknowledgments ix
Introduction
1(30)
Karyotype
2(1)
Nomenclature
3(1)
Conventional cytogenetics
4(5)
Fluorescence in situ hybridization
9(10)
Molecular pathology
19(4)
Immunophenotyping by flow cytometry
23(3)
Immunohistochemistry
26(5)
Applications of cytogenetics, Fish, and PCR in diagnosis, prognosis, and disease monitoring
31(84)
Most common chromosomal/molecular abnormalities
31(66)
Application of chromosomal and molecular markers in diagnosis
97(9)
Application of chromosomal and molecular markers in prognostification
106(2)
Application of chromosomal and molecular markers in disease monitoring
108(7)
Hematologic malignancies: correlation between morphology, phenotype, and chromosomal/genetic markers
115(120)
B-cell lymphoproliferations
115(51)
Peripheral (mature) T-cell lymphoproliferative disorders
166(16)
Hodgkin lymphoma
182(1)
Acute myeloid leukemia
183(15)
Precursor lymphoblastic lymphoma/leukemia (acute lymphoblastic leukemia)
198(7)
Chronic myeloproliferative disorders
205(19)
Mastocytosis
224(1)
Myeloproliferative/myelodysplastic diseases
225(1)
Myelodysplastic syndromes
226(7)
Abbreviations/terminology
233(2)
References 235(76)
Index 311


Director of Hematopathology/Oncology Services (New York), Genzyme Genetics, USA
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