This book explains the fundamental characteristics and biofunctionality of Alzheimers Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimers Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimers disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimers disease treatment.
Chapter 1.Deciphering New Drug Targets in Alzheimers Disease.
Chapter
2. Novel Therapeutic Targets for Treating Alzheimers Disease.
Chapter
3. Modified Investigation Tools and Techniques Useful in Alzheimers Disease
Research.
Chapter 4. Dual Specificity Tyrosine Phosphorylation Regulated
Kinase1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for
Alzheimers Disease.
Chapter 5. -secretase as a primary drug target of
Alzheimer disease: Function, Structure, and Inhibition.
Chapter 6. Endocrine
Receptors: The Potential Therapeutic Targets for Alzheimers.
Chapter
7. Calcium Channels as a Potential Therapeutic Target for Alzheimers
Disease.
Chapter 8. Traversing Through the Trajectory of Pathogenic
Astrocytes in Alzheimers Disease.
Chapter 9. Targeting Mitochondrial
Dynamics as a Restorative Approach in the Treatment of Alzheimers Disease.-
Chapter 10. Epigenetic Therapy for Alzheimers Disease.
Chapter
11. Exploring the Diverse Roles of GSK-3ß Kinase in Alzheimers Disease .-
Chapter 12. Role of Target Fishing in Discovery of Novel Anti-Alzheimers
Agents: In Silico Applications.
Chapter 13. Multi-Target Directed Ligand
Approach in Anti-Alzheimers Drug Discovery .
Chapter 14. Investigating the
Role of Tau Proteins in Alzheimers Disease-From Typical Functioning MAPs to
Aberrant Fibrillary Deposits in the Brain.
Chapter 15. The Overview of Drugs
Used in Alzheimers Disease and Their Molecular Targets.
Dr. Dileep Kumar Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharti Vidyapeeth University, India Dr. Vaishali M. Patil KIET School of Pharmacy, KIET Group of Institutions, Uttar Pradesh, India Dr. Dee WuDepartment of Radiological Sciences, Section of Med PhysicsMedical Physics Education Program Dr. Nanasaheb ThoratUniversity of Oxford, Medical Science DivisionNuffield Department of Women's & Reproductive Health
