This book discusses the design of neural stimulator systems which are an established treatment methodology for a wide variety of brain disorders such as Parkinson, depression and tinnitus. Whereas many existing books treating neural stimulation focus on one particular design aspect, such as the electrical design of the stimulator, this book uses a multidisciplinary approach, combining the fields of neuroscience, electrophysiology and electrical engineering, to create a thorough understanding of the complete stimulation chain from the stimulation chip down to the neural cell. The authors multidisciplinary approach enables readers to gain new insights into stimulator design, while they provide context by presenting innovative design examples.
Recenzijos
This is an excellent monograph on the electronics of neural stimulators for clinical and experimental recordings including chronic spine devices for the control of pain. The parameters of safe operation and application are discussed for neurophysiologists, engineering specialists, fellows, and students in graduate school. Junior undergraduate students will find the discussions very relevant and helpful in their work and studies. (Joseph J. Grenier, Amazon.com, April, 2016)
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1 | (10) |
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1.2 Case Study: SCS Device |
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3 | (1) |
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4 | (1) |
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1.3.1 Neural Recruitment Strategies |
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5 | (1) |
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5 | (2) |
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7 | (4) |
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Part I Towards Safe and Efficient Neural Stimulation |
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2 Modeling the Activation of Neural Cells |
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2.1 Physiological Principles of Neural Cells |
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11 | (5) |
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2.1.2 Modeling of the Cell Membrane |
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12 | (2) |
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14 | (2) |
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2.2 Stimulation of Neural Tissue |
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2.2.1 The Electrode Level: Electrode-Tissue Model |
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16 | (3) |
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2.2.2 Tissue Level: Electric Field Distribution |
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19 | (3) |
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2.2.3 Neuronal Level: Axonal Activation |
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22 | (2) |
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24 | (1) |
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24 | (1) |
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3 Electrode--Tissue Interface During a Stimulation Cycle |
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25 | (24) |
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25 | (2) |
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3.1.1 Mechanically Induced Damage |
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25 | (1) |
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3.1.2 Electrically Induced Damage |
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26 | (1) |
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3.2 The Consequences of Using Coupling Capacitors |
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27 | (11) |
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28 | (5) |
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3.2.2 Measurement Results |
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33 | (1) |
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34 | (4) |
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38 | (1) |
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3.3 Reversibility of Charge Transfer Processes During Stimulation |
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38 | (8) |
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39 | (1) |
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40 | (2) |
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3.3.3 Measurement Results |
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42 | (2) |
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44 | (2) |
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46 | (3) |
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46 | (3) |
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4 Efficacy of High Frequency Switched-Mode Neural Stimulation |
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49 | (18) |
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49 | (2) |
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51 | (7) |
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4.2.1 Tissue Material Properties |
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51 | (2) |
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4.2.2 Tissue Membrane Properties |
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53 | (5) |
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58 | (2) |
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58 | (1) |
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59 | (1) |
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60 | (2) |
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62 | (1) |
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63 | (4) |
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63 | (4) |
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Part II Electrical Design of Neural Stimulators |
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5 System Design of Neural Stimulators |
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67 | (12) |
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5.1 System Properties of Neural Stimulators |
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67 | (7) |
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5.1.1 Location of the System |
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67 | (1) |
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5.1.2 Electrode Configuration |
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68 | (1) |
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5.1.3 Stimulation Waveform |
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69 | (2) |
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5.1.4 Charge Cancellation Schemes |
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71 | (3) |
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5.2 System Implementation Aspects |
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74 | (2) |
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5.2.1 Power Efficiency of Neural Stimulators |
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74 | (1) |
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5.2.2 Bidirectional Stimulation |
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75 | (1) |
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76 | (3) |
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77 | (2) |
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6 Design of an Arbitrary Waveform Charge Balanced Stimulator |
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79 | (3) |
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82 | (2) |
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84 | (3) |
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87 | (1) |
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6.2.4 Full System Simulations |
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88 | (1) |
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89 | (3) |
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90 | (1) |
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6.3.2 Measurement Results |
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91 | (1) |
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6.4 Application: Multimodal Stimulation for the Reduction of Tinnitus |
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92 | (5) |
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93 | (2) |
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95 | (2) |
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7 Switched-Mode High Frequency Stimulator Design |
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97 | (24) |
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7.1 High Frequency Dynamic Stimulation |
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98 | (4) |
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7.1.1 Power Efficiency of Current Source Based Stimulators |
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98 | (3) |
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7.1.2 High Frequency Dynamic Stimulation |
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101 | (1) |
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102 | (4) |
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7.2.1 High Frequency Dynamic Stimulator Requirements |
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102 | (2) |
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7.2.2 General System Architecture |
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104 | (1) |
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7.2.3 Digital Control Design |
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104 | (2) |
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106 | (6) |
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106 | (5) |
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7.3.2 Clock and Duty Cycle Generator |
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111 | (1) |
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112 | (6) |
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113 | (1) |
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7.4.2 Biphasic Stimulation Pulse |
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114 | (1) |
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7.4.3 Multichannel Operation |
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115 | (1) |
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7.4.4 PBS Solution Measurements |
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116 | (1) |
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117 | (1) |
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118 | (3) |
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118 | (3) |
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121 | (2) |
| Index |
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123 | |
Marijn N. van Dongen was born in Pijnacker, The Netherlands, in 1984. He received the M.Sc. and Ph.D. degrees in electrical engineering from the Delft University of Technology, Delft, The Netherlands, in 2010 and 2015, respectively. His research interests include the design of neural stimulator output circuits as well as the modeling of the electrophysiological and electrochemical processes during electrical stimulation. Currently he is working for NXP Semiconductors, Nijmegen, The Netherlands. Dr. van Dongen served as the Financial Chair of the IEEE BioCAS2013 Conference.
Wouter A. Serdijn (M'98, SM'08, F'11) was born in Zoetermeer ('Sweet Lake City'), the Netherlands, in 1966. He received the M.Sc. (cum laude) and Ph.D. degrees from Delft University of Technology, Delft, The Netherlands, in 1989 and 1994, respectively. Currently, he full professor of bioelectronics at Delft University of Technology, where he heads the Section Bioelectronics. His research interests include low-voltage, ultra-low-power and ultra wideband integrated circuits and systems for biosignal conditioning and detection, neuroprosthetics, transcutaneous wireless communication, power management and energy harvesting as applied in, e.g., hearing instruments, cardiac pacemakers, cochlear implants, neurostimulators, portable, wearable, implantable and injectable medical devices and electroceuticals.
He is co-editor and co-author of 9 books, 8 book chapters and more than 300 scientific publications and presentations. He teaches Circuit Theory, Analog Signal Processing, Micropower Analog IC Design and Bioelectronics. He received the Electrical Engineering Best Teacher Award in 2001, 2004 and 2015. Wouter A. Serdijn is an IEEE Fellow, an IEEE Distuingished Lecturer and a Mentor of the IEEE.
