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El. knyga: Developmental Neuropathology

Series edited by , Edited by (Université Paris Diderot (P7), Hōpital Robert Debré, Paris, France), Series edited by , Edited by (Children's Hospital of Philadelphia, Philadelphia, PA, USA), Edited by (Harvard Medical School)

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A definitive, clinically oriented guide to the pathology of genetics of developmental neuropathology

Developmental neuropathology relates to the wide range of disorders affecting the developing brain or pre- and post-natal life, with emphasis on the genetic and molecular mechanisms involved. This book provides a practical guide to diagnosing and understanding these disorders affecting this vulnerable population and potentially stimulates further advances in this exciting area. It also addresses the controversies in inflicted head injury in infants.

The fourth major title to be approved by the International Society of Neuropathology (ISN), Developmental Neuropathology offers in-depth chapter coverage of brain development; chromosomal changes; malformations; secondary malformations and destructive pathologies; developmental vascular disorders; acquired metabolic and exogenous toxins; metabolic disorders; Rett syndrome and autism; and infectious diseases. The text provides:

  • Clinical, disease-oriented approach to the pathology and genetics developmental neuropathology
  • Fuses classical and contemporary investigative approaches
  • Includes genetic and molecular biological pathogeneses
  • Fully illustrated
  • Approved and endorsed by International Society of Neuropathology

Developmental Neuropathology is the perfect book for practicing neuropathologists, pediatric pathologists, general pathologists, neurologists, and geneticists in deciphering the pathology and pathogenesis of these complex disorders affecting the nervous system of the embryo, fetus, and child.

List of Contributors
vii
Introduction xiii
1 Central Nervous System Manifestations of Chromosomal Change
1(12)
Joseph R. Siebert
2 Neural Tube Defects
13(16)
Andrew J. Copp
Brian N. Harding
3 Midline Patterning Defects
29(12)
Edwin S. Monuki
Jeffrey A. Golden
4 Microcephaly
41(14)
Sandrine Passemard
Annie Laquerriere
Nathalie Joumiac
Pierre Gressens
5 Hemimegalencephaly and Dysplastic Megalencephaly
55(8)
Ghayda Mirzaa
Achira Roy
William B. Dobyns
Kathleen Millen
Robert F. Hevner
6 Lissencephaly, Type I
63(12)
Jeffrey A. Golden
7 Lissencephaly, Type II (Cobblestone Lissencephaly)
75(10)
Jeffrey A. Golden
8 Polymicrogyria
85(6)
Jeffrey A. Golden
9 Cerebral Heterotopia
91(10)
Edwin S. Monuki
Keith L. Ligon
10 Hippocampal Sclerosis, Granule Cell Dispersion, and Cortical Dysplasia
101(16)
Maria Thom
11 Tuberous Sclerosis Complex
117(16)
Shino D. Magaki
Harry V. Vinters
12 Chiari Malformations
133(8)
Homa Adle-Biassette
Jeffrey A. Golden
13 Dandy-Walker Malformation, Mega Cisterna Magna, and Blake's Pouch Cyst
141(10)
Robert F. Hevner
Kathleen Milieu
William B. Dobyns
14 Joubert Syndrome
151(8)
Robert F. Hevner
William B. Dobyns
Enza Maria Valente
15 Cerebellar Heterotopia and Dysplasia
159(8)
Marie Rivera-Zengolita
Anthony T. Yachnis
16 Brainstem Malformations
167(12)
Brian N. Harding
17 Spinal Cord Lesions
179(8)
Annie Laquerriere
Florent Marguet
18 Hydrocephalus
187(12)
Homa Adle-Biassette
19 Antenatal Disruptive Lesions
199(4)
Brian N. Harding
20 Hemorrhagic Lesions
203(10)
Marc R. Del Bigio
21 White Matter Lesions in the Perinatal Period
213(16)
Robin L. Haynes
Rebecca D. Folkerth
22 Gray Matter Lesions
229(12)
Marc R. Del Bigio
23 Pediatric Head Injury
241(10)
Colin Smith
Thomas S. Jacques
R. Ross Reichard
24 Pediatric Vascular Malformations
251(18)
Shino D. Magaki
Randy Tashjian
Harry V. Vinters
25 Sudden Infant Death Syndrome
269(12)
Hannah C. Kinney
Marco M. Hefli
Richard D. Goldstein
Robin L. Haynes
26 Kernicterus
281(4)
Mariarita Santi
Lucy B. Rorke
27 Lesions Induced by Toxins
285(8)
Mariarita Santi
Lucy B. Rorke
Catherine Keohane
28 Disorders of Carbohydrate Metabolism
293(20)
Josefine Radke
Carsten G. Bonnemann
Werner Sienzel
Hans-H. Goebel
29 Sphingolipidoses and Related Disorders
313(56)
Annie Laquerriere
Soumeya Bekri
Kinoko Suzuki
Brian N. Harding
30 The Neuronal Ceroid Lipofuscinoses
369(12)
Josefine Radke
Kryslina E. Wisniewski
Werner Stenzel
Hans-H. Goebel
31 Peroxisomal Disorders
381(12)
Phyllis L. Faust
32 Mitochondrial Disorders
393(10)
Anders Oldfors
Brian N. Harding
33 Disorders of Amino Acid Metabolism and Canavan Disease
403(14)
Dimitri P. Agamanolis
34 Pelizaeus--Merzbacher Disease
417(10)
Brian N. Harding
35 Cockayne Syndrome
427(10)
Karen M. Weidenheim
P. J. Brooks
36 Vanishing White Matter Disease
437(10)
Marianna Bugiani
James M. Powers
Marjo S. van der Knaap
37 Alexander Disease
447(8)
James E. Goldman
Mel B. Feany
38 Neuroaxonal Dystrophy/Neurodegeneration with Brain Iron Accumulation
455(14)
Abi Li
Sarah Wiethoff
Charles Arber
Henry Houlden
Tamas Revesz
Janice L. Holton
39 Spinal Muscular Atrophy
469(8)
Brian N. Harding
40 Autism Spectrum Disorders
477(20)
Matthew P. Anderson
41 Intrauterine Infections
497(14)
Catherine Keohane
Homa Adle-Biassette
42 Perinatal and Postnatal Infections
511(20)
Catherine Keohane
43 Rasmussen Encephalitis
531(6)
Harry V. Vinters
Shino D. Magaki
Geoffrey C. Owens
Index 537
Homa Adle-Biassette Inserm U676, Université Paris Diderot (P7), Hōpital Robert Debré, Paris, France.

Brian Harding Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Jeffrey Golden Ramzi S. Cotran Professor of Pathology, Harvard Medical School, and Chair of Pathology Brigham and Women's Hospital, Boston, MA, USA.