"Clinicians working in maternal-fetal medicine and a range of internal medicine specialties. Basic scientists working in the fields of physiology, nutrition, endocrinology and metabolism, developmental biology, molecular biology and epigenetics, human biology and anthropology, evolutionary developmental biology. Nutritionists, epidemiologists, social scientists, economists, public health specialists and policy makers"--
Fully revised new edition highlighting the scientific and clinical advances in the field of developmental origins of health and disease. Explores new understanding of mechanisms such as epigenetics and the role of environmental influences on the fetus. Interventions throughout the lifespan and implications for public health are also covered.
The concept of the early life developmental origins of health and disease (DOHaD) in adults has stimulated a new approach to understanding disease trajectories, with major public health implications. Indeed, the principle of the 'lifecourse of disease' now influences health policies internationally. Environmental influences during pregnancy and early life that affect lifelong health are well documented, but there is a new focus on the preconception period and the significance of paternal health on the fetus. This fully revised second edition highlights scientific and clinical advances in the field, exploring new understanding of mechanisms such as epigenetics and the increasingly recognised role of external influences, including pollution. The book is structured logically, covering environment, clinical outcomes, mechanisms of DOHaD, interventions throughout the lifespan and finally implications for public health and policy. Clinicians and scientists alike will improve their understanding of the developmental origins of health and disease with this essential text.
Daugiau informacijos
Fully revised new edition highlighting the scientific and clinical advances in the field of developmental origins of health and disease.
Section I. Overview:
1. Overview and introduction to the 2nd edition of
the developmental origins of health and disease (DOHaD) Lucilla Poston, Keith
M. Godfrey, Sir Peter D. Gluckman and Mark A. Hanson; Section II. Exposures
driving long-term DOHaD effects:
2. The evolutionary basis of DOHaD Felicia M
Low, Peter D Gluckman and Mark A Hanson;
3. Timing: Critical DOHaD windows
with lifelong effects Keith M. Godfrey, Tom Fleming, Mary Barker, Judith
Stephenson, Mark Vickers, Frank Bloomfield and Rachael Taylor;
4. Long-term
effects of food insecurity and undernutrition in early life Sophie E. Moore;
5. Short and long-term effects of maternal obesity and dysglycaemia for women
and their children Jodie M. Dodd, Amanda J Poprzeczny, Andrea R. Duessen and
Jennie Louise;
6. Long-term DOHaD effects of prenatal maternal stress and
mental health Matthias Schwab and Florian Rakers;
7. Environmental exposures
in early life: effects of air pollution, chemicals and climate change on
human health and wellbeing Kirsten R. Poore, Marie Pedersen and Sibylle
Ermler;
8. Developmental programming and the microbiome: How the maternal
environment and early life shapes the infant gut microbiome pathway(s) and
risk of disease Kameron Y. Sugino and Jacob E. Friedman;
9. Exposures driving
long-term effects of DOHaD effects: Influence of assisted reproductive
technologies Daniel R. Brison, John C. M. Dumoulin, Hannah L. Morgan, Tessa
J. Roseboom and Adam J. Watkins; Section III. Outcomes:
10. Cardiometabolic
and renal DOHaD outcomes in offspring of complicated pregnancy Dino A.
Giussani, Rebecca M. Reynolds, Paul Leeson, Karen M. Moritz, John F. Bertram
and Susan E. Ozanne;
11. Development origins of chronic respiratory diseases
Liesbeth Duijts, Annemiek Mian, Tarik Karramass and Vincent W. V. Jaddoe;
12.
Early life adversity and female reproductive outcomes: How growth, diet and
nutrition impact reproductive function and accelerated reproductive ageing
Patrycja A. Jazwiec and Deborah M. Sloboda;
13. Developmental programming of
ageing induced by poor maternal nutrition; evidence from rodent studies Elena
Zambrano and Peter W. Nathanielsz; Section IV. Mechanisms:
14. Visualizing
structural underpinnings of DOHaD Kent L. Thornburg, John Bertram, Jacob E.
Friedman, David Hill, Kevin Kolahi and Christopher Kroenke;
15. Molecular and
epigenetic mechanisms of DOHaD Richard Saffery, Amanda Vlahos and Toby
Mansell;
16. The role of the placenta in DOHaD Rohan M. Lewis and Amanda N.
Sferruzzi-Perri; Section V. Interventions:
17. Interventions to prevent DOHaD
effects in pregnancy Lucilla Poston;
18. Interventions to prevent DOHaD
effects in infancy and early childhood Bartomiej Mateusz Zalewski, Bernadeta
Patro-Gob, Barbara Boek, M. Koodziej, Kathryn V. Dalrymple, Lucilla
Poston and Hania Szajewska; Section VI. Public health and policy implications
of interventions;
19. Education and science communication: Translation of
DOHaD evidence for health benefit Jacquie L. Bay and Suzanne Trask;
20. DOHaD
engaging with new global issues to inform policy Peter D. Gluckman and Mark
A. Hanson.
Lucilla Poston is Tommy's Charity Professor of Maternal and Fetal Health in the Department of Women and Children's Health and Head of the School of Life Course and Population Sciences at King's College London, UK. Keith M. Godfrey is Nutrition, Lifestyle and Metabolism Theme Lead in the National Institute for Health and Care Research Southampton Biomedical Research Centre. He is Professor of Epidemiology & Human Development at the University of Southampton and Director of the Centre for Developmental Origins of Health & Disease, UK. Peter D. Gluckman holds a Distinguished University Professorship at the Liggins Institute of the University of Auckland, Australia. Mark A. Hanson is Emeritus Professor of Human Development and Health and British Heart Foundation Professor at The University of Southampton, UK.
