Preface |
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xv | |
Acknowledgements |
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xvii | |
Abbreviations and symbols |
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xix | |
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Section 1 The causes of psychosis |
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3 | (3) |
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1.1 The definitions of psychosis |
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3 | (1) |
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1.2 Scope and threshold for inclusion |
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3 | (1) |
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1.3 Emphasis on non-psychiatric phenotype in diagnosing secondary psychosis, and on psychopathology in diagnosing primary psychosis |
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4 | (1) |
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1.4 Two useful approaches to the diagnosis of psychosis |
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5 | (1) |
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1.5 Arrangement of this book |
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5 | (1) |
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6 | (1) |
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7 | (3) |
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7 | (1) |
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8 | (2) |
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4 Neurodevelopmental disorders and chromosomal abnormalities |
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10 | (6) |
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4.1 Velocardiofacial syndrome |
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10 | (1) |
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11 | (1) |
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4.3 Other chromosomal abnormalities |
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11 | (1) |
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4.4 Agenesis of the corpus callosum |
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12 | (1) |
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4.5 Prader-Willi syndrome |
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12 | (1) |
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13 | (1) |
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4.7 X-linked mental retardation syndromes |
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13 | (1) |
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4.8 Other rare genetic conditions presenting early in life |
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13 | (2) |
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4.9 Other rare neurodevelopmental disorders |
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15 | (1) |
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5 Neurodegenerative disorders |
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16 | (9) |
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16 | (1) |
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17 | (1) |
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5.3 Parkinson's disease and "Parkinson's plus" syndromes |
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17 | (1) |
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5.4 Dementia with Lewy bodies |
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18 | (1) |
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5.5 Asymmetric cortical degeneration syndromes, including frontotemporal dementia and Pick's disease |
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18 | (1) |
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19 | (1) |
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20 | (1) |
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5.8 Dentatorubropallidoluysian atrophy |
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21 | (1) |
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5.9 Spinocerebellar ataxia |
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21 | (1) |
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21 | (1) |
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5.11 Basal ganglia calcification |
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22 | (1) |
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5.12 Pantothenate kinase-associated neurodegeneration |
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22 | (1) |
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23 | (1) |
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5.14 Argyrophilic grain disease |
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23 | (1) |
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5.15 Thalamic degeneration |
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24 | (1) |
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5.16 Other rare genetic conditions presenting late in life |
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24 | (1) |
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6 Focal neurological disease |
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25 | (13) |
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6.1 Cerebrovascular disease |
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25 | (2) |
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27 | (4) |
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6.2.1 Classification of seizures |
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27 | (1) |
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6.2.2 Psychosis and epilepsy |
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28 | (3) |
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6.2.3 EEG features of relevance and underlying causes |
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31 | (1) |
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31 | (2) |
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6.4 Hypertensive encephalopathy and posterior reversible encephalopathy syndrome |
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33 | (1) |
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6.5 Head injury (traumatic brain injury) |
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33 | (1) |
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6.6 Normal-pressure hydrocephalus |
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34 | (1) |
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6.7 Intracranial mass lesions (tumours) and obstructive hydrocephalus |
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34 | (1) |
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35 | (1) |
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6.9 Central pontine and extrapontine myelinolysis |
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36 | (1) |
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36 | (2) |
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38 | (2) |
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8 Infectious and postinfectious syndromes |
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40 | (20) |
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41 | (7) |
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8.1.1 Pyogenic bacterial infection |
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41 | (1) |
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41 | (1) |
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8.1.3 Lyme disease (borreliosis) |
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42 | (2) |
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8.1.4 Bartonella infection |
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44 | (1) |
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44 | (1) |
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44 | (1) |
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45 | (1) |
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46 | (1) |
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8.1.9 Other systemic bacterial infections with prominent neuropsychiatric effects |
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47 | (1) |
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48 | (6) |
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8.2.1 Herpesvirus encephalitis |
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49 | (2) |
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8.2.2 HIV encephalitis and AIDS dementia |
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51 | (1) |
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8.2.3 Other acute viral encephalitides |
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52 | (1) |
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8.2.4 Other subacute viral encephalitides |
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53 | (1) |
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54 | (2) |
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54 | (1) |
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54 | (1) |
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55 | (1) |
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8.4 Fungal infection (mycosis) |
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56 | (1) |
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8.5 Eosinophilic meningitis and meningoencephalitis, helminths, and macroparasites |
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56 | (1) |
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8.6 Protein infection: Creutzfeldt-Jakob disease and other prion diseases |
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57 | (1) |
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8.7 Autoimmune disease following infection |
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58 | (2) |
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8.7.1 Sydenham's chorea and PANDAS |
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58 | (1) |
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8.7.2 Encephalitis lethargica |
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59 | (1) |
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8.7.3 Postinfectious encephalomyelitis and acute disseminated encephalomyelitis |
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59 | (1) |
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60 | (8) |
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9.1 Hypothyroidism and hyperthyroidism |
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60 | (3) |
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9.2 Glucocorticoid excess |
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63 | (1) |
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64 | (1) |
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65 | (1) |
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9.5 Hypoparathyroidism and hyperparathyroidism |
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65 | (1) |
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9.6 Sex hormones and psychosis |
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66 | (2) |
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9.6.1 Schizophrenia and sex hormones |
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66 | (1) |
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9.6.2 Puerperal (postpartum) psychosis and other oestrogen withdrawal states |
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66 | (1) |
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9.6.3 Other relationships between sex hormones and psychosis |
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67 | (1) |
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10 Inborn errors of metabolism |
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68 | (14) |
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10.1 Hyperammonaemia and urea cycle disorders |
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68 | (1) |
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69 | (2) |
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10.3 Disorders of amino acid metabolism |
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71 | (2) |
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10.3.1 Hereditary tyrosinaemia |
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71 | (1) |
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10.3.2 Hyperhomocysteinaemia and homocystinuria |
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71 | (1) |
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72 | (1) |
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10.3.4 Maple syrup urine disease |
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72 | (1) |
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73 | (1) |
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74 | (6) |
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10.5.1 Neuronal ceroid lipofuscinosis |
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74 | (1) |
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10.5.2 Niemann-Pick disease, type C |
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74 | (1) |
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10.5.3 Hexosaminidase deficiency (GM2 gangliosidosis) |
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75 | (1) |
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10.5.4 Mucopolysaccharidosis |
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75 | (1) |
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76 | (1) |
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10.5.6 Aspartylglucosaminuria |
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76 | (1) |
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10.5.7 Metachromatic leukodystrophy |
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77 | (1) |
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10.5.8 X-linked adrenoleuko-dystrophy |
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77 | (1) |
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10.5.9 Cerebrotendinous xanthomatosis |
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78 | (1) |
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10.5.10 Alpha-mannosidosis |
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78 | (1) |
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10.5.11 Krabbe's disease (globoid cell leukodystrophy) |
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79 | (1) |
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10.5.12 Gaucher's disease |
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79 | (1) |
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10.5.13 Vanishing white matter leukoencephalopathy |
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80 | (1) |
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10.5.14 Diffuse sclerosis |
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80 | (1) |
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10.6 Mitochondrial encephalopathies |
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80 | (1) |
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10.7 Glucose-6-phosphate dehydrogenase deficiency |
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81 | (1) |
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11 Nutritional deficiency |
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82 | (7) |
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11.1 Thiamine (vitamin B1) deficiency |
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82 | (1) |
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11.2 Niacin (vitamin B3, nicotinic acid) deficiency |
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83 | (1) |
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11.3 Pyridoxine (vitamin B6) deficiency |
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84 | (1) |
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11.4 Cobalamin (vitamin B12) deficiency, and methylmalonic aciduria |
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85 | (2) |
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11.5 Folate (vitamin B9) deficiency |
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87 | (1) |
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88 | (1) |
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88 | (1) |
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88 | (1) |
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12 Other acquired metabolic disorders |
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89 | (10) |
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12.1 Global cerebral hypoxia |
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89 | (1) |
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12.2 Disturbances of pH and hypercapnic encephalopathy |
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89 | (1) |
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90 | (1) |
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91 | (3) |
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91 | (1) |
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12.4.2 Hepatic encephalopathy |
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92 | (1) |
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12.4.3 Pancreatic encephalopathy |
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93 | (1) |
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93 | (1) |
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12.5 Electrolyte disturbances |
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94 | (5) |
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94 | (1) |
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95 | (1) |
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95 | (1) |
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96 | (1) |
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96 | (1) |
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97 | (1) |
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97 | (2) |
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13 Autoimmune rheumatic disorders and vasculitides |
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99 | (14) |
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13.1 Connective tissue disorders |
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99 | (4) |
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13.1.1 Systemic lupus erythematosus |
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99 | (3) |
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13.1.2 Antiphospholipid syndrome |
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102 | (1) |
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13.1.3 Sjogren's syndrome |
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102 | (1) |
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13.1.4 Systemic sclerosis |
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103 | (1) |
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13.1.5 Mixed connective tissue disease |
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103 | (1) |
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103 | (6) |
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13.2.1 Giant cell (temporal) arteritis |
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104 | (1) |
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13.2.2 Primary CNS angiitis |
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105 | (1) |
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13.2.3 Polyarteritis nodosa |
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105 | (1) |
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13.2.4 ANCA-associated small-vessel vasculitides |
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106 | (2) |
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13.2.5 Other forms of CNS vasculitis |
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108 | (1) |
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109 | (1) |
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13.4 Reiter's disease (reactive arthritis) |
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109 | (1) |
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109 | (2) |
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111 | (1) |
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13.7 Thrombotic thrombocytopenic purpura |
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111 | (1) |
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13.8 Hyperviscosity and cryoglobulinemia |
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111 | (2) |
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14 Other autoimmune encephalopathies |
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113 | (5) |
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14.1 Hashimoto's encephalopathy |
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113 | (1) |
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14.2 Autoimmune limbic encephalopathy, including paraneoplastic limbic encephalitis |
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113 | (3) |
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14.2.1 Antibodies against voltage-gated potassium channels |
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114 | (1) |
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14.2.2 Antibodies against NMDA glutamate receptors |
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115 | (1) |
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14.2.3 Other antibodies against neuropil and neuronal surface proteins |
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116 | (1) |
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14.2.4 Other antibodies against intraneuronal antigens |
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116 | (1) |
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14.3 Non-vasculitic autoimmune inflammatory meningoencephalitis |
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116 | (2) |
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118 | (22) |
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118 | (6) |
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124 | (1) |
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15.3 Recreational drugs, drugs of abuse, and withdrawal states |
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125 | (4) |
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15.4 Anticholinergic poisoning |
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129 | (1) |
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15.5 Animal, plant, and fungus poisoning |
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129 | (2) |
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15.5.1 Spider venom (neurotoxic araneism) |
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129 | (1) |
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129 | (1) |
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15.5.3 Fish poisoning (ichthyoallyeinotoxism) |
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130 | (1) |
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15.5.4 Plant and fungus poisoning |
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130 | (1) |
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15.6 Metal and metalloid poisoning |
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131 | (4) |
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15.6.1 Mercury (Hg) poisoning |
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131 | (1) |
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15.6.2 Arsenic (As) poisoning |
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132 | (1) |
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15.6.3 Thallium (Tl) poisoning |
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132 | (1) |
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15.6.4 Lead (Pb) poisoning |
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133 | (1) |
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15.6.5 Manganese (Mn) poisoning |
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134 | (1) |
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15.6.6 Copper (Cu) poisoning |
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134 | (1) |
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15.6.7 Aluminium (Al) poisoning |
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135 | (1) |
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15.6.8 Bismuth (Bi) poisoning |
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135 | (1) |
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15.6.9 Molybdenum (Mo) poisoning |
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135 | (1) |
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15.7 Poisoning by other organic and non-metallic substances |
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135 | (5) |
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15.7.1 Carbon monoxide (CO) poisoning |
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136 | (1) |
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15.7.2 Poisoning by other organic compounds |
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136 | (4) |
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140 | (2) |
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17 Sensory deprivation and impairment |
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142 | (1) |
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143 | (3) |
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143 | (1) |
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18.2 Idiopathic hypereosinophilic syndrome |
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144 | (1) |
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18.3 Idiopathic intracranial pachymeningitis |
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144 | (1) |
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144 | (1) |
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18.5 Serine- and glycine-evoked psychosis |
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144 | (1) |
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145 | (1) |
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145 | (1) |
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145 | (1) |
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146 | (5) |
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146 | (1) |
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19.2 Malignant catatonia and neuroleptic malignant syndrome |
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147 | (1) |
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19.3 Other catatonic syndromes |
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148 | (1) |
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19.4 Mimics and causes of catatonia |
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148 | (3) |
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20 Agitation and bizarre behaviour |
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151 | (1) |
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21 Primary psychiatric disease |
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152 | (16) |
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152 | (3) |
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21.2 Manic psychosis (psychotic mania) |
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155 | (1) |
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21.3 Depressive psychosis (psychotic depression) |
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156 | (1) |
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21.4 Schizoaffective disorders (F25) |
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157 | (1) |
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21.5 Other affective psychoses |
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157 | (1) |
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21.6 Schizotypal disorder (F21) |
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157 | (1) |
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21.7 Persistent delusional disorder (F22) |
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158 | (1) |
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21.8 Acute and transient psychotic disorders (F23) |
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159 | (1) |
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21.9 Induced delusional disorder (F24) |
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160 | (1) |
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21.10 Obsessive-compulsive disorder (F42) |
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160 | (1) |
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21.11 Panic attacks with psychotic features |
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161 | (1) |
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21.12 Post-traumatic stress disorder (F43.1) |
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161 | (1) |
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21.13 Psychosis in the context of eating disorders (F50) |
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161 | (1) |
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21.14 Psychotic and near-psychotic phenomena in the context of personality disorder |
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161 | (2) |
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21.14.1 Paranoid personality disorder (F60.0) |
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162 | (1) |
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21.14.2 Schizoid personality disorder (F60.1) |
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162 | (1) |
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21.14.3 Emotionally unstable personality disorder, borderline type (F60.31) |
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162 | (1) |
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21.15 Chronic hallucinatory psychosis and other nonorganic psychotic disorders (F28) |
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163 | (1) |
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21.16 Unspecified nonorganic psychosis (F29) |
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163 | (1) |
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21.17 Late-onset psychosis |
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163 | (1) |
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21.18 Conditions labelled as "psychotic" historically |
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164 | (1) |
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165 | (1) |
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21.20 Normal and prodromal symptoms |
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165 | (3) |
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21.20.1 Pseudohallucinations |
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165 | (1) |
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21.20.2 Personality and predisposition to psychosis |
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165 | (1) |
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21.20.3 Stress and psychosis |
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166 | (1) |
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21.20.4 Prodromes and prediction of serious mental illness |
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166 | (2) |
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22 Factitious disorder and malingering |
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168 | (1) |
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23 Multiple simultaneous causes of psychosis, and questions of causality |
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169 | (4) |
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Section 2 A clinical approach to the diagnosis of psychosis |
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24 History and examination |
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173 | (10) |
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173 | (4) |
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24.2 Probe questions for psychotic symptoms |
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177 | (3) |
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24.3 Probe questions for depression and mania |
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180 | (2) |
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24.4 Rapid exclusion of medical emergencies presenting as psychosis |
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182 | (1) |
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25 Initial investigations relevant to psychosis |
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183 | (7) |
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25.1 Suggested initial investigations in psychosis |
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183 | (2) |
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25.2 Clues from routine and other first-line investigations |
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185 | (5) |
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26 Putting it together: clinical and paraclinical clues |
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190 | (40) |
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27 Further investigations relevant to psychosis |
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230 | (18) |
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28 Classificatory approach for psychosis of unknown aetiology |
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248 | (31) |
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28.1 Classificatory approach to psychosis of unknown aetiology, based on ICD-10 |
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249 | (3) |
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28.2 ICD-10 criteria for mood disorders |
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252 | (4) |
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28.3 ICD-10 criteria for schizophrenia |
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256 | (3) |
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28.4 ICD-10 criteria for schizotypal disorder and personality disorders associated with psychotic symptoms |
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259 | (3) |
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28.5 Classifactory approach to psychosis of unknown aetiology, based on DSM-IV-TR |
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262 | (5) |
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28.6 DSM-IV criteria for mood disorders |
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267 | (4) |
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28.7 DSM-IV criteria for schizophrenia |
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271 | (2) |
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28.8 DSM-IV criteria for personality disorders associated with psychotic symptoms |
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273 | (4) |
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28.9 Examination for catatonia |
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277 | (1) |
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28.10 Fink & Taylor criteria for catatonia |
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278 | (1) |
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279 | (2) |
Appendix A Selected conditions not known to cause psychosis |
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281 | (3) |
Appendix B Relevant changes proposed in DSM-V |
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284 | (5) |
References |
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289 | (73) |
Index |
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362 | |