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El. knyga: Dimethyl Sulfoxide (DMSO) in Trauma and Disease

(Professor of Psychology (Adjunct), University of Texas, Austin), (Gerlinger Professor, Department of Surgery, Oregon Health Sciences University, Portland, Oregon)
  • Formatas: 270 pages
  • Išleidimo metai: 07-Apr-2015
  • Leidėjas: CRC Press Inc
  • Kalba: eng
  • ISBN-13: 9781040071410
Kitos knygos pagal šią temą:
  • Formatas: 270 pages
  • Išleidimo metai: 07-Apr-2015
  • Leidėjas: CRC Press Inc
  • Kalba: eng
  • ISBN-13: 9781040071410
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First isolated as a chemical compound by a Russian chemist in 1866, dimethyl sulfoxide (DMSO) proved to be a near-perfect solvent for decades before its remarkable biological and medical activities were discovered. DMSO is one of the most prodigious agents ever to come out of the world of drug development. Its wide range of biological actions involving plants, animals, and humans has led to the publication of tens of thousands of articles in the scientific literature.Dimethyl Sulfoxide (DMSO) in Trauma and Disease examines the major clinical uses of DMSO in humans as supported by basic evidence derived from experiments in animals, including its effects in disorders such as osteoarthritis, interstitial cystitis, gastrointestinal inflammatory changes, scleroderma, respiratory distress, myasthenia gravis, cardiac disease, traumatic brain injury, and Alzheimer’s disease.The effects of DMSO on pain, cancer, stroke, and spinal cord injury are also discussed. The book explores how its chemical structure is able to react and deactivate toxic molecules generated by DNA damage, free radical formation, inflammation, oxidation, and infection. For the first time, the collective data on the biological, chemical, and medical actions of DMSO are presented and analyzed from the published scientific literature.Clearly written, the book incorporates easy-to-understand scientific descriptions that appeal both to health care professionals and the millions of people worldwide who have used DMSO for an assortment of ailments as a prescriptive or off-label medication.
Foreword ix
Authors xi
Introduction xiii
Chapter 1 Chemistry of DMSO
1(14)
Chemical Structure and Properties of DMSO
1(2)
DMSO Solvation and Chemical Activity
3(1)
Protein Folding
4(1)
Permeability Enhancement
4(1)
DMSO as a Chemical Chaperone
5(3)
DMSO as an Electrolyte
8(1)
Cryoprotection
9(1)
DMSO in the Sea and the Atmosphere
10(1)
References
11(4)
Chapter 2 DMSO in Basic Pharmacology
15(34)
Absorption, Fate, and Excretion of DMSO
15(1)
Penetration
16(1)
Chemical Chaperones
16(1)
DMSO as a Pain Medication
17(4)
Anti-Inflammatory
21(1)
Prostaglandins
21(3)
Cardiac Disease
24(4)
Ulcerative Colitis
28(1)
Skin Penetrant
29(1)
Wound Healing
29(1)
Burns and Scar Tissue
30(2)
Respiratory Stimulation
32(1)
Acute Respiratory Distress Syndrome
33(1)
Experimental Blunt Chest Trauma
34(1)
Autophagy
35(1)
Diuresis
36(1)
Cholinesterase Inhibition
36(1)
Solvent Action
37(1)
Veterinary Uses
37(1)
Teratology and LD50
38(1)
Ocular Effects
39(1)
Intrawound Administration of DMSO
40(1)
References
40(9)
Chapter 3 DMSO Clinical Pharmacology
49(32)
DMSO in Disease
49(1)
Pain
50(9)
Interstitial Cystitis
59(2)
Gastrointestinal Disorders
61(1)
Autoimmune Disorders
61(1)
Respiration
62(1)
Amyloidosis and Scleroderma
62(1)
Thromboembolic Events
63(3)
Platelet Deaggregation and Free Radical Scavenging
66(2)
Tissue Factor and Inflammation
68(2)
Clinical Toxicology
70(1)
References
71(10)
Chapter 4 DMSO in Genetics
81(18)
Protection from Ionizing Radiation
81(2)
DMSO Protection of Single- and Double-Stranded DNA Breaks
83(5)
DMSO in Cellular Differentiation
88(4)
Cancer Stem Cells and Differentiation
92(1)
References
93(6)
Chapter 5 DMSO in Basic Microbiology
99(16)
DMSO in Bacterial Infections
99(1)
Era of Antimicrobials
99(2)
DMSO and Pathogens
101(7)
DMSO in Viral and Fungal Pathology
108(3)
References
111(4)
Chapter 6 DMSO in Clinical Microbiology
115(8)
How Bacteria Achieve Antibiotic Resistance
115(1)
DMSO in Multidrug-Resistant Tuberculosis
116(5)
References
121(2)
Chapter 7 DMSO in Malignancy
123(10)
DMSO and Neoplasia
123(1)
Friend Leukemia Cells
123(1)
HL-60 Human Cell Line
124(1)
Metastatic Liver Disease
125(1)
DMSO Combined with Anticancer Agents
126(1)
DMSO in Extravasation
127(1)
Cancer and Radiation
127(1)
Onyx Embolization
128(1)
References
129(4)
Chapter 8 DMSO in Basic Neuroprotection
133(70)
Brain Trauma Overview
133(2)
Secondary Injury and Ischemic Penumbral Neurons
135(2)
DMSO in Experimental Brain Trauma
137(7)
Free Radicals in Brain Injury
144(2)
Cerebral Hemodynamic Function in Brain Injury
146(2)
Prostaglandins
148(3)
Tissue Factor
151(2)
Cerebral Blood Flow
153(1)
Concussions
154(3)
DMSO in Brain Concussion
157(1)
DMSO Combined with a Glycolytic Intermediate
157(3)
DMSO in Experimental Brain Ischemia
160(3)
Ethical Considerations for Using Nonhuman Primates in CNS Injuries
163(1)
Role of DMSO in Experimental Stroke
164(8)
DMSO in Missile Injury to the Brain
172(4)
DMSO Compared to Mannitol in Missile Injury
176(1)
DMSO in Aging Research
176(2)
DMSO in Experimental Dementia
178(4)
DMSO in Experimental Spinal Cord Injury
182(5)
DMSO as a Solvent
187(1)
References
188(15)
Chapter 9 DMSO in Clinical Neuroprotection
203(38)
Overview of Clinical Traumatic Brain Injury
203(4)
Head Injury in Children
207(1)
Cost and Consequences of Traumatic Brain Injury
207(1)
Chronic Traumatic Encephalopathy
208(1)
Treating Traumatic Brain Injury
209(2)
DMSO in Traumatic Brain Injury
211(3)
Optimal DMSO Dose for Traumatic Brain Injury
214(2)
Comparing DMSO Doses, Duration of Treatment, and Use as a First- or Second-Line Treatment for Traumatic Brain Injury
216(5)
DMSO in Intracranial Aneurysm Hemorrhage
221(3)
DMSO Compared to Progesterone for Traumatic Brain Injury
224(3)
DMSO + Fructose-1,6-Disphosphate (FDP) for Ischemic Stroke
227(4)
References
231(10)
Index 241
Stanley W. Jacob was a professor emeritus of surgery at the Oregon Health Sciences University in Portland. He received his MD from Ohio State University and completed his surgical training at Beth Israel Hospital in Boston. He was a chief resident in surgery at Harvard Surgical Services and an instructor in surgery at Harvard School of Medicine before he was appointed to the faculty at Oregon Health Sciences University. Dr. Jacob discovered the medicinal properties of dimethyl sulfoxide (DMSO). This discovery led to more than 20,000 publications in such areas as pain, inflammation, scleroderma, interstitial cystitis, arthritis, resistant tuberculosis, cancer, cryobiology, free radicals, stroke, and neuroprotection. Dr. Jacob received many honors during his career and also authored a dozen medical textbooks and more than 170 peer-reviewed articles.



Jack C. de la Torre is an adjunct professor of psychology at the University of Texas in Austin. He began his work on dimethyl sulfoxide (DMSO) in the early 1970s shortly after his appointment as assistant professor in neurosurgery at the University of Chicago. Dr. de la Torres research revealed DMSOs ability to quickly reduce intracranial pressure, restore cerebral blood flow, and stabilize respiration in nonhuman primates sustaining lethal traumatic brain injuries. For the next eight years, he extended his brain trauma findings and showed that intravenous administration of DMSO was effective in treating primary and secondary damage following experimental ischemic stroke and spinal cord trauma. Dr. de la Torre has published more than 180 peer-reviewed research articles and written or edited a dozen medical texts on pathology, neurotransmitters, and Alzheimers disease.