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El. knyga: Discovery and Development of Anti-inflammatory Agents from Natural Products

Edited by (Goutam Brahmachari, PhDFull Professor, Organic Chemistry, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan, West Bengal, India)
  • Formatas: EPUB+DRM
  • Serija: Natural Product Drug Discovery
  • Išleidimo metai: 11-Jul-2019
  • Leidėjas: Elsevier Science Publishing Co Inc
  • Kalba: eng
  • ISBN-13: 9780128169933
Kitos knygos pagal šią temą:
Discovery and Development of Anti-inflammatory Agents from Natural ProductsDidesnis paveikslėlis
  • Formatas: EPUB+DRM
  • Serija: Natural Product Drug Discovery
  • Išleidimo metai: 11-Jul-2019
  • Leidėjas: Elsevier Science Publishing Co Inc
  • Kalba: eng
  • ISBN-13: 9780128169933
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Discovery and Development of Anti-Inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products.

Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases.

  • Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations
  • Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases
  • Offers an authoritative source of information on the industrial application of natural products for medicinal purposes
Contributors xiii
Editor Biography xv
Foreword xix
Preface xxi
1 Discovery and development of anti-inflammatory agents from natural products: an overview
1(6)
Goutam Brahmachari
1 Introduction
1(1)
2 Overview of the book
2(1)
2.1
Chapter 2
2(1)
2.2
Chapter 3
3(1)
2.3
Chapter 4
3(1)
2.4
Chapter 5
4(1)
2.5
Chapter 6
4(1)
2.6
Chapter 7
4(1)
2.7
Chapter 8
5(1)
2.8
Chapter 9
5(1)
2.9
Chapter 10
5(1)
3 Concluding remarks
6(1)
2 Curcumin: current evidence of its therapeutic potential as a lead candidate for anti-inflammatory drugs---an overview
7(25)
Carlos Fernandez-Moriano
Elena Gonzaez-Burgos
M. Pilar Gomez-Serranillos
1 Introduction: general features and ethnopharmacological relevance
7(3)
2 Isolation, chemical biosynthesis, and characterization of curcumin
10(3)
3 Pharmacokinetics of curcumin
13(3)
4 Pharmacodynamics in inflammatory processes
16(2)
5 Semisynthesis of novel molecules from curcumin
18(4)
6 Preclinical studies: in vitro and animal research on the anti-inflammatory properties of curcumin and its derivatives
22(10)
6.1 Edema and global inflammation
22(5)
6.2 Arthritic diseases
27(1)
6.3 Gastrointestinal diseases
27(1)
6.4 Pancreatitis
28(1)
6.5 Allergy and bronchial asthma
29(1)
6.6 Cystic fibrosis
30(1)
6.7 Psoriasis
31(1)
6.8 Neurodegenerative diseases and cancer
31(1)
7 Clinical evidence of curcumin's anti-inflammatory benefits
32(29)
7.1 Arthritic diseases
38(1)
7.2 Inflammatory diseases of gastrointestinal tract
39(1)
7.3 Pancreatitis
40(1)
7.4 Allergy and inflammatory diseases of respiratory tract
41(1)
7.5 Psoriasis
42(1)
7.6 Ocular conditions
43(1)
7.7 Neurodegenerative diseases and cancer
44(2)
7.8 Other conditions
46(1)
8 Curcumin as an anti-inflammatory drug: the reality and limitations
47(1)
9 Concluding remarks
48(1)
List of abbreviations
49(2)
References
51(10)
3 Anti-inflammatory efficacy of some potentially bioactive natural products against rheumatoid arthritis
61(40)
Sushweta Mahalanobish
Sukanya Saha
Sayanta Dutta
Shatadal Ghosh
Parames C. Sil
1 Introduction
61(1)
2 Etiology of disease progression
62(3)
2.1 Genetic susceptibilities
62(1)
2.2 Autoimmunity and role of proinflammatory cytokines
63(2)
3 Current pharmacological treatments of rheumatoid arthritis and their drawbacks
65(5)
3.1 Nonsteroidal anti-inflammatory drugs
65(1)
3.2 Glucocorticoids
66(1)
3.3 Disease-modifying antirheumatic drugs
66(2)
3.4 Biological agents
68(2)
4 Protective role of naturally occurring anti-inflammatory compounds
70(15)
4.1 Phenolic compounds
70(13)
4.2 Terpenoid compounds
83(1)
4.3 Alkaloid compounds
84(1)
5 Concluding remarks: challenges and future prospects
85(3)
List of abbreviations
88(1)
References
89(12)
4 Natural anti-inflammatory agents for the management of osteoarthritis
101(40)
Saleha Rehman
Bushra Nabi
Sanjula Baboota
Javed Ali
1 Introduction
101(2)
2 Current treatments and their disadvantages
103(1)
2.1 Nonpharmacological therapy
103(1)
2.2 Pharmacological therapy
103(1)
3 Significance of natural products in the management of osteoarthritis
104(1)
4 Natural anti-inflammatory agents for management of osteoarthritis
105(19)
4.1 Boswellia serrata
105(2)
4.2 Harpagophytum procumbens
107(4)
4.3 Glycosaminoglycans
111(6)
4.4 Flavocoxid
117(4)
4.5 Resveratrol
121(3)
4.6 Other agents
124(1)
5 Concluding remarks
124(4)
List of abbreviations
128(1)
Acknowledgements
128(1)
References
128(13)
5 Portrait of the synthesis of some potent anti-inflammatory natural products
141(44)
Muhammad Faisal
Aamer Saeed
Danish Shahzad
1 Introduction
141(1)
2 Total synthetic approaches for some anti-inflammatory natural products
142(33)
2.1 Parthenolide
142(1)
2.2 C-7 epimer of parthenolide
143(2)
2.3 1,8-Cineole and 1,4-cineole
145(2)
2.4 Botryosphaeridione
147(2)
2.5 Cucurbitaceae
149(4)
2.6 Astaxanthin
153(4)
2.7 Pseudopterosins
157(3)
2.8 Fuscosides
160(3)
2.9 Flavonoids
163(3)
2.10 Manoalide
166(4)
2.11 Saponins
170(5)
3 Concluding remarks
175(2)
List of Abbreviations
177(1)
References
178(5)
Further reading
183(2)
6 Recent developments in the anti-inflammatory potential of sesquiterpene lactones and their semisynthetic analogs
185(22)
Devdutt Chaturvedi
1 Introduction
185(2)
2 Anti-inflammatory activity of sesquiterpene lactones
187(12)
2.1 Costunolide
187(3)
2.2 Parthenolide
190(2)
2.3 Helenalin
192(1)
2.4 Miscellaneous guaianolides
192(1)
2.5 Miscellaneous germacranolides
193(2)
2.6 Eudesmanes
195(1)
2.7 Budlein
195(1)
2.8 Frullanolides
196(1)
2.9 Miscellaneous sesquiterpene lactones
197(2)
3 Structure---activity relationships (SAR) of sesquiterpenes lactones
199(1)
4 Concluding remarks
200(1)
List of abbreviations
200(1)
Acknowledgments
200(1)
References
201(6)
7 Hesperetin and naringenin: protective effects against metabolic syndrome---associated inflammation
207(34)
Vania Mayumi Nakajima
Amanda Roggia Ruviaro
Paula de Paula Menezes Barbosa
Isadora Ferreira da Silva
Amanda Rejane Alves de Avila
1 Introduction
207(3)
1.1 Obesity and metabolic syndrome
207(1)
1.2 Inflammatory pathways in metabolic syndrome
208(1)
1.3 Drugs effects in metabolic syndrome---associated inflammation
209(1)
2 Hesperetin and naringenin: effects on metabolic syndrome---associated inflammation
210(4)
2.1 Hesperetin
211(1)
2.2 Naringenin
212(2)
3 Flavanone chemistry, structure---activity relation, and natural sources
214(5)
3.1 Flavanone chemistry
214(1)
3.2 Structure---activity relations
215(1)
3.3 Natural sources of naringenin and hesperetin
216(3)
4 Fermentative and enzymatic biotransformation for hesperetin and naringenin
219(6)
4.1 Enzymatic biotransformation
219(5)
4.2 Microbial biotransformation
224(1)
5 Flavanone purification and identification
225(5)
5.1 Flavanone extraction
225(3)
5.2 Flavanone purification
228(1)
5.3 Flavanone identification
229(1)
6 Concluding remarks
230(1)
List of abbreviations
231(1)
References
232(9)
8 Therapeutic implications of anti-inflammatory natural products in Alzheimer's disease
241(18)
Satarupa Deb
Muhammed Khairujjaman Mazumder
Ankumoni Dutta
Banashree Chetia Phukan
Pallab Bhattacharya
Rajib Paul
Anupom Borah
1 Introduction
241(1)
2 Neuroinflammation in Alzheimer's disease
242(1)
3 Implementation of anti-inflammatory natural products in Alzheimer's disease
243(7)
3.1 Curcumin
243(2)
3.2 Apigenin
245(1)
3.3 Resveratrol
245(1)
3.4 Cannabinoids
246(1)
3.5 Lipoic acid
246(1)
3.6 Omega-3 fatty acids
247(1)
3.7 Epigallocatechin-3-gallate
247(1)
3.8 Diosgenin
248(1)
3.9 Prosapogenin III
248(1)
3.10 Quercetin
248(1)
3.11 Rosmarinic acid
249(1)
3.12 6-Shogaol
249(1)
3.13 Huperzine A
250(1)
4 Concluding remarks
250(1)
List of Abbreviations
251(1)
References
252(7)
9 Anti-inflammatory effects of probiotics
259(24)
Maria Rosa Machado Prado
Christian Boller
1 Introduction
259(1)
2 Historical aspects
260(1)
3 Probiotic strains
260(5)
3.1 Genus Lactobacillus
261(1)
3.2 Genus Bifidobacterium
262(1)
3.3 Other microorganisms
263(1)
3.4 Safety
263(2)
4 Mechanisms of action
265(4)
4.1 Cell-to-cell interaction
266(1)
4.2 Antimicrobial activity
267(1)
4.3 Immunomodulatory activity
268(1)
5 Therapeutic use of probiotics
269(5)
5.1 Gastrointestinal diseases
269(2)
5.2 Respiratory diseases
271(2)
5.3 Allergies and dermatitis
273(1)
5.4 Cancer
273(1)
6 Concluding remarks
274(1)
List of Abbreviations
275(1)
References
275(7)
Further reading
282(1)
10 6-Gingerol: a therapeutically potent lead candidate in anti-inflammatory drug discovery
283(14)
Goutam Brahmachari
1 Introduction
283(1)
2 Biosynthesis of 6-gingerol
283(3)
3 Anti-inflammatory potential of 6-gingerol
286(4)
4 Pharmacokinetics of 6-gingerol
290(1)
5 Safety of 6-gingerol
291(1)
6 Concluding remarks
291(1)
References
291(6)
Index 297
Born on April 14, 1969 in Barala, a village in the district of Murshidabad (West Bengal, India), Goutam Brahmachari had his early education in his native place. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher Secondary Education (WBCHSE). Then, he moved to Visva-Bharati (a Central University founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, he completed his masters in 1992, specializing in organic chemistry. After receiving his Ph.D. 1997 in chemistry from the same university, he joined his alma mater the next year and has been a full professor of chemistry since 2011. The research interests of Prof. Brahmacharis group include synthetic organic chemistry, green chemistry, natural products chemistry, and the medicinal chemistry of natural and natural product-inspired synthetic molecules. With more than 25 years of experience in teaching and research, he has produced over 260 scientific publications, including original research papers, review articles, books, and invited book chapters in the field of natural products and green chemistry. He has already authored/edited 27 books published by internationally reputed major publishing houses, namely, Elsevier Science (The Netherlands), Academic Press (Oxford), Wiley-VCH (Germany), Alpha Science International (Oxford), De Gruyter (Germany), World Scientific (Singapore), CRC Press (Taylor & Francis Group, USA), Royal Society of Chemistry (Cambridge), etc. Prof. Brahmachari serves several scientific bodies in India and abroad, and also many international journals as an editorial member. He has also been serving as co-editor-in-chief for Current Green Chemistry. Prof. Brahmachari is the founder series editor of the Elsevier Book Series Natural Product Drug Discovery. Prof. Brahmachari is an elected fellow of the Royal Society of Chemistry and a recipient of the CRSI (Chemical Research Society of India) Bronze Medal-2021 (for his contribution to research in chemistry), Dr Basudev Banerjee Memorial Award-2021 (for his contribution to the field of chemical sciences) from the Indian Chemical Society, INSA (Indian National Science Academy) Teachers Award-2019, Dr Kalam Best Teaching Faculty Award-2017, and Academic Brilliance Award, 2015 (Excellence in Research). Prof. Brahmachari was featured in the World Ranking of the Top 2% Scientists (Organic Chemistry Category) in 2020-23, the AD Scientific World Ranking of Scientists in 2022-2024, and as the Scholar GPS Highly Ranked Scholar-2024 (Lifetime, securing a position in the top 0.05% of all scholars worldwide).
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