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El. knyga: Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

Edited by (Goutam Brahmachari, PhDFull Professor, Organic Chemistry, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan, West Bengal, India)
  • Formatas: PDF+DRM
  • Serija: Natural Product Drug Discovery
  • Išleidimo metai: 15-Apr-2019
  • Leidėjas: Elsevier Science Publishing Co Inc
  • Kalba: eng
  • ISBN-13: 9780128157244
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Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical DiseasesDidesnis paveikslėlis
  • Formatas: PDF+DRM
  • Serija: Natural Product Drug Discovery
  • Išleidimo metai: 15-Apr-2019
  • Leidėjas: Elsevier Science Publishing Co Inc
  • Kalba: eng
  • ISBN-13: 9780128157244
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Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more.

In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases.

  • Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery
  • Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases
  • Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases
List of Contributors
xiii
Editor Biography xvii
Foreword xxi
Preface xxiii
1 Therapeutics from natural products against neglected tropical diseases: an overview
1(6)
Goutam Brahmachari
1.1 Introduction
1(1)
1.2 An overview of the book
2(4)
1.3 Concluding remarks
6(1)
2 Marine natural products as strategic prototypes in the development of a new generation of antimalarial agents
7(42)
Jean Fotie
2.1 Introduction
7(2)
2.2 Antimalarial marine natural products
9(25)
2.2.1 Phenolic compounds and polyketides
9(5)
2.2.2 Terpenoids
14(2)
2.2.3 Endoperoxides and polyethers
16(8)
2.2.4 Alkaloids
24(7)
2.2.5 Peptides and depsipeptides
31(2)
2.2.6 Phosphotriesters
33(1)
2.3 Concluding remarks
34(1)
List of abbreviations
35(1)
References
36(11)
Further reading
47(2)
3 Sesquiterpene lactones: a versatile class of structurally diverse natural products and their semisynthetic analogs as potential antimalarials
49(38)
Devdutt Chaturvedi
3.1 Introduction
49(2)
3.2 Antimalarial potential of plant derived sesquiterpene lactones
51(28)
3.2.1 Artemisinin and its C-12 oxa (ether/ester) derivatives
51(21)
3.2.2 Germacranolides, guaianolides, and pseudoguiainolides antimalarials SLs
72(6)
3.2.3 Miscellaneous antimalarial sesquiterpene lactones
78(1)
3.3 Structural---activity relationships of sesquiterpene lactones
79(1)
3.4 Concluding remarks
79(1)
Acknowledgments
80(1)
List of abbreviations
80(1)
References
81(6)
4 Natural and synthetic quinoline molecules against tropical parasitic pathologies: an analysis of activity and structural evolution for developing new quinoline-based antiprotozoal agents
87(78)
Vladimir V. Kouznetsov
Carlos M. Melendez Gomez
Jose Luis Valencia Pena
Leonor Y. Vargas-Mendez
4.1 Introduction
88(1)
4.2 Leishmaniasis, Chagas disease, and African sleeping sickness as protozoan neglected tropical diseases and quinoline-based molecules: background
89(4)
4.2.1 Leishmaniasis
90(2)
4.2.2 Chagas disease
92(1)
4.2.3 Human African trypanosomiasis
93(1)
4.3 Current chemotherapy and drugs on clinical trials
93(2)
4.4 Recent phytoresearch on alkaloid extracts from plants and marine organisms for drug development against NTDs
95(4)
4.5 Quinolines: functional and structural diversity
99(2)
4.6 Natural sources of quinoline alkaloids with antiparasitic activity
101(4)
4.7 Synthetic efforts for targeted quinoline compounds
105(22)
4.7.1 Synthesis of polyfunctionalized quinolines from unsubstituted anilines: Route A
106(13)
4.7.2 Synthesis of polyfunctionalized quinolines from ortho-substituted anilines: Route B
119(8)
4.8 Quinoline compounds as antitrypanosomal agents
127(21)
4.8.1 Simple polyfunctionalized quinolines
127(15)
4.8.2 Polycyclic quinoline molecules
142(6)
4.9 Concluding remarks
148(1)
Acknowledgment
148(1)
List of abbreviations
149(1)
References
150(14)
Further reading
164(1)
5 Promising trypanocidal heterocyclic compounds of natural origin and their synthetic analogs
165(54)
Edeildo F. da Silva-Junior
Tanja Schirmeister
Joao X. de Araujo-Junior
5.1 Introduction
166(2)
5.2 Trypanosomiasis: Chagas disease and African sleeping sickness
168(4)
5.2.1 Chagas disease
168(2)
5.2.2 Human African trypanosomiasis or sleeping sickness
170(2)
5.3 Promising heterocyclic compounds from natural resources
172(22)
5.3.1 Amaranthaceae family
172(1)
5.3.2 Amaryllidaceae family
173(1)
5.3.3 Annonaceae family
174(1)
5.3.4 Asteraceae family
175(4)
5.3.5 Bignoniaceae family
179(1)
5.3.6 Bufonidae family
180(1)
5.3.7 Compositae family
181(1)
5.3.8 Didemnidae family
181(1)
5.3.9 Fabaceae family
182(1)
5.3.10 Malvaceae family
183(1)
5.3.11 Menispermaceae family
184(1)
5.3.12 Piperaceae family
184(1)
5.3.13 Podospongiidae family
184(2)
5.3.14 Ranunculaceae family
186(1)
5.3.15 Rhamnaceae family
187(1)
5.3.16 Rubiaceae family
187(3)
5.3.17 Rutaceae family
190(2)
5.3.18 Sapindaceae family
192(1)
5.3.19 Vesiculariidae family
193(1)
5.3.20 Zygophyllaceae family
193(1)
5.4 Synthesis of promising active compounds inspired by nature
194(25)
5.4.1 Almiramide analogs
194(3)
5.4.2 β-Carboline analogs
197(1)
5.4.3 Crassiflorone analogs
197(2)
5.4.4 Guanidine analogs
199(1)
5.4.5 Lycorine analogs
199(2)
5.4.6 Epoxy-α-acyloxycarboxamide analogs
201(2)
5.4.7 Cinchona alkaloids and bile acid hybrids
203(1)
5.4.8 Bistacrine analogs
203(2)
5.4.9 Isoxazole analogs
205(14)
5.5 Concluding remarks 206(1)
5.6 List of abbreviations 206(1)
Acnowledgments 207(1)
References 207(206)
6 Oxidative stress in schistosomiasis, echinococcosis, and trypanosomiasis: a therapeutic approach
219(22)
Sumit Ghosh
Abhishek Kumar Das
Poulami Sarkar
Parames C. Sil
6.1 Introduction
219(2)
6.2 Life cycles of echinococcosis, trypanosomiasis, and schistosomiasis
221(2)
6.2.1 Echinococcosis
221(1)
6.2.2 Trypanosomiasis and Chagas disease
221(2)
6.2.3 Schistosomiasis
223(1)
6.3 Role of oxidative stress in the pathogenesis of schistosomiasis, echinococcosis, and trypanosomiasis
223(1)
6.4 Oxidative stress associated therapeutic strategies
224(9)
6.4.1 Chagas disease and trypanosomiasis
224(4)
6.4.2 Echinoccosis
228(2)
6.4.3 Schistosomiasis
230(3)
6.5 Concluding remarks
233(1)
List of abbreviations
234(1)
References
235(6)
7 Plant-derived compounds against protozoan neglected diseases: toward sustainable drug development
241(52)
Nimisha Sarah Mathew
Pradeep Singh Negi
7.1 Introduction
241(3)
7.1.1 Protozoan neglected diseases
243(1)
7.1.2 Current treatment approaches and limitations
244(1)
7.2 Natural products as therapeutic agents against protozoan diseases
244(4)
7.2.1 Plant-derived secondary metabolites as antiprotozoal leads and drugs
245(1)
7.2.2 Isolation and extraction of plant-derived antiprotozoal agents
245(3)
7.3 Human African trypanosomiasis
248(17)
7.3.1 Etiology of the disease
248(3)
7.3.2 Antitrypanosomal drugs and associated challenges
251(1)
7.3.3 Plant-derived antihuman trypanosomal products
252(13)
7.4 Chagas disease
265(7)
7.4.1 Etiology of the disease
265(1)
7.4.2 Antichagasic drugs and associated challenges
265(1)
7.4.3 Plant-derived antichagasic products
266(6)
7.5 Leishmaniasis
272(10)
7.5.1 Etiology of the disease
272(1)
7.5.2 Antileishmanial drugs and associated challenges
273(1)
7.5.3 Plant-derived antileishmanial products
274(8)
7.6 Concluding remarks
282(1)
List of abbreviations
282(1)
References
283(9)
Further reading
292(1)
8 Leishmaniasis control: limitations of current drugs and prospects of natural products
293(58)
Neeraj Tiwari
Arun Kumar
Ashish K. Singh
Surabhi Bajpai
Anand K. Agrahari
Dhiraj Kishore
Vinod K. Tiwari
Rakesh K. Singh
8.1 Introduction
293(2)
8.2 Leishmaniasis: etiology and epidemiology
295(3)
8.3 Parasites' survival mechanisms and possible drug targets
298(3)
8.4 Current therapeutic options and their limitations
301(4)
8.4.1 Pentavalent antimonials
301(2)
8.4.2 Miltefosine
303(1)
8.4.3 Pentamidine and paromomycin
303(1)
8.4.4 Amphotericin B and its lipid formulation, AmBisome
304(1)
8.5 Prospects of natural products in antileishmanial drug discovery
305(27)
8.5.1 Alkaloids
306(8)
8.5.2 Terpenoids
314(8)
8.5.3 Sterols
322(1)
8.5.4 Phenolics
322(8)
8.5.5 Iridoids
330(1)
8.5.6 Quinones
331(1)
8.6 Therapeutic role of natural products in combating multidrug resistance
332(2)
8.7 Concluding remarks
334(1)
List of abbreviations
335(1)
References
335(16)
9 Natural antileprotic agents: a boon for the management of leprosy
351(22)
Bushra Nabi
Saleha Rehman
Sanjula Baboota
Javed Ali
9.1 Introduction
351(1)
9.2 Current available treatments and their associated disadvantages
352(1)
9.3 Role of natural agents in the treatment of leprosy
353(1)
9.4 Plant-derived antileprotic agents
354(8)
9.4.1 Centella asiatica
354(2)
9.4.2 Chaulmoogra oil
356(1)
9.4.3 Abutilon indicum
357(1)
9.4.4 Azadirachta indica
358(1)
9.4.5 Bauhinia variegata
359(1)
9.4.6 Hemidesmus indicus
360(1)
9.4.7 Butea monosperma
360(1)
9.4.8 Lanata camara
361(1)
9.4.9 Calotropis procera
361(1)
9.5 Animal/microbe-derived antileprotic agents
362(2)
9.5.1 Fusidic acid
362(1)
9.5.2 Globefish
363(1)
9.6 Patents associated with herbal agents in leprosy
364(1)
9.7 Concluding remarks
364(5)
List of abbreviations
369(1)
References
369(4)
10 Aloe vera: a promising hope against Buruli ulcer
373(12)
Goutam Brahmachari
10.1 Introduction
373(2)
10.2 Aloe vera: a promising hope against Buruli ulcer
375(3)
10.2.1 The plant
375(1)
10.2.2 Active principles
376(1)
10.2.3 Studies with Aloe vera against Buruli ulcer
376(2)
10.3 Future hopes and concluding remarks
378(1)
References
379(6)
11 Plant and marine products: a promising hope in the search of therapeutics against dengue
385(22)
Nivedita Jena
Chandralata Bal
Ashoke Sharon
11.1 Introduction
385(1)
11.1.1 Dengue: a pandemic concern
386(1)
11.2 Transmission and potential strategies for inhibition of dengue
386(3)
11.3 Clinical molecules and therapies
389(1)
11.4 Natural product-based antidengue research
389(10)
11.4.1 Plant-derived compounds with antidengue potential
391(6)
11.4.2 Marine natural products for the treatment of dengue
397(2)
11.5 Concluding remarks
399(2)
List of abbreviations
401(1)
References
401(6)
12 Total synthetic approaches for lucidone: a promising natural lead candidate against dengue infection
407(6)
Goutam Brahmachari
12.1 Introduction
407(1)
12.2 The molecule
408(1)
12.2.1 Lucidone
408(1)
12.2.2 Spectral properties of lucidone
409(1)
12.3 Total synthetic approaches for lucidone
409(2)
12.4 Concluding remarks
411(1)
References
411(2)
Index 413
Born on April 14, 1969 in Barala, a village in the district of Murshidabad (West Bengal, India), Goutam Brahmachari had his early education in his native place. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher Secondary Education (WBCHSE). Then, he moved to Visva-Bharati (a Central University founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, he completed his masters in 1992, specializing in organic chemistry. After receiving his Ph.D. 1997 in chemistry from the same university, he joined his alma mater the next year and has been a full professor of chemistry since 2011. The research interests of Prof. Brahmacharis group include synthetic organic chemistry, green chemistry, natural products chemistry, and the medicinal chemistry of natural and natural product-inspired synthetic molecules. With more than 25 years of experience in teaching and research, he has produced over 260 scientific publications, including original research papers, review articles, books, and invited book chapters in the field of natural products and green chemistry. He has already authored/edited 27 books published by internationally reputed major publishing houses, namely, Elsevier Science (The Netherlands), Academic Press (Oxford), Wiley-VCH (Germany), Alpha Science International (Oxford), De Gruyter (Germany), World Scientific (Singapore), CRC Press (Taylor & Francis Group, USA), Royal Society of Chemistry (Cambridge), etc. Prof. Brahmachari serves several scientific bodies in India and abroad, and also many international journals as an editorial member. He has also been serving as co-editor-in-chief for Current Green Chemistry. Prof. Brahmachari is the founder series editor of the Elsevier Book Series Natural Product Drug Discovery. Prof. Brahmachari is an elected fellow of the Royal Society of Chemistry and a recipient of the CRSI (Chemical Research Society of India) Bronze Medal-2021 (for his contribution to research in chemistry), Dr Basudev Banerjee Memorial Award-2021 (for his contribution to the field of chemical sciences) from the Indian Chemical Society, INSA (Indian National Science Academy) Teachers Award-2019, Dr Kalam Best Teaching Faculty Award-2017, and Academic Brilliance Award, 2015 (Excellence in Research). Prof. Brahmachari was featured in the World Ranking of the Top 2% Scientists (Organic Chemistry Category) in 2020-23, the AD Scientific World Ranking of Scientists in 2022-2024, and as the Scholar GPS Highly Ranked Scholar-2024 (Lifetime, securing a position in the top 0.05% of all scholars worldwide).
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