Atnaujinkite slapukų nuostatas

Drug Safety Evaluation: Methods and Protocols Softcover reprint of the original 2nd ed. 2017 [Minkštas viršelis]

Edited by
  • Formatas: Paperback / softback, 427 pages, aukštis x plotis: 254x178 mm, weight: 832 g, 28 Illustrations, color; 30 Illustrations, black and white; XI, 427 p. 58 illus., 28 illus. in color., 1 Paperback / softback
  • Serija: Methods in Molecular Biology 1641
  • Išleidimo metai: 08-Aug-2018
  • Leidėjas: Humana Press Inc.
  • ISBN-10: 1493984063
  • ISBN-13: 9781493984060
Kitos knygos pagal šią temą:
Drug Safety Evaluation: Methods and Protocols Softcover reprint of the original 2nd ed. 2017Didesnis paveikslėlis
  • Formatas: Paperback / softback, 427 pages, aukštis x plotis: 254x178 mm, weight: 832 g, 28 Illustrations, color; 30 Illustrations, black and white; XI, 427 p. 58 illus., 28 illus. in color., 1 Paperback / softback
  • Serija: Methods in Molecular Biology 1641
  • Išleidimo metai: 08-Aug-2018
  • Leidėjas: Humana Press Inc.
  • ISBN-10: 1493984063
  • ISBN-13: 9781493984060
Kitos knygos pagal šią temą:
Pastovi nuoroda: https://www.kriso.lt/db/9781493984060.html

This second edition provides up-to-date chapters and new chapters focusing on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls.

Authoritative and practical, Drug Safety Evaluation: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Nonclinical Development of Combination Drugs.- Juvenile Non-Clinical
Safety Studies in Support of Pediatric Drug Development.- Procedures of
Necropsy and Tissue Sampling.- Tissue Sampling and Processing for
Histopathology Evaluation.- Principles and Methods of Immunohistochemistry.-
Applications of Mass Spectrometry Imaging for Safety Evaluation.- In vivo rat
T-lymphocyte Pig-a assay: detection and expansion of cells deficient in the
GPI-anchored CD48 surface marker for analysis of mutation in the endogenous
Pig-a gene.- Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone
Marrow Erythroids.- The Use of Bacterial Repair Endonucleases in the Comet
Assay.- Automated Patch-Clamp methods for the hERG Cardiac Potassium
Channel.- Impedance Measurement in Induced Pluripotent Stem Cell Derived 
Cardiomyocytes.- Target Safety Assessment: Strategies and Resources.- NMR and
MS Methods for Metabolomics.- Protocols and Applications of Cellular
Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon
13 NMR.- Statistical Analysis of Quantitative RT-PCR Results.- Evaluation of
Mitochondrial Respiration in Cultured Rat Hepatocytes.- FETAX Assay for
Evaluation of Developmental Toxicity.- Evaluation of Embryotoxicity Using the
Zebrafish Model.- Absolute Quantification of Toxicological Biomarkers via
Mass Spectrometry.- Next-Generation Sequencing to investigate urinary
microRNAs from Macaca fascicularis (Cynomolgus Monkey).- Quantitative RT-PCR
for MicroRNAs in Biofluids.- Chromogenic In Situ Hybridization Methods for
microRNA Biomarker Monitoring of Drug Safety and Efficacy.- Urine Exosome
Isolation and Characterization.