| Foreword |
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vii | |
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| Contributors |
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xv | |
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Part I Basic Foundations of Normal and Abnormal Cardiac Electrical Activity |
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The Past and Promise of Basic Cardiac Electrophysiology |
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3 | (8) |
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Basic Physiology of Ion Channel Function |
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11 | (13) |
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Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form |
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24 | (13) |
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Anatomic and Histopathological Characteristics of the Conductive Tissues of the Heart |
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37 | (15) |
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Neural Regulation of the Heart in Health and Disease |
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52 | (13) |
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Mechanisms of Cardiac Arrhythmia |
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65 | (68) |
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Mechanisms of Action of Antiarrhythmic Drugs |
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133 | (12) |
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Mechanoelectrical Interactions and Their Role in Electrical Function of the Heart |
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145 | (16) |
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The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogeneis: Contribution of the Late Sodium Current |
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161 | (9) |
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Sodium Ion Channelopathies |
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170 | (17) |
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L-Type Calcium Channel Disease |
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187 | (7) |
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K+ Channelopathies (IKs and IKr) |
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194 | (13) |
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Channelopathies of Cardiac Inwardly Rectifying Potassium Channels |
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207 | (11) |
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Calcium Release Channels (Ryanodine Receptors) and Arrhythmogenesis |
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218 | (14) |
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Caveolae and Arrhythmogenesis |
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232 | (15) |
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Senescence and Arrhythmogenesis |
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247 | (14) |
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Comparisons of Substrates Responsible for Atrial Versus Ventricular Fibrillation |
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261 | (20) |
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Single Nucleotide Polymorphisms in Health and Cardiac Disease |
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281 | (9) |
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Electrophysiological Remodeling in Dilated Cardiomyopathy and Heart Failure |
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290 | (15) |
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Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy |
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305 | (11) |
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Physiological and Other Biological Pacemakers |
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316 | (15) |
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Part II Clinical Rhythmology: Diagnostic Methods and Tools |
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Diagnostic Electrocardiography |
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331 | (13) |
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Ambulatory Monitoring (Holter, Event Recorders, External, and Implantable Loop Recorders and Wireless Technology) |
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344 | (9) |
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Signal Averaged Electrocardiogram |
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353 | (12) |
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Heart Rate Variability: Measurements and Risk Stratification |
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365 | (14) |
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Surface Mapping and Magnetoelectrocardiography |
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379 | (15) |
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Microvolt T Wave Alternans: Mechanisms and Implications for Prediction of Sudden Cardiac Death |
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394 | (15) |
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Invasive Electrophysiologic Testing: Role in Sudden Death Prediction |
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409 | (15) |
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Provocative Testing in Inherited Arrhythmias |
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424 | (10) |
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Novel Predictors of Sudden Cardiac Death |
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434 | (10) |
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444 | (18) |
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Part III Heritable Cardiac Channelopathies, Primary Electrical Diseases, and Clinical Syndromes |
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Celebrating the Challenge of Cardiac Arrhythmias |
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461 | (1) |
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Congenital Long QT Syndrome |
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462 | (21) |
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Brugada Syndrome: Clinical and Genetic Aspects |
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483 | (17) |
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Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy |
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500 | (36) |
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Catecholaminergic Polymorphic Ventricular Tachycardia |
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536 | (9) |
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Andersen-Tawil and Timothy Syndromes |
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545 | (9) |
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554 | (10) |
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Progressive Cardiac Conduction Disease |
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564 | (13) |
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Familial Atrial Fibrillation and Standstill |
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577 | (11) |
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Idiopathic Ventricular Fibrillation |
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588 | (22) |
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Part IV Secondary Hereditary Electrical Diseases and Clinical Syndromes |
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607 | (3) |
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Arrhythmogenic Malignancies in Hypertrophic Cardiomyopathy |
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610 | (17) |
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Sudden Death in Dilated Cardiomyopathy and Skeletal Myopathies |
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627 | (16) |
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Ventricular Arrhythmias in Right Ventricular Dysplasia/Cardiomyopathy |
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643 | (11) |
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The Wolff-Parkinson-White Syndrome and the Risk of Sudden Death |
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654 | (23) |
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Part V Iatrongenic (Drug-Induced) Cardiac Channelopathies and Sudden Cardiac Death |
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Drug-Induced Enhanced Risk for Sudden Cardiac Death in Clinical Practice, Clinical Research, and Drug Development |
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673 | (4) |
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Pharmacogenomics in Drug Development and Clinical Research |
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677 | (14) |
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Mechanisms of Drug-Induced Cardiac Toxicity |
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691 | (14) |
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Acquired (Drug-Induced) Long QT Syndrome |
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705 | (14) |
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Acquired Form of Brugada Syndrome |
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719 | (14) |
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Part VI Treatment Modalities |
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731 | (2) |
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Clinical Role of Antiarrhythmic Drugs in the Prevention of Sudden Death |
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733 | (27) |
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Nonantiarrhythmic Drugs in Sudden Death Prevention |
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760 | (12) |
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The Implantable Cardioverter Defibrillator: Technical and Clinical Considerations |
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772 | (9) |
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Beyond Sudden Death Prevention: Minimizing Implantable Cardioverter Defibrillator Shocks and Morbidity and Optimizing Efficacy |
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781 | (20) |
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Pacing and Cardiac Resynchronization |
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801 | (8) |
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Device Therapy for Remote Patient Management |
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809 | (17) |
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Catheter Ablation of Ventricular Tachycardia and Fibrillation |
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826 | (13) |
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Surgical Treatment of Atrial Fibrillation |
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839 | (14) |
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Part VII Risk Stratification and Prevention of Sudden Cardiac Death in Acquired Clinical Conditions |
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Screening for Risk of Sudden Cardiac Death |
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851 | (2) |
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Clinical Trials in Sudden Cardiac Death Prevention: Principles and Endpoints |
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853 | (5) |
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Risk Stratification for Sudden Death in Patients with Coronary Artery Disease |
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858 | (15) |
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Heart Failure and Sudden Death |
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873 | (15) |
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Neurological Conditions and Sudden Death |
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888 | (10) |
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Obstructive Sleep Apnea and Sudden Death |
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898 | (13) |
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Sudden Cardiac Death in Athletes |
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911 | (13) |
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Sudden Cardiac Death in Infancy: Focus on Prolonged Repolarization |
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924 | (10) |
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Sudden Cardiac Death in Kidney Diseases |
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934 | (9) |
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| Index |
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943 | |
