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El. knyga: Epidemiology and Biology of Multiple Myeloma

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  • Formatas: PDF+DRM
  • Išleidimo metai: 06-Dec-2012
  • Leidėjas: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Kalba: eng
  • ISBN-13: 9783642766558
Kitos knygos pagal šią temą:
Epidemiology and Biology of Multiple MyelomaDidesnis paveikslėlis
  • Formatas: PDF+DRM
  • Išleidimo metai: 06-Dec-2012
  • Leidėjas: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Kalba: eng
  • ISBN-13: 9783642766558
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On March 27, 1990, the National Cancer Institute sponsored a workshop on the epidemiology of multiple myeloma, held at the National Institutes of Health. This book comprises articles prepared by participants in this work­ shop. Discussed in these papers are: the descriptive and analytic epidemi­ ology, differences in risk factors between blacks and whites, monoclonal gammopathies and their progression, and hypotheses regarding the etiology and pathogenesis of multiple myeloma. Several epidemiologic research areas received particular attention during this workshop, and are reviewed in detail in this volume. There have been striking increases in the incidence of multiple myeloma over the past thirty years, especially among older individuals and blacks, which may not be entirely explained by changes in diagnostic capabilities. Occupational and environmental exposures have been associated with an increased risk of multiple myeloma, including farming exposures, occupational exposure to petroleum and rubber processing, exposure to ionizing radiation, and asso­ ciations with persistent virus infections. The most striking epidemiological finding is reflected in the differences in incidence rates of multiple myeloma which are twice as high in blacks as compared with whites. Further, since 1950 the mortality rates for multiple myeloma have quadrupled in blacks while doubling for whites. Among hematopoietic malignancies, multiple myeloma is the only one with increased incidence and mortality rates among blacks. 1\vo major possibilities for explaining ethnic/racial differences in suscepti­ bility to multiple myeloma are genetic and environmental factors.

Daugiau informacijos

Springer Book Archives
Descriptive and Analytical Epidemiology of Multiple Myeloma.-
Descriptive Epidemiology of Multiple Myeloma.- Epidemiologic Studies of
Multiple Myeloma: Occupational and Radiation Effects.- Multiple Myeloma in
Iowa Farmers.- Risk of Multiple Myeloma, Allergies and Agricultural
Exposures.- Leads for Future Studies from a Case-Control Study of
Occupational Exposures and Multiple Myeloma in Denmark.- Familial and Genetic
Associations.- Black/White Differences in Risk of Multiple Myeloma.- Racial
Variations in Immune Function and Hematological Parameters: Description of
Study Design and Objectives.- The Influence of Race on T-Cell Subset
Distributions.- Investigating Risk Factors for Multiple Myeloma among Black
and White Americans.- Race and Socioeconomic Status Differences in Multiple
Myeloma Survival.- Use of Veterans Administration Data to Identify Possible
Risk Factors for Multiple Myeloma among Blacks and Whites.- Multiple Myeloma
in Sub-Sahara Africa.- Monoclonal Gammopathies and Multiple Myeloma.- Case
Definition: Issues Related to Monoclonal Gammopathies and Multiple Myeloma.-
The Frequency of Monoclonal Gammopathy of Unknown Significance in Black and
Caucasian Veterans in a Hospital Population.- Racial Differences in the
Expression of Shared Idiotypes by Paraproteins from Patients with Monoclonal
Gammopathies.- Etiologic Hypotheses.- Is Chronic Antigenic Stimulation
Etiologically Related to Multiple Myeloma?.- The Etiology of Multiple
Myeloma: A Role for Viruses?.- Clinical Studies.- Biology of Multiple Myeloma
An Overview.- Open Discussion on the Biology of Multiple Myeloma.
Chairmans Introductory Remarks.- In Vitro Studies Provide Evidence that
Multiple Paracrine Loops may be Operating in Multiple Myeloma.- The Origin of
Bone Marrow Plasma Cells.-Cytogenetic Abnormalities in Multiple Myeloma.-
Multiple Myeloma Evolves from a Malignant Hematopoietic Stem Cell.-
Amylase-Producing Multiple Myeloma.- Experimental Studies.- The C57BL/KaLwRij
Mouse Model of B-Cell Proliferative Disorders. Is there a relationship
between benign monoclonal gammapathy and multiple myeloma?.- Louvain Rats and
Their Immunocytomas.- Induced Plasmacytoma Formation in Mice.
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