Fully updated and expanded, Essentials of Clinical Radiation Oncology, 3rd Edition remains the most comprehensive and accessible clinical review for radiation oncologists, designed for optimal information retention and quick reference. Each chapter guides readers from clinical presentation to evidence-based decision-making, ensuring clarity and usability for both trainees and experienced practitioners. Chapters begin with "quick hit" summaries of each disease site, followed by high-yield coverage of epidemiology, risk factors, anatomy, pathology, genetics, screening, clinical presentation, workup, prognostic factors, staging, and medical management. Treatment paradigms outline the latest multidisciplinary standards of care including need-to-know radiation indications, prescription guidelines, and toxicities. To reinforce learning, each chapter concludes with an evidence-based question-and-answer section, summarizing key studies and practice-changing data that inform clinical decisions. Throughout the book, comprehensive tables consolidate critical information on staging, treatment options, patient selection, and clinical management for streamlined reference.
Authored by expert clinicians and residents, this trusted clinical resource replicates the structure of a "house manual" making it an essential guide for radiation oncology residents, practicing radiation oncologists, and the broader radiation therapy team. Purchase includes digital access for use on most mobile devices or computers.
Key Features:
- Logical organization structured chapters present high-yield information for focused review
- Evidence-based information presents clinical studies and data using an engaging, question and answer approach
- Essential Updates reflects the latest research and clinical advancements in radiation oncology
- Quick Reference includes comprehensive tables summarizing staging, treatment options, patient selection criteria, workup protocols, and prognostic factors by disease site
- Expanded Coverage provides new clinical guidance about stereotactic radiosurgery for spinal tumors and head and neck cancers, altered fractionation, immunotherapy, radiotherapy for recurrent genitourinary cancers, pretransplant radiotherapy for leukemias, stereotactic radiotherapy for pediatric cases, treatment of oligometastatic disease, radiotherapy for benign conditions, and more.
Contributors
Preface
About the Format of This Book
I. CENTRAL NERVOUS SYSTEM
1. Glioblastoma, IDH-Wildtype by Salem Alfaifi, Martin C. Tom, Jennifer S.
Yu, and Samuel T. Chao
2. IDH-Mutant Gliomas: Grade 3 by Salem Alfaifi, Shireen Parsai, Jennifer S.
Yu, Samuel T. Chao, and Martin C. Tom
3. Low Grade Gliomas by Adannia N. Ufondu, Erik M. Davies, Martin C. Tom, and
Erin S. Murphy
4. Meningioma by Anirudh Bommireddy, Abigail L. Stockham, Martin C. Tom, and
Jennifer S. Yu
5. Primary Central Nervous System Lymphoma by Sean M. Parker, Erin S. Murphy,
and Samuel T. Chao
6. Pituitary Neuroendocrine Tumor by Bryn Myers, John H. Suh, and Praveen
Pendyala
7. Trigeminal Neuralgia by Jana M. Kobeissi and Samuel T. Chao
8. Vestibular Schwannoma by Elizabeth E. Obi, Jeffrey A. Kittel, John H. Suh,
and Praveen Pendyala
9. Uveal Melanoma by Bryn Myers, Gaurav Marwaha, John H. Suh, and Arun D.
Singh
10. Spine Tumors by Elizabeth E. Obi, Sarah S. Kilic, Ehsan H. Balagamwala,
and Samuel T. Chao
II. HEAD AND NECK
11. Oropharynx Cancer by Zachary S. Mayo, Shireen Parsai, Aditya Juloori, and
Jacob A. Miller
12. Oral Cavity Cancer by Adannia N. Ufondu, Kailin Yang, Bindu V. Manyam,
and Neil M. Woody
13. Nasopharyngeal Cancer by Erik M. Davies, Christopher W. Fleming, Nikhil
P. Joshi, and Jacob A. Miller
14. Laryngeal Cancer by David S. Buchberger, Aditya Juloori, and Shauna R.
Campbell
15. Salivary Gland Tumors by Jenna E. Kocsis, Sarah S. Kilic, and Shlomo A.
Koyfman
16. Carcinoma of Unknown Primary of the Head and Neck by Jana M. Kobeissi,
Monica E. Shukla, Jeffrey A. Kittel, and Shauna R. Campbell
17. Postoperative Radiation for Head and Neck Cancer by Bryn M. Myers,
Timothy D. Smile, Carryn M. Anderson, and Jacob A. Miller
18. Thyroid Cancer by David S. Buchberger, Nikhil P. Joshi, and Neil M.
Woody
19. Sinonasal Tumors by Katherine R. Amarell, Timothy D. Smile, and Jacob A.
Miller
III. SKIN
20. Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma by Bryn M.
Myers, Timothy D. Smile, Nikhil P. Joshi, Neil M. Woody, and Shlomo A.
Koyfman
21. Merkel Cell Carcinoma by Katherine R. Amarell, Ian Winter, Nikhil P.
Joshi, and Shlomo A. Koyfman
22. Malignant Cutaneous Melanoma by Cole Billena, Sarah S. Kilic, Nikhil P.
Joshi, and Neil M. Woody
23. Mycosis Fungoides by Anirudh Bommireddy, Matthew C. Ward, and Gregory M.
M. Videtic
IV. BREAST
24. Early-Stage Breast Cancer by Katherine R. Amarell, Kailin Yang, Rahul D.
Tendulkar, and Chirag S. Shah
25. Locally Advanced Breast Cancer by Adannia N. Ufondu, Yvonne D. Pham,
Rahul D. Tendulkar, and Chirag S. Shah
26. Ductal Carcinoma In Situ by Sean M. Parker, Timothy D. Smile, Rahul D.
Tendulkar, and Chirag S. Shah
27. Recurrent Breast Cancer by Zachary S. Mayo and Chirag S. Shah
V. THORACIC
28. Early-Stage NonSmall-Cell Lung Cancer by Salem Alfaifi, Gaurav Marwaha,
Kevin L. Stephans, and Gregory M. M. Videtic
29. Stage III NonSmall-Cell Lung Cancer by Jenna E. Kocsis, Aditya Juloori,
Kevin L. Stephans, and Gregory M. M. Videtic
30. Small-Cell Lung Cancer by Anirudh Bommireddy and Gregory M. M. Videtic
31. Mesothelioma by David S. Buchberger and Gregory M. M. Videtic
32. Thymoma by Cole Billena, Christopher W. Fleming, and Gregory M. M.
Videtic
VI. GASTROINTENTINAL
33. Esophageal Cancer by Sean Parker, Ehsan Balagamwala, and Gregory M. M.
Videtic
34. Gastric Cancer by Ahmed Halima, Kevin L. Stephans, and Gregory M. M.
Videtic
35. Hepatocellular Carcinoma by Erik M. Davies and Kevin L. Stephans
36. Pancreatic Adenocarcinoma by Ahmed Halima, James R. Broughman, Jacob A.
Miller and Ehsan H. Balagamwala
37. Rectal Cancer by David S. Buchberger, Ian W. Winter, Jacob A. Miller, and
Sudha R. Amarnath
38. Anal Cancer by Katherine R. Amarell, Jacob A. Miller, and Sudha R.
Amarnath
39. Cholangiocarcinoma by Winston Vuong, Christopher W. Fleming, and Kevin L.
Stephans
VII. GENITOURINARY
40. Low-Risk Prostate Cancer by Zachary S. Mayo, Timothy D. Smile, Omar Y.
Mian, and Rahul D. Tendulkar
41. Intermediate- and High-Risk Prostate Cancer by Cole Billena, Omar Y.
Mian, and Rahul D. Tendulkar
42. Post-Prostatectomy Radiation Therapy by Sean M. Parker, James R.
Broughman, Omar Y. Mian, and Rahul D. Tendulkar
43. Bladder Cancer by Winston Vuong, Erik M. Davies, Omar Y. Mian, and Rahul
D. Tendulkar
44. Testicular Cancer by Zachary S. Mayo, Omar Y. Mian, and Rahul D.
Tendulkar
45. Penile Cancer by Cole Billena, Rahul D. Tendulkar, and Omar Y. Mian
46. Urethral Cancer by Winston Vuong, Rahul D. Tendulkar, and Omar Y. Mian
47. Renal Cell Carcinoma by Salem Alfaifi, Omar Y. Mian, and Rahul D.
Tendulkar
VIII. GYNECOLOGIC
48. Cervical Cancer by Adannia N. Ufondu, Sheen Cherian, and Sudha R.
Amarnath
49. Uterine Cancer: Endometrial Cancer and Uterine Sarcoma by David S.
Buchberger, Sarah M. C. Sittenfeld, Sheen Cherian, and Sudha R. Amarnath
50. Vulvar Cancer by Jana M. Kobeissi, Sheen Cherian, and Sudha R. Amarnath
51. Vaginal Cancer by Erik M. Davies, Sheen Cherian, and Sudha R. Amarnath
IX. HEMATOLOGIC
52. Adult Hodgkin's Lymphoma by Sean M. Parker, Matthew C. Ward and Sheen
Cherian
53. Aggressive Non-Hodgkin's Lymphoma by Anirudh Bommireddy, Chirag S. Shah,
and Sheen Cherian
54. Indolent Non-Hodgkin's Lymphoma by Jenna E. Kocsis, Aryavarta M. S.
Kumar, and Christopher W. Fleming
55. Multiple Myeloma and Plasmacytoma by Anirudh Bommireddy, Kailin Yang and
Sheen Cherian
56. Leukemia by Erik M. Davies, Erin S. Murphy, and Sheen Cherian
X. SARCOMAS
57. Soft Tissue Sarcoma by Anirudh Bommireddy, Jacob G. Scott, and Shauna R.
Campbell
XI. PEDIATRIC
58. Medulloblastoma by Adannia N. Ufondu and Erin S. Murphy
59. Ependymoma by Adannia N. Ufondu, John H. Suh, and Erin S. Murphy
60. Brainstem Glioma by Jenna E. Kocsis, Jason W. D. Hearn, and John H. Suh
61. Craniopharyngioma by Zachary S. Mayo, Timothy D. Smile, and Martin C.
Tom
62. Rhabdomyosarcoma by Cole Billena, Shauna R. Campbell, and Erin S. Murphy
63. Neuroblastoma by Salem Alfaifi, Praveen Pendyala, and Erin S. Murphy
64. Wilms Tumor by Salem Alfaifi, Praveen Pendyala, and Erin S. Murphy
65. Ewings Sarcoma by Jenna E. Kocsis, Shauna R. Campbell, and Erin S.
Murphy
66. Pediatric Hodgkin's Lymphoma by Katherine R. Amarell, Sarah M. C.
Sittenfeld, and Erin S. Murphy
67. Miscellaneous CNS Pediatric Tumors by Katherine R. Amarell, Praveen
Pendyala, and Erin S. Murphy
XII. METASTASES AND PALLIATIVE RADIOTHERAPY
68. Brain Metastases by Winston Vuong, Martin C. Tom, and John H. Suh
69. Bone and Spine Metastasis by Sean M. Parker, Ehsan H. Balagamwala, Samuel
T. Chao, and Andrew D. Vassil
70. Malignant Spinal Cord Compression by Cole Billena and Samuel T. Chao
71. Superior Vena Cava Syndrome by Anirudh Bommireddy and Gregory M. M.
Videtic
72. Palliative Radiotherapy by David S. Buchberger, Matthew C. Ward, and
Andrew Vassil
73. Oligometastatic Disease by Salem Alfaifi, Ian W. Winter, Martin C. Tom,
Rahul D. Tendulkar, and Ehsan H. Balagamwala
XIII. BENIGN DISEASES
74. Radiation Therapy for Benign Diseases by Ahmed Halima, Rahul D.
Tendulkar, and Chirag S. Shah
Abbreviations
Index
Jenna E. Kocsis, MD, Lead Resident, Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio
Sarah M. C. Sittenfeld, MD, Assistant Professor, Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio
Matthew C. Ward, MD, Adjunct Assistant Professor, Department of Radiation Oncology, Levine Cancer Institute, Atrium Health, Charlotte, North Carolina
Rahul D. Tendulkar, MD FASTRO, Professor, Cleveland Clinic Lerner College of Medicine; Staff Physician, Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio
Gregory M. M. Videtic, MD, CM, FRCPC, Professor of Medicine, Cleveland Clinic Lerner College of Medicine; Staff Physician, Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio
