| Introduction to Pathophysiology |
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xix | |
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Unit 1 Cell and Tissue Function |
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1 | (158) |
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Chapter 1 Cell Structure and Function |
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1 | (32) |
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Functional Components of the Cell |
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1 | (8) |
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Cell Metabolism and Energy Storage |
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9 | (3) |
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Integration of Cell Function |
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12 | (8) |
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20 | (13) |
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Chapter 2 Cellular Responses to Stress, Injury, and Aging |
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33 | (18) |
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Cellular Responses to Persistent Stress |
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33 | (5) |
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Cell Injury, Death, and Senescence |
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38 | (13) |
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Chapter 3 Inflammation, the Inflammatory Response, and Fever |
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51 | (22) |
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General Features of Inflammation |
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51 | (4) |
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55 | (8) |
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63 | (1) |
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Systemic Manifestations of Inflammation |
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64 | (9) |
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Chapter 4 Cell Proliferation and Tissue Regeneration and Repair |
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73 | (16) |
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Cell Proliferation and Tissue Regeneration |
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73 | (7) |
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Healing by Connective Tissue Repair |
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80 | (9) |
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Chapter 5 Genetic Control of Cell Function and Inheritance |
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89 | (20) |
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Genetic Control of Cell Function |
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89 | (8) |
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97 | (3) |
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100 | (3) |
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103 | (6) |
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Chapter 6 Genetic and Congenital Disorders |
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109 | (22) |
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Genetic and Congenital Disorders |
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Genetic and Chromosomal Disorders |
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109 | (14) |
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Disorders Due to Environmental Influences |
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123 | (3) |
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Prenatal Screening and Diagnosis |
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126 | (5) |
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131 | (28) |
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Characteristics of Benign and Malignant Neoplasms |
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131 | (8) |
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139 | (7) |
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146 | (2) |
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Screening, Diagnosis, and Treatment |
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148 | (6) |
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154 | (5) |
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Unit 2 Integrative Body Functions |
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159 | (84) |
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Chapter 8 Disorders of Fluid, Electrolyte, and Acid-Base Balance |
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159 | (50) |
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Composition and Compartmental Distribution of Body Fluids |
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159 | (8) |
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167 | (11) |
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178 | (5) |
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Calcium and Magnesium Balance |
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183 | (9) |
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192 | (17) |
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Chapter 9 Stress and Adaptation |
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209 | (15) |
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209 | (9) |
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Disorders of the Stress Response |
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218 | (6) |
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Chapter 10 Disorders of Nutritional Status |
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224 | (19) |
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Energy Metabolism and Nutritional Status |
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224 | (7) |
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231 | (4) |
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Undernutrition and Eating Disorders |
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235 | (8) |
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Unit 3 Hematopoietic Function |
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243 | (56) |
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Chapter 11 Disorders of White Blood Cells and Lymphoid Tissues |
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243 | (20) |
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Hematopoietic and Lymphoid Tissues |
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243 | (5) |
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Nonneoplastic Disorders of White Blood Cells |
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248 | (3) |
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Neoplastic Disorders of Hematopoietic and Lymphoid Origin |
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251 | (12) |
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Chapter 12 Disorders of Hemostasis |
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263 | (16) |
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Hemostasis and Blood Coagulation |
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263 | (6) |
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Hypercoagulability States |
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269 | (2) |
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271 | (8) |
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Chapter 13 Disorders of Red Blood Cells |
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279 | (20) |
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279 | (5) |
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284 | (9) |
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293 | (1) |
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Age-Related Changes in Red Blood Cells |
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293 | (6) |
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Unit 4 Infection and Immunity |
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299 | (78) |
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Chapter 14 Mechanisms of Infectious Disease |
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299 | (20) |
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299 | (8) |
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Epidemiology of Infectious Diseases |
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307 | (5) |
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312 | (4) |
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New and Emerging Infectious Diseases |
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316 | (3) |
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Chapter 15 Innate and Adaptive Immunity |
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319 | (26) |
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Introduction to the Immune System |
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319 | (7) |
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326 | (6) |
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332 | (10) |
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Developmental Aspects of the Immune System |
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342 | (3) |
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Chapter 16 Disorders of the Immune Response |
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345 | (32) |
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Hypersensitivity Disorders |
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345 | (8) |
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Transplantation Immunopathology |
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353 | (2) |
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355 | (4) |
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Immunodeficiency Disorders |
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359 | (18) |
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Unit 5 Circulatory Function |
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377 | (136) |
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Chapter 17 Control of Cardiovascular Function |
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377 | (28) |
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Organization of the Circulatory System |
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377 | (3) |
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380 | (4) |
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384 | (12) |
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The Systemic Circulation and Control of Blood Flow |
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396 | (6) |
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Neural Control of Circulatory Function |
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402 | (3) |
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Chapter 18 Disorders of Blood Flow and Blood Pressure |
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405 | (42) |
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Blood Vessel Structure and Function |
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405 | (2) |
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Disorders of the Arterial Circulation |
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407 | (15) |
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Disorders of Arterial Blood Pressure |
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422 | (17) |
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Disorders of the Venous Circulation |
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439 | (8) |
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Chapter 19 Disorders of Cardiac Function |
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447 | (39) |
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Disorders of the Pericardium |
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447 | (3) |
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450 | (11) |
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461 | (5) |
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Endocardial and Valvular Disorders |
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466 | (8) |
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Heart Disease in Infants and Children |
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474 | (12) |
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Chapter 20 Heart Failure and Circulatory Shock |
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486 | (27) |
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486 | (13) |
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Circulatory Failure (Shock) |
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499 | (9) |
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Heart Failure in Children and the Elderly |
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508 | (5) |
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Unit 6 Respiratory Function |
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513 | (88) |
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Chapter 21 Control of Respiratory Function |
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513 | (27) |
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Structural Organization of the Respiratory System |
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513 | (7) |
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Exchange of Gases Between the Atmosphere and the Lungs |
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520 | (8) |
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Exchange and Transport of Gases |
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528 | (8) |
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536 | (4) |
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Chapter 22 Respiratory Tract Infections, Neoplasms, and Childhood Disorders |
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540 | (26) |
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Respiratory Tract Infections |
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540 | (14) |
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554 | (3) |
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Respiratory Disorders in Children |
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557 | (9) |
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Chapter 23 Disorders of Ventilation and Gas Exchange |
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566 | (35) |
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Physiologic Effects of Ventilation and Diffusion Disorders |
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566 | (3) |
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Disorders of Lung Inflation |
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569 | (4) |
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Obstructive Airway Disorders |
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573 | (13) |
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Interstitial Lung Diseases |
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586 | (3) |
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Disorders of the Pulmonary Circulation |
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589 | (4) |
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Acute Respiratory Disorders |
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593 | (8) |
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Unit 7 Kidney and Urinary Tract Function |
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601 | (78) |
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Chapter 24 Structure and Function of the Kidney |
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601 | (19) |
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Kidney Structure and Function |
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601 | (15) |
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616 | (4) |
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Chapter 25 Disorders of Renal Function |
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620 | (21) |
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Disorders of Glomerular Function |
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620 | (7) |
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Tubulointerstitial Disorders |
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627 | (3) |
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Cystic Diseases of the Kidney |
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630 | (3) |
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633 | (4) |
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Malignant Tumors of the Kidney |
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637 | (4) |
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Chapter 26 Acute Renal Failure and Chronic Kidney Disease |
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641 | (18) |
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641 | (4) |
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645 | (10) |
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Chronic Kidney in Children and Elderly Persons |
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655 | (4) |
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Chapter 27 Disorders of the Bladder and Lower Urinary Tract |
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659 | (20) |
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Control of Urine Elimination |
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659 | (4) |
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Disorders of Bladder Structure and Function |
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663 | (8) |
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671 | (4) |
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675 | (4) |
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Unit 8 Gastrointestinal and Hepatobiliary Function |
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679 | (82) |
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Chapter 28 Structure and Function of the Gastrointestinal System |
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679 | (21) |
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Structure and Organization of the Gastrointestinal Tract |
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679 | (5) |
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684 | (6) |
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Hormonal, Secretory, and Microflora Functions |
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690 | (4) |
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694 | (3) |
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Anorexia, Nausea, and Vomiting |
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697 | (3) |
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Chapter 29 Disorders of Gastrointestinal Function |
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700 | (29) |
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Disorders of the Esophagus |
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700 | (5) |
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705 | (5) |
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Disorders of the Small and Large Intestines |
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710 | (19) |
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Chapter 30 Disorders of Hepatobiliary and Exocrine Pancreas Function |
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729 | (32) |
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The Liver and Hepatobiliary System |
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729 | (8) |
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Disorders of Hepatic and Biliary Function |
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737 | (15) |
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Disorders of the Gallbladder and Exocrine Pancreas |
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752 | (9) |
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761 | (68) |
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Chapter 31 Mechanisms of Endocrine Control |
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761 | (13) |
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761 | (13) |
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Chapter 32 Disorders of Endocrine Control of Growth and Metabolism |
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774 | (25) |
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General Aspects of Altered Endocrine Function |
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774 | (1) |
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Pituitary and Growth Disorders |
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775 | (7) |
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782 | (8) |
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Disorders of Adrenal Cortical Function |
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790 | (9) |
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Chapter 33 Diabetes Mellitus and the Metabolic Syndrome |
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799 | (30) |
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Hormonal Control of Nutrient Metabolism and Storage |
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799 | (6) |
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805 | (24) |
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829 | (180) |
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Chapter 34 Organization and Control of Neural Function |
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829 | (34) |
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829 | (4) |
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833 | (4) |
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Developmental Organization of the Nervous System |
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837 | (8) |
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845 | (10) |
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The Autonomic Nervous System |
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855 | (8) |
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Chapter 35 Somatosensory Function, Pain, and Headache |
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863 | (28) |
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Organization and Control of Somatosensory Function |
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863 | (7) |
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870 | (10) |
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Alterations in Pain Sensitivity and Special Types of Pain |
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880 | (3) |
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Headache and Associated Pain |
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883 | (3) |
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Pain in Children and Older Adults |
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886 | (5) |
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Chapter 36 Disorders of Neuromuscular Function |
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891 | (36) |
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Organization and Control of Motor Function |
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891 | (8) |
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Disorders of the Motor Unit |
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899 | (9) |
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Disorders of the Cerebellum and Basal Ganglia |
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908 | (5) |
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Upper Motor Neuron Disorders |
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913 | (14) |
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Chapter 37 Disorders of Brain Function |
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927 | (39) |
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Mechanisms and Manifestations of Brain Injury |
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927 | (14) |
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941 | (10) |
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Infections and Brain Tumors |
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951 | (4) |
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955 | (4) |
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Disorders of Memory and Cognition |
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959 | (7) |
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Chapter 38 Disorders of Special Sensory Function: Vision, Hearing, and Vestibular Function |
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966 | (43) |
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The Eye and Disorders of Vision |
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966 | (22) |
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The Ear and Disorders of Auditory Function |
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988 | (12) |
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The Vestibular System and Disorders of Equilibrium |
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1000 | (9) |
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Unit 11 Genitourinary and Reproductive Function |
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1009 | (72) |
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Chapter 39 Disorders of the Male Genitourinary System |
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1009 | (24) |
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Physiologic Basis of Male Reproductive Function |
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1009 | (7) |
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Disorders of the Penis, the Scrotum and Testes, and the Prostate |
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1016 | (12) |
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Disorders in Childhood and Aging Changes |
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1028 | (5) |
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Chapter 40 Disorders of the Female Genitourinary System |
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1033 | (34) |
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Structure and Function of the Female Reproductive System |
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1033 | (8) |
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Disorders of the Female Reproductive Organs |
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1041 | (14) |
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1055 | (4) |
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1059 | (8) |
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Chapter 41 Sexually Transmitted Infections |
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1067 | (14) |
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Infections of the External Genitalia |
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1068 | (4) |
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1072 | (2) |
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Vaginal-Urogenital-Systemic Infections |
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1074 | (7) |
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Unit 12 Musculoskeletal Function |
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1081 | (78) |
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Chapter 42 Structure and Function of the Skeletal System |
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1081 | (15) |
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Structures of the Skeletal System |
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1081 | (11) |
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1092 | (4) |
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Chapter 43 Disorders of the Skeletal System: Trauma, Infections, Neoplasms, and Childhood Disorders |
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1096 | (34) |
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Injury and Trauma of Musculoskeletal Structures |
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1096 | (13) |
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Bone Infections and Osteonecrosis |
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1109 | (4) |
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1113 | (3) |
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Skeletal Disorders in Children |
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1116 | (14) |
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Chapter 44 Disorders of the Skeletal System: Metabolic and Rheumatic Disorders |
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1130 | (29) |
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1130 | (8) |
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1138 | (15) |
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Rheumatic Diseases in Children and the Elderly |
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1153 | (6) |
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Unit 13 Integumentary Function |
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1159 | (48) |
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Chapter 45 Structure and Function of the Skin |
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1159 | (13) |
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Structure and Function of the Skin |
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1159 | (7) |
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Manifestations of Skin Disorders |
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1166 | (6) |
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Chapter 46 Disorders of Skin Integrity and Function |
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1172 | (35) |
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Primary Disorders of the Skin |
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1172 | (16) |
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Ultraviolet Radiation, Thermal, and Pressure Injury |
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1188 | (6) |
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1194 | (4) |
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Age-Related Skin Manifestations |
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1198 | (9) |
| Glossary |
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1207 | (10) |
| Appendix A Laboratory Values |
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1217 | (2) |
| Index |
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1219 | |
