I. Characterization of the Multipotential Stem Cell (CFU-s).-
1. The
Appearance of the Multipotential Hemopoietic Stem Cell.- The spleen colony
assay of rat HSC.- Concentration and identification of rat HSC.- Summary.-
Acknowledgments.- References.-
2. An Immunologic Approach to Cell Cycle
Analysis of the Stem Cell.- Materials and methods.- Results.- Discussion.-
Summary.- Acknowledgments.- References.-
3. Physical Separation of the
Cycling and Noncycling Compartments of Murine Hemopoietic Stem Cells.-
Theory.- Materials and methods.- Results and discussion.- Summary.-
Acknowledgments.- References.-
4. Characterization of Bone Marrow and Lymph
Node Repopulating Cells by Transplanting Mononuclear Cells into Radiated
Dogs.- Experimental approach.- Results.- Discussion.- Summary.-
Acknowledgments.- References.- II. Humoral and Cellular Control Agents.-
5.
Concepts and Observations on the Regulation of Granulocyte Production.-
Materials and methods.- Results.- Summary.- Acknowledgment.- References.-
6.
The Regulatory Role of the Macrophage in Normal and Neoplastic Hemopoiesis.-
Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.-
References.-
7. Humoral Regulation of Eosinophil Granulocytopoiesis.-
Eosinophil granulocytopoiesis: A model system.- Production of humoral
factor(s) in vitro.- Summary.- Acknowledgments.- References.-
8. Studies of
the Erythroid Inductive Microenvironment in Vitro.- Materials and methods.-
Results.- Discussion.- Summary.- Acknowledgments.- References.-
9. In Vivo
Colony Forming Unit Population Sizes in Hypertransfused Sl/Sld Mice.-
Methods.- Results.- Discussion.- Summary.- References.- III. Physiology of
Committed Stem Cells (CFU-e and CFU-m).-
10. Recognition of Hemopoietic
Progenitors.- Summary.- References.-
11. Relationships between Early
Hemopoietic Progenitor Cells Determined by Correlation Analysis of Their
Numbers in Individual Spleen Colonies.- Experimental.- Results.- Discussion.-
Summary.- Acknowledgments.- References.-
12. Some Characteristics of in Vitro
Erythroid Colony and Burst-Forming Units.- Methods and materials.- Results.-
Discussion.- Summary.- Acknowledgments.- References.-
13. Colony-Forming
Unit, Megakaryocyte (CFU-m): Its Use in Elucidating the Kinetics and Humoral
Control of the Megakaryocytic Committed Progenitor Cell Compartment.-
Materials and methods.- Results.- Discussion.- Summary.- Acknowledgment.-
References.- IV. Physiology of Committed Stem Cells (CFU-c).-
14. Negative
and Positive Feedback Control of the Committed Granulocytic Stem Cell
Compartment.- Physiologic control of the CFU-c.- Positive feedback system for
CFU-c regulation.- Negative feedback system for CFU-c control.- Possible
interaction of the two feedback systems in the regulation of the CFU-c
compartment.- Summary.- References.-
15. Colony-Stimulating Factor and the
Differentiation of Granulocytes and Macrophages.- Materials and methods.-
Results.- Discussion.- Summary.- Acknowledgments.- References.-
16.
Characteristics of the in Vitro Monocyte-Macrophage Colony-Forming Cells
Detected within Mouse Thymus and Lymph Nodes.- Materials and methods.-
Results.- Discussion.- Summary.- Acknowledgments.- References.-
17. Physical
Characterization of a Subpopulation of Granulocyte/Monocyte Progenitor Cells
(CFU-c).- Materials and methods.- Results.- Discussion.- Summary.-
Acknowledgments.- References.-
18. Cell-Factor Interaction in Populations of
Normal and Leukemic Blood Cells.- Results.- Discussion.- Summary.-
Acknowledgments.- References.- V. Bone Marrow Transplantation Immunology.-
19. Bone Marrow Transplantation Immunology.- Summary.- Acknowledgments.-
References.-
20. Modulation of Graft-versus-Host (GvH) Disease in the Rat;
Effect of Hydroxyurea on the Mixed Lymphocyte Reaction and Graft-versus-Host
Reactivity.- Materials and methods.- Results.- Discussion.- Summary.-
Acknowledgments.- References.-
21. Mechanism of Donor to Host Tolerance in
Rat Bone Marrow Chimeras.- Materials and methods.- Results.- Discussion.-
Summary.- Acknowledgment.- References.-
22. Effects of a Cell-Free Helper
Factor(s) on the Kinetics of T-Cell Responses to Histocompatibility
Antigens.- Materials and methods.- Results.- Discussion.- Summary.-
Acknowledgment.- References.- VI. Experimental Models of Clinical Conditions
in Hematology.-
23. The E(AkR)-Leukemia as Murine Model of Human Acute
Lymphoid Leukemia for Immunotherapy Trials.- Summary.- References.-
24.
Experimental Chemotherapy: A Rat Model for Human Acute Myeloid Leukemia.-
Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.-
References.-
25. Serum Colony Stimulating Factor: A Marker for
Graft-versus-Host Disease in Humans.- Methods.- Results.- Discussion.-
Summary.- Acknowledgments.- Appendix: Case histories.- References.-
26.
Changes in Human Bone Marrow Colony-Forming Cells following Chemotherapy
Using an Agar Diffusion-Chamber Technique.- Methods.- Results.- Discussion.-
Summary.- Acknowledgments.- References.-
27. Graft-versus-Leukemia, Donor
Selection for Adoptive Immunotherapy in Mice.- Materials and methods.-
Results.- Discussion.- Summary.- Acknowledgments.- References.
